HRP20220138T1 - Peptidni pripravci i postupci uporabe - Google Patents
Peptidni pripravci i postupci uporabe Download PDFInfo
- Publication number
- HRP20220138T1 HRP20220138T1 HRP20220138TT HRP20220138T HRP20220138T1 HR P20220138 T1 HRP20220138 T1 HR P20220138T1 HR P20220138T T HRP20220138T T HR P20220138TT HR P20220138 T HRP20220138 T HR P20220138T HR P20220138 T1 HRP20220138 T1 HR P20220138T1
- Authority
- HR
- Croatia
- Prior art keywords
- retinal
- disease
- preparation
- macular degeneration
- treatment
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 7
- 238000000034 method Methods 0.000 title claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 208000002780 macular degeneration Diseases 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 201000010099 disease Diseases 0.000 claims 11
- 206010064930 age-related macular degeneration Diseases 0.000 claims 9
- 206010038848 Retinal detachment Diseases 0.000 claims 7
- 239000002736 nonionic surfactant Substances 0.000 claims 7
- 230000004264 retinal detachment Effects 0.000 claims 7
- 230000006907 apoptotic process Effects 0.000 claims 6
- 208000019553 vascular disease Diseases 0.000 claims 6
- 208000017442 Retinal disease Diseases 0.000 claims 5
- 206010046851 Uveitis Diseases 0.000 claims 5
- 210000001525 retina Anatomy 0.000 claims 5
- 210000001927 retinal artery Anatomy 0.000 claims 5
- 208000010412 Glaucoma Diseases 0.000 claims 4
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 4
- 230000030833 cell death Effects 0.000 claims 4
- 230000021597 necroptosis Effects 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 230000002207 retinal effect Effects 0.000 claims 4
- 208000004644 retinal vein occlusion Diseases 0.000 claims 4
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 208000029977 White Dot Syndromes Diseases 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 201000005667 central retinal vein occlusion Diseases 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 210000000608 photoreceptor cell Anatomy 0.000 claims 3
- 108091008695 photoreceptors Proteins 0.000 claims 3
- 210000003994 retinal ganglion cell Anatomy 0.000 claims 3
- 208000014882 Carotid artery disease Diseases 0.000 claims 2
- 208000002691 Choroiditis Diseases 0.000 claims 2
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 201000002563 Histoplasmosis Diseases 0.000 claims 2
- 101100369992 Homo sapiens TNFSF10 gene Proteins 0.000 claims 2
- 208000001344 Macular Edema Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000003971 Posterior uveitis Diseases 0.000 claims 2
- 208000002367 Retinal Perforations Diseases 0.000 claims 2
- 201000007527 Retinal artery occlusion Diseases 0.000 claims 2
- 206010038910 Retinitis Diseases 0.000 claims 2
- 206010038923 Retinopathy Diseases 0.000 claims 2
- 208000027073 Stargardt disease Diseases 0.000 claims 2
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 2
- 108700012411 TNFSF10 Proteins 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 239000006184 cosolvent Substances 0.000 claims 2
- 210000000981 epithelium Anatomy 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000000790 retinal pigment Substances 0.000 claims 2
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 208000006379 syphilis Diseases 0.000 claims 2
- 208000011841 Abnormal homeostasis Diseases 0.000 claims 1
- 208000004142 Acute Retinal Necrosis Syndrome Diseases 0.000 claims 1
- 206010002329 Aneurysm Diseases 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 208000009137 Behcet syndrome Diseases 0.000 claims 1
- 201000007795 Bietti crystalline corneoretinal dystrophy Diseases 0.000 claims 1
- 208000003569 Central serous chorioretinopathy Diseases 0.000 claims 1
- 208000005590 Choroidal Neovascularization Diseases 0.000 claims 1
- 206010070957 Choroidal haemangioma Diseases 0.000 claims 1
- 206010060823 Choroidal neovascularisation Diseases 0.000 claims 1
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 208000021089 Coats disease Diseases 0.000 claims 1
- 206010010356 Congenital anomaly Diseases 0.000 claims 1
- 206010058202 Cystoid macular oedema Diseases 0.000 claims 1
- 206010012688 Diabetic retinal oedema Diseases 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 208000019878 Eales disease Diseases 0.000 claims 1
- 208000001351 Epiretinal Membrane Diseases 0.000 claims 1
- 208000028506 Familial Exudative Vitreoretinopathies Diseases 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- 208000003923 Hereditary Corneal Dystrophies Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- 206010058558 Hypoperfusion Diseases 0.000 claims 1
- 206010022557 Intermediate uveitis Diseases 0.000 claims 1
- 206010022941 Iridocyclitis Diseases 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 206010025412 Macular dystrophy congenital Diseases 0.000 claims 1
- 208000031471 Macular fibrosis Diseases 0.000 claims 1
- 206010025415 Macular oedema Diseases 0.000 claims 1
- 208000035719 Maculopathy Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000009857 Microaneurysm Diseases 0.000 claims 1
- 208000010164 Multifocal Choroiditis Diseases 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 208000006123 Myiasis Diseases 0.000 claims 1
- 206010065119 Necrotising herpetic retinopathy Diseases 0.000 claims 1
- 206010069385 Ocular ischaemic syndrome Diseases 0.000 claims 1
- 206010065700 Ocular sarcoidosis Diseases 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
- 206010065373 Papillophlebitis Diseases 0.000 claims 1
- 208000004788 Pars Planitis Diseases 0.000 claims 1
- 208000034247 Pattern dystrophy Diseases 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 206010064714 Radiation retinopathy Diseases 0.000 claims 1
- 208000008709 Retinal Telangiectasis Diseases 0.000 claims 1
- 201000007737 Retinal degeneration Diseases 0.000 claims 1
- 208000032430 Retinal dystrophy Diseases 0.000 claims 1
- 208000032398 Retinal pigment epitheliopathy Diseases 0.000 claims 1
- 206010038899 Retinal telangiectasia Diseases 0.000 claims 1
- 206010038915 Retinitis viral Diseases 0.000 claims 1
- 206010038934 Retinopathy proliferative Diseases 0.000 claims 1
- 206010038935 Retinopathy sickle cell Diseases 0.000 claims 1
- 206010039705 Scleritis Diseases 0.000 claims 1
- 206010040925 Skin striae Diseases 0.000 claims 1
- 208000022758 Sorsby fundus dystrophy Diseases 0.000 claims 1
- 208000036038 Subretinal fibrosis Diseases 0.000 claims 1
- 206010042742 Sympathetic ophthalmia Diseases 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 201000005485 Toxoplasmosis Diseases 0.000 claims 1
- 208000001445 Uveomeningoencephalitic Syndrome Diseases 0.000 claims 1
- 208000034705 Vogt-Koyanagi-Harada syndrome Diseases 0.000 claims 1
- 201000001408 X-linked juvenile retinoschisis 1 Diseases 0.000 claims 1
- 208000017441 X-linked retinoschisis Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000019672 acute posterior multifocal placoid pigment epitheliopathy Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 201000004612 anterior uveitis Diseases 0.000 claims 1
- 206010072959 birdshot chorioretinopathy Diseases 0.000 claims 1
- 208000015294 blood coagulation disease Diseases 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000005845 branch retinal artery occlusion Diseases 0.000 claims 1
- 201000005849 central retinal artery occlusion Diseases 0.000 claims 1
- 208000027129 choroid disease Diseases 0.000 claims 1
- 208000020656 combined hamartoma of the retina and retinal pigment epithelium Diseases 0.000 claims 1
- 201000008615 cone dystrophy Diseases 0.000 claims 1
- 208000006623 congenital stationary night blindness Diseases 0.000 claims 1
- 201000010206 cystoid macular edema Diseases 0.000 claims 1
- 201000011190 diabetic macular edema Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010014801 endophthalmitis Diseases 0.000 claims 1
- 201000006902 exudative vitreoretinopathy Diseases 0.000 claims 1
- 208000034737 hemoglobinopathy Diseases 0.000 claims 1
- 230000013632 homeostatic process Effects 0.000 claims 1
- 230000001631 hypertensive effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000019420 lymphoid neoplasm Diseases 0.000 claims 1
- 208000029233 macular holes Diseases 0.000 claims 1
- 201000010230 macular retinal edema Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 201000002165 neuroretinitis Diseases 0.000 claims 1
- 208000008940 ocular tuberculosis Diseases 0.000 claims 1
- 208000008798 osteoma Diseases 0.000 claims 1
- 230000000649 photocoagulation Effects 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 229920001992 poloxamer 407 Polymers 0.000 claims 1
- 229940044476 poloxamer 407 Drugs 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 201000004849 posterior scleritis Diseases 0.000 claims 1
- 201000002267 posterior uveal melanoma Diseases 0.000 claims 1
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 claims 1
- 210000000844 retinal pigment epithelial cell Anatomy 0.000 claims 1
- 210000001957 retinal vein Anatomy 0.000 claims 1
- 201000007714 retinoschisis Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical class CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims 1
- 229960004224 tyloxapol Drugs 0.000 claims 1
- 229920001664 tyloxapol Polymers 0.000 claims 1
- 230000001982 uveitic effect Effects 0.000 claims 1
- 230000003074 vasoproliferative effect Effects 0.000 claims 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155711P | 2015-05-01 | 2015-05-01 | |
| PCT/US2016/030098 WO2016178993A1 (en) | 2015-05-01 | 2016-04-29 | Peptide compositions and methods of use |
| EP16789830.3A EP3288379B1 (en) | 2015-05-01 | 2016-04-29 | Peptide compositions and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220138T1 true HRP20220138T1 (hr) | 2022-05-27 |
Family
ID=57217771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220138TT HRP20220138T1 (hr) | 2015-05-01 | 2016-04-29 | Peptidni pripravci i postupci uporabe |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US10508134B2 (enExample) |
| EP (3) | EP4623925A2 (enExample) |
| JP (2) | JP6884755B2 (enExample) |
| KR (2) | KR20240046280A (enExample) |
| CN (2) | CN113651873B (enExample) |
| AU (1) | AU2016258837B2 (enExample) |
| CA (1) | CA2984154A1 (enExample) |
| CY (1) | CY1124911T1 (enExample) |
| DK (1) | DK3288379T3 (enExample) |
| EA (2) | EA035293B1 (enExample) |
| ES (1) | ES2906173T3 (enExample) |
| HR (1) | HRP20220138T1 (enExample) |
| HU (1) | HUE057883T2 (enExample) |
| LT (1) | LT3288379T (enExample) |
| MX (1) | MX387317B (enExample) |
| PL (1) | PL3288379T3 (enExample) |
| PT (1) | PT3288379T (enExample) |
| RS (1) | RS62866B1 (enExample) |
| SI (1) | SI3288379T1 (enExample) |
| SM (1) | SMT202200069T1 (enExample) |
| WO (1) | WO2016178993A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6884755B2 (ja) * | 2015-05-01 | 2021-06-09 | オーエヌエル セラピューティクス，インコーポレーテッド | ペプチド組成物および使用方法 |
| EP3768301A4 (en) * | 2018-03-20 | 2022-06-08 | ONL Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR FAS INHIBITION |
| AU2019288296B2 (en) * | 2018-06-19 | 2022-11-24 | Cella Therapeutics, Llc | Sustained-release drug delivery systems comprising an intraocular pressure lowering agent, a CNP compound, an NPR-B compound, a Tie-2 agonist, or neurotrophic agent for use for treating glaucoma or ocular hypertension |
| CN115119501A (zh) * | 2019-12-18 | 2022-09-27 | 细胞疗法有限责任公司 | 包含神经营养剂、凋亡信号传导片段抑制剂（FAS）或FAS配体（FASL）抑制剂、肿瘤坏死因子-α（TNF-α）或TNF受体抑制剂、线粒体肽、寡核苷酸、趋化因子抑制剂或半胱氨酸-天冬氨酸蛋白酶抑制剂的药物递送系统 |
| WO2022266127A1 (en) * | 2021-06-15 | 2022-12-22 | Onl Therapeutics, Inc. | Methods and compositions for treating ocular disorders and diseases |
| JP2024525805A (ja) * | 2021-07-13 | 2024-07-12 | オーエヌエル セラピューティクス，インク． | 眼の疾患および障害における視機能を改善するための方法および組成物 |
| WO2023129766A1 (en) * | 2021-12-27 | 2023-07-06 | Onl Therapeutics, Inc. | Sfasl for inhibiting rpe cell death and associated disorders |
| WO2024031022A2 (en) * | 2022-08-05 | 2024-02-08 | Onl Therapeutics, Inc. | Peptide compositions and methods of use |
| WO2024031024A1 (en) * | 2022-08-05 | 2024-02-08 | Onl Therapeutics, Inc. | Peptide compositions and methods of use |
| WO2024220669A1 (en) * | 2023-04-19 | 2024-10-24 | Onl Therapeutics, Inc. | Methods and compositions for treating rnfl thinning |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5532123A (en) * | 1990-07-11 | 1996-07-02 | New York University | Receptor-type phosphotyrosine phosphatase-γ |
| US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
| JP3187201B2 (ja) * | 1992-05-14 | 2001-07-11 | 三共株式会社 | Ｃ末端にプロリンアミドを有するペプチドの製法 |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| US5631237A (en) | 1992-12-22 | 1997-05-20 | Dzau; Victor J. | Method for producing in vivo delivery of therapeutic agents via liposomes |
| JP3460863B2 (ja) | 1993-09-17 | 2003-10-27 | 三菱電機株式会社 | 半導体装置の製造方法 |
| US5714353A (en) | 1994-05-24 | 1998-02-03 | Research Corporation Technologies, Inc. | Safe vectors for gene therapy |
| US5527928A (en) | 1994-09-30 | 1996-06-18 | Nantz; Michael H. | Cationic transport reagents |
| US5650096A (en) | 1994-12-09 | 1997-07-22 | Genzyme Corporation | Cationic amphiphiles for intracellular delivery of therapeutic molecules |
| US5719131A (en) | 1994-12-09 | 1998-02-17 | Genzyme Corporation | Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules |
| US5711964A (en) | 1995-06-07 | 1998-01-27 | United States Of America | Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D |
| US5705385A (en) | 1995-06-07 | 1998-01-06 | Inex Pharmaceuticals Corporation | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
| US6001962A (en) | 1996-11-15 | 1999-12-14 | The Regents Of The University Of California | Modified Fas ligands |
| US7091047B2 (en) * | 1997-05-23 | 2006-08-15 | A&G Pharmaceutical, Inc. | Methods and kits for diagnosing tumorigenicity |
| US6363020B1 (en) | 1999-12-06 | 2002-03-26 | Virage Logic Corp. | Architecture with multi-instance redundancy implementation |
| US6480428B2 (en) | 2000-12-19 | 2002-11-12 | Winbond Electronics Corporation | Redundant circuit for memory device |
| EP1730186A2 (en) * | 2004-03-31 | 2006-12-13 | Xencor, Inc. | Bmp-7 variants with improved properties |
| EP1737483A2 (en) | 2004-04-23 | 2007-01-03 | University of Pittsburgh of the Commonwealth System of Higher Education | Cell death modulation via antagonists of fasl and fas activation |
| WO2006121963A2 (en) * | 2005-05-10 | 2006-11-16 | Alcon, Inc. | Suspension formulations comprising an active principle, a poloxamer or meroxapol surfactant and a glycol, its use for the manufacture of a medicament for treating ophthalmic disorders |
| EP1956906A4 (en) * | 2005-11-09 | 2009-12-30 | Combinatorx Inc | METHODS, COMPOSITIONS AND KITS FOR THE TREATMENT OF PATHOLOGIES |
| US20080280834A1 (en) | 2005-12-01 | 2008-11-13 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compounds and methods for inhibiting apoptosis |
| WO2009086131A1 (en) * | 2007-12-21 | 2009-07-09 | Stryker Corporation | Bmp mutants with decreased susceptibility to noggin |
| US8343931B2 (en) * | 2009-03-03 | 2013-01-01 | The Regents Of The University Of Michigan | Methods of inhibiting photoreceptor apoptosis |
| JP2010254672A (ja) * | 2009-03-30 | 2010-11-11 | Santen Pharmaceut Co Ltd | ＪＮＫ（ｃ−Ｊｕｎアミノ末端キナーゼ）阻害ペプチドを有効成分として含有する網膜疾患の予防または治療剤 |
| EP2462128B1 (en) * | 2009-08-04 | 2016-09-21 | Amira Pharmaceuticals, Inc. | Compounds as lysophosphatidic acid receptor antagonists |
| BR112013021494B1 (pt) | 2011-02-22 | 2021-09-08 | California Institute Of Technology | Vetor viral, polinucleotídeo isolado, uso de um vírus adeno-associado (aav) recombinante e método para produzir o mesmo |
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