HUE029147T2 - Pneumocandin B0-nak pneumocandin C0-tól történõ elválasztása és/vagy megtisztítása - Google Patents

Pneumocandin B0-nak pneumocandin C0-tól történõ elválasztása és/vagy megtisztítása

Info

Publication number
HUE029147T2
HUE029147T2 HUE10747327A HUE10747327A HUE029147T2 HU E029147 T2 HUE029147 T2 HU E029147T2 HU E10747327 A HUE10747327 A HU E10747327A HU E10747327 A HUE10747327 A HU E10747327A HU E029147 T2 HUE029147 T2 HU E029147T2
Authority
HU
Hungary
Prior art keywords
pneumocandin
purification
separation
Prior art date
Application number
HUE10747327A
Other languages
English (en)
Inventor
Anders Brunsvik
Original Assignee
Xellia Pharmaceuticals Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xellia Pharmaceuticals Aps filed Critical Xellia Pharmaceuticals Aps
Publication of HUE029147T2 publication Critical patent/HUE029147T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/30—Partition chromatography
    • B01D15/305—Hydrophilic interaction chromatography [HILIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/322—Normal bonded phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/364—Amphoteric or zwitterionic ion-exchanger
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HUE10747327A 2009-08-14 2010-08-11 Pneumocandin B0-nak pneumocandin C0-tól történõ elválasztása és/vagy megtisztítása HUE029147T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23383809P 2009-08-14 2009-08-14

Publications (1)

Publication Number Publication Date
HUE029147T2 true HUE029147T2 (hu) 2017-02-28

Family

ID=42734660

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE10747327A HUE029147T2 (hu) 2009-08-14 2010-08-11 Pneumocandin B0-nak pneumocandin C0-tól történõ elválasztása és/vagy megtisztítása

Country Status (9)

Country Link
US (1) US8839962B2 (hu)
EP (1) EP2464374B1 (hu)
KR (1) KR20120059554A (hu)
CN (1) CN102481336B (hu)
DK (1) DK2464374T3 (hu)
ES (1) ES2574646T3 (hu)
HU (1) HUE029147T2 (hu)
IL (1) IL217831A (hu)
WO (1) WO2011019285A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2464977B1 (en) * 2009-08-14 2014-06-25 Xellia Pharmaceuticals ApS Method of detecting pneumocandin compounds
CN103205479B (zh) * 2012-01-17 2017-10-27 上海医药工业研究院 一种用于生产棘白菌素b的培养基
CN103387606B (zh) * 2012-05-11 2015-05-20 浙江震元制药有限公司 制备棘白菌素b母核的方法
CN103193868B (zh) * 2013-04-25 2015-10-28 华北制药集团新药研究开发有限责任公司 一种棘白菌素类抗真菌药阿尼芬净的纯化方法
CN104447961B (zh) * 2013-09-13 2018-05-15 浙江震元制药有限公司 棘白菌素b母核的提取方法
CN104558123A (zh) * 2014-12-01 2015-04-29 江苏汉邦科技有限公司 一种采用动态轴向压缩柱系统制备纽莫康定b0的方法
CN105218645B (zh) * 2015-10-14 2018-08-07 成都雅途生物技术有限公司 一种高纯度高收率的卡泊芬净杂质c0的制备方法
CN107674116B (zh) * 2016-08-02 2020-09-04 北大方正集团有限公司 一种纽莫康定b0的纯化方法
CN108250273A (zh) * 2016-12-28 2018-07-06 浙江华谱新创科技有限公司 纽莫康定高效分离纯化方法
CN108250274A (zh) * 2016-12-28 2018-07-06 浙江华谱新创科技有限公司 米卡芬净高效分离纯化方法
CN111380974A (zh) * 2018-12-30 2020-07-07 山东新时代药业有限公司 一种棘白菌素的检测方法
CN112430256A (zh) * 2020-11-23 2021-03-02 苏州纳微科技股份有限公司 一种阿尼芬净母核的分离纯化方法
CN114236018B (zh) * 2022-02-24 2022-08-19 深圳市海滨制药有限公司 一种醋酸卡泊芬净及其异构体的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021341A (en) 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
JP2007504460A (ja) * 2003-09-05 2007-03-01 メルク　エンド　カムパニー　インコーポレーテッド 固定相及び該固定相を用いた精製プロセス
US7557232B2 (en) * 2007-05-25 2009-07-07 Dionex Corporation Compositions useful as chromatography stationary phases

Also Published As

Publication number Publication date
EP2464374B1 (en) 2016-05-04
DK2464374T3 (en) 2016-06-06
EP2464374A1 (en) 2012-06-20
IL217831A (en) 2015-04-30
WO2011019285A1 (en) 2011-02-17
IL217831A0 (en) 2012-03-29
CN102481336A (zh) 2012-05-30
KR20120059554A (ko) 2012-06-08
ES2574646T3 (es) 2016-06-21
US20120142893A1 (en) 2012-06-07
CN102481336B (zh) 2015-11-25
US8839962B2 (en) 2014-09-23

Similar Documents

Publication Publication Date Title
IL217831A0 (en) Separation and/or purification of pneumocandin b0 from c0
IL261147A (en) Methods for purification of polypeptides
EP2482959A4 (en) GAS CLEANING CONFIGURATIONS AND METHODS
EP3422006C0 (en) RECOGNIZING THE RISK OF PRECLAMPSIA
EP2513142A4 (en) MEMBRANES AND APPROPRIATE PROCEDURES FOR CLEANING ANTIBODIES
GB201004638D0 (en) Separation of gases
IL225650A0 (en) Protein purification processes
IL214567A0 (en) Means for purifying a protein of blood plasma and methods for implementing same
EP2504082A4 (en) MEMBRANE AND MEMBRANE SEPARATION SYSTEM
EP3715356C0 (en) PROCESS FOR PURIFYING POLYPEPTIDES
IL214434A0 (en) Purification of immunoglobulins
EP2456541A4 (en) PROCESS FOR OXYGEN SEPARATION AND DISTRIBUTION
EP2621607A4 (en) APPARATUS AND METHOD FOR PURIFYING GAS CURRENT
IL216658A0 (en) Peptoid ligands for isolation and treatment of autoimmune t-cells
EP2577296A4 (en) METHODS FOR DESIGNING FILTERING MEMBRANES
SI2552941T1 (sl) Čiščenje vmesnih spojin kaspofungina
EP2519537A4 (en) CLEANING PROTEINS
GB2456691A8 (en) Separation of hydrocarbons and nitrogen
GB0814556D0 (en) Purification of gas stream
HK1168363A1 (en) Novel peptide and use thereof
EP2478010A4 (en) PART PEPTIDE OF LACRITINE
ZA201107046B (en) Gas stream processing
IL214762A0 (en) Modifications of cupredoxin derives peptides and methods of use thereof
GB201012110D0 (en) Separation of gases
GB201001710D0 (en) Separation of gases