AU2013249111B2 - Aminosteroids for the treatment of a PTP1B associated disease - Google Patents

Aminosteroids for the treatment of a PTP1B associated disease Download PDF

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Publication number
AU2013249111B2
AU2013249111B2 AU2013249111A AU2013249111A AU2013249111B2 AU 2013249111 B2 AU2013249111 B2 AU 2013249111B2 AU 2013249111 A AU2013249111 A AU 2013249111A AU 2013249111 A AU2013249111 A AU 2013249111A AU 2013249111 B2 AU2013249111 B2 AU 2013249111B2
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AU
Australia
Prior art keywords
available
compound
pharmaceutically acceptable
ptp1b
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2013249111A
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English (en)
Other versions
AU2013249111A1 (en
Inventor
W. Lee Maloy
Michael Mclane
Inez Ruiz-White
Henry R. Wolfe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Depymed Inc
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Depymed Inc
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Publication date
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Publication of AU2013249111A1 publication Critical patent/AU2013249111A1/en
Application granted granted Critical
Publication of AU2013249111B2 publication Critical patent/AU2013249111B2/en
Priority to AU2018256561A priority Critical patent/AU2018256561B2/en
Priority to AU2020203736A priority patent/AU2020203736B2/en
Assigned to DEPYMED INC. reassignment DEPYMED INC. Request for Assignment Assignors: OHR PHARMACEUTICAL, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2013249111A 2012-04-20 2013-04-19 Aminosteroids for the treatment of a PTP1B associated disease Active AU2013249111B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2018256561A AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease
AU2020203736A AU2020203736B2 (en) 2012-04-20 2020-06-05 Aminosteroids for the treatment of a PTP1B associated disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636252P 2012-04-20 2012-04-20
US61/636,252 2012-04-20
PCT/US2013/037330 WO2013158970A2 (en) 2012-04-20 2013-04-19 Aminosteroids for the treatment of a ptp1b associated disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018256561A Division AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease

Publications (2)

Publication Number Publication Date
AU2013249111A1 AU2013249111A1 (en) 2014-11-06
AU2013249111B2 true AU2013249111B2 (en) 2018-08-09

Family

ID=48325893

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013249111A Active AU2013249111B2 (en) 2012-04-20 2013-04-19 Aminosteroids for the treatment of a PTP1B associated disease
AU2018256561A Active AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease
AU2020203736A Active AU2020203736B2 (en) 2012-04-20 2020-06-05 Aminosteroids for the treatment of a PTP1B associated disease

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2018256561A Active AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease
AU2020203736A Active AU2020203736B2 (en) 2012-04-20 2020-06-05 Aminosteroids for the treatment of a PTP1B associated disease

Country Status (15)

Country Link
US (6) US9546194B2 (enExample)
EP (2) EP3556765B1 (enExample)
JP (4) JP6165843B2 (enExample)
KR (3) KR102057812B1 (enExample)
AU (3) AU2013249111B2 (enExample)
CA (1) CA2870671C (enExample)
DK (1) DK2838907T3 (enExample)
ES (1) ES2736310T3 (enExample)
HR (1) HRP20191348T1 (enExample)
HU (1) HUE044769T2 (enExample)
MX (2) MX367255B (enExample)
PL (1) PL2838907T3 (enExample)
PT (1) PT2838907T (enExample)
TR (1) TR201911039T4 (enExample)
WO (1) WO2013158970A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6165843B2 (ja) 2012-04-20 2017-07-19 オーエイチアール・ファーマシューティカル・インコーポレイテッドＯｈｒ Ｐｈａｒｍａｃｅｕｔｉｃａｌ，Ｉｎｃ． Ｐｔｐ１ｂ関連疾患の処置のためのアミノステロイド化合物
US10040817B2 (en) 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
US11083735B2 (en) 2017-09-08 2021-08-10 Enterin, Inc. Methods for treating sleep disorders, sleep disturbances, and related symptoms using aminosterol compositions
CN107802626B (zh) * 2017-10-11 2020-01-21 南昌大学 降血糖组合物及其制备方法、用途
AU2018360845B2 (en) * 2017-11-06 2024-05-02 Cold Spring Harbor Laboratory Method and compositions for forming a copper-containing complex and uses thereof
CN112312917A (zh) * 2018-03-27 2021-02-02 因特尔公司 用于治疗幻觉及其相关病症的方法和组合物
CN112867728B (zh) * 2018-07-20 2024-04-05 冷泉港实验室 与铜螯合的(吡啶基亚甲基)丁二胺衍生物
JP2022543244A (ja) * 2019-08-02 2022-10-11 エンターイン、 インコーポレイテッド ヒトスクアラミン誘導体、それを含む関連組成物、およびそれを用いた方法
CN114929724B (zh) * 2019-08-02 2024-12-10 因特尔公司 氨基固醇ent-03化合物、包含其的相关组合物以及其使用方法
WO2023230593A1 (en) 2022-05-27 2023-11-30 Cold Spring Harbor Laboratory Ptp1b inhibitors for treating lung injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040151A1 (en) * 1995-06-07 1996-12-19 Magainin Pharmaceuticals Inc. Use of squalamine for the manufacture of a medicament for inhibiting nhe
WO2001042273A2 (en) * 1999-12-09 2001-06-14 Genaera Corporation Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
WO2009032321A2 (en) * 2007-09-06 2009-03-12 Genaera Corporation A method for treating diabetes

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2403683A (en) * 1942-04-25 1946-07-09 Relchstein Tadeus Compounds of the cyclopentanopolyhydrophenanthrene series and process of making same
US3636210A (en) * 1968-02-02 1972-01-18 Merck & Co Inc Cholanic acid and cholenic acid compositions and method of treatment
IT1255450B (it) * 1992-06-30 1995-10-31 Montefarmaco Spa Uso di acidi biliari come agenti antivirali
AU6392894A (en) * 1993-02-26 1994-09-14 Magainin Pharmaceuticals, Inc. Chemical synthesis of squalamine
ATE169930T1 (de) * 1993-03-10 1998-09-15 Magainin Pharma Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
US5856535A (en) 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
PT832094E (pt) * 1995-06-07 2004-06-30 Genaera Corp Compostos de aminoesterol uteis como inibidores do permutador sodio/protao )nhe) metodos e composicoes farmaceuticas empregando estes inibidores e processos para avaliacao da eficacia inibidora de nhe dos compostos
US7410959B1 (en) * 2000-07-13 2008-08-12 Genaera Corporation Therapeutic uses for aminosterol compounds
EP1214060A2 (en) 1999-09-10 2002-06-19 Novo Nordisk A/S Method of inhibiting protein tyrosine phosphatase 1b and/or t-cell protein tyrosine phosphatase and/or other ptpases with an asp residue at position 48
ATE309250T1 (de) 1999-09-10 2005-11-15 Novo Nordisk As Modulatoren der protein tyrosin phosphatase (ptpases)
WO2001019830A1 (en) 1999-09-10 2001-03-22 Novo Nordisk A/S MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases)
AU2003292939A1 (en) * 2002-12-24 2004-07-22 The University Of British Columbia Angiogenic compounds and uses thereof
JP2006165843A (ja) * 2004-12-06 2006-06-22 Matsushita Electric Ind Co Ltd 画像処理装置
JP2009534391A (ja) * 2006-04-21 2009-09-24 ジェネーラ・コーポレーション 体重減少の誘発およびｐｔｐ１ｂの選択的阻害
KR101260221B1 (ko) * 2011-12-01 2013-05-06 주식회사 엘지화학 마스크
JP6165843B2 (ja) * 2012-04-20 2017-07-19 オーエイチアール・ファーマシューティカル・インコーポレイテッドＯｈｒ Ｐｈａｒｍａｃｅｕｔｉｃａｌ，Ｉｎｃ． Ｐｔｐ１ｂ関連疾患の処置のためのアミノステロイド化合物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040151A1 (en) * 1995-06-07 1996-12-19 Magainin Pharmaceuticals Inc. Use of squalamine for the manufacture of a medicament for inhibiting nhe
WO2001042273A2 (en) * 1999-12-09 2001-06-14 Genaera Corporation Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
WO2009032321A2 (en) * 2007-09-06 2009-03-12 Genaera Corporation A method for treating diabetes

Also Published As

Publication number Publication date
JP2019059781A (ja) 2019-04-18
US20170129914A1 (en) 2017-05-11
HRP20191348T1 (hr) 2019-10-18
CA2870671C (en) 2020-05-12
WO2013158970A2 (en) 2013-10-24
KR101963312B1 (ko) 2019-03-28
AU2018256561B2 (en) 2020-03-05
JP2021073250A (ja) 2021-05-13
US11434257B2 (en) 2022-09-06
MX2019009539A (es) 2019-09-26
US20190202858A1 (en) 2019-07-04
US9546194B2 (en) 2017-01-17
JP6165843B2 (ja) 2017-07-19
AU2020203736A1 (en) 2020-06-25
EP2838907A2 (en) 2015-02-25
US20230203088A1 (en) 2023-06-29
KR20160091435A (ko) 2016-08-02
ES2736310T3 (es) 2019-12-27
KR102057812B1 (ko) 2019-12-19
US20250002525A1 (en) 2025-01-02
AU2013249111A1 (en) 2014-11-06
KR20190034685A (ko) 2019-04-02
WO2013158970A3 (en) 2013-12-12
KR20150003798A (ko) 2015-01-09
US10556923B2 (en) 2020-02-11
EP3556765A1 (en) 2019-10-23
US20150099727A1 (en) 2015-04-09
US20200270300A1 (en) 2020-08-27
MX367255B (es) 2019-08-12
CA2870671A1 (en) 2013-10-24
AU2020203736B2 (en) 2021-12-02
TR201911039T4 (tr) 2019-08-21
JP2015514781A (ja) 2015-05-21
EP2838907B1 (en) 2019-05-22
EP3556765B1 (en) 2022-02-23
PL2838907T3 (pl) 2019-12-31
AU2018256561A1 (en) 2018-11-22
JP6457010B2 (ja) 2019-01-23
HK1205516A1 (en) 2015-12-18
MX2014012619A (es) 2015-01-15
PT2838907T (pt) 2019-08-05
DK2838907T3 (da) 2019-08-05
HUE044769T2 (hu) 2019-11-28
JP2017178951A (ja) 2017-10-05

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: DEPYMED INC.

Free format text: FORMER OWNER(S): OHR PHARMACEUTICAL, INC.