HU190498B - Process for preparing 4-amino-5-/dialkoxy-methyl/-pyrimidine derivatives - Google Patents
Process for preparing 4-amino-5-/dialkoxy-methyl/-pyrimidine derivatives Download PDFInfo
- Publication number
- HU190498B HU190498B HU832627A HU262783A HU190498B HU 190498 B HU190498 B HU 190498B HU 832627 A HU832627 A HU 832627A HU 262783 A HU262783 A HU 262783A HU 190498 B HU190498 B HU 190498B
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- Hungary
- Prior art keywords
- formula
- mixture
- mmol
- amino
- reaction
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- 238000004519 manufacturing process Methods 0.000 title abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 28
- 239000007858 starting material Substances 0.000 claims abstract description 14
- 150000001409 amidines Chemical class 0.000 claims abstract description 11
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- 150000001875 compounds Chemical class 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 239000005977 Ethylene Substances 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
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- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 3
- 239000012442 inert solvent Substances 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000001424 substituent group Chemical group 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- OQLZINXFSUDMHM-UHFFFAOYSA-N Acetamidine Chemical compound CC(N)=N OQLZINXFSUDMHM-UHFFFAOYSA-N 0.000 claims description 2
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 2
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 37
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- GOJNFUXEBVBARW-UHFFFAOYSA-N 4-amino-6-chloropyrimidine-5-carbaldehyde Chemical compound NC1=NC=NC(Cl)=C1C=O GOJNFUXEBVBARW-UHFFFAOYSA-N 0.000 description 1
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- CBTMVNREUWQZLS-UHFFFAOYSA-N 5-(dimethoxymethyl)-2-phenylpyrimidin-4-amine Chemical compound N1=C(N)C(C(OC)OC)=CN=C1C1=CC=CC=C1 CBTMVNREUWQZLS-UHFFFAOYSA-N 0.000 description 1
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- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 229950011008 tetrachloroethylene Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57156687A JPS5946255A (ja) | 1982-09-10 | 1982-09-10 | ２−アルコキシメチレン−３，３−ジアルコキシプロパンニトリル類の製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU190498B true HU190498B (en) | 1986-09-29 |
Family
ID=15633128
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU832627A HU190498B (en) | 1982-09-10 | 1983-07-26 | Process for preparing 4-amino-5-/dialkoxy-methyl/-pyrimidine derivatives |
| HU854785A HU193617B (en) | 1982-09-10 | 1983-07-26 | Process for producing 2-/dialkoxy-methyl/-3,3-dialkoxy-propane-nitril derivatives |
| HU854784A HU194810B (en) | 1982-09-10 | 1983-07-26 | Process for producing new 2-/alkoxy-methylene/-3,3-dialkoxy-propanonitril derivatives |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU854785A HU193617B (en) | 1982-09-10 | 1983-07-26 | Process for producing 2-/dialkoxy-methyl/-3,3-dialkoxy-propane-nitril derivatives |
| HU854784A HU194810B (en) | 1982-09-10 | 1983-07-26 | Process for producing new 2-/alkoxy-methylene/-3,3-dialkoxy-propanonitril derivatives |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0103126B1 (en, 2012) |
| JP (1) | JPS5946255A (en, 2012) |
| KR (1) | KR900001179B1 (en, 2012) |
| AT (1) | ATE25680T1 (en, 2012) |
| CA (1) | CA1253498A (en, 2012) |
| DK (2) | DK159432C (en, 2012) |
| HU (3) | HU190498B (en, 2012) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3829850A1 (de) * | 1988-09-02 | 1990-03-15 | Basf Ag | Verfahren zur herstellung von 2-n-propyl-4-amino-5-methoxymethyl-pyrimidin |
| US6395920B1 (en) * | 2000-01-28 | 2002-05-28 | Creanova, Inc. | Process for preparing substituted acetals of malondialdehyde |
| CN101627017B (zh) * | 2006-03-15 | 2013-02-27 | 帝斯曼知识产权资产管理有限公司 | 用于制造维生素b1前体的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE937057C (de) * | 1954-04-02 | 1956-08-09 | Shionogi & Co | Verfahren zur Herstellung von 2-Methyl-4-amino-5-acetaminomethyl-(bzw. -5-aminomethyl-) pyrimidin |
| DE1016266B (de) * | 1954-09-01 | 1957-09-26 | Shionogi & Co | Verfahren zur Herstellung von 2-Methyl-4-amino-5-acetaminomethylpyrimidin |
| US4319024A (en) * | 1979-03-29 | 1982-03-09 | Dynamit Nobel Aktiengesellschaft | Method of preparing β-alkoxyacrlonitriles |
-
1982
- 1982-09-10 JP JP57156687A patent/JPS5946255A/ja active Granted
-
1983
- 1983-07-19 CA CA000432781A patent/CA1253498A/en not_active Expired
- 1983-07-26 DK DK342383A patent/DK159432C/da not_active IP Right Cessation
- 1983-07-26 HU HU832627A patent/HU190498B/hu not_active IP Right Cessation
- 1983-07-26 HU HU854785A patent/HU193617B/hu not_active IP Right Cessation
- 1983-07-26 HU HU854784A patent/HU194810B/hu not_active IP Right Cessation
- 1983-07-27 EP EP83107398A patent/EP0103126B1/en not_active Expired
- 1983-07-27 KR KR1019830003495A patent/KR900001179B1/ko not_active Expired
- 1983-07-27 AT AT83107398T patent/ATE25680T1/de not_active IP Right Cessation
-
1989
- 1989-09-01 DK DK434689A patent/DK434689D0/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK434689A (da) | 1989-09-01 |
| CA1273347C (en, 2012) | 1990-08-28 |
| ATE25680T1 (de) | 1987-03-15 |
| CA1253498A (en) | 1989-05-02 |
| DK342383D0 (da) | 1983-07-26 |
| JPS5946255A (ja) | 1984-03-15 |
| DK159432C (da) | 1991-03-18 |
| JPS6121624B2 (en, 2012) | 1986-05-28 |
| HU194810B (en) | 1988-03-28 |
| DK434689D0 (da) | 1989-09-01 |
| KR900001179B1 (ko) | 1990-02-27 |
| HU193617B (en) | 1987-11-30 |
| EP0103126A1 (en) | 1984-03-21 |
| DK159432B (da) | 1990-10-15 |
| KR840006217A (ko) | 1984-11-22 |
| EP0103126B1 (en) | 1987-03-04 |
| DK342383A (da) | 1984-03-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee | ||
| HRH9 | Withdrawal of annulment decision |