JP3032576B2 - ヌクレオシドの新規なリン脂質誘導体、それらの製造法、並びに抗ウイルス性医薬としてのそれらの使用 - Google Patents

ヌクレオシドの新規なリン脂質誘導体、それらの製造法、並びに抗ウイルス性医薬としてのそれらの使用

Info

Publication number
JP3032576B2
JP3032576B2 JP3513882A JP51388291A JP3032576B2 JP 3032576 B2 JP3032576 B2 JP 3032576B2 JP 3513882 A JP3513882 A JP 3513882A JP 51388291 A JP51388291 A JP 51388291A JP 3032576 B2 JP3032576 B2 JP 3032576B2
Authority
JP
Japan
Prior art keywords
dideoxy
propyl ester
decyloxy
dodecylmercapto
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP3513882A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06500543A (ja
Inventor
ツィルヒ，ハラルド
ライナート，ハーバート
マーテンス，アルフレッド
ヘルマン，ディーター
Original Assignee
ロシュ ダイアグノスティックス ゲーエムベーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4026265A external-priority patent/DE4026265A1/de
Application filed by ロシュ ダイアグノスティックス ゲーエムベーハー filed Critical ロシュ ダイアグノスティックス ゲーエムベーハー
Publication of JPH06500543A publication Critical patent/JPH06500543A/ja
Application granted granted Critical
Publication of JP3032576B2 publication Critical patent/JP3032576B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP3513882A 1990-08-20 1991-08-14 ヌクレオシドの新規なリン脂質誘導体、それらの製造法、並びに抗ウイルス性医薬としてのそれらの使用 Expired - Fee Related JP3032576B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4026265,0 1990-08-20
DE4026265A DE4026265A1 (de) 1990-08-20 1990-08-20 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
PCT/EP1991/001541 WO1992003462A1 (de) 1990-08-20 1991-08-14 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Publications (2)

Publication Number Publication Date
JPH06500543A JPH06500543A (ja) 1994-01-20
JP3032576B2 true JP3032576B2 (ja) 2000-04-17

Family

ID=6412536

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3513882A Expired - Fee Related JP3032576B2 (ja) 1990-08-20 1991-08-14 ヌクレオシドの新規なリン脂質誘導体、それらの製造法、並びに抗ウイルス性医薬としてのそれらの使用

Country Status (10)

Country Link
JP (1) JP3032576B2 (cs)
KR (1) KR970011307B1 (cs)
CZ (1) CZ287942B6 (cs)
HU (1) HU220611B1 (cs)
MX (1) MX9100676A (cs)
NZ (1) NZ239422A (cs)
RO (1) RO115163B1 (cs)
RU (1) RU2104282C1 (cs)
TW (1) TW207544B (cs)
ZA (1) ZA916542B (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
RU2293739C2 (ru) * 2002-07-26 2007-02-20 Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ" 5`-холинфосфат 3`-азидо-3`-дезокситимидина как антивирусный агент

Also Published As

Publication number Publication date
HU9300468D0 (en) 1993-05-28
HUT62910A (en) 1993-06-28
RO115163B1 (ro) 1999-11-30
MX9100676A (es) 1992-04-01
RU2104282C1 (ru) 1998-02-10
CZ287942B6 (cs) 2001-03-14
TW207544B (cs) 1993-06-11
ZA916542B (en) 1992-05-27
JPH06500543A (ja) 1994-01-20
KR970011307B1 (ko) 1997-07-09
HU220611B1 (hu) 2002-03-28
KR930701470A (ko) 1993-06-11
NZ239422A (en) 1993-09-27
CZ18093A3 (en) 1993-06-16

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