HUE032004T2 - Egy pirazolszármazék alkalmazása krónikus obstruktív légúti betegségek akut súlyos állapotainak kezelésénél - Google Patents
Egy pirazolszármazék alkalmazása krónikus obstruktív légúti betegségek akut súlyos állapotainak kezelésénél Download PDFInfo
- Publication number
- HUE032004T2 HUE032004T2 HUE13710851A HUE13710851A HUE032004T2 HU E032004 T2 HUE032004 T2 HU E032004T2 HU E13710851 A HUE13710851 A HU E13710851A HU E13710851 A HUE13710851 A HU E13710851A HU E032004 T2 HUE032004 T2 HU E032004T2
- Authority
- HU
- Hungary
- Prior art keywords
- treatment
- hydrate
- cyclopropyl
- pyrazol
- amino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (1)
- fe: phazois/mmazék alkalmasa Krónikus obstruktiv légnti betegségek akm súhos áUup'jUúrísk kcodéránéi I.; 3-i S'-^aim^ip^lasolHjnzrinv-pu&xol* i ' ií {-N-cikiopropsl· 'i mx et II hí· n anno d v úgy avopssmt kxg dnrandham soj í mdmtu ^a.' á®b.nií Knu'ki-s Ost.„'km k guü ha<V'-. gok mpn si lyos*: állapota i nnk keit- lés éné I tórténó u I kaim a «á«r% ili A 3“{S-3ïriinO'i-{.}-cis8<îbes:Â>îi)-pîra?.oi'hilj-N--eikiopiopiM»metilhenzauud vagy gvógyá, < \ t , fog, >rk'> s pák, tudtam *k v k'< s oh * ' t,tk o s ·' i óo' <o vo mk-s «ο^οον u k ^ liegst gok ukv s-,k>í" alti pataomk ks»v osOm'l n t\" * alkaho s\ u t 3. Λ 34?'tvmino‘M3^i&nohanzoiik-pirazol«1 -ilj«N-cikk->proi>ih4mtetühenzumidt>t, gpogytis^p sag; sPogadhato sóját, hidrádat vagy s.x<>fvátj|é.t tartalmazó omits gwgyàsmù készítmény krô«ik«s. obstynktt's légiid betegségek akta súlyos éliapounnak kezelésénél történő alkalmiméra, i, Λ 3, igénypont szerinti alkalmazásra ssosgóK:; gyógyászati készítmény, âülly thH0(kmi;3-[$*. «mme i (y ,<m > vo^od'- \i« ί'Ί \v.»kÄ'< j -, -i s ,οο htm, mohot vm>o v> s vassal km eh.,. gudhàio sóját, hidrát]át vagy szöívátjáí tsttshnaszss. !. :&4> igénypont szerrnll alî&liiiitzâam szolgáló gyógyászati készítmény·: amely 60-90 mg 3-(s. .,^|ti^#^|k#i#Móonwit)«pitazol4dikH^Ík^rnpíi~4»metHbenzamídot vagy gyigyMÄläg: «l%,: pdbiil sfpp hídiayat sags *,o!xatp*ttauatatawa fi Λζ S. igénypont szerinti alkalmazásra szolgáló gyógyászati készítmény,, amely 75 mg f,.. vagy gyógyapíitllgg gadható söják hidráját vagy divatját tartalmazza. '7. Λ n von pont s.v <f «hmotams » -/ohm o xogv ^vtt kos/'tnn·'s noJv " mg x- s amm-u-M *mmnobuxzoih-fn,mol· I Uj'h-viUopropiM'mteHlbeniamtdot mualmuz szakad íó; vurv-n % A tv igénypont Mótíntí alkalmazásra szolgáló gyógyászán készítmény labiutis Ihtmáíáten % \ " monvn<'m avutm alkalm *z.ia«4 amlf$&f:gy$g^ászat$tó^
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613187P | 2012-03-20 | 2012-03-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE032004T2 true HUE032004T2 (hu) | 2017-08-28 |
Family
ID=47901996
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE13710851A HUE032004T2 (hu) | 2012-03-20 | 2013-03-19 | Egy pirazolszármazék alkalmazása krónikus obstruktív légúti betegségek akut súlyos állapotainak kezelésénél |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US9339491B2 (hu) |
| EP (1) | EP2827860B1 (hu) |
| JP (1) | JP6091593B2 (hu) |
| KR (1) | KR101793777B1 (hu) |
| CN (1) | CN104203234B (hu) |
| AU (1) | AU2013237503B2 (hu) |
| BR (1) | BR112014023107B1 (hu) |
| CA (1) | CA2866108C (hu) |
| CL (1) | CL2014002471A1 (hu) |
| CY (1) | CY1118327T1 (hu) |
| DK (1) | DK2827860T3 (hu) |
| ES (1) | ES2605942T3 (hu) |
| HK (1) | HK1200352A1 (hu) |
| HR (1) | HRP20161514T1 (hu) |
| HU (1) | HUE032004T2 (hu) |
| IL (1) | IL234537A (hu) |
| LT (1) | LT2827860T (hu) |
| MA (1) | MA37455B1 (hu) |
| MX (1) | MX351996B (hu) |
| NZ (1) | NZ628392A (hu) |
| PH (1) | PH12014502107A1 (hu) |
| PL (1) | PL2827860T3 (hu) |
| PT (1) | PT2827860T (hu) |
| RU (1) | RU2625762C2 (hu) |
| SG (1) | SG11201404941WA (hu) |
| SI (1) | SI2827860T1 (hu) |
| TN (1) | TN2014000350A1 (hu) |
| TW (1) | TWI583381B (hu) |
| WO (1) | WO2013139809A1 (hu) |
| ZA (1) | ZA201405871B (hu) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2600833C1 (ru) * | 2015-09-03 | 2016-10-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) | Способ лечения хронической обструктивной болезни легких |
| RU2600822C1 (ru) * | 2015-09-03 | 2016-10-27 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ (ФГБУ "РНЦРХТ" Минздрава России) | Способ лечения хронического обструктивного бронхита |
| RU2709509C1 (ru) * | 2016-03-08 | 2019-12-18 | Мерео Байофарма 1 Лимитед | Режим дозирования для лечения острых обострений воспалительных состояний |
| AU2016397047B2 (en) * | 2016-03-08 | 2022-04-07 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
| US10331542B2 (en) * | 2016-06-23 | 2019-06-25 | International Business Machines Corporation | System and method for detecting and alerting unexpected behavior of software applications |
| GB201612240D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide |
| GB201612238D0 (en) * | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| CA3077499C (en) | 2017-10-05 | 2021-09-21 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
| US11234967B2 (en) | 2017-12-11 | 2022-02-01 | Mereo Biopharma 1 Limited | Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease |
| AU2018382895B2 (en) | 2017-12-11 | 2024-05-16 | Mereo Biopharma 1 Limited | Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2298743T1 (sl) * | 2003-06-26 | 2012-12-31 | Novartis Ag | Inhibitorji p38-kinaze na osnovi 5-ÄŤlenskih heterociklov |
| GB0603684D0 (en) * | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
-
2013
- 2013-03-19 CA CA2866108A patent/CA2866108C/en active Active
- 2013-03-19 KR KR1020147025904A patent/KR101793777B1/ko active IP Right Grant
- 2013-03-19 PL PL13710851T patent/PL2827860T3/pl unknown
- 2013-03-19 DK DK13710851.0T patent/DK2827860T3/en active
- 2013-03-19 US US14/386,174 patent/US9339491B2/en active Active
- 2013-03-19 PT PT137108510T patent/PT2827860T/pt unknown
- 2013-03-19 TW TW102109739A patent/TWI583381B/zh active
- 2013-03-19 NZ NZ628392A patent/NZ628392A/en unknown
- 2013-03-19 MA MA37455A patent/MA37455B1/fr unknown
- 2013-03-19 LT LTEP13710851.0T patent/LT2827860T/lt unknown
- 2013-03-19 HU HUE13710851A patent/HUE032004T2/hu unknown
- 2013-03-19 ES ES13710851.0T patent/ES2605942T3/es active Active
- 2013-03-19 EP EP13710851.0A patent/EP2827860B1/en active Active
- 2013-03-19 SG SG11201404941WA patent/SG11201404941WA/en unknown
- 2013-03-19 AU AU2013237503A patent/AU2013237503B2/en active Active
- 2013-03-19 MX MX2014011291A patent/MX351996B/es active IP Right Grant
- 2013-03-19 JP JP2015500892A patent/JP6091593B2/ja active Active
- 2013-03-19 CN CN201380015703.5A patent/CN104203234B/zh active Active
- 2013-03-19 BR BR112014023107-9A patent/BR112014023107B1/pt active IP Right Grant
- 2013-03-19 RU RU2014141893A patent/RU2625762C2/ru active
- 2013-03-19 WO PCT/EP2013/055730 patent/WO2013139809A1/en active Application Filing
- 2013-03-19 SI SI201330397A patent/SI2827860T1/sl unknown
-
2014
- 2014-08-11 TN TNP2014000350A patent/TN2014000350A1/fr unknown
- 2014-08-11 ZA ZA2014/05871A patent/ZA201405871B/en unknown
- 2014-09-08 IL IL234537A patent/IL234537A/en active IP Right Grant
- 2014-09-17 CL CL2014002471A patent/CL2014002471A1/es unknown
- 2014-09-22 PH PH12014502107A patent/PH12014502107A1/en unknown
-
2015
- 2015-01-29 HK HK15101000.9A patent/HK1200352A1/zh unknown
-
2016
- 2016-04-29 US US15/143,356 patent/US20160243081A1/en not_active Abandoned
- 2016-11-16 HR HRP20161514TT patent/HRP20161514T1/hr unknown
- 2016-11-18 CY CY20161101194T patent/CY1118327T1/el unknown
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