HUE044769T2 - Aminoszteroidok PTP1B-vel összefüggõ betegségek kezelésére - Google Patents
Aminoszteroidok PTP1B-vel összefüggõ betegségek kezeléséreInfo
- Publication number
- HUE044769T2 HUE044769T2 HUE13721176A HUE044769T2 HU E044769 T2 HUE044769 T2 HU E044769T2 HU E13721176 A HUE13721176 A HU E13721176A HU E044769 T2 HUE044769 T2 HU E044769T2
- Authority
- HU
- Hungary
- Prior art keywords
- aminosteroids
- treatment
- associated disease
- ptp1b
- ptp1b associated
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636252P | 2012-04-20 | 2012-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE044769T2 true HUE044769T2 (hu) | 2019-11-28 |
Family
ID=48325893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13721176 HUE044769T2 (hu) | 2012-04-20 | 2013-04-19 | Aminoszteroidok PTP1B-vel összefüggõ betegségek kezelésére |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US9546194B2 (enExample) |
| EP (2) | EP3556765B1 (enExample) |
| JP (4) | JP6165843B2 (enExample) |
| KR (3) | KR102057812B1 (enExample) |
| AU (3) | AU2013249111B2 (enExample) |
| CA (1) | CA2870671C (enExample) |
| DK (1) | DK2838907T3 (enExample) |
| ES (1) | ES2736310T3 (enExample) |
| HR (1) | HRP20191348T1 (enExample) |
| HU (1) | HUE044769T2 (enExample) |
| MX (2) | MX367255B (enExample) |
| PL (1) | PL2838907T3 (enExample) |
| PT (1) | PT2838907T (enExample) |
| TR (1) | TR201911039T4 (enExample) |
| WO (1) | WO2013158970A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6165843B2 (ja) | 2012-04-20 | 2017-07-19 | オーエイチアール・ファーマシューティカル・インコーポレイテッドＯｈｒ Ｐｈａｒｍａｃｅｕｔｉｃａｌ，Ｉｎｃ． | Ｐｔｐ１ｂ関連疾患の処置のためのアミノステロイド化合物 |
| US10040817B2 (en) | 2013-10-03 | 2018-08-07 | Enterin Laboratories, Inc. | Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same |
| GB201700567D0 (en) | 2017-01-12 | 2017-03-01 | Genagon Therapeutics Ab | Therapeutic agents |
| US11083735B2 (en) | 2017-09-08 | 2021-08-10 | Enterin, Inc. | Methods for treating sleep disorders, sleep disturbances, and related symptoms using aminosterol compositions |
| CN107802626B (zh) * | 2017-10-11 | 2020-01-21 | 南昌大学 | 降血糖组合物及其制备方法、用途 |
| AU2018360845B2 (en) * | 2017-11-06 | 2024-05-02 | Cold Spring Harbor Laboratory | Method and compositions for forming a copper-containing complex and uses thereof |
| CN112312917A (zh) * | 2018-03-27 | 2021-02-02 | 因特尔公司 | 用于治疗幻觉及其相关病症的方法和组合物 |
| CN112867728B (zh) * | 2018-07-20 | 2024-04-05 | 冷泉港实验室 | 与铜螯合的(吡啶基亚甲基)丁二胺衍生物 |
| JP2022543244A (ja) * | 2019-08-02 | 2022-10-11 | エンターイン、 インコーポレイテッド | ヒトスクアラミン誘導体、それを含む関連組成物、およびそれを用いた方法 |
| CN114929724B (zh) * | 2019-08-02 | 2024-12-10 | 因特尔公司 | 氨基固醇ent-03化合物、包含其的相关组合物以及其使用方法 |
| WO2023230593A1 (en) | 2022-05-27 | 2023-11-30 | Cold Spring Harbor Laboratory | Ptp1b inhibitors for treating lung injury |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2403683A (en) * | 1942-04-25 | 1946-07-09 | Relchstein Tadeus | Compounds of the cyclopentanopolyhydrophenanthrene series and process of making same |
| US3636210A (en) * | 1968-02-02 | 1972-01-18 | Merck & Co Inc | Cholanic acid and cholenic acid compositions and method of treatment |
| IT1255450B (it) * | 1992-06-30 | 1995-10-31 | Montefarmaco Spa | Uso di acidi biliari come agenti antivirali |
| AU6392894A (en) * | 1993-02-26 | 1994-09-14 | Magainin Pharmaceuticals, Inc. | Chemical synthesis of squalamine |
| ATE169930T1 (de) * | 1993-03-10 | 1998-09-15 | Magainin Pharma | Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel |
| US5856535A (en) | 1994-08-18 | 1999-01-05 | Magainin Pharmaceuticals, Inc. | Aminosterol ester compounds |
| US5792635A (en) * | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
| PT832094E (pt) * | 1995-06-07 | 2004-06-30 | Genaera Corp | Compostos de aminoesterol uteis como inibidores do permutador sodio/protao )nhe) metodos e composicoes farmaceuticas empregando estes inibidores e processos para avaliacao da eficacia inibidora de nhe dos compostos |
| US7410959B1 (en) * | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
| EP1214060A2 (en) | 1999-09-10 | 2002-06-19 | Novo Nordisk A/S | Method of inhibiting protein tyrosine phosphatase 1b and/or t-cell protein tyrosine phosphatase and/or other ptpases with an asp residue at position 48 |
| ATE309250T1 (de) | 1999-09-10 | 2005-11-15 | Novo Nordisk As | Modulatoren der protein tyrosin phosphatase (ptpases) |
| WO2001019830A1 (en) | 1999-09-10 | 2001-03-22 | Novo Nordisk A/S | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) |
| AU784795B2 (en) * | 1999-12-09 | 2006-06-22 | Genaera Corporation | Asthma associated factors as targets for treating atopic allergies including asthma and related disorders |
| AU2003292939A1 (en) * | 2002-12-24 | 2004-07-22 | The University Of British Columbia | Angiogenic compounds and uses thereof |
| JP2006165843A (ja) * | 2004-12-06 | 2006-06-22 | Matsushita Electric Ind Co Ltd | 画像処理装置 |
| JP2009534391A (ja) * | 2006-04-21 | 2009-09-24 | ジェネーラ・コーポレーション | 体重減少の誘発およびｐｔｐ１ｂの選択的阻害 |
| WO2009032321A2 (en) * | 2007-09-06 | 2009-03-12 | Genaera Corporation | A method for treating diabetes |
| KR101260221B1 (ko) * | 2011-12-01 | 2013-05-06 | 주식회사 엘지화학 | 마스크 |
| JP6165843B2 (ja) * | 2012-04-20 | 2017-07-19 | オーエイチアール・ファーマシューティカル・インコーポレイテッドＯｈｒ Ｐｈａｒｍａｃｅｕｔｉｃａｌ，Ｉｎｃ． | Ｐｔｐ１ｂ関連疾患の処置のためのアミノステロイド化合物 |
-
2013
- 2013-04-19 JP JP2015507213A patent/JP6165843B2/ja active Active
- 2013-04-19 WO PCT/US2013/037330 patent/WO2013158970A2/en not_active Ceased
- 2013-04-19 KR KR1020197008179A patent/KR102057812B1/ko active Active
- 2013-04-19 PL PL13721176T patent/PL2838907T3/pl unknown
- 2013-04-19 EP EP19175554.5A patent/EP3556765B1/en active Active
- 2013-04-19 TR TR2019/11039T patent/TR201911039T4/tr unknown
- 2013-04-19 DK DK13721176.9T patent/DK2838907T3/da active
- 2013-04-19 AU AU2013249111A patent/AU2013249111B2/en active Active
- 2013-04-19 KR KR1020167019758A patent/KR101963312B1/ko not_active Expired - Fee Related
- 2013-04-19 MX MX2014012619A patent/MX367255B/es active IP Right Grant
- 2013-04-19 EP EP13721176.9A patent/EP2838907B1/en active Active
- 2013-04-19 KR KR1020147031485A patent/KR20150003798A/ko not_active Ceased
- 2013-04-19 HR HRP20191348TT patent/HRP20191348T1/hr unknown
- 2013-04-19 HU HUE13721176 patent/HUE044769T2/hu unknown
- 2013-04-19 ES ES13721176T patent/ES2736310T3/es active Active
- 2013-04-19 US US14/394,789 patent/US9546194B2/en active Active
- 2013-04-19 PT PT13721176T patent/PT2838907T/pt unknown
- 2013-04-19 CA CA2870671A patent/CA2870671C/en active Active
-
2014
- 2014-10-17 MX MX2019009539A patent/MX2019009539A/es unknown
-
2016
- 2016-10-06 US US15/286,646 patent/US20170129914A1/en not_active Abandoned
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2017
- 2017-05-02 JP JP2017091568A patent/JP6457010B2/ja active Active
-
2018
- 2018-10-31 AU AU2018256561A patent/AU2018256561B2/en active Active
- 2018-12-19 JP JP2018237492A patent/JP2019059781A/ja not_active Withdrawn
-
2019
- 2019-03-12 US US16/299,872 patent/US10556923B2/en active Active
-
2020
- 2020-01-30 US US16/777,253 patent/US11434257B2/en active Active
- 2020-06-05 AU AU2020203736A patent/AU2020203736B2/en active Active
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2021
- 2021-01-25 JP JP2021009651A patent/JP2021073250A/ja active Pending
-
2022
- 2022-07-29 US US17/877,498 patent/US20230203088A1/en not_active Abandoned
-
2024
- 2024-01-29 US US18/425,572 patent/US20250002525A1/en not_active Abandoned
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