HUE028100T2 - Dextrometorfánt és kindint tartalmazó gyógyszerkészítmények neurológiai rendellenességek kezelésére - Google Patents
Dextrometorfánt és kindint tartalmazó gyógyszerkészítmények neurológiai rendellenességek kezelésére Download PDFInfo
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- HUE028100T2 HUE028100T2 HUE08154443A HUE08154443A HUE028100T2 HU E028100 T2 HUE028100 T2 HU E028100T2 HU E08154443 A HUE08154443 A HU E08154443A HU E08154443 A HUE08154443 A HU E08154443A HU E028100 T2 HUE028100 T2 HU E028100T2
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- dextromethorphan
- quinidine
- salts
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/49—Cinchonan derivatives, e.g. quinine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
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- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Claims (2)
- Szabadalmi Igénypontok I« Dextrometorfán klnidlnnel kombínádóban pszeodobulbárls állapot kezelési eljárásában történő a lkai maxisra , ahol a dextmmetorfánt és a ki didin! egy kombinált dózisban adagoljak* a kinldln mennyisége agy dextromatorfán tömeg eg y ség re vonatkoztatva 0*7S tömegrési vagy kevesebb,, és a naponta adagolt mennyiség IS mg és öS mg közötti és a naponta adagolt klnldln mennyiség 2,5 mg és .20 mg .közötti. 2* A kombináció az :L Igénypont szerinti eljárásban történő alkalmazásra, ahol a naponta adagolt klnldln mennyiség 2ö mg, egyszeri dózisban vagy osztott dózisokban, &. A kombináció az 1. Igénypont szerinti eljárásban történő alkalmazásra:, ahol a naponta adagolt dextronietorfán dózis mg-öan a klnldln dózisának mg-jáboz viszonyítva 30:20,40:20, 50:20 vagy 60:20,
- 4, A kombináció az előző igénypontok bármelyike szerinti eljárásban történi alkalmazásra, aboi a dextrometorfant és a klnldln! napi egyszeri dózisban vagy osztott dózisokban :{2~, 3-, 4-szer vagy többször naponta} adagoltok, •5* A kùmbinàcïè az előző igénypontok bármelyike szerinti eljárásban történő alkalmazásra, aboi a klnldln és a dextrometorfán legalább egyike gyógyszerészetilag elfogadható só alakban van jelen, 6* A kombinácié az. előző igénypontok bármelyike szerinti eljárásban történő alkalmazásra, aboi a klnldln és a dextfometorfen legalább egyike gyógy sxerészetileg elfo-gadöalő só alakban ven jelen, amelyet az alábblakbő! álló csoportból választónk: aikáHfemsök, lltiemsok, netrlumsók, kéllumsók, eikálfföldösrnsók, káfeiumsék, magnéziomsók, iizinsők, az fl,N''-dl~benzli~eti?én-diamin sói, klór-proksín-sók, koinsók, dletsnoi-amín-sók, etilén-dlamlo-sök, megiuminsok, prokainsék, írisz-sók, szabad savak sói, szabad bázisok sói, szervetlen sók, szalfátsók, hldrokioridsék és hidrobromidsók, 7» A. kombináció az előző igénypontok bármelyike szerint: eljárásban: történő alkalmazásra, ahol 3: klnldln klnldln-szálfát alakban van jelen, B, A kombináció az előző igénypontok bármelyike szerinti eljárásban történő alkalmazásra, aboi a dextrometorfán dextrometorfán-bromld alakban van jelen.
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| HUS1300069C HUS1300069I1 (hu) | 2002-07-17 | 2013-11-14 | Dextrometorfánt és kinidint tartalmazó gyógyászati készítmények neurológiai rendellenességek kezelésére |
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| HUS1300069C HUS1300069I1 (hu) | 2002-07-17 | 2013-11-14 | Dextrometorfánt és kinidint tartalmazó gyógyászati készítmények neurológiai rendellenességek kezelésére |
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| TWI326214B (en) * | 2002-07-17 | 2010-06-21 | Avanir Pharmaceuticals Inc | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders |
| AU2003291302A1 (en) * | 2002-11-06 | 2004-06-03 | Azaya Therapeutics, Inc. | Method for treatment of premature ejaculation in humans |
| WO2006038070A2 (en) * | 2004-03-30 | 2006-04-13 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
| US20070191411A1 (en) * | 2004-10-07 | 2007-08-16 | Smith Richard A | Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| CA2641392A1 (en) * | 2006-02-03 | 2007-08-16 | Avanir Pharmaceuticals | Pharmaceutical compositions for treating depression, anxiety and neurodegenerative disorders |
| US20160143901A1 (en) * | 2006-02-03 | 2016-05-26 | Avanir Pharmaceuticals, Inc. | Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of agitation in dementia |
| EP3825306B8 (en) | 2007-05-01 | 2023-08-02 | Sun Pharmaceutical Industries, Inc. | Morphinan compounds |
| EP3632916B1 (en) | 2007-05-01 | 2022-06-08 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| PL2345653T3 (pl) * | 2007-05-01 | 2013-05-31 | Concert Pharmaceuticals Inc | Związki morfianu |
| WO2009006194A1 (en) * | 2007-06-28 | 2009-01-08 | Avanir Pharmaceuticals | Pharmaceutical compositions for the treatment of involuntary emotional expression disorder |
| SI2334678T1 (sl) | 2008-09-19 | 2013-05-31 | Concert Pharmaceuticals Inc. | Spojine morfinana |
| US20120122848A1 (en) * | 2009-07-29 | 2012-05-17 | Green Cross Corporation | (+)-3-hydroxymorphinan derivatives as neuroprotectants |
| US20110212987A1 (en) * | 2009-08-28 | 2011-09-01 | Avanir Pharmaceuticals, Inc. | Method of reducing cns and gastrointestinal side affects associated with long-term dextromethorphan/low-dose quinidine combination therapy |
| US20130053411A1 (en) * | 2010-05-03 | 2013-02-28 | Tsh Biopharm Corporation Ltd. | Pharmaceutical composition and method for treating hypertension |
| WO2012123449A1 (en) * | 2011-03-14 | 2012-09-20 | Boehringer Ingelheim International Gmbh | N- cyclopropyl - n- piperidinylbenzamides as gpr119 modulators |
| US8569328B1 (en) * | 2011-05-24 | 2013-10-29 | Antecip Bioventures Ii Llc | Compositions and methods comprising tilidine or related compounds and dextromethorphan |
| EP2718288B1 (en) | 2011-06-09 | 2015-03-11 | Boehringer Ingelheim International GmbH | Substituted piperidines as gpr119 modulators for the treatment of metabolic disorders |
| US20130274282A1 (en) * | 2012-04-16 | 2013-10-17 | Herriot Tabuteau | Compositions and methods comprising celecoxib or related compounds and dextromethorphan |
| HUE051406T2 (hu) | 2012-11-14 | 2021-03-01 | Grace W R & Co | Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók |
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