HUE025155T2 - Multipotens sejtek azonosítása és izolálása nem-oszteokondrális mezenchimális szövetbõl - Google Patents

Multipotens sejtek azonosítása és izolálása nem-oszteokondrális mezenchimális szövetbõl Download PDF

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Publication number
HUE025155T2
HUE025155T2 HUE10183073A HUE10183073A HUE025155T2 HU E025155 T2 HUE025155 T2 HU E025155T2 HU E10183073 A HUE10183073 A HU E10183073A HU E10183073 A HUE10183073 A HU E10183073A HU E025155 T2 HUE025155 T2 HU E025155T2
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cells
cell
multipotent adult
markers
population
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HUE10183073A
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Castro Rosa Ana Garcia
Miguel Maria Gema Fernandez
Arranz Mariano Garcia
De La Peòa Manuel Angel Gonzalez
Olmo Damian Garcia
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Tigenix S A U
Univ Madrid Autonoma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457282&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE025155(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tigenix S A U, Univ Madrid Autonoma filed Critical Tigenix S A U
Publication of HUE025155T2 publication Critical patent/HUE025155T2/hu

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
    • C12N2506/1384—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from adipose-derived stem cells [ADSC], from adipose stromal stem cells
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Claims (2)

  1. μοεϊμτmm sejtek azonosítása is izolálása kem-oszteokömomális SfEZlHCBltóOS SZÖVETBŐL SzafesdaJtoíí %é:8>;poaiok
    1. Léiiveg&ss JiöíKiögésí, sosozateaa pimÁ, íZöl&lirs^^pMdö, &roe%: *»ul%siem felnőtt sejtekéi: iaröfeaz;, amelyek {a) zsirszoveíMt irfáltal, .(¾} a következőket exisresszáiiák: €D9,: ÓDIO, CD 13, CD29,. CD44, CD49A, CD5I, CD54, CD5S, C^S^CÖS^ 0390 és: 00105¾ és («} »em exjsresszáf ák a követezőket: CDi ib, C.DI4, CDS 5. CDié, CD3L CD34, Cím, CD49t:; CDi02, CDi04, CD106 és CDI 33. 2. A* L igé^oot s2sSffi:í pxátíspetess tefe§íts^:^|®pkíCíóv mé$ a. kővetkezőket írntgátssn fogtálé eljárással izolált: (a) zsírszövet gyűjtése, ('·>} sejtezus^nzió dMilííása eoxfoiatikus emésztéssel, (e): a sejtek ökpÉéseíeevészkOzeghea, és (4) & se$tek fosyásxíéss skeíIíSííííI folbleies,«» « san.árd fdükiíiSz adkéziét aeíamuMá sejtek eijxmHáÍásaS: (e) a sejtek ezparsKléja sexozaios gasszálással, 3,. iQyőgfSmti íóteítofey, amely 1,. vagy 2. tgéKypoat szerinti isxtáli: sejipopniádét is győgyászaiikg: elfogadható hordozót tartalmaz.
  2. 4, Az 1. vagy 2, igénypont szerinti kóláit ssjípopfoáclé: terápiába» történ© alkalmazásra.
HUE10183073A 2004-10-04 2005-10-04 Multipotens sejtek azonosítása és izolálása nem-oszteokondrális mezenchimális szövetbõl HUE025155T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200402355A ES2313805B1 (es) 2004-10-04 2004-10-04 Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.

Publications (1)

Publication Number Publication Date
HUE025155T2 true HUE025155T2 (hu) 2016-03-29

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ID=35457282

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Application Number Title Priority Date Filing Date
HUE10183073A HUE025155T2 (hu) 2004-10-04 2005-10-04 Multipotens sejtek azonosítása és izolálása nem-oszteokondrális mezenchimális szövetbõl

Country Status (17)

Country Link
US (3) US20060073124A1 (hu)
EP (5) EP2292736B1 (hu)
JP (2) JP2008515413A (hu)
KR (1) KR20070085294A (hu)
CN (1) CN101056974B (hu)
AU (1) AU2005291353A1 (hu)
CA (1) CA2583151C (hu)
CY (1) CY1116198T1 (hu)
DK (1) DK2292736T3 (hu)
ES (2) ES2313805B1 (hu)
HU (1) HUE025155T2 (hu)
IL (1) IL182441A (hu)
PL (1) PL2292736T3 (hu)
PT (1) PT2292736E (hu)
SG (2) SG158853A1 (hu)
SI (1) SI2292736T1 (hu)
WO (1) WO2006037649A1 (hu)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7807458B2 (en) 2003-01-30 2010-10-05 The United States Of America As Represented By The Secretary Of The Department Of Veterans Affairs Multilineage-inducible cells and uses thereof
DE602004027479D1 (de) * 2003-04-24 2010-07-15 Koninkl Philips Electronics Nv Eingriffsfreie links-herzkammervolumenbestimmung
US7266519B2 (en) * 2003-06-30 2007-09-04 Qualcomm Incorporated Billing system with authenticated wireless device transaction event data
ITRM20030376A1 (it) * 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US20060045872A1 (en) * 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
WO2006052925A2 (en) * 2004-11-08 2006-05-18 The Johns Hopkins University Cardiac stem cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US20090130067A1 (en) 2005-09-23 2009-05-21 Dirk Buscher Cell Population Having Immunoregulatory Activity, Method for Isolation and Uses
EP1978977A4 (en) * 2006-01-24 2010-03-17 Christopher J Centeno METHOD AND SYSTEM FOR ISOLATION AND TRANSPLANTATION OF MESENCHYMAL STEM CELLS FOR USE IN CLINICAL MEDIA
US20080025953A1 (en) * 2006-07-25 2008-01-31 Kiminobu Sugaya Vigor Enhancement of Animals Via Administration of Stem Cells
KR100827660B1 (ko) 2006-10-25 2008-05-07 대한민국 (식품의약품안전청장) Ｃｄ9를 발현하는 인간 중간엽 줄기세포의 선별 및배양방법
ES2441560T3 (es) * 2006-11-03 2014-02-05 Aastrom Biosciences, Inc. Poblaciones celulares mixtas para la reparación de tejidos y técnica de separación para el procesamiento celular
US20100093089A1 (en) * 2006-11-09 2010-04-15 Eduardo Marban Dedifferentiation of adult mammalian cardiomyocytes into cardiac stem cells
FR2918073B1 (fr) * 2007-06-27 2012-10-19 Univ Paris Curie Cellules fixatrices de cellules tumorales.
US9095562B2 (en) * 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
WO2009085969A2 (en) * 2007-12-19 2009-07-09 Regenerative Sciences, Llc Compositions and methods to promote implantation and engrafment of stem cells
WO2009114785A2 (en) * 2008-03-14 2009-09-17 Regenerative Sciences, Inc. Compositions and methods for cartilage repair
AU2015268704B2 (en) * 2008-08-04 2017-08-10 Consejo Superior De Investigaciones Cientificas Uses of mesenchymal stem cells
GB0814249D0 (en) * 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells
US9090678B2 (en) 2008-08-18 2015-07-28 Mesoblast, Inc. Monoclonal antibody STRO-4
WO2010065854A1 (en) 2008-12-05 2010-06-10 Regenerative Sciences, Llc Methods and compositions to facilitate repair of avascular tissue
US20100168022A1 (en) * 2008-12-11 2010-07-01 Centeno Christopher J Use of In-Vitro Culture to Design or Test Personalized Treatment Regimens
US20110054929A1 (en) * 2009-09-01 2011-03-03 Cell Solutions Colorado Llc Stem Cell Marketplace
JP5810435B2 (ja) * 2009-09-30 2015-11-11 国立大学法人 熊本大学 内胚葉細胞、腸管細胞又は膵細胞の検出方法
US9113950B2 (en) 2009-11-04 2015-08-25 Regenerative Sciences, Llc Therapeutic delivery device
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
ES2803499T3 (es) 2011-06-29 2021-01-27 Biorestorative Therapies Inc Composiciones y métodos de células grasas marrones
EP2634195B1 (en) * 2012-03-01 2017-02-01 Miltenyi Biotec GmbH Separation of living untouched neurons
EP2861238A4 (en) 2012-06-05 2016-03-16 Capricor Inc OPTIMIZED METHODS FOR GENERATING CARDIAC STEM CELLS FROM CARDIAC TISSUE AND THEIR USE IN CARDIAC THERAPY
EP2882445B1 (en) 2012-08-13 2019-04-24 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
EP2986714B1 (en) 2013-04-19 2021-01-06 Biorestorative Therapies, Inc. Human brown adipose derived stem cells and uses
AU2014296259B2 (en) 2013-07-30 2017-04-27 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
BR102013033827B1 (pt) * 2013-12-27 2021-09-08 Regenera - Medicina Veterinária Avançada Ltda. Concentrado multipotente e imunocompatível de células-tronco e biofármaco e forma de dosagem que o compreendem
US11357799B2 (en) 2014-10-03 2022-06-14 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN108289915A (zh) 2015-11-24 2018-07-17 日本乐敦制药株式会社 包含脂肪组织来源基质细胞的肝病治疗剂及其制造方法
WO2017094260A1 (ja) * 2015-12-01 2017-06-08 学校法人 慶應義塾 脊椎動物の脂肪組織由来間葉系細胞株の製造方法
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
CN109863399B (zh) * 2016-08-26 2022-12-20 朱诺治疗学股份有限公司 计数存在于细胞组合物中的颗粒的方法
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
EP3612191A4 (en) 2017-04-19 2020-12-30 Cedars-Sinai Medical Center METHODS AND COMPOSITIONS FOR TREATING SKELETAL MUSCLE DYSTROPHY
EP3417888A1 (de) * 2017-06-25 2018-12-26 co.don AG Verfahren zum herstellen von transplantierbarem knorpelgewebe
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
JP7542258B2 (ja) 2018-01-29 2024-08-30 中国科学院動物研究所 細胞の機械的恒常性を破壊し、組織器官の再生と修復を促進する方法、およびその使用
CN110090300A (zh) * 2018-01-29 2019-08-06 中国科学院动物研究所 一种促进组织器官的再生修复的方法及其应用
ES2957507A1 (es) * 2022-06-09 2024-01-19 Fundacion Instituto De Investig Sanitaria Fundacion Jimenez Diaz Tratamiento de la disfuncion de las glandulas de meibomio

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
AU2808397A (en) 1996-04-26 1997-11-19 Case Western Reserve University Skin regeneration using mesenchymal stem cells
AU9127098A (en) 1997-09-04 1999-03-22 Osiris Therapeutics, Inc. Ligands that modulate differentiation of mesenchymal stem cells
DK1066052T3 (da) 1998-03-18 2006-06-12 Osiris Therapeutics Inc Mesenchymstamceller til forebyggelse og behandling af immunreaktioner ved transplantationer
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US20050153442A1 (en) * 1999-03-10 2005-07-14 Adam Katz Adipose-derived stem cells and lattices
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
EP1165830B1 (en) 1999-03-10 2017-07-12 University of Pittsburgh of the Commonwealth System of Higher Education Adipose-derived stem cells and lattices
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
AU2001238695B2 (en) * 2000-02-26 2005-11-24 Artecel Sciences, Inc. Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof
EP1990350A1 (en) * 2002-06-14 2008-11-12 Cartela R&D AB Marker for mesenchymal stem cells and its use
CA2493532C (fr) * 2002-07-31 2014-05-27 Yves Saint-Laurent Parfums Cellules souches issues de tissu adipeux et cellules differenciees issues de ces cellules
ES2265199B1 (es) * 2003-06-12 2008-02-01 Cellerix, S.L. Celulas madre adultas multipotentes procedentes de condrocitos desdiferenciados y sus aplicaciones.
WO2005035738A1 (en) * 2003-10-07 2005-04-21 Biomaster Inc. Cell differentiation of adipose-derived precursor cells
KR100821128B1 (ko) * 2003-11-04 2008-04-14 가부시키가이샤 바이오마스타 지방 조직으로부터 줄기세포를 생성하는 방법 및 시스템
CA2564679C (en) 2004-03-22 2015-06-23 Osiris Therapeutics, Inc. Mesenchymal stem cells and uses therefor
RU2252252C1 (ru) * 2004-04-09 2005-05-20 Тепляшин Александр Сергеевич Способ выделения мезенхимальных стволовых клеток
ES2264862B8 (es) 2004-08-25 2017-01-20 Cellerix, S.L. Biomaterial para sutura.
ES2313805B1 (es) 2004-10-04 2009-12-23 Cellerix, S.L. Identificacion y aislamiento de celulas multipotentes de tejido mesenquimal no osteocondral.
GB0814249D0 (en) * 2008-08-04 2008-09-10 Cellerix Sa Uses of mesenchymal stem cells

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