|
US7109003B2
(en)
|
1998-12-23 |
2006-09-19 |
Abgenix, Inc. |
Methods for expressing and recovering human monoclonal antibodies to CTLA-4
|
|
EE05627B1
(et)
*
|
1998-12-23 |
2013-02-15 |
Pfizer Inc. |
CTLA-4 vastased inimese monoklonaalsed antikehad
|
|
US7605238B2
(en)
|
1999-08-24 |
2009-10-20 |
Medarex, Inc. |
Human CTLA-4 antibodies and their uses
|
|
US7030219B2
(en)
|
2000-04-28 |
2006-04-18 |
Johns Hopkins University |
B7-DC, Dendritic cell co-stimulatory molecules
|
|
US7357928B2
(en)
*
|
2002-04-08 |
2008-04-15 |
University Of Louisville Research Foundation, Inc. |
Method for the diagnosis and prognosis of malignant diseases
|
|
BR0309254A
(pt)
*
|
2002-04-12 |
2005-03-01 |
Medarex Inc |
Uso de um anticorpo anti-ctla-4
|
|
NZ566539A
(en)
*
|
2002-09-06 |
2010-01-29 |
Medarex Inc |
Therapeutic human anti-IL-1R1 monoclonal antibody
|
|
US20040197312A1
(en)
*
|
2003-04-02 |
2004-10-07 |
Marina Moskalenko |
Cytokine-expressing cellular vaccine combinations
|
|
US7465446B2
(en)
|
2003-05-30 |
2008-12-16 |
Medarex, Inc. |
Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
|
|
CN104059147A
(zh)
*
|
2003-06-27 |
2014-09-24 |
艾默根佛蒙特有限公司 |
针对表皮生长因子受体的缺失突变体的抗体及其使用
|
|
UY28424A1
(es)
|
2003-07-22 |
2005-02-28 |
Schering Ag |
Anticuerpos rgi y usos de los mismos.
|
|
AU2004266246A1
(en)
|
2003-08-14 |
2005-03-03 |
Dyax Corp. |
Endotheliase-2 ligands
|
|
EP1515505A1
(en)
*
|
2003-09-12 |
2005-03-16 |
Siemens Aktiengesellschaft |
Reachability maintainance of a moving network based on temporary name identifiers
|
|
US20050136055A1
(en)
*
|
2003-12-22 |
2005-06-23 |
Pfizer Inc |
CD40 antibody formulation and methods
|
|
CA2554779A1
(en)
*
|
2004-02-03 |
2005-08-18 |
The Regents Of The University Of Michigan |
Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
|
|
KR100845354B1
(ko)
*
|
2004-03-26 |
2008-07-09 |
화이자 프로덕츠 인코포레이티드 |
항－ｃｔｌａ－4 항체의 용도
|
|
US7785591B2
(en)
|
2004-10-14 |
2010-08-31 |
Morphosys Ag |
Identification and characterization of function-blocking anti-ED-B-fibronectin antibodies
|
|
EP1819735A1
(en)
*
|
2004-11-04 |
2007-08-22 |
Pfizer Products Inc. |
Ctla-4 antibody and aromatase inhibitor or combination treatment for breast cancer
|
|
KR100996801B1
(ko)
|
2005-03-08 |
2010-11-25 |
파마시아 앤드 업존 캄파니 엘엘씨 |
항-ＭＡｄＣＡＭ 항체 조성물
|
|
WO2006101691A1
(en)
*
|
2005-03-23 |
2006-09-28 |
Pfizer Products Inc. |
Therapy of prostate cancer with ctla4 antibodies and hormonal therapy
|
|
WO2006101692A1
(en)
*
|
2005-03-23 |
2006-09-28 |
Pfizer Products Inc. |
Anti-ctla4 antibody and indolinone combination therapy for treatment of cancer
|
|
EP2418278A3
(en)
*
|
2005-05-09 |
2012-07-04 |
Ono Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
|
|
DK1907000T4
(da)
|
2005-06-08 |
2020-03-30 |
The President And Fellows Of Harvard College |
Fremgangsmåder og sammensætninger til behandling af persisterende HIV-infektioner ved hæmning af reaktionsvejen for programmeret celledød 1 (PD-1).
|
|
CN101268101A
(zh)
*
|
2005-07-07 |
2008-09-17 |
科利制药集团公司 |
用于癌症治疗的抗-CTLA-4抗体和含有CpG基序的合成寡脱氧核苷酸联合治疗
|
|
WO2007067959A2
(en)
|
2005-12-07 |
2007-06-14 |
Medarex, Inc. |
Ctla-4 antibody dosage escalation regimens
|
|
EP2007423A2
(en)
*
|
2006-04-05 |
2008-12-31 |
Pfizer Products Incorporated |
Ctla4 antibody combination therapy
|
|
JP2010534719A
(ja)
*
|
2007-07-27 |
2010-11-11 |
ファイザー・リミテッド |
沈殿化による抗体精製方法
|
|
JP2010540534A
(ja)
|
2007-09-28 |
2010-12-24 |
イントレキソン コーポレーション |
生体治療分子の発現のための治療遺伝子スイッチ構築物およびバイオリアクター、ならびにその使用
|
|
RU2373836C2
(ru)
*
|
2007-12-18 |
2009-11-27 |
Федеральное государственное учреждение "Научно-исследовательский институт онкологии имени Н.Н. Петрова Федерального агентства по высокотехнологичной медицинской помощи" |
Способ оптимизации лечебной тактики при лимфоме ходжкина у детей и подростков
|
|
AU2009204194A1
(en)
*
|
2008-01-08 |
2009-07-16 |
Bristol-Myers Squibb Company |
Combination of anti-CTLA4 antibody with tubulin modulating agents for the treatment of proliferative diseases
|
|
WO2010014784A2
(en)
*
|
2008-08-01 |
2010-02-04 |
Bristol-Myers Squibb Company |
Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
|
|
EP2456790A1
(en)
*
|
2009-07-20 |
2012-05-30 |
Bristol-Myers Squibb Company |
Combination of anti-ctla4 antibody with diverse therapeutic regimens for the synergistic treatment of proliferative diseases
|
|
RU2421217C2
(ru)
*
|
2009-09-03 |
2011-06-20 |
Учреждение Российской академии медицинских наук Гематологический научный центр РАМН (ГНЦ РАМН) |
Способ дифференцированного лечения диффузных в-крупноклеточных лимфосарком лимфоидных органов взрослых
|
|
US20140178368A1
(en)
|
2011-04-19 |
2014-06-26 |
Leslie Lynne SHARP |
Combinations of anti-4-1bb antibodies and adcc-inducing antibodies for the treatment of cancer
|
|
ES2880291T3
(es)
|
2011-06-02 |
2021-11-24 |
Univ Louisville Res Found Inc |
Nanopartículas conjugadas a un agente antinucleolina
|
|
MX365139B
(es)
|
2012-03-13 |
2019-05-24 |
Hoffmann La Roche |
Uso de una terapia combinada de bevacizumab y paclitaxel en el tratamiento de cáncer de ovario epitelial resistente al platino, carcinoma de las trompas de falopio resistente al platino, o carcinoma peritoneal primario resistente al platino.
|
|
SG11201406592QA
(en)
|
2012-05-04 |
2014-11-27 |
Pfizer |
Prostate-associated antigens and vaccine-based immunotherapy regimens
|
|
KR102355959B1
(ko)
*
|
2012-08-23 |
2022-01-27 |
어젠시스 인코포레이티드 |
158p1d7 단백질에 결합하는 항체 약물 컨쥬게이트(ａｄｃ)
|
|
CN104968364A
(zh)
*
|
2012-12-03 |
2015-10-07 |
百时美施贵宝公司 |
强化免疫调变性Fc融合蛋白的抗癌活性
|
|
EP3995507B1
(en)
|
2013-08-08 |
2023-10-04 |
Cytune Pharma |
Il-15 and il-15ralpha sushi domain based on modulokines
|
|
LT3030262T
(lt)
|
2013-08-08 |
2020-03-10 |
Cytune Pharma |
Kombinuota farmacinė kompozicija
|
|
EP3057990B1
(en)
*
|
2013-10-18 |
2019-09-04 |
Regeneron Pharmaceuticals, Inc. |
Compositions comprising a combination of a vegf antagonist and an anti-ctla-4 antibody
|
|
AU2015240884B2
(en)
*
|
2014-03-31 |
2020-06-18 |
Biomed Valley Discoveries, Inc. |
Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-CTLA-4 and/or anti-PD-1 antibodies to treat solid tumor malignancies
|
|
SG11201609032WA
(en)
*
|
2014-05-01 |
2016-12-29 |
Anaeropharma Science Inc |
Heterogeneous polypeptide expression cassette
|
|
TW202132337A
(zh)
|
2014-05-28 |
2021-09-01 |
美商艾吉納斯公司 |
抗糖皮質素誘導性ｔｎｆｒ家族相關性受體（ｇｉｔｒ）抗體類及使用彼等之方法
|
|
CN105296433B
(zh)
|
2014-08-01 |
2018-02-09 |
中山康方生物医药有限公司 |
一种ctla4抗体、其药物组合物及其用途
|
|
ES2727137T3
(es)
|
2014-08-28 |
2019-10-14 |
Halozyme Inc |
Terapia combinada con una enzima de degradación de hialuronano y un inhibidor de puntos de control inmunitario
|
|
WO2016057367A1
(en)
|
2014-10-06 |
2016-04-14 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
KR102122463B1
(ko)
|
2014-10-14 |
2020-06-15 |
할로자임, 아이엔씨 |
아데노신 디아미네이즈-2(ada2)의 조성물, 이의 변이체 및 이를 사용하는 방법
|
|
EP3835312A1
(en)
|
2014-12-31 |
2021-06-16 |
Checkmate Pharmaceuticals, Inc. |
Combination tumor immunotherapy
|
|
WO2016130986A1
(en)
*
|
2015-02-13 |
2016-08-18 |
Sorrento Therapeutics, Inc. |
Antibody therapeutics that bind ctla4
|
|
WO2016179394A1
(en)
|
2015-05-05 |
2016-11-10 |
Malik Mohammad Tariq |
Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents
|
|
SI3303394T1
(sl)
*
|
2015-05-29 |
2020-10-30 |
Agenus Inc. |
Protitelesa proti-CTLA-4 in postopki njihove uporabe
|
|
TWI733687B
(zh)
*
|
2015-07-22 |
2021-07-21 |
美商索倫多醫療公司 |
結合ｌａｇ３之抗體治療劑
|
|
WO2017031157A1
(en)
*
|
2015-08-18 |
2017-02-23 |
Mateon Therapeutics, Inc. |
Use of vdas to enhance immunomodulating therapies against tumors
|
|
EP3383430A4
(en)
|
2015-12-02 |
2019-12-18 |
Agenus Inc. |
ANTIBODIES AND METHOD FOR USE THEREOF
|
|
WO2017165742A1
(en)
|
2016-03-24 |
2017-09-28 |
Millennium Pharmaceuticals, Inc. |
Methods of treating gastrointestinal immune-related adverse events in anti-ctla4 anti-pd-1 combination treatments
|
|
WO2017165778A1
(en)
|
2016-03-24 |
2017-09-28 |
Millennium Pharmaceuticals, Inc. |
Methods of treating gastrointestinal immune-related adverse events in immune oncology treatments
|
|
WO2017173334A1
(en)
|
2016-04-01 |
2017-10-05 |
Checkmate Pharmaceuticals, Inc. |
Fc receptor-mediated drug delivery
|
|
EA039322B1
(ru)
*
|
2016-04-15 |
2022-01-13 |
Эйдженус Инк. |
Антитела против ctla-4 и способы их применения
|
|
WO2018035710A1
(en)
|
2016-08-23 |
2018-03-01 |
Akeso Biopharma, Inc. |
Anti-ctla4 antibodies
|
|
CN109906088A
(zh)
*
|
2016-08-26 |
2019-06-18 |
奥野哲治 |
微血管血流减少剂及其应用
|
|
JP7106538B2
(ja)
|
2016-12-07 |
2022-07-26 |
アジェナス インコーポレイテッド |
抗体およびその使用方法
|
|
IL266918B2
(en)
|
2016-12-07 |
2024-03-01 |
Agenus Inc |
Anti-ctla-4 antibodies and methods of use thereof
|
|
US12129299B2
(en)
|
2018-02-02 |
2024-10-29 |
OncoC4, Inc. |
Mutant anti-CTLA-4 antibodies with improved immunotherapeutic effect but attenuated adverse effects
|
|
EP3752194A4
(en)
|
2018-02-13 |
2022-03-16 |
Checkmate Pharmaceuticals, Inc. |
COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY
|
|
US20230167177A1
(en)
*
|
2018-03-19 |
2023-06-01 |
WuXi Biologics Ireland Limited |
Novel anti-ctla-4 antibody polypeptide
|
|
IL277680B2
(en)
|
2018-04-09 |
2025-08-01 |
Checkmate Pharmaceuticals Inc |
Packaging oligonucleotides into virus-like particles
|
|
JP7340591B2
(ja)
|
2018-07-11 |
2023-09-07 |
アクティム・セラピューティクス・インコーポレイテッド |
遺伝子操作された免疫刺激性細菌菌株およびその使用
|
|
CN110092826B
(zh)
*
|
2019-02-28 |
2022-04-15 |
天津大学 |
CTLA-4类似物CFN13及CFN13-Fc基因和蛋白
|
|
CN115803343A
(zh)
*
|
2020-05-26 |
2023-03-14 |
百奥泰生物制药股份有限公司 |
多特异性抗体及其应用
|
|
CN116113406B
(zh)
|
2020-07-10 |
2025-08-29 |
密歇根大学董事会 |
Gas41抑制剂及其使用方法
|
|
EP4229222A2
(en)
|
2020-10-19 |
2023-08-23 |
Dana-Farber Cancer Institute, Inc. |
Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy
|
|
US20240424090A1
(en)
|
2021-04-20 |
2024-12-26 |
Institut Curie |
Compositions and methods for use in immunotherapy
|