HU198194B - Process for production of new derivatives of dioxazocin and medical compositions containing them - Google Patents
Process for production of new derivatives of dioxazocin and medical compositions containing them Download PDFInfo
- Publication number
- HU198194B HU198194B HU865513A HU551386A HU198194B HU 198194 B HU198194 B HU 198194B HU 865513 A HU865513 A HU 865513A HU 551386 A HU551386 A HU 551386A HU 198194 B HU198194 B HU 198194B
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- HU
- Hungary
- Prior art keywords
- formula
- mol
- chloro
- dioxazocine
- compound
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 29
- 238000000034 method Methods 0.000 title claims description 16
- 150000001875 compounds Chemical class 0.000 claims description 48
- MNPXCHCSWCJIDS-UHFFFAOYSA-N dioxazocine Chemical compound C1=CC=NOOC=C1 MNPXCHCSWCJIDS-UHFFFAOYSA-N 0.000 claims description 22
- 239000002253 acid Substances 0.000 claims description 16
- 150000003839 salts Chemical class 0.000 claims description 15
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
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- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
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- 238000002360 preparation method Methods 0.000 claims description 4
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- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000001589 carboacyl group Chemical group 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 238000002690 local anesthesia Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 125000002757 morpholinyl group Chemical group 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- HRBASXKYUKFHKC-UHFFFAOYSA-N n-cyclohexyl-n-methylaniline Chemical compound C=1C=CC=CC=1N(C)C1CCCCC1 HRBASXKYUKFHKC-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004193 piperazinyl group Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N propanoyl chloride Chemical compound CCC(Cl)=O RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229960001404 quinidine Drugs 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000048 toxicity data Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/01—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (27)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU865513A HU198194B (en) | 1986-12-30 | 1986-12-30 | Process for production of new derivatives of dioxazocin and medical compositions containing them |
| YU02352/87A YU235287A (en) | 1986-12-30 | 1987-12-22 | Process for obtaining new amino-alcanoil-dibenzo-/d,g//1,3,6/-dioxazocine |
| CN198787108190A CN87108190A (zh) | 1986-12-30 | 1987-12-28 | 新型氨基烷酰基-二苯并[d，g][1，3，6]二氧杂氮杂辛因及其制备方法 |
| IL84976A IL84976A (en) | 1986-12-30 | 1987-12-29 | Aminoalkanoyl-dibenzo-(d,g)(1,3,6)dioxazocines,their preparation and pharmaceutical compositions containing them |
| CH5095/87A CH675877A5 (cs) | 1986-12-30 | 1987-12-29 | |
| DD87311670A DD267038A5 (de) | 1986-12-30 | 1987-12-29 | Verfahren zur herstellung von neuen aminoalkanoyl-dibenzo [d,g][1,3,6]dioxazocinderivaten |
| NO875465A NO169230B (no) | 1986-12-30 | 1987-12-29 | Analogifremgangsmaate for fremstilling av terapeutisk aktive aminoalkanoyl-dibenzo(d,g)(1,3,6)dioxazociner |
| CS8710091A CS270579B2 (en) | 1986-12-30 | 1987-12-29 | Method of new aminoalkanoyl-dibenzo (d,g) (1,3,6) dioxazocines production |
| SE8705187A SE465429B (sv) | 1986-12-30 | 1987-12-29 | Nya aminoalkanoyl-dibenso /d,g/ /1,3,6/ dioxazociner, foerfarande foer framstaellning daerav samt farmaceutisk beredning |
| FR878718272A FR2609030B1 (fr) | 1986-12-30 | 1987-12-29 | Nouvelles aminoalcanoyldibenzo (d, q) (1,3,6) dioxazocines, leur procede de preparation et compositions pharmaceutiques les contenant |
| PH36312A PH24384A (en) | 1986-12-30 | 1987-12-29 | Aminoalkanoyl-dibenzo (d,g) (1,3,6) dioxazocines and composition thereof |
| NL8703150A NL8703150A (nl) | 1986-12-30 | 1987-12-29 | Nieuwe aminoalkanoyl-dibenzo d,g 1,3,6 dioxazocinen en een werkwijze voor de bereiding ervan. |
| BE8701495A BE1001240A3 (fr) | 1986-12-30 | 1987-12-29 | Nouvelles aminoalcanoyldibenzo [d,g][1,3,6] dioxazocines et leur procede de preparation. |
| ZA879733A ZA879733B (en) | 1986-12-30 | 1987-12-29 | Novel aminoalkanoyl-dibenzo(d,g)(1,3,6)dioxazocines and a process for the preparation thereof |
| ES8800216A ES2006539A6 (es) | 1986-12-30 | 1987-12-29 | Procedimiento de preparar nuevas aminoalcanoil-dibenzo(d,g)(1,3,6)dioxazocinas. |
| DK691087A DK691087A (da) | 1986-12-30 | 1987-12-29 | Dioxazocinderivater |
| AU83140/87A AU596258B2 (en) | 1986-12-30 | 1987-12-30 | Novel aminoalkanoyl-dibenzo(d,g)(1,3,6)dioxazocines and a process for the preparation thereof |
| DE19873744549 DE3744549A1 (de) | 1986-12-30 | 1987-12-30 | 12h-12-(carbamoyl)- beziehungsweise 12h-12-aminoalkanoyl)-dibenzo(d,g)(1,3,6)dioxazocinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| KR1019870015470A KR880007502A (ko) | 1986-12-30 | 1987-12-30 | 신규의 아미노알카노일-디벤조[d, g][1,3,6]디옥사조신 및 그의 제조방법 |
| GB8730298A GB2199827B (en) | 1986-12-30 | 1987-12-30 | Novel aminoalkanoyl-dibenzo[d,g][1,3,6]dioxazocines and a process for the preparation thereof |
| SU874203954A SU1575938A3 (ru) | 1986-12-30 | 1987-12-30 | Способ получени производных аминоалканоилдибензо ( @ , @ ) (1,3,6) диоксазоцина или их фармацевтически приемлемых аддитивных солей с кислотами |
| IT8723271A IT1233443B (it) | 1986-12-30 | 1987-12-30 | Amminoalcanoil-dibenzo (d,g,) (1,3,6) diossazocine e procedimento per la loro preparazione |
| GR872083A GR872083B (en) | 1986-12-30 | 1987-12-30 | Preparation process of aminoalkanoyl-dibenzo (d,g),(1,3,6) dioxazocines |
| AT0345087A AT389304B (de) | 1986-12-30 | 1987-12-30 | Neue aminoalkanoyl-dibenzo (d,g) (1,3,6)dioxazocinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FI875767A FI875767A7 (fi) | 1986-12-30 | 1987-12-30 | Foerfarande foer framstaellning av nya aminoalkanoyl-dibenso (d,g) (1,3,6) dioxaziner. |
| PL1987269812A PL151402B1 (en) | 1986-12-30 | 1987-12-30 | Novel aminoalkanoyl-dibenzo(d g)(1 3 6)dioxazocines & process for preparation thereof |
| JP63000045A JPS63174978A (ja) | 1986-12-30 | 1988-01-04 | 新規なアミノアルカイノイルージベンゾ−ｄ，ｇ−１，３，６−ジオキサゾシン及びその製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU865513A HU198194B (en) | 1986-12-30 | 1986-12-30 | Process for production of new derivatives of dioxazocin and medical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT47260A HUT47260A (en) | 1989-02-28 |
| HU198194B true HU198194B (en) | 1989-08-28 |
Family
ID=10970381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU865513A HU198194B (en) | 1986-12-30 | 1986-12-30 | Process for production of new derivatives of dioxazocin and medical compositions containing them |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS63174978A (cs) |
| KR (1) | KR880007502A (cs) |
| CN (1) | CN87108190A (cs) |
| AT (1) | AT389304B (cs) |
| AU (1) | AU596258B2 (cs) |
| BE (1) | BE1001240A3 (cs) |
| CH (1) | CH675877A5 (cs) |
| CS (1) | CS270579B2 (cs) |
| DD (1) | DD267038A5 (cs) |
| DE (1) | DE3744549A1 (cs) |
| DK (1) | DK691087A (cs) |
| ES (1) | ES2006539A6 (cs) |
| FI (1) | FI875767A7 (cs) |
| FR (1) | FR2609030B1 (cs) |
| GB (1) | GB2199827B (cs) |
| GR (1) | GR872083B (cs) |
| HU (1) | HU198194B (cs) |
| IL (1) | IL84976A (cs) |
| IT (1) | IT1233443B (cs) |
| NL (1) | NL8703150A (cs) |
| NO (1) | NO169230B (cs) |
| PL (1) | PL151402B1 (cs) |
| SE (1) | SE465429B (cs) |
| SU (1) | SU1575938A3 (cs) |
| YU (1) | YU235287A (cs) |
| ZA (1) | ZA879733B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201318B (en) * | 1987-12-31 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same |
| ES2058761T3 (es) * | 1989-10-20 | 1994-11-01 | Akzo Nv | Proceso para la preparacion de derivados de dibenzodioxazecina y dibenzodioxaazacicloundecina. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2659M (fr) * | 1963-04-25 | 1964-08-14 | Millot Lab | Médicament a base de dérivé de la phénothiazine. |
| HU174126B (hu) * | 1977-08-02 | 1979-11-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina |
| HU195491B (en) * | 1985-12-20 | 1988-05-30 | Egyt Gyogyszervegyeszeti Gyar | Process for production of optically active 2-chlor-12-/3-/dimethil-amin/-2-methil-prophil/-12h-dibenzol /d,g/ /1,3,6/-diaxazocine and medical compositions containing such compounds |
| HU201318B (en) * | 1987-12-31 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same |
-
1986
- 1986-12-30 HU HU865513A patent/HU198194B/hu not_active IP Right Cessation
-
1987
- 1987-12-22 YU YU02352/87A patent/YU235287A/xx unknown
- 1987-12-28 CN CN198787108190A patent/CN87108190A/zh active Pending
- 1987-12-29 NL NL8703150A patent/NL8703150A/nl not_active Application Discontinuation
- 1987-12-29 CH CH5095/87A patent/CH675877A5/de not_active IP Right Cessation
- 1987-12-29 NO NO875465A patent/NO169230B/no unknown
- 1987-12-29 ZA ZA879733A patent/ZA879733B/xx unknown
- 1987-12-29 CS CS8710091A patent/CS270579B2/cs unknown
- 1987-12-29 BE BE8701495A patent/BE1001240A3/fr not_active IP Right Cessation
- 1987-12-29 FR FR878718272A patent/FR2609030B1/fr not_active Expired - Lifetime
- 1987-12-29 SE SE8705187A patent/SE465429B/sv not_active IP Right Cessation
- 1987-12-29 ES ES8800216A patent/ES2006539A6/es not_active Expired
- 1987-12-29 DK DK691087A patent/DK691087A/da not_active Application Discontinuation
- 1987-12-29 IL IL84976A patent/IL84976A/xx unknown
- 1987-12-29 DD DD87311670A patent/DD267038A5/de not_active IP Right Cessation
- 1987-12-30 GR GR872083A patent/GR872083B/el unknown
- 1987-12-30 FI FI875767A patent/FI875767A7/fi not_active Application Discontinuation
- 1987-12-30 AT AT0345087A patent/AT389304B/de not_active IP Right Cessation
- 1987-12-30 GB GB8730298A patent/GB2199827B/en not_active Expired - Lifetime
- 1987-12-30 IT IT8723271A patent/IT1233443B/it active
- 1987-12-30 AU AU83140/87A patent/AU596258B2/en not_active Ceased
- 1987-12-30 SU SU874203954A patent/SU1575938A3/ru active
- 1987-12-30 DE DE19873744549 patent/DE3744549A1/de not_active Withdrawn
- 1987-12-30 PL PL1987269812A patent/PL151402B1/pl unknown
- 1987-12-30 KR KR1019870015470A patent/KR880007502A/ko not_active Withdrawn
-
1988
- 1988-01-04 JP JP63000045A patent/JPS63174978A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |