HUE029933T2 - Administration of anti-tumor agent - Google Patents

Administration of anti-tumor agent Download PDF

Info

Publication number
HUE029933T2
HUE029933T2 HUE13711004A HUE13711004A HUE029933T2 HU E029933 T2 HUE029933 T2 HU E029933T2 HU E13711004 A HUE13711004 A HU E13711004A HU E13711004 A HUE13711004 A HU E13711004A HU E029933 T2 HUE029933 T2 HU E029933T2
Authority
HU
Hungary
Prior art keywords
day
days
treatment
compound
cancer
Prior art date
Application number
HUE13711004A
Other languages
English (en)
Hungarian (hu)
Inventor
Kelli Glenn
Brian Higgins
Gwen Nichols
Kathryn E Packman
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HUE029933T2 publication Critical patent/HUE029933T2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401Proline; Derivatives thereof, e.g. captopril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HUE13711004A 2012-03-19 2013-03-15 Administration of anti-tumor agent HUE029933T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261612429P 2012-03-19 2012-03-19

Publications (1)

Publication Number Publication Date
HUE029933T2 true HUE029933T2 (en) 2017-04-28

Family

ID=47913395

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE13711004A HUE029933T2 (en) 2012-03-19 2013-03-15 Administration of anti-tumor agent

Country Status (21)

Country Link
US (4) US20130245089A1 (https=)
EP (1) EP2827858B1 (https=)
JP (2) JP6224690B2 (https=)
KR (4) KR102438597B1 (https=)
CN (2) CN104203232A (https=)
BR (1) BR112014018135A8 (https=)
CA (1) CA2859940C (https=)
CY (1) CY1118070T1 (https=)
DK (1) DK2827858T3 (https=)
ES (1) ES2593066T3 (https=)
HK (1) HK1204934A1 (https=)
HR (1) HRP20161295T1 (https=)
HU (1) HUE029933T2 (https=)
LT (1) LT2827858T (https=)
MX (1) MX356948B (https=)
PL (1) PL2827858T3 (https=)
PT (1) PT2827858T (https=)
RS (1) RS55250B1 (https=)
RU (1) RU2638795C2 (https=)
SI (1) SI2827858T1 (https=)
WO (1) WO2013139687A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014114575A1 (en) * 2013-01-22 2014-07-31 F. Hoffmann-La Roche Ag Pharmaceutical composition with improved bioavailability
EP3131878A1 (en) * 2014-04-15 2017-02-22 F. Hoffmann-La Roche AG Solid forms of a pharmaceutically active compound
TW201613576A (en) 2014-06-26 2016-04-16 Novartis Ag Intermittent dosing of MDM2 inhibitor
EP3204776B1 (en) * 2014-10-10 2019-09-04 F.Hoffmann-La Roche Ag Methods for personalizing patient cancer therapy with an mdm2 antagonist
SG11201808728QA (en) 2016-04-06 2018-11-29 Univ Michigan Regents Mdm2 protein degraders
WO2018092020A1 (en) * 2016-11-15 2018-05-24 Novartis Ag Dose and regimen for hdm2-p53 interaction inhibitors
CN110461881B (zh) 2017-03-27 2023-06-23 诺伊尓免疫生物科技株式会社 嵌合抗原受体
JP6617208B2 (ja) 2017-03-31 2019-12-11 ノバルティス アーゲー 血液腫瘍におけるhdm2−p53相互作用阻害剤の用量およびレジメン
TWI791794B (zh) 2018-03-20 2023-02-11 瑞士商諾華公司 藥物組合
EP3897648B1 (en) 2018-12-20 2023-08-23 Novartis AG Extended low dose regimens for mdm2 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0713119A2 (pt) * 2006-06-30 2012-04-17 Schering Corp piperidinas substituìdas que aumentam a atividade de p53 e os usos destas
PL2101759T3 (pl) * 2006-12-14 2019-05-31 Exelixis Inc Sposoby stosowania inhibitorów MEK
US8354444B2 (en) * 2008-09-18 2013-01-15 Hoffmann-La Roche Inc. Substituted pyrrolidine-2-carboxamides
US20120010235A1 (en) * 2010-07-12 2012-01-12 Xin-Jie Chu N-substituted pyrrolidines
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders

Also Published As

Publication number Publication date
RS55250B1 (sr) 2017-02-28
CN104203232A (zh) 2014-12-10
DK2827858T3 (en) 2016-08-22
JP2015510906A (ja) 2015-04-13
KR20210016073A (ko) 2021-02-10
WO2013139687A1 (en) 2013-09-26
US20190328708A1 (en) 2019-10-31
ES2593066T3 (es) 2016-12-05
KR20190035957A (ko) 2019-04-03
LT2827858T (lt) 2016-10-10
BR112014018135A2 (https=) 2017-06-20
MX2014010586A (es) 2014-09-18
JP6224690B2 (ja) 2017-11-01
JP2017061461A (ja) 2017-03-30
US20130245089A1 (en) 2013-09-19
EP2827858B1 (en) 2016-07-20
US20150126575A1 (en) 2015-05-07
CN110013478A (zh) 2019-07-16
RU2014141365A (ru) 2016-05-10
BR112014018135A8 (pt) 2021-10-19
KR102438597B1 (ko) 2022-08-31
HRP20161295T1 (hr) 2016-11-18
US11738003B2 (en) 2023-08-29
PL2827858T3 (pl) 2017-01-31
RU2638795C2 (ru) 2017-12-15
PT2827858T (pt) 2016-09-23
HK1204934A1 (en) 2015-12-11
EP2827858A1 (en) 2015-01-28
KR20160089549A (ko) 2016-07-27
KR20140133583A (ko) 2014-11-19
CA2859940C (en) 2020-03-24
MX356948B (es) 2018-06-20
CA2859940A1 (en) 2013-09-26
SI2827858T1 (sl) 2016-11-30
US20210069149A1 (en) 2021-03-11
CY1118070T1 (el) 2017-06-28

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