HUE028544T2 - Eljárás pirazol-karboxamid sztereoszelektív elõállítására - Google Patents

Eljárás pirazol-karboxamid sztereoszelektív elõállítására Download PDF

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Publication number
HUE028544T2
HUE028544T2 HUE13703616A HUE13703616A HUE028544T2 HU E028544 T2 HUE028544 T2 HU E028544T2 HU E13703616 A HUE13703616 A HU E13703616A HU E13703616 A HUE13703616 A HU E13703616A HU E028544 T2 HUE028544 T2 HU E028544T2
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HU
Hungary
Prior art keywords
formula
compound
bis
group
diphenylphosphino
Prior art date
Application number
HUE13703616A
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English (en)
Inventor
Tomas Smejkal
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of HUE028544T2 publication Critical patent/HUE028544T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
    • C07C251/64—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids
    • C07C251/66—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids with the esterifying carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/573—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/693—Unsaturated compounds containing a keto groups being part of a ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (2)

  1. MMÀ&M FMAZ-OL-KáRBOXAMÍB sztereosxfaâïïv előállítására SxsfeacfeíM igé»ypentek EÉprás p?) i^sÉí |~d5ÍtonHetil-ií-metil'ÍÍÍ:^)irs»o1'4"kaÁöRs&v~(ÍS,4R}'9“dMöSRdiá8-lí2>3:s4·· teRahidfo44'ai8t;aK)nafnih'ti-5'i!}'amid en«utùtt>>:dek.t jv e fôâ f I áására,
    iséïy eipíus tartelxruuraa a* aílfebsafeaí: a) (Π) këjïleiü vegyük! redukálása
    euáadosgelektív smgufisse! (Ele) kéjM-Si uagySlePj
    fej a fl Ma) tëpletû vegyükî defeïîkàias» SavJdköMkhen (1 Va) kápietü. vagyîikîk,
    a) a 0 Va) keplçîü vegyiikt reagáír&fása hkhuKiixumuuas (Va) kepkdû vegyülstk
    é;·: (Vaj képl vegyidet oldösse? é§ aeilssêsz&r jelenlétében, és végűi á fotpotl »msät resgâlÂs 03} \ egyiHcüel
    /agy s) m (V) képlet» vegyidet reagálíaiása &amp;áesle#«fi adott, < Vi) k&amp;t^/mgyâk®é,
    2, As i, Igénypont sgeriMi eljárás, ahei a (U) Mpmû vegyidet eo&amp;ntkaszsk'fcUv redukálását isklrogése·· gásásl, átmenetifém j&amp;salMkii jeletdátáhen végezzük. I À« k Igénypont szerinti eljárás, ajtói a (II) kéoleïâ vegyMel: enarásoszelsktív redukálását transsfô^îêi-rogeesÎîéseelf átmeeeíiféís katalizátor jejteftiéí#«» vég«®*., 4:< Az i. igénypont szerinti eljárás, ahol az eauajoszeiekav retiens mlètbum kata!izstor. II Ä 2. iiiaypoîit szsrlsÉ d|àîàs* Ai^ÂÂs^s|^#:|^8g«atô' Aîtépskt» katalizátor, b. A 3. igéeypöJit szerinti eljárás, aíol, az enanrioszelektlv reagens ratémum katalizátor.
    7. Az 1, igénypont szerirdi eljárás, ahol az enantbsseiskttv reagens k.!ôr- KR>~i t- )-2,24 -lals^ftlíílí,.?'· s 83 I ^ÉÉÉ8É|· mténlutsijpjj.· I, As: L Iglsypfâaisgmniî $11¾¾ #«$ m «aápdöázeleMiy reágesis g, A Cils) képtstö
    es (IJíft-(ühsí) képied* k-:osöer|eí
    îôv A {1¾) képletü (îS!4E^9-i|:îkS:émeîié3^23^,6ï?,?;:-kexsfeidro--lH~ie4-aïisîa»pas^s!îa--5'-os ^egÿflei
    és (!Vb). (I Vc) és (IVd) képkaii Smseçjel::
    H, Az (Va) képletû vsgyülei
    és CVb); (Ve) ês (Vd) Idpteti) ««mserjd:·
  2. (2, (XXUia) kàpletû vegygka
    sbiíi X jeleskse axigéa vsgy fcés, R* jskíRáse Cr^flfe©3d, &amp;ae«ksöfKSfi m$$ tiMèr- meksi-csfiçîoî't. 13:. (XX! Vs; k^lsM vsgySk!
    skd X jelsakse oxigéfî vagy Rés.
HUE13703616A 2012-02-15 2013-02-13 Eljárás pirazol-karboxamid sztereoszelektív elõállítására HUE028544T2 (hu)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12155526 2012-02-15
EP12173642 2012-06-26
EP12177606 2012-07-24
EP12182799 2012-09-03

Publications (1)

Publication Number Publication Date
HUE028544T2 true HUE028544T2 (hu) 2016-12-28

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HUE13703616A HUE028544T2 (hu) 2012-02-15 2013-02-13 Eljárás pirazol-karboxamid sztereoszelektív elõállítására

Country Status (21)

Country Link
US (1) US9120759B2 (hu)
EP (1) EP2814813B1 (hu)
JP (1) JP6216332B2 (hu)
KR (1) KR102037942B1 (hu)
CN (1) CN104114539B (hu)
AP (1) AP4027A (hu)
AR (1) AR089989A1 (hu)
AU (1) AU2013220443B2 (hu)
BR (1) BR112014020011B1 (hu)
CA (1) CA2863725C (hu)
CO (1) CO7030966A2 (hu)
EA (1) EA026529B1 (hu)
ES (1) ES2568638T3 (hu)
HR (1) HRP20160381T1 (hu)
HU (1) HUE028544T2 (hu)
PL (1) PL2814813T3 (hu)
RS (1) RS54672B1 (hu)
TW (1) TWI510472B (hu)
UY (1) UY34626A (hu)
WO (1) WO2013120860A1 (hu)
ZA (1) ZA201405565B (hu)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093347A (en) 1991-01-28 1992-03-03 Monsanto Company 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use
JP4004123B2 (ja) 1997-12-26 2007-11-07 独立行政法人科学技術振興機構 ルテニウム錯体を触媒とするアルコール化合物の製造方法
WO2004007506A1 (ja) 2002-07-15 2004-01-22 Nippon Soda Co.,Ltd. ルテニウム化合物、ジアミン配位子および光学活性アルコールの製造方法
ITPD20040115A1 (it) 2004-05-04 2004-08-04 Univ Degli Studi Udine Complessi di rutenio con 2-(amminometil)piridine e fosfine, loro preparazione ed uso come catalizzatori
CN1331874C (zh) 2005-01-27 2007-08-15 中国科学院上海有机化学研究所 过渡金属络合物、合成方法及其用途
DE602006018506D1 (de) 2005-10-25 2011-01-05 Syngenta Participations Ag Als mikrobiozide geeignete heterocyclische amidderivate
CN101328191B (zh) * 2008-06-13 2013-06-05 中国科学院上海有机化学研究所 一类含氮配体过渡金属络合物、合成方法及其用途
GEP20135747B (en) * 2008-10-27 2013-02-11 Syngenta Participations Ag Method of benzonorbornenes production
AU2010280923B2 (en) * 2009-08-06 2014-08-07 Syngenta Participations Ag Process for the preparation of pyrazole carboxylic acid amides
KR101808261B1 (ko) 2010-04-28 2017-12-12 다카사고 고료 고교 가부시키가이샤 루테늄 착체 및 광학적으로 활성인 알코올 화합물의 제조방법
AR083987A1 (es) 2010-12-01 2013-04-10 Bayer Cropscience Ag Amidas de acido pirazolcarboxilico utiles para la reduccion de la contaminacion de micotoxina en las plantas
TWI534126B (zh) 2011-01-25 2016-05-21 先正達合夥公司 用於製備吡唑羧酸醯胺之方法

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Publication number Publication date
EP2814813A1 (en) 2014-12-24
AP4027A (en) 2017-02-04
UY34626A (es) 2013-09-30
CA2863725A1 (en) 2013-08-22
CN104114539B (zh) 2016-10-12
KR102037942B1 (ko) 2019-10-29
ES2568638T3 (es) 2016-05-03
US9120759B2 (en) 2015-09-01
BR112014020011A2 (hu) 2017-06-20
CN104114539A (zh) 2014-10-22
PL2814813T3 (pl) 2016-07-29
RS54672B1 (en) 2016-08-31
TW201345897A (zh) 2013-11-16
AU2013220443A1 (en) 2014-08-28
TWI510472B (zh) 2015-12-01
CA2863725C (en) 2019-10-01
CO7030966A2 (es) 2014-08-21
EA201400904A1 (ru) 2015-01-30
KR20140128429A (ko) 2014-11-05
AU2013220443B2 (en) 2016-10-27
ZA201405565B (en) 2016-01-27
EA026529B1 (ru) 2017-04-28
HRP20160381T1 (hr) 2016-05-20
WO2013120860A1 (en) 2013-08-22
AP2014007855A0 (en) 2014-08-31
JP6216332B2 (ja) 2017-10-18
BR112014020011A8 (pt) 2017-07-11
AR089989A1 (es) 2014-10-01
JP2015506997A (ja) 2015-03-05
US20140364622A1 (en) 2014-12-11
EP2814813B1 (en) 2016-02-10
BR112014020011B1 (pt) 2019-08-20

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