HRP970560B1 - Substituted gamma aminobutyric acids as pharmaceutical agents - Google Patents

Substituted gamma aminobutyric acids as pharmaceutical agents

Info

Publication number
HRP970560B1
HRP970560B1 HR970560A HRP970560A HRP970560B1 HR P970560 B1 HRP970560 B1 HR P970560B1 HR 970560 A HR970560 A HR 970560A HR P970560 A HRP970560 A HR P970560A HR P970560 B1 HRP970560 B1 HR P970560B1
Authority
HR
Croatia
Prior art keywords
pct
gamma aminobutyric
pharmaceutical agents
aminobutyric acids
disorders
Prior art date
Application number
HR970560A
Other languages
English (en)
Inventor
Justin Stephen Bryans
David Christopher Horwell
Clare Octavia Kneen
David Juergen Wustrow
Andrew John Thorpe
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of HRP970560A2 publication Critical patent/HRP970560A2/hr
Publication of HRP970560B1 publication Critical patent/HRP970560B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
HR970560A 1996-10-23 1997-10-23 Substituted gamma aminobutyric acids as pharmaceutical agents HRP970560B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2960196P 1996-10-23 1996-10-23
US5990097P 1997-09-24 1997-09-24

Publications (2)

Publication Number Publication Date
HRP970560A2 HRP970560A2 (en) 1998-08-31
HRP970560B1 true HRP970560B1 (en) 2003-02-28

Family

ID=26705131

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970560A HRP970560B1 (en) 1996-10-23 1997-10-23 Substituted gamma aminobutyric acids as pharmaceutical agents

Country Status (11)

Country Link
US (1) US6153650A (fr)
EP (1) EP0937032B1 (fr)
JP (1) JP2002514187A (fr)
AT (1) ATE361909T1 (fr)
AU (1) AU733896B2 (fr)
BR (1) BR9712651A (fr)
CA (1) CA2263663C (fr)
DE (1) DE69737719D1 (fr)
HR (1) HRP970560B1 (fr)
NZ (1) NZ334898A (fr)
WO (1) WO1998017627A1 (fr)

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US6329429B1 (en) 1997-06-25 2001-12-11 Warner-Lambert Company Use of GABA analogs such as Gabapentin in the manufacture of a medicament for treating inflammatory diseases
HRP980342A2 (en) * 1997-06-25 1999-02-28 Warner Lambert Co Anti-inflammatory method
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
AU8668598A (en) 1997-08-20 1999-03-08 University Of Oklahoma, The Gaba analogs to prevent and treat gastrointestinal damage
DK1045839T3 (da) * 1997-12-16 2004-07-05 Warner Lambert Co Hidtil ukendte aminer som farmaceutiske midler
EP0974351A3 (fr) * 1998-04-24 2000-12-13 Jouveinal Médicament pour la prévention et le traitement des dommages gastrointestinaux
PL345340A1 (en) * 1998-07-09 2001-12-17 Warner Lambert Co Compositions comprising gaba analogs and caffeine
WO2000023067A1 (fr) * 1998-10-16 2000-04-27 Warner-Lambert Company Traitement de la manie et des troubles bipolaires
AU1602100A (en) * 1998-11-25 2000-06-13 Warner-Lambert Company Improved gamma amino butyric acid analogs
FR2791982B1 (fr) * 1999-04-06 2002-12-27 Inst Nat Sante Rech Med Inhibiteurs de lta4 hydrolase et leurs applications therapeutiques.
DE60012508T2 (de) * 1999-05-26 2005-06-23 Warner-Lambert Company Llc Aminosäuren mit polycyclischer struktur als pharmaka
GEP20074142B (en) * 1999-06-10 2007-07-10 Warner Lambert Co Mono- and Disubstituted 3-Propyl Gamma-Aminobutyric Acids
EP1840117A1 (fr) * 1999-06-10 2007-10-03 Warner-Lambert Company LLC Acides 3-propyle gamma-aminobutyriques monosubstitués et disubstitués
US6642398B2 (en) 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
US7164034B2 (en) 1999-06-10 2007-01-16 Pfizer Inc. Alpha2delta ligands for fibromyalgia and other disorders
CA2320556A1 (fr) * 1999-09-29 2001-03-29 Queen's University At Kingston N',n'-dichloro-omega-aminoacides et leurs derives et leurs utilisations
JP2003528148A (ja) * 2000-03-28 2003-09-24 デロレンゾ、ロバート・ジェイ 損傷に際して神経細胞中に形成される新規カルシウム損傷電流の阻害は神経細胞死を抑制する
US6992076B2 (en) 2000-10-06 2006-01-31 Xenoport, Inc. Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration
AU2002230398A1 (en) 2000-10-06 2002-04-29 Xenoport, Inc. Bile-acid conjugates for providing sustained systemic concentrations of drugs
US6620829B2 (en) 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
ES2296956T5 (es) 2001-06-11 2011-07-12 Xenoport, Inc. Profármacos de análogos de gaba, composiciones y sus usos.
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
WO2002100344A2 (fr) 2001-06-11 2002-12-19 Xenoport, Inc. Conjugues d'amino acides permettant d'obtenir des concentrations systemiques soutenues d'analogues du gaba
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
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KR20040081478A (ko) 2002-01-31 2004-09-21 워너-램버트 캄파니 엘엘씨 이명을 치료하기 위한 알파 2 델타 리간드
WO2003077902A1 (fr) 2002-02-19 2003-09-25 Xenoport, Inc. Procede de synthese de promedicaments a partir de derives de 1-acyl-alkyl et compositions correspondantes
AU2003222033A1 (en) 2002-03-20 2003-10-08 Xenoport Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
WO2003099338A2 (fr) 2002-05-17 2003-12-04 Xenoport, Inc. Conjugues d'acides amines permettant d'obtenir des concentrations systemiques prolongees d'analogues gaba
WO2004002462A2 (fr) * 2002-06-27 2004-01-08 Warner-Lambert Company Llc Methode de traitement du trouble d'hyperactivite avec deficit de l'attention
WO2004052360A1 (fr) 2002-12-11 2004-06-24 Xenoport, Inc. Promedicaments d'analogues gaba fusionnes, compositions pharmaceutiques, et utilisations correspondantes
KR20050085563A (ko) 2002-12-13 2005-08-29 워너-램버트 캄파니 엘엘씨 하부요로증상을 치료하기 위한 알파-2-델타 리간드
KR100845932B1 (ko) * 2002-12-13 2008-07-11 워너-램버트 캄파니 엘엘씨 섬유근육통 및 기타 관련 질환의 치료를 위한 프레가발린및 그의 유도체
CA2451267A1 (fr) 2002-12-13 2004-06-13 Warner-Lambert Company Llc Utilisations pharmaceutiques de ligands alpha2delta
JP2006513257A (ja) 2002-12-13 2006-04-20 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 線維筋痛症および他の障害を処置するためのプレガバリン誘導体
NZ545884A (en) 2003-09-11 2010-01-29 Xenoport Inc Treating and/or preventing urinary incontinence using prodrugs of GABA analogs
BRPI0414343A (pt) 2003-09-12 2006-11-07 Pfizer combinações que compreendem ligantes de alfa-2-delta e inibidores da reabsorção de serotonina/noradrenalina
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CA2548917C (fr) 2003-12-11 2014-09-23 Sepracor Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression
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TWI369202B (en) 2008-01-25 2012-08-01 Xenoport Inc Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
EP2344447B1 (fr) 2008-10-08 2016-06-08 Xgene Pharmaceutical Inc Conjugués gaba et procédés d'utilisation de ceux-ci
US9066853B2 (en) 2013-01-15 2015-06-30 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
WO2014117176A1 (fr) 2013-01-28 2014-07-31 Lopez Hector L Procédés d'amélioration de la tolérance à β-alanine, de sa pharmacodynamie et de son efficacité et son utilisation
CN107857710A (zh) * 2017-11-23 2018-03-30 河南师范大学 一种抗癫痫药普瑞巴林的制备方法
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Also Published As

Publication number Publication date
WO1998017627A1 (fr) 1998-04-30
AU4669797A (en) 1998-05-15
ATE361909T1 (de) 2007-06-15
EP0937032A1 (fr) 1999-08-25
DE69737719D1 (de) 2007-06-21
BR9712651A (pt) 1999-10-26
CA2263663A1 (fr) 1998-04-30
JP2002514187A (ja) 2002-05-14
AU733896B2 (en) 2001-05-31
HRP970560A2 (en) 1998-08-31
US6153650A (en) 2000-11-28
CA2263663C (fr) 2006-05-30
EP0937032B1 (fr) 2007-05-09
NZ334898A (en) 2000-09-29

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