HUE032862T2 - Dabigatran-amidoximsav-észterek mint prodrug formák és ezek alkalmazása gyógyszerként - Google Patents
Dabigatran-amidoximsav-észterek mint prodrug formák és ezek alkalmazása gyógyszerként Download PDFInfo
- Publication number
- HUE032862T2 HUE032862T2 HUE11175230A HUE11175230A HUE032862T2 HU E032862 T2 HUE032862 T2 HU E032862T2 HU E11175230 A HUE11175230 A HU E11175230A HU E11175230 A HUE11175230 A HU E11175230A HU E032862 T2 HUE032862 T2 HU E032862T2
- Authority
- HU
- Hungary
- Prior art keywords
- plasma
- dabigatran
- treatment
- samples
- prodrugs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (1)
- S/ABADAt Ml R<T\\ iOS'i'OK : 11 amel yonfc l||p|;!®le amelyben:1¾. jslesttese ·Ή, elágazó \iíg> egyenes, mbseït vagy telítetlen. nem sznbsztkuáit szénhidrogén 11¾¾ ahol a lànc.howùssiga I .12,. és a értéke 1 %, :&£ É> iglpypÖ«t SZ#ri'tÉí VOgyMbsíMí W jëlsnfee;:eï& ë. Az l e. igém pontok ezonnsl > egy öleké- sós. s/olv&tj8j é\ a sók szóivá! iái. A ' sgsnsp nVi be ' eb me vet tót v. tg oses !v5. ^víg0g kezek Men e- espy kkgeivk evlke : torié nö 3 Ik&lma zásra.·, 5. M 1-3. igénypontok bármelyike szerinti ^gyület tiiatóll Méplpk MzekMbert étvágy .'negeiozesvnen tét sértő alkalmazóra. é Az S~k igénypernek bármely) ke szénán vegyüfet tsonísbotíkus események, különösen vénás tromhoemlvUa h< re levében C' \ *p\ negdo/evebett UMdi%Valkát*'«ázá|:rá ?. A? 1- k igénypontok bármelyike szerinti vegyidet gutaöiés» atí\ infarktus ésAntgy sbMs fibrüiásJé és «uthmia kezeléseim êsMgy megelőzéséin..n történd alkalmazásra. 8, A? ' ut\.> o\ hi>s ό „ -> o .rt \ ' po'bt «. s gvv ''Poy * sAolbgiás betegségek kezeiéttébert és/vugy megdbzéséNm történő alkalmazásra. b. Gyögvszerkészilmény. amely îartalÏK» legalább egy. az 1-3. igéstypomok bármelyike szerinti ve-gjüiertet, a ?rombio~kió? meghosszabbító hatással teíÉln gáíió motHon év vagy tob szeritmroMzokni «vakomIt gálláMissal. JO. < lyf^yszetkes/iimém, amely tartalmaz legalább égy, a« ki tgénypátilök. bármely lka :gj dtvtet, adott esetheti egy vagy több »χ·α, nent kv<»lus, gyégyszerészettleg· *tlkaimmdhat& mgéé* anyaggal kombinálva. ! uv*« w.\nvnm.'ii\ son nótáim «' kyv1 dé» i s, t ' n\ w von banne K λ? v , imt se igydleték ídöb további hatóanyaggal kombinál vst. 12, âHieiÿ tajtâlIssllK ligaiaii agy, gg !·ϋ igêyygakkgk ^âitôçlÿlks 'sxssiàftîf ve~ gyülsíat, oMHs vagy ^am«t«rélk· 13. A 3*1. L o*' s vu f ηκ V ko \ ? * - ' 'U \ ^ ' < κ s meæysf,. bogy* $$$%?* smïkésÆmêny .gysmomYval ssmmbev ia/Aneas tbrmabao va*· kis?A-relvô. ! 4. Eljárás a/ 1*3, igágy gbikök bÄylyjke: sásrlnfí vbgplst è:|dà111i:i3:ssrïa;i ^¾¾^] jellöm^víS;. litíígsr (A) kegletű nlírili (A!aniklybéá Éj Meitösg -ll elkgakö v&gy esyaí'íySs tklliett va|k telöertók, namyAs-bsAikiäk sirlsbiäm* gok- íáítc, ahol a lánc bosszsAaga 1 - 12, iB; kápkfb anbdoximmá slalcltUBk(S) as ag így swell sögilöklmoí |Gj .kipllííl·( £ ^ amohboo n .irtáig 3;s,Mpletü vcgyükáíé alakijuk
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11175230.9A EP2550966B1 (de) | 2011-07-25 | 2011-07-25 | Dabigatran-Amidoximsäureesters als Prodrugs und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE032862T2 true HUE032862T2 (hu) | 2017-11-28 |
Family
ID=46466528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE11175230A HUE032862T2 (hu) | 2011-07-25 | 2011-07-25 | Dabigatran-amidoximsav-észterek mint prodrug formák és ezek alkalmazása gyógyszerként |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8853245B2 (hu) |
| EP (2) | EP2550966B1 (hu) |
| JP (1) | JP2014521619A (hu) |
| KR (1) | KR20140049021A (hu) |
| CN (1) | CN103945845A (hu) |
| AU (1) | AU2012289112B2 (hu) |
| BR (1) | BR112014001970A2 (hu) |
| CA (1) | CA2842304A1 (hu) |
| CY (1) | CY1118294T1 (hu) |
| DK (1) | DK2550966T3 (hu) |
| ES (1) | ES2611610T3 (hu) |
| HK (1) | HK1201738A1 (hu) |
| HR (1) | HRP20161675T1 (hu) |
| HU (1) | HUE032862T2 (hu) |
| LT (1) | LT2550966T (hu) |
| PL (1) | PL2550966T3 (hu) |
| PT (1) | PT2550966T (hu) |
| RU (1) | RU2014106866A (hu) |
| SI (1) | SI2550966T1 (hu) |
| WO (1) | WO2013013946A1 (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040045742A1 (en) * | 2001-04-10 | 2004-03-11 | Halliburton Energy Services, Inc. | Force-balanced roller-cone bits, systems, drilling methods, and design methods |
| WO2016019846A1 (zh) * | 2014-08-06 | 2016-02-11 | 四川海思科制药有限公司 | 一种达比加群酯衍生物及其制备方法和在药学上的用途 |
| WO2016019848A1 (zh) * | 2014-08-06 | 2016-02-11 | 四川海思科制药有限公司 | 一种达比加群硫酯衍生物及其制备方法和在药学上的用途 |
| DE102016102887A1 (de) * | 2016-02-18 | 2017-08-24 | Develco Pharma Schweiz Ag | Orale Darreichungsform eines Dabigatran-Prodrugs zur Behandlung von Krankheiten |
| CN110448557A (zh) * | 2019-09-05 | 2019-11-15 | 黄筱茜 | 抗凝血药达比加群酯的新药用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| DE10235639A1 (de) | 2002-08-02 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE10341043A1 (de) | 2003-09-03 | 2005-03-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue oral zu applizierende Darreichungsform für 3-[(2-{[4-Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester und dessen Salze |
| CA2657269A1 (en) * | 2006-07-17 | 2008-01-24 | Boehringer Ingelheim International Gmbh | New indications for direct thrombin inhibitors |
| DE102008007440A1 (de) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Aminosäurederivate als Arzneistoffe |
| DE102008007381A1 (de) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten |
| NZ592615A (en) * | 2008-11-11 | 2013-06-28 | Boehringer Ingelheim Int | Method for treating or preventing thrombosis using 150 mg b.i.d. of dabigatran etexilate or a salt thereof with improved efficacy over conventional warfarin therapy |
| KR20110082563A (ko) * | 2008-11-11 | 2011-07-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 통상의 와파린 요법에 비해 효능이 향상된 다비가트란 에텍실레이트 또는 이의 염을 사용하여 혈전증을 치료하거나 예방하는 방법 |
| DE102009004204A1 (de) * | 2009-01-09 | 2010-07-15 | Christian-Albrechts-Universität Zu Kiel | Verfahren zur verbesserten Bioaktivierung von Arzneistoffen |
-
2011
- 2011-07-25 PT PT111752309T patent/PT2550966T/pt unknown
- 2011-07-25 PL PL11175230T patent/PL2550966T3/pl unknown
- 2011-07-25 DK DK11175230.9T patent/DK2550966T3/en active
- 2011-07-25 HU HUE11175230A patent/HUE032862T2/hu unknown
- 2011-07-25 ES ES11175230.9T patent/ES2611610T3/es active Active
- 2011-07-25 SI SI201130999A patent/SI2550966T1/sl unknown
- 2011-07-25 LT LTEP11175230.9T patent/LT2550966T/lt unknown
- 2011-07-25 EP EP11175230.9A patent/EP2550966B1/de active Active
-
2012
- 2012-07-05 EP EP12733105.6A patent/EP2773347B1/de not_active Not-in-force
- 2012-07-05 WO PCT/EP2012/063071 patent/WO2013013946A1/de active Application Filing
- 2012-07-05 AU AU2012289112A patent/AU2012289112B2/en not_active Ceased
- 2012-07-05 RU RU2014106866/04A patent/RU2014106866A/ru not_active Application Discontinuation
- 2012-07-05 BR BR112014001970A patent/BR112014001970A2/pt not_active IP Right Cessation
- 2012-07-05 CA CA2842304A patent/CA2842304A1/en not_active Abandoned
- 2012-07-05 CN CN201280037040.2A patent/CN103945845A/zh active Pending
- 2012-07-05 KR KR1020147004769A patent/KR20140049021A/ko not_active Application Discontinuation
- 2012-07-05 JP JP2014522017A patent/JP2014521619A/ja active Pending
- 2012-07-24 US US13/556,612 patent/US8853245B2/en active Active
-
2015
- 2015-03-06 HK HK15102313.9A patent/HK1201738A1/xx unknown
-
2016
- 2016-12-06 CY CY20161101252T patent/CY1118294T1/el unknown
- 2016-12-08 HR HRP20161675TT patent/HRP20161675T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8853245B2 (en) | 2014-10-07 |
| EP2773347B1 (de) | 2017-09-13 |
| WO2013013946A1 (de) | 2013-01-31 |
| BR112014001970A2 (pt) | 2017-02-21 |
| US20130030023A1 (en) | 2013-01-31 |
| EP2550966A1 (de) | 2013-01-30 |
| PL2550966T3 (pl) | 2017-03-31 |
| PT2550966T (pt) | 2017-01-31 |
| SI2550966T1 (sl) | 2017-01-31 |
| AU2012289112B2 (en) | 2017-01-05 |
| LT2550966T (lt) | 2017-01-25 |
| CA2842304A1 (en) | 2013-01-31 |
| CN103945845A (zh) | 2014-07-23 |
| EP2773347A1 (de) | 2014-09-10 |
| AU2012289112A1 (en) | 2014-02-13 |
| ES2611610T3 (es) | 2017-05-09 |
| KR20140049021A (ko) | 2014-04-24 |
| RU2014106866A (ru) | 2015-08-27 |
| HK1201738A1 (en) | 2015-09-11 |
| DK2550966T3 (en) | 2017-02-06 |
| HRP20161675T1 (hr) | 2017-02-24 |
| JP2014521619A (ja) | 2014-08-28 |
| EP2550966B1 (de) | 2016-10-19 |
| CY1118294T1 (el) | 2017-06-28 |
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