HRP20240187T1 - Farmaceutske kompozicije koje sadrže konjugat hijaluronske kiseline i karnozina i odgovarajuća primjena - Google Patents
Farmaceutske kompozicije koje sadrže konjugat hijaluronske kiseline i karnozina i odgovarajuća primjena Download PDFInfo
- Publication number
- HRP20240187T1 HRP20240187T1 HRP20240187TT HRP20240187T HRP20240187T1 HR P20240187 T1 HRP20240187 T1 HR P20240187T1 HR P20240187T T HRP20240187T T HR P20240187TT HR P20240187 T HRP20240187 T HR P20240187T HR P20240187 T1 HRP20240187 T1 HR P20240187T1
- Authority
- HR
- Croatia
- Prior art keywords
- carnosine
- hyaluronic acid
- pharmaceutical composition
- use according
- conjugate
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims 15
- 229920002674 hyaluronan Polymers 0.000 title claims 15
- 229960003160 hyaluronic acid Drugs 0.000 title claims 15
- 108010087806 Carnosine Proteins 0.000 title claims 9
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 title claims 8
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 title claims 8
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 title claims 8
- 229940044199 carnosine Drugs 0.000 title claims 8
- 239000008194 pharmaceutical composition Substances 0.000 title claims 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 2
- 238000001212 derivatisation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- -1 amide derivative of HA Chemical class 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical class CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (6)
1. Farmaceutska kompozicija koja sadrži konjugat hijaluronska kiselina (HA)/karnozin sa direktnom amidnom vezom između karboksilne grupe hijaluronske kiseline i aminske grupe karnozina za primjenu u prevenciji i liječenju osteoartritisa i liječenju reumatoidnog artritisa (RA), pri čemu se stupanj derivatizacije karboksilnih grupa iz HA karnozinom kreće od 30 do 60%, a prosječna molekulska masa za HA kreće se od 1×105 Da do 1×106 Da.
2. Farmaceutska kompozicija za primjenu prema patentnom zahtjevu 1, pri čemu se konjugat hijaluronska kiselina (HA)/karnozin dobiva kovalentnom konjugacijom dipeptida karnozina sa hijaluronskom kiselinom formiranjem direktne amidne veze između karboksilne grupe iz HA i aminske grupe karnozina, sa stupnjom derivatizacije, tj. amidacijom, karboksilnih grupa iz HA karnozinom koji varira u opsegu od 35±3% ili 45±5% i smjese istog.
3. Farmaceutska kompozicija za primjenu prema jednom ili više prethodnih patentnih zahtjeva, pri čemu se prosječna molekulska masa za HA kreće u opsegu od 130-220 k Da ili 500-750 k Da i smjese istog.
4. Farmaceutska kompozicija za primjenu prema jednom ili više prethodnih patentnih zahtjeva, pri čemu hijaluronska kiselina koja se koristi za pripremu amidnog derivata od HA sa karnozinom je natrijeva sol od HA ili tetrabutilamonijeva sol od HA.
5. Farmaceutska kompozicija za primjenu prema jednom ili više prethodnih patentnih zahtjeva za lokalnu, oralnu, intraartikularnu, parenteralnu ili kiruršku primjenu.
6. Farmaceutska kompozicija za primjenu prema prethodnim patentnim zahtjevima, koja je u vezi sa farmakološki i/ili biološki aktivnim supstancama i/ili sa sistemima za kontrolirano oslobađanje lijekova i/ili prirodnih polimera ili polimera sintetičke prirode.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000110784A IT201700110784A1 (it) | 2017-10-03 | 2017-10-03 | Composizioni farmaceutiche contenenti Acido Ialuronico e Carnosina e relativo uso |
| EP18796748.4A EP3691691B1 (en) | 2017-10-03 | 2018-10-03 | Pharmaceutical compositions containing a conjugate of hyaluronic acid and carnosine and relative use |
| PCT/IB2018/057697 WO2019069258A1 (en) | 2017-10-03 | 2018-10-03 | PHARMACEUTICAL COMPOSITIONS CONTAINING HYALURONIC ACID AND CARNOSINE AND USE THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240187T1 true HRP20240187T1 (hr) | 2024-05-10 |
Family
ID=61024973
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240187TT HRP20240187T1 (hr) | 2017-10-03 | 2018-10-03 | Farmaceutske kompozicije koje sadrže konjugat hijaluronske kiseline i karnozina i odgovarajuća primjena |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20200289604A1 (hr) |
| EP (1) | EP3691691B1 (hr) |
| KR (1) | KR20200091380A (hr) |
| CN (1) | CN111163808A (hr) |
| AR (1) | AR114337A1 (hr) |
| CA (1) | CA3073797A1 (hr) |
| DK (1) | DK3691691T3 (hr) |
| EA (1) | EA202090524A1 (hr) |
| ES (1) | ES2971097T3 (hr) |
| FI (1) | FI3691691T3 (hr) |
| HR (1) | HRP20240187T1 (hr) |
| IT (1) | IT201700110784A1 (hr) |
| LT (1) | LT3691691T (hr) |
| PL (1) | PL3691691T3 (hr) |
| PT (1) | PT3691691T (hr) |
| RS (1) | RS65191B1 (hr) |
| SI (1) | SI3691691T1 (hr) |
| WO (1) | WO2019069258A1 (hr) |
| ZA (1) | ZA202001174B (hr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000014017A1 (it) | 2020-06-11 | 2021-12-11 | Fidia Farm Spa | Nuovi derivati ottenuti da acido ialuronico e carnosina |
| CN117700583A (zh) * | 2023-12-22 | 2024-03-15 | 珠海瑞玞生物工程有限公司 | 一种透明质酸基生物材料的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05010778A (es) * | 2003-04-09 | 2005-12-12 | Genentech Inc | Terapia para enfermedad autoinmune en un paciente con una respuesta inadecuada a un inhibidor tnf-alfa. |
| ITPD20040053A1 (it) * | 2004-02-27 | 2004-05-27 | Fidia Advanced Biopolymers Srl | Biomateriali costituiti da derivati dell'acido ialuronico come nuova terapia di cura per la protezione e la la riparazione della cartilagine articolare danneggiata per osteoartrosi |
| KR101234476B1 (ko) * | 2004-03-05 | 2013-02-18 | 덴끼 가가꾸 고교 가부시키가이샤 | 히알루론산/메토트렉세이트 화합물 |
| ITPD20050056A1 (it) * | 2005-03-02 | 2006-09-03 | Fidia Farmaceutici | Derivati ammidici del'acido ialuronico in osteoartrosi |
| IT1391251B1 (it) * | 2008-10-15 | 2011-12-01 | Innovative Nutrition & Pharma Srl | Composizione per il trattamento delle patologie articolari |
| US20120321603A1 (en) * | 2011-06-16 | 2012-12-20 | Nayan Patel | Composition and method for stabilization and delivery of therapeutic molecules |
| CN106573957B (zh) * | 2014-07-31 | 2021-10-26 | 塞巴斯蒂安诺·舒托 | 由透明质酸和肌肽得到的衍生物 |
-
2017
- 2017-10-03 IT IT102017000110784A patent/IT201700110784A1/it unknown
-
2018
- 2018-10-03 EP EP18796748.4A patent/EP3691691B1/en active Active
- 2018-10-03 EA EA202090524A patent/EA202090524A1/ru unknown
- 2018-10-03 DK DK18796748.4T patent/DK3691691T3/da active
- 2018-10-03 CA CA3073797A patent/CA3073797A1/en active Pending
- 2018-10-03 WO PCT/IB2018/057697 patent/WO2019069258A1/en active Application Filing
- 2018-10-03 PT PT187967484T patent/PT3691691T/pt unknown
- 2018-10-03 PL PL18796748.4T patent/PL3691691T3/pl unknown
- 2018-10-03 US US16/753,152 patent/US20200289604A1/en not_active Abandoned
- 2018-10-03 AR ARP180102854A patent/AR114337A1/es unknown
- 2018-10-03 LT LTEPPCT/IB2018/057697T patent/LT3691691T/lt unknown
- 2018-10-03 ES ES18796748T patent/ES2971097T3/es active Active
- 2018-10-03 CN CN201880064442.9A patent/CN111163808A/zh active Pending
- 2018-10-03 SI SI201831056T patent/SI3691691T1/sl unknown
- 2018-10-03 RS RS20240114A patent/RS65191B1/sr unknown
- 2018-10-03 FI FIEP18796748.4T patent/FI3691691T3/fi active
- 2018-10-03 KR KR1020207008125A patent/KR20200091380A/ko not_active Application Discontinuation
- 2018-10-03 HR HRP20240187TT patent/HRP20240187T1/hr unknown
-
2020
- 2020-02-25 ZA ZA2020/01174A patent/ZA202001174B/en unknown
-
2021
- 2021-09-23 US US17/482,696 patent/US20220031797A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220031797A1 (en) | 2022-02-03 |
| WO2019069258A1 (en) | 2019-04-11 |
| DK3691691T3 (da) | 2024-02-05 |
| IT201700110784A1 (it) | 2019-04-03 |
| ES2971097T3 (es) | 2024-06-03 |
| ZA202001174B (en) | 2021-08-25 |
| CN111163808A (zh) | 2020-05-15 |
| EP3691691A1 (en) | 2020-08-12 |
| PL3691691T3 (pl) | 2024-04-29 |
| FI3691691T3 (fi) | 2024-02-08 |
| RS65191B1 (sr) | 2024-03-29 |
| EA202090524A1 (ru) | 2020-05-28 |
| SI3691691T1 (sl) | 2024-03-29 |
| US20200289604A1 (en) | 2020-09-17 |
| LT3691691T (lt) | 2024-02-26 |
| CA3073797A1 (en) | 2019-04-11 |
| PT3691691T (pt) | 2024-01-31 |
| EP3691691B1 (en) | 2023-12-13 |
| AR114337A1 (es) | 2020-08-26 |
| KR20200091380A (ko) | 2020-07-30 |
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