HU203562B - Process for producing new steroide diols and pharmaceutical compositions containing them - Google Patents

Process for producing new steroide diols and pharmaceutical compositions containing them Download PDF

Info

Publication number
HU203562B
HU203562B HU891156A HU115689A HU203562B HU 203562 B HU203562 B HU 203562B HU 891156 A HU891156 A HU 891156A HU 115689 A HU115689 A HU 115689A HU 203562 B HU203562 B HU 203562B
Authority
HU
Hungary
Prior art keywords
preparation
hydrogen
formula
process according
hydrogen atom
Prior art date
Application number
HU891156A
Other languages
English (en)
Hungarian (hu)
Inventor
Csaba Molnar
Gyoergy Hajos
Laszlo Szporny
Jozsef Toth
Arpad Kiraly
Lajosne Boor
Janos Csoergei
Krisztina Szekely
Lilla Forgacs
Gyoergy Fekete
Bulcsu Herenyi
Sandor Holly
Jozsef Szunyog
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Priority to HU891156A priority Critical patent/HU203562B/hu
Priority to IL9347890A priority patent/IL93478A/en
Priority to IN185/CAL/90A priority patent/IN170846B/en
Priority to CA002011282A priority patent/CA2011282A1/en
Priority to PH40143A priority patent/PH26676A/en
Priority to ZA901752A priority patent/ZA901752B/xx
Priority to JP2055162A priority patent/JPH06104679B2/ja
Priority to AU51102/90A priority patent/AU623503B2/en
Priority to NO901103A priority patent/NO177147C/no
Priority to PT93375A priority patent/PT93375A/pt
Priority to KR1019900003056A priority patent/KR930009445B1/ko
Priority to US07/491,683 priority patent/US5082835A/en
Priority to FI901199A priority patent/FI901199A7/fi
Priority to AR90316352A priority patent/AR244700A1/es
Priority to CN90101248A priority patent/CN1045396A/zh
Priority to EP19900302544 priority patent/EP0387091A3/en
Priority to EG16090A priority patent/EG19411A/xx
Publication of HU203562B publication Critical patent/HU203562B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0092—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU891156A 1989-03-09 1989-03-09 Process for producing new steroide diols and pharmaceutical compositions containing them HU203562B (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
HU891156A HU203562B (en) 1989-03-09 1989-03-09 Process for producing new steroide diols and pharmaceutical compositions containing them
IL9347890A IL93478A (en) 1989-03-09 1990-02-21 Pregnadiene (or triene) dioldiones, pharmaceutical compositions containing them and their preparation
IN185/CAL/90A IN170846B (forum.php) 1989-03-09 1990-02-28
CA002011282A CA2011282A1 (en) 1989-03-09 1990-03-01 Steroid diols, pharmaceutical compositions containing them and process for preparing same
PH40143A PH26676A (en) 1989-03-09 1990-03-05 Novel steroid diols pharmaceutical compositions containing them and process for preparing same
ZA901752A ZA901752B (en) 1989-03-09 1990-03-07 Steroid diols,pharmaceutical compositions containing them and process for preparing same
JP2055162A JPH06104679B2 (ja) 1989-03-09 1990-03-08 新規ステロイドジオール，それらを含む医薬組成物、およびそれらの調製方法
AU51102/90A AU623503B2 (en) 1989-03-09 1990-03-08 Novel steroid diols, pharmaceutical compositions containing them and process for preparing same
NO901103A NO177147C (no) 1989-03-09 1990-03-08 Analogifremgangsmåte for fremstilling av nye, terapeutisk aktive steroiddioler
PT93375A PT93375A (pt) 1989-03-09 1990-03-08 Processo para a preparacao de diois de esteroides e de composicoes farmaceuticas que os contem
KR1019900003056A KR930009445B1 (ko) 1989-03-09 1990-03-08 신규 스테로이드 디올과 이들을 함유하는 약제학적 조성물 및 이들의 제조방법
US07/491,683 US5082835A (en) 1989-03-09 1990-03-09 Novel steroid diols, pharmaceutical compositions containing them and process for preparing same
FI901199A FI901199A7 (fi) 1989-03-09 1990-03-09 Uusia steroidi-dioleja, niitä sisältäviä farmaseuttisia yhdistelmiä ja menetelmä niiden valmistamiseksi
AR90316352A AR244700A1 (es) 1989-03-09 1990-03-09 Procedimiento para obtener nuevos dioles de esteroides.
CN90101248A CN1045396A (zh) 1989-03-09 1990-03-09 新的甾二醇，含它们的药物组合物和制备它们的方法
EP19900302544 EP0387091A3 (en) 1989-03-09 1990-03-09 Steroid diols, processes for their preparation and pharmaceutical compositions thereof
EG16090A EG19411A (en) 1989-03-09 1990-03-11 Process for preparing of novel steroid doils, pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU891156A HU203562B (en) 1989-03-09 1989-03-09 Process for producing new steroide diols and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
HU203562B true HU203562B (en) 1991-08-28

Family

ID=10953088

Family Applications (1)

Application Number Title Priority Date Filing Date
HU891156A HU203562B (en) 1989-03-09 1989-03-09 Process for producing new steroide diols and pharmaceutical compositions containing them

Country Status (17)

Country Link
US (1) US5082835A (forum.php)
EP (1) EP0387091A3 (forum.php)
JP (1) JPH06104679B2 (forum.php)
KR (1) KR930009445B1 (forum.php)
CN (1) CN1045396A (forum.php)
AR (1) AR244700A1 (forum.php)
AU (1) AU623503B2 (forum.php)
CA (1) CA2011282A1 (forum.php)
EG (1) EG19411A (forum.php)
FI (1) FI901199A7 (forum.php)
HU (1) HU203562B (forum.php)
IL (1) IL93478A (forum.php)
IN (1) IN170846B (forum.php)
NO (1) NO177147C (forum.php)
PH (1) PH26676A (forum.php)
PT (1) PT93375A (forum.php)
ZA (1) ZA901752B (forum.php)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
FR2675146A1 (fr) * 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
CN104208718B (zh) 2009-02-20 2017-12-29 2-Bbb医疗股份有限公司 基于谷胱甘肽的药物递送系统
KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN110078785A (zh) * 2019-06-04 2019-08-02 博诺康源(北京)药业科技有限公司 一种布地奈德杂质ep-ze的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3167545A (en) * 1959-02-07 1965-01-26 Syntex Corp 16beta-methyl-16alpha, 17 alpha-dihydroxy pregnenes and the 16alpha, 17alpha-cyclic ketals and acetals thereof
US3345362A (en) * 1961-07-27 1967-10-03 Lilly Co Eli Novel pregnenolone acetonides
US4036831A (en) * 1975-10-28 1977-07-19 Steroid Development Company Establishment Trimethyl siloxane steroid intermediates
EP0374185B1 (en) * 1987-08-14 1993-02-10 The Upjohn Company IMPROVED 9$g(a)-DEHALOGENATION PROCESS

Also Published As

Publication number Publication date
CN1045396A (zh) 1990-09-19
NO901103D0 (no) 1990-03-08
PH26676A (en) 1992-09-15
ZA901752B (en) 1991-05-29
FI901199A7 (fi) 1990-09-10
IL93478A0 (en) 1990-11-29
AR244700A1 (es) 1993-11-30
KR930009445B1 (ko) 1993-10-04
FI901199A0 (fi) 1990-03-09
AU5110290A (en) 1990-09-13
IL93478A (en) 1994-11-11
JPH06104679B2 (ja) 1994-12-21
NO177147B (no) 1995-04-18
IN170846B (forum.php) 1992-05-30
EP0387091A2 (en) 1990-09-12
EP0387091A3 (en) 1992-05-06
NO901103L (no) 1990-09-10
CA2011282A1 (en) 1990-09-09
JPH02279695A (ja) 1990-11-15
US5082835A (en) 1992-01-21
KR900014422A (ko) 1990-10-23
AU623503B2 (en) 1992-05-14
NO177147C (no) 1995-07-26
PT93375A (pt) 1990-11-07
EG19411A (en) 1995-01-31

Similar Documents

Publication Publication Date Title
JPS6069019A (ja) 局所抗炎症用薬剤組成物
JPH0253440B2 (forum.php)
HU203562B (en) Process for producing new steroide diols and pharmaceutical compositions containing them
JPS596880B2 (ja) Ｄ−ホモステロイドの製造方法
JPS6411037B2 (forum.php)
US4024131A (en) 16-Methyl-9α-halo steroid esters, ethers and preparation thereof
KR850001208B1 (ko) 17α-아실옥시-5β-코르티코이드 및 17α-아실옥시-5α-코르티코이드의 제조방법
US4181720A (en) Corticosteroid antiinflammatory agents
US5053404A (en) Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same
WO1987005028A1 (en) Anti-inflammatory carboxy pregnane derivatives
AP141A (en) Novel steroid doils.
US4232013A (en) 16,17-Pyrazolino- and 16,17-isopyrazolino-1,4-pregnadiene derivatives
US4185101A (en) 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
US4189440A (en) 2-Bromo-6β-fluoro-3-keto-Δ1,4 -steroids of the pregnane series
GB1589585A (en) 12a-halocorticoids
IE45305B1 (en) New corticoids
AP157A (en) Novel steroid derivatives.
JPS5922719B2 (ja) １６↓−メチル−９α−ハロステロイドのエステル及びエ−テル誘導体
KR810000311B1 (ko) 7-할로-3,20-디옥소-1,4-프레그나디엔 및 -4-프레그넨의 제조 방법
JPS5942399A (ja) ステロイド性９，１１β−ジハロ−〔１６α，１７−ｂ〕〔１，４〕ジオキシン類の製造法
JPS5855157B2 (ja) プレグナンケイノ ２− ブロモ −６ ベ−タ − フルオロ −３− ケト − １，４− ステロイドノセイホウ
EP0179496A1 (en) 16-Sulfinylmethyl-steroids, their preparation and use
HU176255B (en) Process for producing new d-homo-steroides
CS207754B2 (cs) Způsob výroby v poloze 17 substituovaných lljS-hydroxystcroidů substituovaných lljS-hydroxystcroidů
JPS5818400A (ja) アシルオキシステロイドの製造法

Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee