PT2550966T - Ésteres de ácido carboxílico de amidoxima de dabigatrana como pró-drogas e utilização das mesmas como medicamento - Google Patents
Ésteres de ácido carboxílico de amidoxima de dabigatrana como pró-drogas e utilização das mesmas como medicamentoInfo
- Publication number
- PT2550966T PT2550966T PT111752309T PT11175230T PT2550966T PT 2550966 T PT2550966 T PT 2550966T PT 111752309 T PT111752309 T PT 111752309T PT 11175230 T PT11175230 T PT 11175230T PT 2550966 T PT2550966 T PT 2550966T
- Authority
- PT
- Portugal
- Prior art keywords
- dabigatran
- prodrugs
- medicament
- carboxylic acid
- acid esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11175230.9A EP2550966B1 (de) | 2011-07-25 | 2011-07-25 | Dabigatran-Amidoximsäureesters als Prodrugs und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2550966T true PT2550966T (pt) | 2017-01-31 |
Family
ID=46466528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT111752309T PT2550966T (pt) | 2011-07-25 | 2011-07-25 | Ésteres de ácido carboxílico de amidoxima de dabigatrana como pró-drogas e utilização das mesmas como medicamento |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8853245B2 (pt) |
| EP (2) | EP2550966B1 (pt) |
| JP (1) | JP2014521619A (pt) |
| KR (1) | KR20140049021A (pt) |
| CN (1) | CN103945845A (pt) |
| AU (1) | AU2012289112B2 (pt) |
| BR (1) | BR112014001970A2 (pt) |
| CA (1) | CA2842304A1 (pt) |
| CY (1) | CY1118294T1 (pt) |
| DK (1) | DK2550966T3 (pt) |
| ES (1) | ES2611610T3 (pt) |
| HK (1) | HK1201738A1 (pt) |
| HR (1) | HRP20161675T1 (pt) |
| HU (1) | HUE032862T2 (pt) |
| LT (1) | LT2550966T (pt) |
| PL (1) | PL2550966T3 (pt) |
| PT (1) | PT2550966T (pt) |
| RU (1) | RU2014106866A (pt) |
| SI (1) | SI2550966T1 (pt) |
| WO (1) | WO2013013946A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040045742A1 (en) * | 2001-04-10 | 2004-03-11 | Halliburton Energy Services, Inc. | Force-balanced roller-cone bits, systems, drilling methods, and design methods |
| WO2016019848A1 (zh) * | 2014-08-06 | 2016-02-11 | 四川海思科制药有限公司 | 一种达比加群硫酯衍生物及其制备方法和在药学上的用途 |
| WO2016019846A1 (zh) * | 2014-08-06 | 2016-02-11 | 四川海思科制药有限公司 | 一种达比加群酯衍生物及其制备方法和在药学上的用途 |
| DE102016102887A1 (de) * | 2016-02-18 | 2017-08-24 | Develco Pharma Schweiz Ag | Orale Darreichungsform eines Dabigatran-Prodrugs zur Behandlung von Krankheiten |
| CN110448557A (zh) * | 2019-09-05 | 2019-11-15 | 黄筱茜 | 抗凝血药达比加群酯的新药用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE121699A1 (es) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | Heterociclos biciclicos disustituidos como inhibidores de la trombina |
| DE10235639A1 (de) * | 2002-08-02 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Prodrugs von 1-Methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carbonsäure-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amid, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE10341043A1 (de) | 2003-09-03 | 2005-03-31 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue oral zu applizierende Darreichungsform für 3-[(2-{[4-Hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionsäure-ethylester und dessen Salze |
| JP2009543843A (ja) * | 2006-07-17 | 2009-12-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 直接トロンビン阻害剤に関する新規適応 |
| DE102008007381A1 (de) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten |
| DE102008007440A1 (de) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Aminosäurederivate als Arzneistoffe |
| KR20110082564A (ko) * | 2008-11-11 | 2011-07-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 통상의 와파린 요법에 비해 효능이 향상된 다비가트란 에텍실레이트 또는 이의 염을 사용하여 혈전증을 치료하거나 예방하는 방법 |
| EP2358367A1 (en) * | 2008-11-11 | 2011-08-24 | Boehringer Ingelheim International GmbH | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved efficacy over conventional warfarin therapy |
| DE102009004204A1 (de) * | 2009-01-09 | 2010-07-15 | Christian-Albrechts-Universität Zu Kiel | Verfahren zur verbesserten Bioaktivierung von Arzneistoffen |
-
2011
- 2011-07-25 HU HUE11175230A patent/HUE032862T2/en unknown
- 2011-07-25 PT PT111752309T patent/PT2550966T/pt unknown
- 2011-07-25 PL PL11175230T patent/PL2550966T3/pl unknown
- 2011-07-25 LT LTEP11175230.9T patent/LT2550966T/lt unknown
- 2011-07-25 SI SI201130999A patent/SI2550966T1/sl unknown
- 2011-07-25 ES ES11175230.9T patent/ES2611610T3/es active Active
- 2011-07-25 EP EP11175230.9A patent/EP2550966B1/de active Active
- 2011-07-25 DK DK11175230.9T patent/DK2550966T3/en active
-
2012
- 2012-07-05 KR KR1020147004769A patent/KR20140049021A/ko not_active Application Discontinuation
- 2012-07-05 BR BR112014001970A patent/BR112014001970A2/pt not_active IP Right Cessation
- 2012-07-05 CN CN201280037040.2A patent/CN103945845A/zh active Pending
- 2012-07-05 RU RU2014106866/04A patent/RU2014106866A/ru not_active Application Discontinuation
- 2012-07-05 EP EP12733105.6A patent/EP2773347B1/de not_active Not-in-force
- 2012-07-05 CA CA2842304A patent/CA2842304A1/en not_active Abandoned
- 2012-07-05 WO PCT/EP2012/063071 patent/WO2013013946A1/de active Application Filing
- 2012-07-05 AU AU2012289112A patent/AU2012289112B2/en not_active Ceased
- 2012-07-05 JP JP2014522017A patent/JP2014521619A/ja active Pending
- 2012-07-24 US US13/556,612 patent/US8853245B2/en active Active
-
2015
- 2015-03-06 HK HK15102313.9A patent/HK1201738A1/xx unknown
-
2016
- 2016-12-06 CY CY20161101252T patent/CY1118294T1/el unknown
- 2016-12-08 HR HRP20161675TT patent/HRP20161675T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2773347A1 (de) | 2014-09-10 |
| HRP20161675T1 (hr) | 2017-02-24 |
| CA2842304A1 (en) | 2013-01-31 |
| HK1201738A1 (en) | 2015-09-11 |
| US8853245B2 (en) | 2014-10-07 |
| ES2611610T3 (es) | 2017-05-09 |
| SI2550966T1 (sl) | 2017-01-31 |
| KR20140049021A (ko) | 2014-04-24 |
| BR112014001970A2 (pt) | 2017-02-21 |
| JP2014521619A (ja) | 2014-08-28 |
| WO2013013946A1 (de) | 2013-01-31 |
| CY1118294T1 (el) | 2017-06-28 |
| DK2550966T3 (en) | 2017-02-06 |
| HUE032862T2 (en) | 2017-11-28 |
| CN103945845A (zh) | 2014-07-23 |
| LT2550966T (lt) | 2017-01-25 |
| US20130030023A1 (en) | 2013-01-31 |
| AU2012289112B2 (en) | 2017-01-05 |
| EP2550966A1 (de) | 2013-01-30 |
| PL2550966T3 (pl) | 2017-03-31 |
| EP2550966B1 (de) | 2016-10-19 |
| RU2014106866A (ru) | 2015-08-27 |
| AU2012289112A1 (en) | 2014-02-13 |
| EP2773347B1 (de) | 2017-09-13 |
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