HRP20210693T1 - Inhibitori beta-laktamaze - Google Patents
Inhibitori beta-laktamaze Download PDFInfo
- Publication number
- HRP20210693T1 HRP20210693T1 HRP20210693TT HRP20210693T HRP20210693T1 HR P20210693 T1 HRP20210693 T1 HR P20210693T1 HR P20210693T T HRP20210693T T HR P20210693TT HR P20210693 T HRP20210693 T HR P20210693T HR P20210693 T1 HRP20210693 T1 HR P20210693T1
- Authority
- HR
- Croatia
- Prior art keywords
- image
- compound according
- alkyl
- hydrogen
- pharmaceutically acceptable
- Prior art date
Links
- 239000003781 beta lactamase inhibitor Substances 0.000 title 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 4
- 150000001204 N-oxides Chemical class 0.000 claims 4
- 229910052731 fluorine Inorganic materials 0.000 claims 4
- 239000011737 fluorine Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 239000000460 chlorine Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 2
- WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 claims 2
- 229960003644 aztreonam Drugs 0.000 claims 2
- 239000003782 beta lactam antibiotic agent Substances 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000002132 β-lactam antibiotic Substances 0.000 claims 2
- 229940124586 β-lactam antibiotics Drugs 0.000 claims 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- -1 -C(O)-R4 Chemical group 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462010968P | 2014-06-11 | 2014-06-11 | |
US201462010969P | 2014-06-11 | 2014-06-11 | |
US201462010940P | 2014-06-11 | 2014-06-11 | |
US201562118227P | 2015-02-19 | 2015-02-19 | |
PCT/US2015/035407 WO2015191907A1 (en) | 2014-06-11 | 2015-06-11 | Beta-lactamase inhibitors |
EP15806746.2A EP3154989B1 (en) | 2014-06-11 | 2015-06-11 | Beta-lactamase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210693T1 true HRP20210693T1 (hr) | 2021-06-11 |
Family
ID=54834346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20210693TT HRP20210693T1 (hr) | 2014-06-11 | 2021-05-04 | Inhibitori beta-laktamaze |
Country Status (16)
Country | Link |
---|---|
US (4) | US9637504B2 (es) |
EP (2) | EP3154989B1 (es) |
JP (2) | JP6622721B2 (es) |
KR (2) | KR20220065084A (es) |
CN (2) | CN109988186A (es) |
AU (2) | AU2015274530B2 (es) |
BR (1) | BR112016027988B1 (es) |
CA (1) | CA2950917C (es) |
ES (1) | ES2874579T3 (es) |
HR (1) | HRP20210693T1 (es) |
IL (2) | IL249043B (es) |
PL (1) | PL3154989T3 (es) |
PT (1) | PT3154989T (es) |
RU (1) | RU2686740C2 (es) |
WO (1) | WO2015191907A1 (es) |
ZA (1) | ZA201608847B (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3666778B1 (en) | 2010-08-10 | 2021-11-10 | Melinta Therapeutics, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
EP2928898B1 (en) | 2012-12-07 | 2021-04-14 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2014110442A1 (en) | 2013-01-10 | 2014-07-17 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
EP2970340B1 (en) | 2013-03-14 | 2020-02-12 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
BR112016026291A2 (pt) | 2014-05-19 | 2017-08-15 | Rempex Pharmaceuticals Inc | Derivados do ácido borônico e usos terapêuticos dos mesmos |
RU2686740C2 (ru) | 2014-06-11 | 2019-04-30 | Венаторкс Фармасьютикалс, Инк. | Ингибиторы бета-лактамазы |
US20150361108A1 (en) * | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Orally bioavailable beta-lactamase inhibitors |
US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
ES2761778T3 (es) | 2014-12-19 | 2020-05-21 | Rempex Pharmaceuticals Inc | Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US10399996B2 (en) | 2015-09-11 | 2019-09-03 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
ES2894251T3 (es) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Derivados de ácido borónico y usos terapéuticos de los mismos |
WO2018027062A1 (en) | 2016-08-04 | 2018-02-08 | VenatoRx Pharmaceuticals, Inc. | Boron-containing compounds |
CN110678186A (zh) | 2017-03-06 | 2020-01-10 | 维纳拓尔斯制药公司 | 包含β-内酰胺酶抑制剂的固体形式和组合式组合物及其用途 |
JPWO2018181997A1 (ja) * | 2017-03-31 | 2020-02-06 | 国立大学法人大阪大学 | カルバペネマーゼ産生菌の検出方法 |
WO2018218154A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
US11332485B2 (en) | 2017-05-26 | 2022-05-17 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
CN111212843A (zh) | 2017-10-11 | 2020-05-29 | Qpex生物制药有限公司 | 硼酸衍生物及其合成 |
CN112424209A (zh) | 2018-04-20 | 2021-02-26 | Qpex生物制药有限公司 | 硼酸衍生物及其治疗用途 |
CA3098433A1 (en) | 2018-04-27 | 2019-10-31 | Sumitomo Dainippon Pharma Co., Ltd. | Oxo-substituted compound |
CN108586445A (zh) * | 2018-06-03 | 2018-09-28 | 曾庆强 | 酰胺类衍生物及其作为内皮素受体拮抗剂在心脑血管、肺动脉高压等疾病中的应用 |
CN108658958A (zh) * | 2018-06-03 | 2018-10-16 | 曾庆强 | 一种酰胺类衍生物及其作为内皮素受体拮抗剂的应用 |
CN108570056A (zh) * | 2018-06-03 | 2018-09-25 | 曾庆强 | 一种酰胺类衍生物及其在心脑血管、肺动脉高压等疾病中的应用 |
CN108570055A (zh) * | 2018-06-03 | 2018-09-25 | 曾庆强 | 一种酰胺类衍生物及其在心脑血管、肺动脉高压等疾病中的应用 |
CN108586472A (zh) * | 2018-06-03 | 2018-09-28 | 曾庆强 | 酰胺类衍生物及其作为内皮素受体拮抗剂在心脑血管、肺动脉高压等疾病中的应用 |
US20220125812A1 (en) * | 2018-11-29 | 2022-04-28 | VenatoRx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor and uses thereof |
WO2020178316A1 (en) | 2019-03-05 | 2020-09-10 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. S.P.A. | 5- or 7-azaindazoles as beta-lactamase inhibitors |
CN113905741A (zh) * | 2019-04-02 | 2022-01-07 | 维纳拓尔斯制药公司 | 经口递送的β-内酰胺酶抑制剂的固体形式及其用途 |
US20220267303A1 (en) * | 2019-06-20 | 2022-08-25 | Baylor College Of Medicine | Compounds and Methods for Treating or Preventing Bacterial Infections |
CA3155559A1 (en) | 2019-10-25 | 2021-04-29 | Sachiko Koike | Novel substituted condensed ring compound |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ177159A (en) | 1974-04-20 | 1978-03-06 | Beecham Group Ltd | Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions |
US7271186B1 (en) * | 2002-12-09 | 2007-09-18 | Northwestern University | Nanomolar β-lactamase inhibitors |
EP1635812A2 (en) | 2003-06-10 | 2006-03-22 | Fulcrum Pharmaceuticals, Inc. | Beta-lactamase inhibitors and methods of use thereof |
EP2377868A1 (en) | 2004-03-30 | 2011-10-19 | Millennium Pharmaceuticals, Inc. | Synthesis of Bortezomib |
CN1965838A (zh) | 2005-11-17 | 2007-05-23 | 李海超 | 含头孢匹胺和β-内酰胺酶抑制剂的药物组合物 |
RS52068B (en) | 2005-12-07 | 2012-06-30 | Basilea Pharmaceutica Ag. | USEFUL MANOBACTAM ANTIBIOTICS |
US20090012075A1 (en) | 2006-01-12 | 2009-01-08 | Miller Thomas A | Fluorinated Arylamide Derivatives |
CN101129382B (zh) | 2006-08-25 | 2013-12-25 | 天津和美生物技术有限公司 | 含β-内酰胺类抗生素和缓冲组分的抗生素复方 |
KR100785656B1 (ko) | 2007-05-14 | 2007-12-17 | 재단법인서울대학교산학협력재단 | 소염제로 사용되는 소디움글리코콜레이트 또는 그 유도체 |
GB0719366D0 (en) | 2007-10-03 | 2007-11-14 | Smithkline Beecham Corp | Compounds |
KR20100113485A (ko) | 2007-11-13 | 2010-10-21 | 프로테즈 파마슈티칼스, 인크. | 베타-락타마제 억제제 |
US20100120715A1 (en) | 2007-11-13 | 2010-05-13 | Burns Christopher J | Beta-lactamase inhibitors |
DK2231667T3 (da) | 2008-01-18 | 2013-12-16 | Merck Sharp & Dohme | Beta-lactamase-hæmmere |
PE20091825A1 (es) | 2008-04-04 | 2009-12-04 | Merck & Co Inc | Hidroximetil pirrolidinas como agonistas del receptor adrenergico beta 3 |
WO2010030810A1 (en) | 2008-09-10 | 2010-03-18 | Achaogen, Inc. | Carbacephem beta-lactam antibiotics |
RS55365B1 (sr) | 2008-10-31 | 2017-03-31 | Shionogi & Co | Cefalosporin sa kateholskom grupom |
US20120022040A1 (en) | 2008-12-01 | 2012-01-26 | Mutz Mitchell W | Antimicrobials |
US20100292185A1 (en) * | 2009-05-12 | 2010-11-18 | Burns Christopher J | Beta-lactamase inhibitors |
JP2013500974A (ja) * | 2009-07-28 | 2013-01-10 | アナコール ファーマシューティカルズ,インコーポレイテッド | 三置換ホウ素含有分子 |
EP3666778B1 (en) | 2010-08-10 | 2021-11-10 | Melinta Therapeutics, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
US9487563B2 (en) | 2011-01-31 | 2016-11-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Virus-like particles and methods of use |
EP2726459B1 (en) | 2011-07-01 | 2019-09-11 | Baruch S. Blumberg Institute | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
EP2768503A1 (en) | 2011-07-26 | 2014-08-27 | Wockhardt Limited | Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor |
US9464064B2 (en) | 2011-09-07 | 2016-10-11 | University Of Kansas | HCV helicase inhibitors and methods of use thereof |
WO2013053372A1 (en) | 2011-10-13 | 2013-04-18 | Therabor Pharmaceuticals | Boronic acid inhibitors of beta-lactamases |
KR101288157B1 (ko) | 2011-12-07 | 2013-07-19 | 백병하 | 기존 세파계 항생제 및 베타 락타마제 저해제로 배합된 내성균주에 기인한 감염증의 치료 및 예방을 위한 복합항생제 |
KR101939710B1 (ko) | 2011-12-21 | 2019-01-17 | 노비라 테라퓨틱스, 인코포레이티드 | B형 간염의 항바이러스성 제제 |
SG11201403254QA (en) * | 2011-12-22 | 2014-07-30 | Ares Trading Sa | Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors |
WO2013122888A2 (en) * | 2012-02-15 | 2013-08-22 | Rempex Pharmaceuticals, Inc. | Methods of treating bacterial infections |
US9216180B2 (en) | 2012-10-02 | 2015-12-22 | New York University | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay |
ES2615744T3 (es) | 2012-12-03 | 2017-06-08 | F. Hoffmann-La Roche Ag | Compuestos de ácido triazol-borónico sustituidos |
EP2928898B1 (en) * | 2012-12-07 | 2021-04-14 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CN104981239B (zh) * | 2013-01-04 | 2019-01-04 | 莱姆派克斯制药公司 | 硼酸衍生物及其治疗用途 |
CA2894891A1 (en) | 2013-01-04 | 2014-07-10 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
WO2014110442A1 (en) * | 2013-01-10 | 2014-07-17 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
EP2970340B1 (en) | 2013-03-14 | 2020-02-12 | Venatorx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2015011281A1 (en) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US9120796B2 (en) | 2013-10-02 | 2015-09-01 | Cubist Pharmaceuticals, Inc. | B-lactamase inhibitor picoline salt |
US11078193B2 (en) | 2014-02-06 | 2021-08-03 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
WO2015157618A1 (en) | 2014-04-11 | 2015-10-15 | The Texas A&M University System | Novel inhibitors of the new delhi metallo beta lactamase (ndm-1) |
EP3139930A4 (en) | 2014-05-05 | 2018-01-17 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
FI3604316T3 (fi) | 2014-05-05 | 2024-02-29 | Melinta Therapeutics Inc | Boronaattisuolojen synteesi |
BR112016026291A2 (pt) | 2014-05-19 | 2017-08-15 | Rempex Pharmaceuticals Inc | Derivados do ácido borônico e usos terapêuticos dos mesmos |
US20150361108A1 (en) * | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Orally bioavailable beta-lactamase inhibitors |
RU2686740C2 (ru) | 2014-06-11 | 2019-04-30 | Венаторкс Фармасьютикалс, Инк. | Ингибиторы бета-лактамазы |
US20150361107A1 (en) * | 2014-06-11 | 2015-12-17 | VenatoRx Pharmaceuticals, Inc. | Orally bioavailable beta-lactamase inhibitors |
US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
CA2952968A1 (en) | 2014-07-01 | 2016-01-07 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
US9949982B2 (en) | 2014-09-04 | 2018-04-24 | Shionogi & Co., Ltd. | Preparation containing cephalosporin having a catechol moiety |
ES2761778T3 (es) | 2014-12-19 | 2020-05-21 | Rempex Pharmaceuticals Inc | Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
US10399996B2 (en) | 2015-09-11 | 2019-09-03 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
AU2017231817B2 (en) | 2016-03-09 | 2021-02-25 | Emory University | Elimination of hepatitis B virus with antiviral agents |
ES2894251T3 (es) | 2016-06-30 | 2022-02-14 | Qpex Biopharma Inc | Derivados de ácido borónico y usos terapéuticos de los mismos |
WO2018027062A1 (en) | 2016-08-04 | 2018-02-08 | VenatoRx Pharmaceuticals, Inc. | Boron-containing compounds |
JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
CN110678186A (zh) | 2017-03-06 | 2020-01-10 | 维纳拓尔斯制药公司 | 包含β-内酰胺酶抑制剂的固体形式和组合式组合物及其用途 |
US11332485B2 (en) | 2017-05-26 | 2022-05-17 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
WO2018218154A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
US11247965B2 (en) | 2017-12-11 | 2022-02-15 | VenatoRx Pharmaceuticals, Inc. | Hepatitis B capsid assembly modulators |
KR102526964B1 (ko) | 2018-02-26 | 2023-04-28 | 길리애드 사이언시즈, 인코포레이티드 | Hbv 복제 억제제로서의 치환된 피롤리진 화합물 |
KR20200136994A (ko) | 2018-03-30 | 2020-12-08 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | N-헤테로시클릭 5-원 고리-함유 캡시드 단백질 조립 억제제, 그의 약학적 조성물, 및 그의 용도 |
EP3802551A4 (en) | 2018-05-25 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | PENICILLIN-BINDING PROTEIN INHIBITORS |
US11891398B2 (en) | 2018-05-25 | 2024-02-06 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 2,3-dihydro-1H-pyrrolizine-7-formamide derivative and application thereof |
CN112513043A (zh) | 2018-05-30 | 2021-03-16 | 维纳拓尔斯制药公司 | 广谱碳青霉烯 |
EP3807246A4 (en) | 2018-06-11 | 2022-03-02 | Venatorx Pharmaceuticals, Inc. | HEPATITIS B CAPSID ASSEMBLY MODULATORS |
EP3849562B1 (en) | 2018-09-12 | 2024-06-26 | Venatorx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor |
US20220125812A1 (en) | 2018-11-29 | 2022-04-28 | VenatoRx Pharmaceuticals, Inc. | Combination compositions comprising a beta-lactamase inhibitor and uses thereof |
CN113905741A (zh) | 2019-04-02 | 2022-01-07 | 维纳拓尔斯制药公司 | 经口递送的β-内酰胺酶抑制剂的固体形式及其用途 |
US20220233549A1 (en) | 2019-05-10 | 2022-07-28 | Venatorx Pharmaceuticals, Inc | Method for alphavirus inhibition |
-
2015
- 2015-06-11 RU RU2016150486A patent/RU2686740C2/ru active
- 2015-06-11 EP EP15806746.2A patent/EP3154989B1/en active Active
- 2015-06-11 KR KR1020227015364A patent/KR20220065084A/ko not_active Application Discontinuation
- 2015-06-11 ES ES15806746T patent/ES2874579T3/es active Active
- 2015-06-11 BR BR112016027988-3A patent/BR112016027988B1/pt active IP Right Grant
- 2015-06-11 JP JP2016569785A patent/JP6622721B2/ja active Active
- 2015-06-11 CN CN201910245094.1A patent/CN109988186A/zh active Pending
- 2015-06-11 EP EP21157549.3A patent/EP3882252A1/en active Pending
- 2015-06-11 PT PT158067462T patent/PT3154989T/pt unknown
- 2015-06-11 AU AU2015274530A patent/AU2015274530B2/en active Active
- 2015-06-11 CN CN201580043262.9A patent/CN106687465B/zh active Active
- 2015-06-11 PL PL15806746T patent/PL3154989T3/pl unknown
- 2015-06-11 WO PCT/US2015/035407 patent/WO2015191907A1/en active Application Filing
- 2015-06-11 CA CA2950917A patent/CA2950917C/en active Active
- 2015-06-11 KR KR1020167036844A patent/KR102396753B1/ko active IP Right Grant
-
2016
- 2016-05-23 US US15/162,395 patent/US9637504B2/en active Active
- 2016-11-17 IL IL249043A patent/IL249043B/en active IP Right Grant
- 2016-12-21 ZA ZA2016/08847A patent/ZA201608847B/en unknown
-
2017
- 2017-02-16 US US15/435,097 patent/US9783555B2/en active Active
- 2017-08-11 US US15/675,253 patent/US9926336B2/en active Active
-
2018
- 2018-03-05 IL IL257880A patent/IL257880B/en active IP Right Grant
-
2019
- 2019-11-12 AU AU2019264537A patent/AU2019264537B9/en active Active
- 2019-11-19 JP JP2019209069A patent/JP6871341B2/ja active Active
-
2020
- 2020-02-21 US US16/798,032 patent/US11008346B2/en active Active
-
2021
- 2021-05-04 HR HRP20210693TT patent/HRP20210693T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20210693T1 (hr) | Inhibitori beta-laktamaze | |
HRP20210879T1 (hr) | Inhibitori beta-laktamaze | |
HRP20180483T1 (hr) | Spoj kinolona | |
HRP20161125T1 (hr) | Makrociklički purini za liječenje virusnih infekcija | |
MX2022005160A (es) | Oxisteroles y metodos de uso de los mismos. | |
PH12019500558A1 (en) | Beta-lactamase inhibitor compounds | |
PE20161372A1 (es) | Inhibidores de dihidropirrolopiridina de ror-gamma | |
PH12018500061A1 (en) | Oxysterols and methods of use thereof | |
PH12014502224A1 (en) | Heterobicyclic compounds as beta-lactamase inhibitors | |
PE20161443A1 (es) | Compuestos | |
EA201890165A1 (ru) | Гетероциклические соединения, применимые в качестве модуляторов tnf-альфа | |
EA201490634A1 (ru) | Производные полимиксина | |
MY194307A (en) | Pyridone derivative having tetrahydropyranylmethyl group | |
SI3102573T1 (en) | SUBSTITUTED TIAZOL OR OXASOL AS ANTAGONISTS OF THE RECEPTOR P2X7 | |
EA201391325A1 (ru) | Новые производные цефалоспорина и их фармацевтические композиции | |
DK2966079T1 (da) | Pyridopyrimidin eller pyrimidopyrimidinforbindelse, fremstillingsmetode, pharmaceutisk præparat og anvendelse heraf | |
HRP20200119T1 (hr) | Azetidiniloksifenilpirolidinski spojevi | |
MX2017007573A (es) | Composicion acuosa novedosa. | |
HRP20200369T1 (hr) | Halogenirani kvinazolin-thf-amini kao inhibitori pde1 | |
PH12018500202B1 (en) | New effective aminoglycoside antibiotic for multidrug-resistant bacteria | |
HRP20201662T1 (hr) | Derivati diamino piridina | |
MX2018000459A (es) | Metodo para la fabricacion de compuestos heterociclicos que contienen nitrogeno y compuestos intermediarios de los mismos. | |
MX2017013099A (es) | Metodos para el tratamiento de trastornos inflamatorios. | |
PH12019502509A1 (en) | Compounds and methods for treating bacterial infections | |
MX2015015614A (es) | Derivados de aril sultama como moduladores del receptor huerfano relacionado con el receptor del retinoide (rorc). |