HRP20201894T1 - Poboljšana metoda dekontaminiranja biološkog materijala razdjeljivanjem i inaktivacijom - Google Patents
Poboljšana metoda dekontaminiranja biološkog materijala razdjeljivanjem i inaktivacijom Download PDFInfo
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- HRP20201894T1 HRP20201894T1 HRP20201894TT HRP20201894T HRP20201894T1 HR P20201894 T1 HRP20201894 T1 HR P20201894T1 HR P20201894T T HRP20201894T T HR P20201894TT HR P20201894 T HRP20201894 T HR P20201894T HR P20201894 T1 HRP20201894 T1 HR P20201894T1
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- biological material
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- chloroform
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- 238000000034 method Methods 0.000 title claims 13
- 239000012620 biological material Substances 0.000 title claims 7
- 230000002779 inactivation Effects 0.000 title 1
- 238000000638 solvent extraction Methods 0.000 title 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Natural products CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 11
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 claims 3
- 239000003960 organic solvent Substances 0.000 claims 3
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims 3
- 239000000275 Adrenocorticotropic Hormone Substances 0.000 claims 2
- 102400000739 Corticotropin Human genes 0.000 claims 2
- 101800000414 Corticotropin Proteins 0.000 claims 2
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical class NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 102100038803 Somatotropin Human genes 0.000 claims 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 2
- 125000001931 aliphatic group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002635 aromatic organic solvent Substances 0.000 claims 2
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 claims 2
- 229960000258 corticotropin Drugs 0.000 claims 2
- 238000005202 decontamination Methods 0.000 claims 2
- 230000003588 decontaminative effect Effects 0.000 claims 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical class C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 claims 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical class NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical class CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 1
- 229930182837 (R)-adrenaline Chemical class 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 102000004881 Angiotensinogen Human genes 0.000 claims 1
- 108090001067 Angiotensinogen Proteins 0.000 claims 1
- 102000015427 Angiotensins Human genes 0.000 claims 1
- 108010064733 Angiotensins Proteins 0.000 claims 1
- 108090000790 Enzymes Chemical class 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102400000921 Gastrin Human genes 0.000 claims 1
- 108010052343 Gastrins Proteins 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- 102400000321 Glucagon Human genes 0.000 claims 1
- 108010086677 Gonadotropins Proteins 0.000 claims 1
- 102000006771 Gonadotropins Human genes 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical class OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Chemical class OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims 1
- 102000029797 Prion Human genes 0.000 claims 1
- 108091000054 Prion Proteins 0.000 claims 1
- 102000003946 Prolactin Human genes 0.000 claims 1
- 108010057464 Prolactin Proteins 0.000 claims 1
- 102100028255 Renin Human genes 0.000 claims 1
- 108090000783 Renin Proteins 0.000 claims 1
- 102000005157 Somatostatin Human genes 0.000 claims 1
- 108010056088 Somatostatin Proteins 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 claims 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 claims 1
- 150000004996 alkyl benzenes Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 claims 1
- NEHMKBQYUWJMIP-NJFSPNSNSA-N chloro(114C)methane Chemical group [14CH3]Cl NEHMKBQYUWJMIP-NJFSPNSNSA-N 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 239000003344 environmental pollutant Substances 0.000 claims 1
- 229960005139 epinephrine Drugs 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- 239000002622 gonadotropin Substances 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 229960001340 histamine Drugs 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Chemical class 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229960002748 norepinephrine Drugs 0.000 claims 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Chemical class NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims 1
- 231100000719 pollutant Toxicity 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 229940097325 prolactin Drugs 0.000 claims 1
- 108090000623 proteins and genes Chemical class 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229940076279 serotonin Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 235000009518 sodium iodide Nutrition 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
- 229960000553 somatostatin Drugs 0.000 claims 1
- 229960003604 testosterone Drugs 0.000 claims 1
- 239000005495 thyroid hormone Substances 0.000 claims 1
- 229940036555 thyroid hormone Drugs 0.000 claims 1
- 125000003944 tolyl group Chemical group 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 239000008096 xylene Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
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- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3695—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with sedimentation by gravity
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- B01D11/04—Solvent extraction of solutions which are liquid
- B01D11/0492—Applications, solvents used
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/15—Biocide distribution means, e.g. nozzles, pumps, manifolds, fans, baffles, sprayers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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Claims (12)
1. Postupak za dekontaminaciju biološkog materijala od virusnih, prionskih i / ili bakterijskih onečišćenja, koji obuhvaća centrifugiranje troslojnog tekućeg sustava koji sadrži:
(a) gornji sloj koji sadrži vodenu otopinu biološkog materijala za dekontaminaciju;
(b) međusloj koji sadrži jedno ili više organskih otapala;
(c) donji sloj koji sadrži inaktivirajuću otopinu za navedena onečišćenja,
gdje navedeni slojevi imaju različitu gustoću, redoslijedom: (a) <(b) <(c), i naznačeni time što se sloj (b) ne miješa sa slojem (a).
2. Postupak prema zahtjevu 1, naznačen time što slojevi (a) i (b) imaju razliku u gustoći od najmanje 0.025 g / ml.
3. Postupak prema zahtjevima 1-2, naznačen time što slojevi (a) i (b) imaju razliku u gustoći između 0.030 i 0.3 g / ml.
4. Postupak prema zahtjevima 1-3, naznačen time što je sloj (b) mješavina halogeniranog alifatskog organskog otapala s aromatičnim organskim otapalom, u volumetrijskim omjerima između 1: 0.5 i 1: 4, poželjno između 1: 0.8 i 1:3.
5. Postupak prema zahtjevima 1-4, naznačen time što je halogenirano alifatsko organsko otapalo odabrano između metil klorida, metilen klorida, kloroforma i ugljičnog tetraklorida, i aromatsko organsko otapalo je odabrano između toluena, benzena, C2-4 alkil benzena, ksilena i njihovih derivata.
6. Postupak prema zahtjevima 1-5, naznačen time što se srednji sloj (b) djelomično miješa sa slojem (c).
7. Postupak prema zahtjevima 1-6, naznačen time što je sloj (c) otopina uree koja ima koncentraciju od najmanje 6M, ili otopina hidroksida alkalnog ili zemno-alkalnog metala s koncentracijom od najmanje 0.5 M.
8. Postupak prema zahtjevima 1-7, naznačen time što je sloj (b) mješavina kloroforma i toluena i / ili sloj (c) sadrži jedan ili više: ditiotreitola, uree, natrijevog bromida, natrijevog klorida, natrijevog jodida i sredstva koje navedenoj mješavini daje pH između 8 i 11.
9. Postupak prema zahtjevima 1-8, naznačen time što biološki materijal pripada jednoj ili više klasa aminokiselina, proteina, enzima, hormona.
10. Postupak prema zahtjevima 1-9, naznačen time što je biološki materijal odabran između FSH, LH, hCG, testosterona, progesterona, estradiola, T3 i / ili T4 hormona štitnjače, inzulina, glukagona, gastrina, somatostatina, somatotropina, hormona rasta, prolaktina, renina, angiotenzinogena, angiotenzina, gonadotropina, kortizola, adrenokortikotropnog hormona (ACTH), modificirane aminokiseline, L-DOPA, dopamina, epinefrina, norepinefrina, serotonina, histamina, GABA i njihovih derivata.
11. Postupak prema zahtjevima 1-10, gdje je zadovoljen jedan ili više sljedećih uvjeta:
- sloj (a) sadrži: navedeni biološki materijal u koncentraciji između 1 i 100 mg / ml, pufersko sredstvo koje sloju (a) daje pH između 6.5 i 8.0;
- sloj (b) je mješavina kloroforma i toluena u volumetrijskim omjerima između 1: 0.5 i 1:4;
- sloj (c) je otopina uree s molarnošću između 7M i 9M, koja sadrži ditiotreitol, NaBr, i pufersko sredstvo koje sloju (c) daje pH između 8.0 i 11.0.
12. Postupak prema zahtjevu 11, gdje je zadovoljen jedan ili više sljedećih uvjeta:
- sloj (a) sadrži: navedeni biološki materijal u koncentraciji između 10 i 50 mg / ml, pufersko sredstvo koje sloju (a) daje pH između 7 i 7.5;
- sloj (b) je mješavina kloroforma i toluena u volumetrijskim omjerima između 1: 0.8 i 1: 3;
- sloj (c) je 8M otopina uree, koja sadrži ditiotreitol, NaBr i pufersko sredstvo koje sloju (c) daje pH između 8.0 i 11.0.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102016000079328A IT201600079328A1 (it) | 2016-07-28 | 2016-07-28 | Metodo migliorato per la decontaminazione di materiale biologico mediante partizione e inattivazione |
| EP17752305.7A EP3490617B1 (en) | 2016-07-28 | 2017-07-25 | Improved method for decontaminating a biological material by partitioning and inactivation |
| PCT/EP2017/068722 WO2018019811A1 (en) | 2016-07-28 | 2017-07-25 | Improved method for decontaminating a biological material by partitioning and inactivation |
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| HRP20201894T1 true HRP20201894T1 (hr) | 2021-01-08 |
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| US (1) | US10927143B2 (hr) |
| EP (1) | EP3490617B1 (hr) |
| CN (1) | CN109414515B (hr) |
| CA (1) | CA3028350A1 (hr) |
| DK (1) | DK3490617T3 (hr) |
| ES (1) | ES2835786T3 (hr) |
| HR (1) | HRP20201894T1 (hr) |
| HU (1) | HUE051800T2 (hr) |
| IL (1) | IL263735B (hr) |
| IT (1) | IT201600079328A1 (hr) |
| PT (1) | PT3490617T (hr) |
| RU (1) | RU2769062C2 (hr) |
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| US4201770A (en) * | 1973-05-07 | 1980-05-06 | The Ohio State University | Antigenic modification of polypeptides |
| DE3682502D1 (de) * | 1985-08-21 | 1991-12-19 | Biotope Inc | Verfahren und geraete zur trennung, vermischung und bestimmung von komponenten in spezifischen bindungstests. |
| US4888427A (en) * | 1987-04-07 | 1989-12-19 | University Of Florida | Amino acids containing dihydropyridine ring systems for site-specific delivery of peptides to the brain |
| CN100507567C (zh) * | 2002-05-23 | 2009-07-01 | 奥索临床诊断有限公司 | 朊病毒蛋白的去除 |
| SE526038C2 (sv) * | 2002-07-08 | 2005-06-21 | Gambro Lundia Ab | Polymeraffinitetsmatris, förfarande för framställning därav och anvädning därav |
| CN1922207B (zh) * | 2004-02-27 | 2012-06-06 | 奥克特珐玛股份有限公司 | 提供纯化的、病毒安全的抗体制剂的方法 |
| ITMI20040891A1 (it) * | 2004-05-04 | 2004-08-04 | Ibsa Inst Biochimique Sa | Nuovo metodo per la partizione ed inattivazione di contaminanti virali e prionici |
| CN100345609C (zh) * | 2005-01-21 | 2007-10-31 | 中国科学院过程工程研究所 | 一种用于液—液—液三相体系的成相剂 |
| WO2008151136A1 (en) * | 2007-06-04 | 2008-12-11 | Pressure Biosciences Inc. | Pressure-enhanced extraction and partitioning of molecules |
| EP2222843B1 (en) * | 2007-11-15 | 2016-03-23 | Abbott Laboratories GmbH | Novel process for separating and determining the viral load in a pancreatin sample |
| EP2271374B1 (en) * | 2008-03-28 | 2014-03-05 | Research Foundation For Medical Devices | Method of viral inactivation of biological fluids by solvent/detergent-treatment |
| CN102046006B (zh) * | 2008-04-09 | 2014-09-24 | 塞鲁斯公司 | 用于红细胞病原体灭活的改进猝灭方法 |
| FR2932093B1 (fr) * | 2008-06-05 | 2012-07-20 | Anios Lab Sarl | Composition pour la desinfection et la decontamination simultanees de corps contamines par des agents transmissibles conventionnels (atc) et non conventionnels (atnc). |
| DE102008031208B4 (de) * | 2008-07-03 | 2010-03-25 | Technische Universität Dortmund | Prozess zur großtechnischen Produktion von Taxanen |
| CN101637667B (zh) * | 2009-08-19 | 2011-09-14 | 大连理工大学 | 一种三液相萃取天然产物有效成分的方法 |
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| Publication number | Publication date |
|---|---|
| WO2018019811A1 (en) | 2018-02-01 |
| EP3490617A1 (en) | 2019-06-05 |
| US10927143B2 (en) | 2021-02-23 |
| ES2835786T3 (es) | 2021-06-23 |
| RU2018140729A (ru) | 2020-08-28 |
| IL263735B (en) | 2022-01-01 |
| CN109414515A (zh) | 2019-03-01 |
| RU2018140729A3 (hr) | 2020-11-20 |
| CN109414515B (zh) | 2021-08-03 |
| CA3028350A1 (en) | 2018-02-01 |
| HUE051800T2 (hu) | 2021-03-29 |
| DK3490617T3 (da) | 2020-12-07 |
| US20190153026A1 (en) | 2019-05-23 |
| RU2769062C2 (ru) | 2022-03-28 |
| IT201600079328A1 (it) | 2018-01-28 |
| PT3490617T (pt) | 2020-11-17 |
| IL263735A (en) | 2019-01-31 |
| SI3490617T1 (sl) | 2021-02-26 |
| EP3490617B1 (en) | 2020-09-02 |
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