HU9503736D0 - New derivatives of trans apovincaminic-acid-esters - Google Patents

New derivatives of trans apovincaminic-acid-esters

Info

Publication number
HU9503736D0
HU9503736D0 HU9503736A HU9503736A HU9503736D0 HU 9503736 D0 HU9503736 D0 HU 9503736D0 HU 9503736 A HU9503736 A HU 9503736A HU 9503736 A HU9503736 A HU 9503736A HU 9503736 D0 HU9503736 D0 HU 9503736D0
Authority
HU
Hungary
Prior art keywords
esters
acid
new derivatives
trans apovincaminic
apovincaminic
Prior art date
Application number
HU9503736A
Other languages
English (en)
Other versions
HU214600B (hu
HUT76555A (en
Inventor
Janos Kreidl
Aniko Gere
Juhasz Ida Deutschne
Jenoene Farkas
Andras Vedres
Dr Paroczai Margi Pellioniszne
Erzsebet Lapis
Istvan Moldvai
Maria Incze
Csaba Szantay
Balazs Maria Zajerne
Adam Sarkadi
Laszlo Czibula
Bela Kiss
Sandor Farkas
Egon Karpati
Andras Szekeres
Ferenc Auth
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to HU9503736A priority Critical patent/HU214600B/hu
Publication of HU9503736D0 publication Critical patent/HU9503736D0/hu
Priority to PT96942534T priority patent/PT876367E/pt
Priority to PCT/HU1996/000075 priority patent/WO1997023481A1/en
Priority to AU11669/97A priority patent/AU1166997A/en
Priority to CA002238635A priority patent/CA2238635A1/en
Priority to IL12409796A priority patent/IL124097A/en
Priority to EP96942534A priority patent/EP0876367B1/en
Priority to SI9630526T priority patent/SI0876367T1/xx
Priority to ES96942534T priority patent/ES2181926T3/es
Priority to PL96328170A priority patent/PL186626B1/pl
Priority to US09/091,260 priority patent/US6093720A/en
Priority to DE69623656T priority patent/DE69623656T2/de
Priority to DK96942534T priority patent/DK0876367T3/da
Priority to CN96199131A priority patent/CN1072670C/zh
Priority to AT96942534T priority patent/ATE223914T1/de
Priority to JP09523441A priority patent/JP2000502676A/ja
Priority to RU98113854/04A priority patent/RU2161157C2/ru
Priority to KR1019980704700A priority patent/KR19990076606A/ko
Priority to CZ19981962A priority patent/CZ290383B6/cs
Priority to UA98052781A priority patent/UA61062C2/uk
Priority to TW085115515A priority patent/TW366348B/zh
Priority to ZA9610646A priority patent/ZA9610646B/xx
Priority to ARP960105829A priority patent/AR005182A1/es
Publication of HUT76555A publication Critical patent/HUT76555A/hu
Publication of HU214600B publication Critical patent/HU214600B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9503736A 1995-12-22 1995-12-22 Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására HU214600B (hu)

Priority Applications (23)

Application Number Priority Date Filing Date Title
HU9503736A HU214600B (hu) 1995-12-22 1995-12-22 Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására
UA98052781A UA61062C2 (en) 1995-12-22 1996-12-13 Racemic and optically active trans apovincaminic acid ester derivatives
US09/091,260 US6093720A (en) 1995-12-22 1996-12-13 Trans apovincaminic acid ester derivatives
DK96942534T DK0876367T3 (da) 1995-12-22 1996-12-13 Trans apovincaminsyreesterderivater som lægemidler
AU11669/97A AU1166997A (en) 1995-12-22 1996-12-13 Trans apovincaminic acid ester derivatives as drugs
CA002238635A CA2238635A1 (en) 1995-12-22 1996-12-13 Trans apovincaminic acid ester derivatives as drugs
IL12409796A IL124097A (en) 1995-12-22 1996-12-13 History of trans-avincaminic acid esters, their preparation, pharmaceutical preparations containing them and their use as medicines
EP96942534A EP0876367B1 (en) 1995-12-22 1996-12-13 Trans apovincaminic acid ester derivatives as drugs
SI9630526T SI0876367T1 (en) 1995-12-22 1996-12-13 Trans apovincaminic acid ester derivatives as drugs
ES96942534T ES2181926T3 (es) 1995-12-22 1996-12-13 Derivados ester de acido trans-apovincaminico en calidad de farmacos.
PL96328170A PL186626B1 (pl) 1995-12-22 1996-12-13 Nowe racemiczne i optycznie czynne pochodne estrowe kwasu trans apowinkaminowego, sposób ich wytwarzania i ich zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania
PT96942534T PT876367E (pt) 1995-12-22 1996-12-13 Derivados de esteres do acido trans-apovincaminico utilizados como farmacos
DE69623656T DE69623656T2 (de) 1995-12-22 1996-12-13 Trans apovincaminsäure-esterderivate als arzneimittel
PCT/HU1996/000075 WO1997023481A1 (en) 1995-12-22 1996-12-13 Trans apovincaminic acid ester derivatives as drugs
CN96199131A CN1072670C (zh) 1995-12-22 1996-12-13 作为药物的反式阿朴长春蔓宁酸酯衍生物
AT96942534T ATE223914T1 (de) 1995-12-22 1996-12-13 Trans apovincaminsäure-esterderivate als arzneimittel
JP09523441A JP2000502676A (ja) 1995-12-22 1996-12-13 薬剤としてのトランスアポビンカミン酸エステル誘導体
RU98113854/04A RU2161157C2 (ru) 1995-12-22 1996-12-13 Рацемические или оптически активные эфирные производные трансаповинкаминовой кислоты
KR1019980704700A KR19990076606A (ko) 1995-12-22 1996-12-13 의약으로서의 트랜스 아포빈카민산 에스테르 유도체
CZ19981962A CZ290383B6 (cs) 1995-12-22 1996-12-13 Racemické a opticky aktivní estery trans-apovinkaminové kyseliny jako léčiva
TW085115515A TW366348B (en) 1995-12-22 1996-12-16 Novel trans apovincaminic acid ester derivatives, pharmaceutical composition containing same, and their preparation processes
ZA9610646A ZA9610646B (en) 1995-12-22 1996-12-18 Novel trans apovincaminic acid ester derivatives
ARP960105829A AR005182A1 (es) 1995-12-22 1996-12-20 Derivados de esteres del acido trans-apovincaminico, composicion que los contiene y procesos para preparar dichos derivados y composicion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9503736A HU214600B (hu) 1995-12-22 1995-12-22 Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására

Publications (3)

Publication Number Publication Date
HU9503736D0 true HU9503736D0 (en) 1996-02-28
HUT76555A HUT76555A (en) 1997-09-29
HU214600B HU214600B (hu) 1998-04-28

Family

ID=10987512

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9503736A HU214600B (hu) 1995-12-22 1995-12-22 Transz-apovinkaminsav-észter-származékok, az azokat tartalmazó gyógyszerkészítmények és eljárás ezek előállítására

Country Status (22)

Country Link
US (1) US6093720A (hu)
EP (1) EP0876367B1 (hu)
JP (1) JP2000502676A (hu)
KR (1) KR19990076606A (hu)
CN (1) CN1072670C (hu)
AR (1) AR005182A1 (hu)
AT (1) ATE223914T1 (hu)
AU (1) AU1166997A (hu)
CA (1) CA2238635A1 (hu)
CZ (1) CZ290383B6 (hu)
DE (1) DE69623656T2 (hu)
DK (1) DK0876367T3 (hu)
ES (1) ES2181926T3 (hu)
HU (1) HU214600B (hu)
IL (1) IL124097A (hu)
PL (1) PL186626B1 (hu)
PT (1) PT876367E (hu)
RU (1) RU2161157C2 (hu)
TW (1) TW366348B (hu)
UA (1) UA61062C2 (hu)
WO (1) WO1997023481A1 (hu)
ZA (1) ZA9610646B (hu)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006054536A1 (ja) * 2004-11-16 2006-05-26 Nippon Shinyaku Co., Ltd. 尿路結石症治療剤
JP2008017734A (ja) * 2006-07-11 2008-01-31 Memory Secret Inc 精神的機能を改善するための栄養補助及び栄養摂取食品用の口経投与組成物
CN102485723A (zh) * 2010-12-02 2012-06-06 江苏斯威森生物医药工程研究中心有限公司 一锅法半合成长春西汀及其水溶性盐制备
CN114920743B (zh) * 2022-05-09 2023-08-04 南京中医药大学 一种吲哚生物碱及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2531108A1 (de) * 1975-07-11 1977-02-03 Synthelabo Vincaminderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
HU186891B (en) * 1981-06-12 1985-10-28 Richter Gedeon Vegyeszet Process for producing esters of apovincaminic acid
IT1142026B (it) * 1981-07-21 1986-10-08 Ausonia Farma Srl Nuovo composto ad attivita' eumetabolica cerebrale
HU187733B (en) * 1982-06-30 1986-02-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing apovincaminic acid derivatives
JPS60248688A (ja) * 1984-05-24 1985-12-09 Sanwa Kagaku Kenkyusho:Kk 新規のアポビンカミン酸エステルおよびその酸付加塩並びにその製造方法

Also Published As

Publication number Publication date
PL328170A1 (en) 1999-01-18
ATE223914T1 (de) 2002-09-15
CN1205701A (zh) 1999-01-20
KR19990076606A (ko) 1999-10-15
AR005182A1 (es) 1999-04-14
PL186626B1 (pl) 2004-02-27
DE69623656D1 (en) 2002-10-17
EP0876367A1 (en) 1998-11-11
RU2161157C2 (ru) 2000-12-27
HU214600B (hu) 1998-04-28
HUT76555A (en) 1997-09-29
AU1166997A (en) 1997-07-17
CZ196298A3 (cs) 1998-10-14
WO1997023481A1 (en) 1997-07-03
ES2181926T3 (es) 2003-03-01
ZA9610646B (en) 1997-06-24
TW366348B (en) 1999-08-11
CA2238635A1 (en) 1997-07-03
DE69623656T2 (de) 2003-05-22
US6093720A (en) 2000-07-25
EP0876367B1 (en) 2002-09-11
UA61062C2 (en) 2003-11-17
JP2000502676A (ja) 2000-03-07
CN1072670C (zh) 2001-10-10
PT876367E (pt) 2003-01-31
DK0876367T3 (da) 2002-12-30
CZ290383B6 (cs) 2002-07-17
IL124097A (en) 2001-12-23

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee