HU220611B1 - Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások - Google Patents
Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások Download PDFInfo
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- HU220611B1 HU220611B1 HU9300468A HU46893A HU220611B1 HU 220611 B1 HU220611 B1 HU 220611B1 HU 9300468 A HU9300468 A HU 9300468A HU 46893 A HU46893 A HU 46893A HU 220611 B1 HU220611 B1 HU 220611B1
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- formula
- phosphoric acid
- decyloxy
- propyl ester
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- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 1
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- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
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- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
- 125000002525 phosphocholine group Chemical class OP(=O)(OCC[N+](C)(C)C)O* 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Chemical class 0.000 description 1
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- 238000000039 preparative column chromatography Methods 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
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- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Chemical class 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
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- 230000003393 splenic effect Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
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- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4026265A DE4026265A1 (de) | 1990-08-20 | 1990-08-20 | Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9300468D0 HU9300468D0 (en) | 1993-05-28 |
| HUT62910A HUT62910A (en) | 1993-06-28 |
| HU220611B1 true HU220611B1 (hu) | 2002-03-28 |
Family
ID=6412536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9300468A HU220611B1 (hu) | 1990-08-20 | 1991-08-14 | Nukleozidok foszfolipidszármazékai, ezeket hatóanyagként tartalmazó gyógyszerkészítmények és az előállításukra szolgáló eljárások |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JP3032576B2 (cs) |
| KR (1) | KR970011307B1 (cs) |
| CZ (1) | CZ287942B6 (cs) |
| HU (1) | HU220611B1 (cs) |
| MX (1) | MX9100676A (cs) |
| NZ (1) | NZ239422A (cs) |
| RO (1) | RO115163B1 (cs) |
| RU (1) | RU2104282C1 (cs) |
| TW (1) | TW207544B (cs) |
| ZA (1) | ZA916542B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| RU2293739C2 (ru) * | 2002-07-26 | 2007-02-20 | Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" | 5`-холинфосфат 3`-азидо-3`-дезокситимидина как антивирусный агент |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU764326A1 (ru) * | 1977-11-16 | 1982-09-23 | Ордена Ленина Институт Химической Физики Ан Ссср | Способ получени спин-меченого производного аденозинтрифосфата |
| US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
-
1991
- 1991-08-12 TW TW080106360A patent/TW207544B/zh active
- 1991-08-14 RU RU93005146A patent/RU2104282C1/ru not_active IP Right Cessation
- 1991-08-14 RO RO93-00149A patent/RO115163B1/ro unknown
- 1991-08-14 KR KR1019930700473A patent/KR970011307B1/ko not_active Expired - Fee Related
- 1991-08-14 JP JP3513882A patent/JP3032576B2/ja not_active Expired - Fee Related
- 1991-08-14 HU HU9300468A patent/HU220611B1/hu unknown
- 1991-08-15 MX MX9100676A patent/MX9100676A/es unknown
- 1991-08-16 NZ NZ239422A patent/NZ239422A/xx not_active IP Right Cessation
- 1991-08-19 ZA ZA916542A patent/ZA916542B/xx unknown
-
1993
- 1993-02-11 CZ CZ1993180A patent/CZ287942B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ287942B6 (cs) | 2001-03-14 |
| TW207544B (cs) | 1993-06-11 |
| RU2104282C1 (ru) | 1998-02-10 |
| HU9300468D0 (en) | 1993-05-28 |
| JP3032576B2 (ja) | 2000-04-17 |
| RO115163B1 (ro) | 1999-11-30 |
| CZ18093A3 (en) | 1993-06-16 |
| HUT62910A (en) | 1993-06-28 |
| JPH06500543A (ja) | 1994-01-20 |
| KR930701470A (ko) | 1993-06-11 |
| MX9100676A (es) | 1992-04-01 |
| ZA916542B (en) | 1992-05-27 |
| KR970011307B1 (ko) | 1997-07-09 |
| NZ239422A (en) | 1993-09-27 |
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