HRP20231438T1 - Formulacije oksitocina koje sadrže magnezij i načini uporabe - Google Patents
Formulacije oksitocina koje sadrže magnezij i načini uporabe Download PDFInfo
- Publication number
- HRP20231438T1 HRP20231438T1 HRP20231438TT HRP20231438T HRP20231438T1 HR P20231438 T1 HRP20231438 T1 HR P20231438T1 HR P20231438T T HRP20231438T T HR P20231438TT HR P20231438 T HRP20231438 T HR P20231438T HR P20231438 T1 HRP20231438 T1 HR P20231438T1
- Authority
- HR
- Croatia
- Prior art keywords
- pain
- oxytocin peptide
- magnesium
- magnesium salt
- oxytocin
- Prior art date
Links
- 101800000989 Oxytocin Proteins 0.000 title claims 24
- 239000000203 mixture Substances 0.000 title claims 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims 6
- 229910052749 magnesium Inorganic materials 0.000 title claims 6
- 239000011777 magnesium Substances 0.000 title claims 6
- XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 title 1
- 102100031951 Oxytocin-neurophysin 1 Human genes 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 title 1
- 229960001723 oxytocin Drugs 0.000 title 1
- 208000002193 Pain Diseases 0.000 claims 17
- 159000000003 magnesium salts Chemical class 0.000 claims 13
- 230000036407 pain Effects 0.000 claims 13
- 229940091250 magnesium supplement Drugs 0.000 claims 5
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010016059 Facial pain Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 101500028587 Homo sapiens Oxytocin Proteins 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010028391 Musculoskeletal Pain Diseases 0.000 claims 2
- 206010028836 Neck pain Diseases 0.000 claims 2
- 208000007613 Shoulder Pain Diseases 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 230000036592 analgesia Effects 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- 210000004889 cervical nerve Anatomy 0.000 claims 2
- 230000001667 episodic effect Effects 0.000 claims 2
- 239000012669 liquid formulation Substances 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- 229960005336 magnesium citrate Drugs 0.000 claims 2
- 235000002538 magnesium citrate Nutrition 0.000 claims 2
- 239000004337 magnesium citrate Substances 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000002195 synergetic effect Effects 0.000 claims 2
- 210000003901 trigeminal nerve Anatomy 0.000 claims 2
- PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 claims 2
- 210000001364 upper extremity Anatomy 0.000 claims 2
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229910001425 magnesium ion Inorganic materials 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/095—Oxytocins; Vasopressins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/08—Inhaling devices inserted into the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562100862P | 2015-01-07 | 2015-01-07 | |
| PCT/US2016/012512 WO2016112205A1 (en) | 2015-01-07 | 2016-01-07 | Magnesium-containing oxytocin formulations and methods of use |
| EP16735422.4A EP3242676B1 (en) | 2015-01-07 | 2016-01-07 | Magnesium-containing oxytocin formulations and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20231438T1 true HRP20231438T1 (hr) | 2024-06-07 |
Family
ID=56285908
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231438TT HRP20231438T1 (hr) | 2015-01-07 | 2016-01-07 | Formulacije oksitocina koje sadrže magnezij i načini uporabe |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US9629894B2 (https=) |
| EP (2) | EP3242676B1 (https=) |
| JP (4) | JP7030517B2 (https=) |
| KR (1) | KR102677904B1 (https=) |
| CN (1) | CN107847552B (https=) |
| AU (3) | AU2016205225A1 (https=) |
| CA (1) | CA2972975A1 (https=) |
| DK (1) | DK3242676T3 (https=) |
| ES (1) | ES2963707T3 (https=) |
| FI (1) | FI3242676T3 (https=) |
| HR (1) | HRP20231438T1 (https=) |
| HU (1) | HUE065385T2 (https=) |
| IL (1) | IL253347B (https=) |
| LT (1) | LT3242676T (https=) |
| MX (1) | MX388286B (https=) |
| PL (1) | PL3242676T3 (https=) |
| PT (1) | PT3242676T (https=) |
| RS (1) | RS65034B1 (https=) |
| RU (1) | RU2017127734A (https=) |
| SG (1) | SG11201705591PA (https=) |
| SI (1) | SI3242676T1 (https=) |
| SM (1) | SMT202400020T1 (https=) |
| WO (1) | WO2016112205A1 (https=) |
| ZA (1) | ZA201705176B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201705591PA (en) * | 2015-01-07 | 2017-08-30 | Trigemina Inc | Magnesium-containing oxytocin formulations and methods of use |
| HUE070412T2 (hu) | 2016-04-12 | 2025-06-28 | Tonix Pharma Ltd | Magnézium tartalmú oxitocin készítmények és alkamazási eljárásaik |
| WO2019049145A1 (en) * | 2017-09-11 | 2019-03-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | COMPOSITIONS AND METHODS FOR NASAL BRAIN MEDICATION ADMINISTRATION FOR SYSTEMIC EFFECT |
| EP3759121A1 (en) * | 2018-03-01 | 2021-01-06 | Trigemina, Inc. | Labeled oxytocin and method of manufacture and use |
| US20230414492A1 (en) * | 2019-04-02 | 2023-12-28 | Nose To Brain Therapeutics Llc | Intranasal delivery of cannabidiol to treat central nervous system disorders |
| CA3152988A1 (en) | 2019-08-29 | 2021-03-04 | New York University | Oxytocin compositions for treatment of tinnitus |
| ES3010259T3 (en) | 2021-03-26 | 2025-04-01 | Ot4B | Treatment of dysphagia |
| GB2607333A (en) * | 2021-06-03 | 2022-12-07 | Horopito Ltd | Pain relief composition |
| WO2023091469A1 (en) * | 2021-11-17 | 2023-05-25 | The Board Of Trustees Of The Leland Stanford Junior University | Targeting periosteal tissue for delivery of therapeutics |
| CN115569186A (zh) * | 2022-08-02 | 2023-01-06 | 北京大学第三医院（北京大学第三临床医学院） | 一种包含催产素的用于治疗干眼症的药物组合物 |
| US20250255930A1 (en) * | 2024-02-08 | 2025-08-14 | Maskbegone Llc | Methods of treatment of tinnitus using derivatives of oxytocin |
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| DE431291C (de) | 1925-03-29 | 1926-07-08 | Contessa Nettel A G | Wechselkassette mit herausziehbarer Wechsellade |
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