BR112014020011A8 - Processo para a preparação enantiosseletiva de pirazol carboxamidas, e compostos - Google Patents

Processo para a preparação enantiosseletiva de pirazol carboxamidas, e compostos

Info

Publication number
BR112014020011A8
BR112014020011A8 BR112014020011A BR112014020011A BR112014020011A8 BR 112014020011 A8 BR112014020011 A8 BR 112014020011A8 BR 112014020011 A BR112014020011 A BR 112014020011A BR 112014020011 A BR112014020011 A BR 112014020011A BR 112014020011 A8 BR112014020011 A8 BR 112014020011A8
Authority
BR
Brazil
Prior art keywords
formula
compound
preparation
enantiosective
carboxamides
Prior art date
Application number
BR112014020011A
Other languages
English (en)
Other versions
BR112014020011A2 (pt
BR112014020011B1 (pt
Inventor
Smejkal Tomas
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of BR112014020011A2 publication Critical patent/BR112014020011A2/pt
Publication of BR112014020011A8 publication Critical patent/BR112014020011A8/pt
Publication of BR112014020011B1 publication Critical patent/BR112014020011B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/44—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atom of at least one of the oxyimino groups being part of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/62—Oximes having oxygen atoms of oxyimino groups esterified
    • C07C251/64—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids
    • C07C251/66—Oximes having oxygen atoms of oxyimino groups esterified by carboxylic acids with the esterifying carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/573—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/693—Unsaturated compounds containing a keto groups being part of a ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PROCESSO PARA A PREPARAÇÃO ESTEREOSSELETIVA DE UMA PIRAZOL CARBOXAMIDA. A presente invenção refere-se a um processo para a preparação enantiosseletiva da ((1S,4R)-9-diclorometileno -1,2,3,4-tetra- hidro-1,4-metano-naftalen-5-il)-amida do ácido 3-difluorometil-1-metil- 1H-pirazol-4-carboxílico da fórmula Ib compreendendo a) redução de um composto da fórmula II; b) desidratação do composto da fórmula IIIe; c) reação do composto da fórmula IVa; d) acilação do oxigênio de oxima do composto da fórmula Va; e e) reação do composto da fórmula V.
BR112014020011-4A 2012-02-15 2013-02-13 Processo para a preparação enantiosseletiva de pirazol carboxamidas, e compostos BR112014020011B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP12155526 2012-02-15
EP12155526.2 2012-02-15
EP12173642.5 2012-06-26
EP12173642 2012-06-26
EP12177606.6 2012-07-24
EP12177606 2012-07-24
EP12182799 2012-09-03
EP12182799.2 2012-09-03
PCT/EP2013/052803 WO2013120860A1 (en) 2012-02-15 2013-02-13 Process for the stereoselective preparation of a pyrazole carboxamide

Publications (3)

Publication Number Publication Date
BR112014020011A2 BR112014020011A2 (pt) 2017-06-20
BR112014020011A8 true BR112014020011A8 (pt) 2017-07-11
BR112014020011B1 BR112014020011B1 (pt) 2019-08-20

Family

ID=47683767

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014020011-4A BR112014020011B1 (pt) 2012-02-15 2013-02-13 Processo para a preparação enantiosseletiva de pirazol carboxamidas, e compostos

Country Status (21)

Country Link
US (1) US9120759B2 (pt)
EP (1) EP2814813B1 (pt)
JP (1) JP6216332B2 (pt)
KR (1) KR102037942B1 (pt)
CN (1) CN104114539B (pt)
AP (1) AP4027A (pt)
AR (1) AR089989A1 (pt)
AU (1) AU2013220443B2 (pt)
BR (1) BR112014020011B1 (pt)
CA (1) CA2863725C (pt)
CO (1) CO7030966A2 (pt)
EA (1) EA026529B1 (pt)
ES (1) ES2568638T3 (pt)
HR (1) HRP20160381T1 (pt)
HU (1) HUE028544T2 (pt)
PL (1) PL2814813T3 (pt)
RS (1) RS54672B1 (pt)
TW (1) TWI510472B (pt)
UY (1) UY34626A (pt)
WO (1) WO2013120860A1 (pt)
ZA (1) ZA201405565B (pt)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093347A (en) 1991-01-28 1992-03-03 Monsanto Company 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use
JP4004123B2 (ja) 1997-12-26 2007-11-07 独立行政法人科学技術振興機構 ルテニウム錯体を触媒とするアルコール化合物の製造方法
AU2002318538A1 (en) 2002-07-15 2004-02-02 Nippon Soda Co., Ltd. Ruthenium compounds, diamine ligands, and process for preparation of optically active alcohols
ITPD20040115A1 (it) 2004-05-04 2004-08-04 Univ Degli Studi Udine Complessi di rutenio con 2-(amminometil)piridine e fosfine, loro preparazione ed uso come catalizzatori
CN1331874C (zh) 2005-01-27 2007-08-15 中国科学院上海有机化学研究所 过渡金属络合物、合成方法及其用途
US7732469B2 (en) 2005-10-25 2010-06-08 Syngenta Crop Protection, Inc. Heterocyclic amide derivatives useful as microbiocides
CN101328191B (zh) * 2008-06-13 2013-06-05 中国科学院上海有机化学研究所 一类含氮配体过渡金属络合物、合成方法及其用途
ES2431818T3 (es) * 2008-10-27 2013-11-28 Syngenta Participations Ag Procedimiento para la preparación de benzonorbornenos
GEP20146010B (en) * 2009-08-06 2014-01-10 Syngenta Participations Ag Method of pyrazole carboxylic acid amides preparation
US9079931B2 (en) * 2010-04-28 2015-07-14 Takasago International Corporation Ruthenium complex and method for preparing optically active alcohol compound
AR083987A1 (es) 2010-12-01 2013-04-10 Bayer Cropscience Ag Amidas de acido pirazolcarboxilico utiles para la reduccion de la contaminacion de micotoxina en las plantas
TWI534126B (zh) * 2011-01-25 2016-05-21 先正達合夥公司 用於製備吡唑羧酸醯胺之方法

Also Published As

Publication number Publication date
KR102037942B1 (ko) 2019-10-29
KR20140128429A (ko) 2014-11-05
CA2863725A1 (en) 2013-08-22
AU2013220443B2 (en) 2016-10-27
TW201345897A (zh) 2013-11-16
AP4027A (en) 2017-02-04
EA201400904A1 (ru) 2015-01-30
US20140364622A1 (en) 2014-12-11
EP2814813A1 (en) 2014-12-24
ES2568638T3 (es) 2016-05-03
HUE028544T2 (en) 2016-12-28
UY34626A (es) 2013-09-30
ZA201405565B (en) 2016-01-27
PL2814813T3 (pl) 2016-07-29
JP6216332B2 (ja) 2017-10-18
BR112014020011A2 (pt) 2017-06-20
US9120759B2 (en) 2015-09-01
WO2013120860A1 (en) 2013-08-22
CN104114539A (zh) 2014-10-22
BR112014020011B1 (pt) 2019-08-20
RS54672B1 (en) 2016-08-31
EA026529B1 (ru) 2017-04-28
TWI510472B (zh) 2015-12-01
JP2015506997A (ja) 2015-03-05
AR089989A1 (es) 2014-10-01
AU2013220443A1 (en) 2014-08-28
CA2863725C (en) 2019-10-01
HRP20160381T1 (hr) 2016-05-20
EP2814813B1 (en) 2016-02-10
CN104114539B (zh) 2016-10-12
AP2014007855A0 (en) 2014-08-31
CO7030966A2 (es) 2014-08-21

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/02/2013, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/02/2013, OBSERVADAS AS CONDICOES LEGAIS