HUE035910T2 - Citarabint és CD38-at specifikusan felismerõ antitesteket tartalmazó tumorellenes kombinációk - Google Patents
Citarabint és CD38-at specifikusan felismerõ antitesteket tartalmazó tumorellenes kombinációk Download PDFInfo
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- HUE035910T2 HUE035910T2 HUE09775304A HUE09775304A HUE035910T2 HU E035910 T2 HUE035910 T2 HU E035910T2 HU E09775304 A HUE09775304 A HU E09775304A HU E09775304 A HUE09775304 A HU E09775304A HU E035910 T2 HUE035910 T2 HU E035910T2
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Claims (7)
- < η \R\HM rs< ivs m smu !kuv< n t roo îmwmi Kt f fpu u wo TVMOin Li.FM'S KOMBINÁCIÓK 5. 'ahajfeimí igétty pontok 1 i. kmnbma«.*ό, an?« N CfNk-nt .>ρ«-'<ϋîKu^an íenstneré «'li«n?,sn\ ag«<* «» 1« gaiább cuarabim tvtú \ >te* vz dívna«?« ag kcpcs i?3a' »cm apnptózissai, elhmsmyagiMggS seiiközvellteö. citotoxidtássdí » v\' ' V, ,Λ >r\ ?«'n O.ol.0 ·.< «?« \k í,,·· *i «> Ό* ívko. I tan
- 2, Az I. Igénypont szerinti kombináció, ahol az ellenanyag hamaolzált ellenanyag.
- 3, Az .1, vagy 2.. igénypont szerinti k<»sbh?ád6, ahol az. ellenanyag felületi módosítással :(„ms«rfectng"} előállítóit híttíntnizáli ellenanyag. 4, A 2.. vagy 3. igénypont szerinti kombináció, almi az ellenanyag, tartalmaz egy vagy tóbb, a kdvetkezókbót álló csoportból ki választón atninosav-szekveoelájú komplementaritást maghatátöző.· régiéi: SEQ l.D'NQ: 1,2, 3,4. 5, 0, 7, S, 9, 16, 11, 12, 1.3, 14, 15, lé, 17, 16, 17,2Q .21,.22,23,24, 25,26,22, 28,29, 30,31, 32, 33,34, 35 és 26, S A 3 vagy 3. igénypont szerint* kombináció, ahol az ellenanyag az egétfele. 33SB19 'ellenanyag bomanlzált. változnia, ahol'az egédde 38S8Î7 ellenanyag oebézlánea bárom egymást köveié kowfcmmariiási megi?a«ározó régiót tartalmaz, melyek sníinosav-szekvenciája a SEQ 10 NO: 13, 14 és 15 szerit?«? szekvencia, és ahol s 36SB1O dlapaoyag kónnytllánea. bárom egymást kdwtó komplementaritást' meghatározó régiéi táfiaiíríísz, melyek tmiiöósavktzefcveficiája a SEQ ID'NÖ: lé. 17 és 13 szerinti '.szekvencia.
- 6. Az 5 igénypont szénné kotnbioácíó, attól a 38SBÎ7 ellet?«!t?y??g az American Type Ctsfmte íloHcstéretté! P .1.4-7670 nyitvántartási számot?, letétbe helyezett hlbrldéísa áittt! előállított ellenanyag.
- 7. Az 1-4, igénypontok bármelyike szerinti. kombináció* ahol az cileaanyag.legalább egy nehézláncotés legalább egy konoyöláncot tefislittáz, ahol a nebézláne SEQ 10 NO: 6ó szerinti szekvenciáié aminosav-szekveöclát tattabház· es/végy a nehéziánt: bárom egymást követé, komplementaritást meghaiárezó régiéi tartalmaz, melyek ámínósav-szekvcttcíája s SEQ ID NÖ: 13, 14 és 15 szerinti szekvencia, ás ahol a.kónnyöláttc SEQ 10 NO: 62 ás 64 szerire? sZékveneiák alkotta csopöribél választott aminosav-szekvenciát lartaimaz, és/vagy a kthmyúiánc bárom egymást köveié, komplementaritást meghaiârozô régiét tartalmaz, melyek amioosgV’S»ek.venoíájá s.SEQ 1DN0: 16, 17 és 18 szerint?·szekvencia.
- 8. Az 1 -4, igénypontok bármelyike szerinti kombináció, ahol az ellenanyag legalább egy nebézláncot és legalább egy kőnny&iáoeot tartalmaz, ahol a nehézlánc SEQ H> NO: 72 szerinti szekveneiájó aminosav-szekvenéiá; tsr|ais??az és/vagy a sehezian« három egymást követő, komplementaritást meghatározó régiét tartalmaz, melyek atninosav-szckveoeiäja <t SLQ 10 NO: 25, 26 és 2? szerint* szekvencia, és ásol tt \öt?r>y'üittt?c ni Q O \t n\ ·> N vuti'i « «loi«.!! s kot * >po?*í 4 « « ?«/« ít < η n « ?« «Henri it ? n<~ és/vagy a kőnsyöiáne három egymást követé, komplementaritást meghatározó régiét tartalmaz, mc'vek > m\ ?· iM«' i'O \O ‘k 0 <, \ts * s ·/, $>'t»i.t7. Az. 1-8. igénypontok bármelyike szerit??; gyógyászait kombináció, ahol a gyógyászaiI kot;?bit?ácló CD38 ellet·* ellenanyagot cítarabinnai együtt tartalmazó gyógyászaii készítmény. tg. Az I iaényporít szerintI gyógyászati kombináció rák kezelésében törtónó alkalmazásra. H \ V txî\ '•v»' ' s wS <»k »na »'s ; Λ Ί vJI w”. »g hamanizálteílenanyag, K S 1 ' > \ ' , V ! < \ " >T <» ,> » c !K"> ! S > < 3 ivvJ ! Z V, Midi»»»».» n\ 1 '. ·. ! Î i'!< !' » ' ! V '"ν'»
- 13. AU, vagy 1 2. igénypont szerinti kemiőnáeio ax ott meghatározott .alkalmazásra,. ahoi gz,. ellenanyag, az «gefiele 33$>Β19 çllennnyag numsnizélî változata, ahol a« egécOle 38Sö3i:9 -ellemtstyag nehézláncs három egymást kövdb, komplementantást meghatározó régiót tartalmaz, melyek aminosav-szekvenctája a SEQ 1D NO: 13, 1,4 és 15 szerből szekvencia, ás nbní á 38SBS9 eliemnyág köőnyölápéa három egymást követő, komplementet há$t meghatározó régiói tartalmaz, melyek aminosav-szekvenciája a SEQ 10 NO: ló, I? és, Ih szerbot: szekvencia. 14. A 13. igénypont szerinti kombináció az ott meghatározott alkalmazásra, ahol a 38SB19 ellenanyag az·. .American Type· Cdtcré Ceőíeeilooüíél PTA'7670 nyilvántartási ssáinpB letétbe helyezett hlbrklónta átnő gjoáiiítoti: ellenanyag, 15. A 10. igénypont szerinti köteWsköó ;:,··: óit rneghadrozen alkalmazásra, «hel az ellenanyag iacieiinaz; egy vagy több, s kővetkezőkből dió csoportból klválssztött nmlnosav-székveselájö, kontplomeatadtásl' meghatározórégiók SEQ IQ 'NO: LX 3,4, $,$, 7, 8, 9, iö, 11, 12, 13, 14,15, 16, 17, 1.8, IP, 20,'21,22,23, 24, 25, 2b, 27, 28,29,50,3i, 32, 33, 34. 35 és 36, tó, A 13. igénypont szerinti kombináció az att meghatározott alkalmazásra, ahol az ellenanyag legalább egy nehézláhéöí és iagalább ág)'' kmmyhlkncot'tettahnaz, ahol a-aehéziáne SEQ -ID NO: 64 szerinti szekvenciája aminosav-szekvenéiát tartalmaz és/eggy á nehçklânç három egymást követő, komplémenwitást tneghalározo e g n ί,ό'Ή me <·*k fi' :>>. ·· · /d ;e i s ' v í 10 \U ' i » l· ,ηπ,ί s \ »«Η < t'ml ' könny e'W SEQ' ΪΟ NG: 43 és §4 szerinti szekvenciák alkotta csopöribói választóit ami'«ösav«sxek:venetát tartalmaz, és/vagy .a kőnayöláno liároöt cgyptási követő, komplcóientarkásí .meghatározó régiói tartalmaz, melyek aminosav-szekvenetája a SEQ 113 NO 16, 17 és 18 szerinti szekvencia, 17. A 13. igénypont szerinti kombináció az ott meghatározott alkalmazásra, ahol az ellenanyag legalább egy nebézláncot és legalább egy kőnnyúláneot tartalmaz, ahol a nehézlánc SEQ 1D NO: 72 szerinti szekvenci&jó amlnosav-szekvenciát táetálmáz és/vegy a. nehéütlábó bárom egymást kővető, komplementaritást meghatározó t, '» '! ! í Sí' ' > fk Si* 1' f-,,χ t , ! í ) * I Q i»1 \O ”* ' d' 's ·>Α ü’t ' d,\ ä !( - '1 íí í kőnnyülánc SEQ 10 NO 68 és 70 szerinti szekvenciák alkotta csoportból választott amiaosav-szekvenctát tartalmaz, és/vagy a könnyálásc három egymást követő, komplementaritást meghatározó régiót tartalmaz, melyek aminosav-szek.vcnciâja a SEQ ÎD NO: 28, 29 és 30 szerint: szekvencia. 18 V' s' í í ke v » >\ < \ t » » IC Is í ‘ a pont» \i ne K k< vx n? ke no,» m o , » d •”egtatvj»?,i·«’ sík » »»» 3 mi » O»cb n<x !>' skoton. ά: -«élőn hend.vss s<-mp ónak té ' Λ » em '>» t wi η k " \ c s :< \ , l,i i » )4' vponío' 't rt·' , ti r ve nt 0' n> mn tő >/ otl megbatározott alkalmazásra, ahol a kombináció alkotórésze» egyidegs beadásra szolgálnak.
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EP2191842A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
US8877899B2 (en) * | 2010-09-27 | 2014-11-04 | Morphosys Ag | Anti-CD38 antibody and lenalidomide or bortezomib for the treatment of multipe myeloma and NHL |
UA112170C2 (uk) * | 2010-12-10 | 2016-08-10 | Санофі | Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб |
JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
PT2900232T (pt) | 2012-09-25 | 2018-02-09 | Morphosys Ag | Combinações e suas utilizações |
US20160022813A1 (en) * | 2013-03-13 | 2016-01-28 | Sanofi | Compositions comprising anti-cd38 antibodies and carfilzomib |
US9732154B2 (en) | 2014-02-28 | 2017-08-15 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia |
US9603927B2 (en) | 2014-02-28 | 2017-03-28 | Janssen Biotech, Inc. | Combination therapies with anti-CD38 antibodies |
MA39070A1 (fr) | 2014-07-31 | 2017-11-30 | Sanofi Sa | Anticorps anti-cd38 spécifiques pour le traitement de cancers humains |
MY192918A (en) | 2014-09-09 | 2022-09-15 | Janssen Biotech Inc | Combination therapies with anti-cd38 antibodies |
US10793630B2 (en) | 2014-12-04 | 2020-10-06 | Janssen Biotech, Inc. | Anti-CD38 antibodies for treatment of acute myeloid leukemia |
JP6827426B2 (ja) | 2015-05-20 | 2021-02-10 | ヤンセン バイオテツク,インコーポレーテツド | 軽鎖アミロイドーシス及びその他のcd38陽性血液悪性疾患の治療のための抗cd38抗体 |
MX2018000265A (es) | 2015-06-22 | 2018-05-23 | Janssen Biotech Inc | Terapias de combinacion para enfermedades malignas hematologicas con anticuerpos anti-cd38 e inhibidores de survivina. |
US20170044265A1 (en) | 2015-06-24 | 2017-02-16 | Janssen Biotech, Inc. | Immune Modulation and Treatment of Solid Tumors with Antibodies that Specifically Bind CD38 |
US10746739B2 (en) * | 2015-09-14 | 2020-08-18 | Leukemia Therapeutics, LLC | Identification of novel diagnostics and therapeutics by modulating RhoH |
US10781261B2 (en) | 2015-11-03 | 2020-09-22 | Janssen Biotech, Inc. | Subcutaneous formulations of anti-CD38 antibodies and their uses |
ES2862425T3 (es) | 2015-11-03 | 2021-10-07 | Janssen Biotech Inc | Formulaciones subcutáneas de anticuerpos anti-CD38 y sus usos |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
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CA3130132A1 (en) | 2019-03-15 | 2020-09-24 | Morphosys Ag | Anti-cd38 antibodies and pharmaceutical compositions thereof for the treatment of autoantibody-mediated autoimmune disease |
US11655302B2 (en) | 2019-06-10 | 2023-05-23 | Sanofi | Anti-CD38 antibodies and formulations |
CN112876563B (zh) * | 2019-11-29 | 2022-08-16 | 康诺亚生物医药科技(成都)有限公司 | 药物组合物及其制备方法和应用 |
EP4069743A1 (en) | 2019-12-05 | 2022-10-12 | Sanofi-Aventis U.S. LLC | Formulations of anti-cd38 antibodies for subcutaneous administration |
MX2023008187A (es) | 2021-01-14 | 2023-07-18 | Morphosys Ag | Anticuerpos anti-cd38 y sus usos. |
TW202302642A (zh) | 2021-03-01 | 2023-01-16 | 德商莫菲西斯公司 | 用於治療抗體介導移植物排斥用途之抗cd38抗體 |
CN113278075B (zh) * | 2021-06-18 | 2021-12-14 | 芜湖森爱驰生物科技有限公司 | 一种炎症检测试剂盒 |
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