HUE034456T2 - Epalresztat új kolin társkristálya - Google Patents
Epalresztat új kolin társkristálya Download PDFInfo
- Publication number
- HUE034456T2 HUE034456T2 HUE09812208A HUE09812208A HUE034456T2 HU E034456 T2 HUE034456 T2 HU E034456T2 HU E09812208 A HUE09812208 A HU E09812208A HU E09812208 A HUE09812208 A HU E09812208A HU E034456 T2 HUE034456 T2 HU E034456T2
- Authority
- HU
- Hungary
- Prior art keywords
- epalrestat
- cocrystal
- choline
- diabetic
- oxo
- Prior art date
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- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 title description 93
- 229960001231 choline Drugs 0.000 title description 92
- 229950010170 epalrestat Drugs 0.000 title description 76
- CHNUOJQWGUIOLD-UHFFFAOYSA-N epalrestate Natural products C=1C=CC=CC=1C=C(C)C=C1SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-UHFFFAOYSA-N 0.000 title description 76
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title description 59
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000010996 solid-state NMR spectroscopy Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Claims (2)
- EPÁLRESOTis) KOUN TÁRSKRISTAIYh 1, e^lörögén-tSsa?^ imtm bydmgen táfskfis!É:iys::|coe;'yslsí}, i. M 5y|:(1Z,2E};>g·'m^t}l·3íβs¾Hprop^nilidéíΐΐ·4:Oxö“gyöö^3>tlδ^?i^íή>s^ϊ¾¾v kői if? fíííárogén <1 issv láísktisfáíyá; éf*é§í lényegében ugyanazon XRPO (röntgen poidiffiakcíé} írgfitááígítsi b=¾ mífí t sms|v t ábrában látható. I, Gyógyászati kompozíció, asriéiy tartalmai 1 IfpgpPl: «Mí«g tia^libínxOGetsaviköfe^idKgán^is.w ur&kr staly!
- 4, Gyógyászáé kompozíció, smiy tartalmaz 2, igénypont szerinti §'f(1 2E}-2'^oso-2-4söxo-3-t;szoild 5 r= - e ceíssv: kcsiín 'Slíárog ér--srfiíga^· társkr1stáivt: 5 Gyógyászati kompozíció, amely tartalmaz 1 igénypont szennk Hí 12 gEvZ-metii'-S· femrmcper&ciöi Go-exo· 2ΰθχο·3· t-azolidíHOsatsav zoiinHciíogóm-disav iárskásíáiyt atkaimazásfa kezelésében és/vsgy maseíazlsébsa s követkézé sHaptMOX valamelyikének szív szöveti iszkémis ischemia). msbeieszes ideggyengeség (diabetic neuropathy), ciíabeteszes vesebai {tJiabehc nephiopathy). diabéteszéé szSvizomgyengeség (diabetic cardfemyspathy), díabetaszes: reknogsttá, dsaöefeszss gyomoitfenuiés (diabetic gasi&présis), szürke hályogok (pateraeí), iábfekéípk (fest ük®),, diábeieazss makroéiheiegség (diabetic maorosngiopafey) iadfeboteszaa niikfaéfbofegságfeiabepcrnicroangfepaaíyp δ. Gyógyászati kompozmio, amely tartalmaz ;2.. igénypont «térig gaaoiiáifi'fecatsav kolimhidrogén-disav társk^Üáyi: ^kaimazástáikézéM^ter M'ftgy m^efüzé#ben a következe asiapofek vgfetbéiyMnóte szik szöveti iszkémia, díaösteszss lideggphg^, ai&sissiér· «ee&ejj,. sia&eieszses; ·9ζΜιμ$$*Ψ*^ d*8öateszás roönopatia, diabeieszes :gysmort>énuSás, szörké hályogok; lábfekélyek. díabafeszes makreérbategség # ckseetesxes mikroérbetsgség. ?. Gyógyászati kompozíció, ameiy táÉiimaz: t igéhypnt szerint tiazoiidm-acetsav koiin-hiőfogen-dssav iársknstátyt aikatmezasm neurológia; és jdegmndszen degenarativ inetAaoegenerasve: rendellenességek ksz&iásápsn megelőzésében és/vagy kifejlődésük halasztásában |defeyfeg|; S Gyógyászati kompozíció, smeiy tartalmaz 2 igénypont szerint 5-|{1Z,2E)-2-meiii-3-fen8^ropenfíídén]-4-oitC"2-tioxo*3" toiidimecetssv kol ín Φ1 cl regén - d lors v társkhstályt alkalmazásra nootoíógisi és ibépmbszárí degeneisílv mndeífsnessépk kézslésábsn, megsiözéséhe!iés/yeg>óéfeji6dés#* halasztásábaii, $< Gyógyászat: kompozíció, amely tartsintaz % Igénypont: szehnll: o-i(1Z!2E)-2'metl#fehíhpropsnitPniG'OxO'2'tiozo4' llazdtfeímecetsav kolin-h«dmgén<#éy (árskiisyiíiytf; áiHslínssásrg aldóz xsdekiá? nsG^abán egy emlSePn ilyen szükséglet esetén. 1G Gyógyászait kompeztcH amely tartalmaz: $<. Igénypöif szerinti ó-tti^i^S)^Sxóáét3^3'féi4íf-P!XjpsiRi!íöé5i|*4^öSá'^-lioxo-^' 1azéii^ece!ttpfákpííft>'hid^ény^ itskrisfelyf eikalnizpra áldó* reduliz giisábáh égy «léiben ilyen sztkségiéi esetén. II. Gyógyászai kbmppzíeiG ameiy iarfeimsz 1 rgánypml; szerinti ^C{12;^)^?s8eíil^*fen»l“í^ofmt5^dé^|»s4>ó«ö~^öK0^3-‘ tsazoifeinmiseisay kolio^dnsgém|isay (árákrisfejyt áiksímazásrs homoaszünuna kezelésében ós/vagy a bemöűtszlein szintinek Hökkenisébsa: a vétszémmban spy emlősben ennek szükségessége esőién. 12; Gyógyászat· Kompziaié, amely tartalmai :|,: igénypont szsrínt Jsgöiirtfe'-edgtsav :k||pÉld?^|éá<l1i|iy GrakristalylSikaimazaera homociszítnurta kezelésében és/vagy m8gafe:zésébéh,::éSíyagy pimmocisztatniszintjeihak osckkahf|séban:a vsmzánjmban egy emfesben enpek szükségessége esetén..
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| US8697735B2 (en) | 2008-07-25 | 2014-04-15 | Bionevia Pharmaceuticals, Inc. | Solid forms of epalrestat |
| ES2639019T3 (es) | 2008-09-06 | 2017-10-25 | Bionevia Pharmaceuticals Inc. | Nuevo cocristal de colina de epalrestat |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| EP3042654A1 (en) | 2011-01-20 | 2016-07-13 | Bionevia Pharmaceuticals Inc. | Modified release compositions of epalrestat or a derivative thereof and methods for using the same |
| ITMI20120586A1 (it) | 2012-04-11 | 2013-10-12 | Milano Politecnico | Co-cristalli di 3-iodiopropinil butilcarbammato |
| CN103951634B (zh) * | 2014-05-07 | 2016-06-08 | 浙江东亚药业股份有限公司 | 一种依帕司他结晶盐水合物和羟基哌啶共晶物及其制备方法和应用 |
| AU2015267312B2 (en) * | 2014-05-27 | 2018-06-28 | Artificial Cell Technologies, Inc. | Automated layer by layer construction of multilayer coated cores by TFF |
| EP3947391A1 (en) | 2019-04-01 | 2022-02-09 | Applied Therapeutics Inc. | Inhibitors of aldose reductase |
| CA3136100A1 (en) * | 2019-05-07 | 2020-11-12 | Stephan L. ZUCHNER | Treatment and detection of inherited neuropathies and associated disorders |
| CN113277962B (zh) * | 2021-06-01 | 2023-02-07 | 天津大学 | 依帕司他-二甲双胍盐水合物及其制备方法和应用 |
| CN113336718B (zh) * | 2021-06-01 | 2023-02-28 | 天津大学 | 依帕司他-二甲双胍盐及其制备方法和应用 |
| CN113292511B (zh) * | 2021-06-01 | 2022-11-25 | 天津大学 | 依帕司他-二甲双胍盐乙醇水双溶剂化物及制备方法和应用 |
| CN113354596B (zh) * | 2021-06-01 | 2022-11-29 | 天津大学 | 依帕司他-二甲双胍盐丙酮溶剂化物及制备方法和应用 |
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| US6696407B1 (en) | 1997-03-21 | 2004-02-24 | The Regents Of The University Of California | Huntington's disease treatment comprising administering aldose reductase inhibitors to increase striatal CNTF |
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| AU2002215160A1 (en) * | 2000-11-30 | 2002-06-11 | Pfizer Products Inc. | Combination of gaba agonists and aldose reductase inhibitors |
| US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| JP3547010B1 (ja) * | 2002-12-27 | 2004-07-28 | 小野薬品工業株式会社 | ５−［（１ｚ，２ｅ）−２−メチル−３−フェニル−２−プロペニリデン］−４−オキソ−２−チオキソ−３−チアゾリジン酢酸の結晶の製造方法およびその製剤 |
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| CA2548281C (en) * | 2003-12-09 | 2013-11-12 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| JP2005298424A (ja) * | 2004-04-13 | 2005-10-27 | Sawai Pharmaceutical Co Ltd | エパルレスタット結晶の製造方法 |
| JP4892821B2 (ja) | 2004-09-30 | 2012-03-07 | 大日本印刷株式会社 | エパルレスタット製造法 |
| JP4892915B2 (ja) * | 2005-10-04 | 2012-03-07 | 大日本印刷株式会社 | エパルレスタット製造法 |
| US20110275695A1 (en) | 2008-06-13 | 2011-11-10 | Bionevia Pharmaceuticals, Inc. | Crystalline forms of zotepine hydrochloride |
| US8697735B2 (en) | 2008-07-25 | 2014-04-15 | Bionevia Pharmaceuticals, Inc. | Solid forms of epalrestat |
| WO2010011926A2 (en) | 2008-07-25 | 2010-01-28 | Bionevia Pharmaceuticals, Inc. | A novel betaine cocrystal of epalrestat |
| WO2010011922A2 (en) | 2008-07-25 | 2010-01-28 | Bionevia Pharmaceuticals, Inc. | Novel crystalline salts of epalrestat |
| ES2639019T3 (es) | 2008-09-06 | 2017-10-25 | Bionevia Pharmaceuticals Inc. | Nuevo cocristal de colina de epalrestat |
-
2009
- 2009-09-03 ES ES09812208.8T patent/ES2639019T3/es active Active
- 2009-09-03 US US13/062,644 patent/US8906948B2/en active Active
- 2009-09-03 AU AU2009288037A patent/AU2009288037B2/en not_active Ceased
- 2009-09-03 PL PL09812208T patent/PL2326632T3/pl unknown
- 2009-09-03 DK DK09812208.8T patent/DK2326632T3/en active
- 2009-09-03 CA CA2738231A patent/CA2738231C/en not_active Expired - Fee Related
- 2009-09-03 PT PT98122088T patent/PT2326632T/pt unknown
- 2009-09-03 LT LTEP09812208.8T patent/LT2326632T/lt unknown
- 2009-09-03 WO PCT/US2009/055868 patent/WO2010028132A2/en active Application Filing
- 2009-09-03 CN CN200980143667.4A patent/CN102216281B/zh not_active Expired - Fee Related
- 2009-09-03 UA UAA201103353A patent/UA106209C2/ru unknown
- 2009-09-03 SI SI200931721T patent/SI2326632T1/sl unknown
- 2009-09-03 GB GB1105528.2A patent/GB2476202B/en not_active Expired - Fee Related
- 2009-09-03 EP EP09812208.8A patent/EP2326632B8/en not_active Not-in-force
- 2009-09-03 EA EA201100245A patent/EA016904B1/ru not_active IP Right Cessation
- 2009-09-03 HU HUE09812208A patent/HUE034456T2/hu unknown
- 2009-09-03 EA EA201200489A patent/EA023435B1/ru not_active IP Right Cessation
-
2014
- 2014-11-04 US US14/532,517 patent/US9611234B2/en active Active
-
2017
- 2017-03-03 US US15/449,723 patent/US10464912B2/en not_active Expired - Fee Related
- 2017-08-30 CY CY20171100917T patent/CY1119752T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201100245A1 (ru) | 2011-08-30 |
| ES2639019T3 (es) | 2017-10-25 |
| PL2326632T3 (pl) | 2017-10-31 |
| US9611234B2 (en) | 2017-04-04 |
| SI2326632T1 (sl) | 2017-11-30 |
| DK2326632T3 (en) | 2017-09-18 |
| GB2476202B (en) | 2012-04-11 |
| WO2010028132A2 (en) | 2010-03-11 |
| WO2010028132A3 (en) | 2010-06-17 |
| US20110275682A1 (en) | 2011-11-10 |
| US8906948B2 (en) | 2014-12-09 |
| AU2009288037B2 (en) | 2014-08-14 |
| GB2476202A (en) | 2011-06-15 |
| US20150057319A1 (en) | 2015-02-26 |
| CY1119752T1 (el) | 2018-06-27 |
| EP2326632B1 (en) | 2017-05-31 |
| LT2326632T (lt) | 2017-09-25 |
| EP2326632A2 (en) | 2011-06-01 |
| AU2009288037A1 (en) | 2010-03-11 |
| US10464912B2 (en) | 2019-11-05 |
| EP2326632B8 (en) | 2017-08-09 |
| EA016904B1 (ru) | 2012-08-30 |
| CA2738231C (en) | 2015-04-07 |
| CN102216281B (zh) | 2014-11-05 |
| US20170174643A1 (en) | 2017-06-22 |
| CN102216281A (zh) | 2011-10-12 |
| EA023435B1 (ru) | 2016-06-30 |
| CA2738231A1 (en) | 2010-03-11 |
| EA201200489A1 (ru) | 2013-01-30 |
| UA106209C2 (en) | 2014-08-11 |
| PT2326632T (pt) | 2017-09-05 |
| GB201105528D0 (en) | 2011-05-18 |
| EP2326632A4 (en) | 2012-05-30 |
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