HUE033738T2 - Antibiotikum vegyület hidrokloridsói - Google Patents
Antibiotikum vegyület hidrokloridsói Download PDFInfo
- Publication number
- HUE033738T2 HUE033738T2 HUE14717248A HUE14717248A HUE033738T2 HU E033738 T2 HUE033738 T2 HU E033738T2 HU E14717248 A HUE14717248 A HU E14717248A HU E14717248 A HUE14717248 A HU E14717248A HU E033738 T2 HUE033738 T2 HU E033738T2
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- HU
- Hungary
- Prior art keywords
- compound
- sucrose
- formula
- pharmaceutical composition
- solution
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims description 92
- 239000003242 anti bacterial agent Substances 0.000 title description 4
- 230000003115 biocidal effect Effects 0.000 title description 3
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 53
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 35
- 229930006000 Sucrose Natural products 0.000 claims description 35
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- 238000002360 preparation method Methods 0.000 claims description 17
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| US4434287A (en) * | 1975-02-20 | 1984-02-28 | Ciba-Geigy Corporation | Cephalosporin derivatives |
| AR228726A1 (es) | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
| US4626534A (en) | 1984-07-23 | 1986-12-02 | Eli Lilly And Company | Pharmaceutical formulation |
| DE3801179A1 (de) | 1988-01-18 | 1989-07-27 | Hoechst Ag | Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten |
| JPH0331449A (ja) | 1989-06-27 | 1991-02-12 | Yamaha Corp | リードフレーム用Ｆｅ―Ｎｉ合金 |
| EP0421297B1 (en) | 1989-09-30 | 1993-12-01 | Eisai Co., Ltd. | Injectable preparations containing cephalosporin medicament and the use thereof |
| JPH03193735A (ja) | 1989-12-22 | 1991-08-23 | Shionogi & Co Ltd | グリコペプチド系抗生物質の安定化組成物 |
| JP4142149B2 (ja) | 1997-07-10 | 2008-08-27 | 明治製菓株式会社 | バンコマイシンの凍結乾燥製剤 |
| TWI335332B (en) * | 2001-10-12 | 2011-01-01 | Theravance Inc | Cross-linked vancomycin-cephalosporin antibiotics |
| DE602004028111D1 (de) * | 2003-04-16 | 2010-08-26 | Sandoz Ag | Verfahren zur herstellung von cefepim |
| JP2007500222A (ja) | 2003-05-23 | 2007-01-11 | セラヴァンス インコーポレーテッド | 架橋グリコペプチド−セファロスポリン抗生物質 |
| US6878868B2 (en) | 2003-06-24 | 2005-04-12 | Mcmillan Stacy L. | Portable high-hat device |
| WO2005005436A2 (en) | 2003-07-11 | 2005-01-20 | Theravance, Inc. | Cross-linked glycopeptide-cephalosporin antibiotics |
| TWI342312B (en) | 2003-10-22 | 2011-05-21 | Theravance Inc | Hydrochloride salts of a glycopeptide phosphonate derivative |
| EP1656930A1 (en) | 2004-11-10 | 2006-05-17 | Basilea Pharmaceutica AG | Stabilized freeze-dried formulation for cephalosporin derivatives |
| US20080103121A1 (en) | 2006-10-30 | 2008-05-01 | Gole Dilip J | Cephalosporin derivative formulation |
| FR2932177B1 (fr) | 2008-06-06 | 2012-11-30 | Inst Francais Du Petrole | Procede d'hydrogenation selective sur un catalyseur contenant de l'or. |
| JP2010105965A (ja) | 2008-10-30 | 2010-05-13 | Taiyo Yakuhin Kogyo Kk | バンコマイシン製剤 |
| WO2011035108A1 (en) | 2009-09-17 | 2011-03-24 | Eagle Pharmaceuticals, Inc. | Formulations of daptomycin |
| EP2504020A4 (en) | 2009-11-23 | 2013-05-29 | Eagle Pharmaceuticals Inc | Daptomycin FORMULATIONS |
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2014
- 2014-03-06 DK DK14717248.0T patent/DK2968446T3/en active
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- 2014-03-06 MD MDA20150101A patent/MD4599C1/ro active IP Right Grant
- 2014-03-06 WO PCT/US2014/021064 patent/WO2014158952A1/en not_active Ceased
- 2014-03-06 PL PL14717248T patent/PL2968446T3/pl unknown
- 2014-03-06 GE GEAP201413957A patent/GEP20186874B/en unknown
- 2014-03-06 ME MEP-2017-133A patent/ME02854B/me unknown
- 2014-03-06 LT LTEP14717248.0T patent/LT2968446T/lt unknown
- 2014-03-06 HR HRP20171188TT patent/HRP20171188T1/hr unknown
- 2014-03-06 HU HUE14717248A patent/HUE033738T2/hu unknown
- 2014-03-06 CN CN201480013969.0A patent/CN105120883B/zh active Active
- 2014-03-06 MX MX2015012170A patent/MX361984B/es active IP Right Grant
- 2014-03-06 CA CA2902720A patent/CA2902720A1/en not_active Abandoned
- 2014-03-06 UA UAA201509921A patent/UA115086C2/uk unknown
- 2014-03-06 PT PT147172480T patent/PT2968446T/pt unknown
- 2014-03-06 BR BR112015022716A patent/BR112015022716A2/pt not_active Application Discontinuation
- 2014-03-06 EP EP14717248.0A patent/EP2968446B1/en active Active
- 2014-03-06 EA EA201591697A patent/EA027282B1/ru unknown
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- 2014-03-06 SI SI201430302T patent/SI2968446T1/sl unknown
- 2014-03-06 KR KR1020157027597A patent/KR20150126659A/ko not_active Withdrawn
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2015
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2017
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2018
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