HRP20191248T1 - Kombinirana terapija za liječenje karcinoma jajnika - Google Patents
Kombinirana terapija za liječenje karcinoma jajnika Download PDFInfo
- Publication number
- HRP20191248T1 HRP20191248T1 HRP20191248TT HRP20191248T HRP20191248T1 HR P20191248 T1 HRP20191248 T1 HR P20191248T1 HR P20191248T T HRP20191248T T HR P20191248TT HR P20191248 T HRP20191248 T HR P20191248T HR P20191248 T1 HRP20191248 T1 HR P20191248T1
- Authority
- HR
- Croatia
- Prior art keywords
- bevacizumab
- patient
- platinum
- use according
- resistant
- Prior art date
Links
- 206010033128 Ovarian cancer Diseases 0.000 title claims 6
- 238000011282 treatment Methods 0.000 title claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 title claims 2
- 238000002648 combination therapy Methods 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 20
- 229960000397 bevacizumab Drugs 0.000 claims 13
- 229910052697 platinum Inorganic materials 0.000 claims 10
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 claims 4
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- 201000001342 Fallopian tube cancer Diseases 0.000 claims 3
- 208000013452 Fallopian tube neoplasm Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 206010003445 Ascites Diseases 0.000 claims 1
- 230000003187 abdominal effect Effects 0.000 claims 1
- 238000011394 anticancer treatment Methods 0.000 claims 1
- 201000001343 fallopian tube carcinoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000002524 peritoneal carcinoma Diseases 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q30/00—Commerce
- G06Q30/02—Marketing; Price estimation or determination; Fundraising
- G06Q30/0241—Advertisements
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q90/00—Systems or methods specially adapted for administrative, commercial, financial, managerial or supervisory purposes, not involving significant data processing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Claims (10)
1. Bevacizumab, naznačen time, da je za uporabu u postupku liječenja pacijentice kojoj je dijagnosticiran epitelni karcinom jajnika rezistentan na platinu (EOC), karcinom Fallopijevih cijevi rezistentan na platinu (FTC) ili primarni peritonealni karcinom rezistentan na platinu (PPC), pri čemu postupak obuhvaća primjenu učinkovite doze bevacizumaba i paklitaksela spomenutoj pacijentici, gdje je spomenuta pacijentica primila dva režima liječenja protiv karcinoma ili manje od toga, dok spomenuti tretman produljuje preživljenje bez napredovanja bolesti za spomenutu pacijenticu u usporedbi s pacijenticom koja ima epitelni karcinom jajnika rezistentan na platinu (EOC), karcinom Fallopijevih cijevi rezistentan na platinu (FTC) ili primarni peritonealni karcinom rezistentan na platinu (PPC), a koja prima samo paklitaksel.
2. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da spomenuta pacijentica nije refraktarna na prethodnu terapiju platinom.
3. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da spomenuta pacijentica ima bolest mjerljivu prema RECIST 1.0 ili bolest procjenjivu prema CA-125 prema GCIG kriterijima.
4. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da spomenuta pacijentica ima status ECOG performansa od 0 do 2 te životni vijek od barem 12 tjedana.
5. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da se spomenuta učinkovita količina paklitaksela primjenjuje pri dozi od 80 mg/m2 kao jednosatna infuzija na dane 1, 8, 15 i 22, svaka 4 tjedna.
6. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da je učinkovita količina bevacizumaba 10 mg/kg intravenski svaka dva tjedna ili 15 mg/kg intravenski svaka tri tjedna.
7. Bevacizumab za uporabu prema patentnom zahtjevu 6, naznačen time, da se učinkovita količina bevacizumaba početno daje intravenski tijekom 90 minuta s posljedičnim infuzijama tijekom 60 minuta, a potom 30 minuta.
8. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da spomenuta pacijentica ima razdoblje bez primanja platine (PFI - eng. Platinum free interval) kraće od 3 mjeseca.
9. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da spomenuta pacijentica ima abdominalni ascites.
10. Bevacizumab za uporabu prema patentnom zahtjevu 1, naznačen time, da spomenuti tretman poboljšava objektivnu stopu odgovora spomenute pacijentice (ORR – eng. objective response rate) u usporedbi s pacijenticom koja ima karcinom jajnika otporan na platinu, a koja prima samo paklitaksel.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610128P | 2012-03-13 | 2012-03-13 | |
| US201261653598P | 2012-05-31 | 2012-05-31 | |
| US201261672987P | 2012-07-18 | 2012-07-18 | |
| EP13708435.6A EP2825558B1 (en) | 2012-03-13 | 2013-03-11 | Combination therapy for the treatment of ovarian cancer |
| PCT/EP2013/054818 WO2013135602A2 (en) | 2012-03-13 | 2013-03-11 | Combination therapy for the treatment of ovarian cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191248T1 true HRP20191248T1 (hr) | 2019-10-18 |
Family
ID=47844333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191248TT HRP20191248T1 (hr) | 2012-03-13 | 2019-07-11 | Kombinirana terapija za liječenje karcinoma jajnika |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20150098988A1 (hr) |
| EP (2) | EP2825558B1 (hr) |
| JP (2) | JP6563197B2 (hr) |
| KR (1) | KR102082363B1 (hr) |
| CN (1) | CN104334577A (hr) |
| AR (1) | AR090313A1 (hr) |
| AU (2) | AU2013231410B2 (hr) |
| BR (1) | BR112014018964A2 (hr) |
| CA (2) | CA2860941C (hr) |
| CO (1) | CO7000770A2 (hr) |
| CR (1) | CR20140400A (hr) |
| CY (1) | CY1121821T1 (hr) |
| DK (1) | DK2825558T3 (hr) |
| EA (1) | EA201400996A1 (hr) |
| ES (1) | ES2736030T3 (hr) |
| HK (1) | HK1202122A1 (hr) |
| HR (1) | HRP20191248T1 (hr) |
| HU (1) | HUE045445T2 (hr) |
| IL (2) | IL234174B (hr) |
| LT (1) | LT2825558T (hr) |
| MX (1) | MX365139B (hr) |
| PE (1) | PE20141909A1 (hr) |
| PH (1) | PH12014501543A1 (hr) |
| PL (1) | PL2825558T3 (hr) |
| PT (1) | PT2825558T (hr) |
| RS (1) | RS58964B1 (hr) |
| SG (1) | SG11201404417PA (hr) |
| SI (1) | SI2825558T1 (hr) |
| TW (1) | TW201343178A (hr) |
| WO (1) | WO2013135602A2 (hr) |
| ZA (1) | ZA201404843B (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20141537A1 (es) | 2011-09-23 | 2014-11-17 | Oncomed Pharm Inc | Agentes de ligacion al factor de crecimiento endotelial vascular/ligando 4 similar a delta (vegf/dll4) y usos de los mismos |
| PL2825558T3 (pl) | 2012-03-13 | 2019-11-29 | Hoffmann La Roche | Terapia skojarzona w leczeniu raka jajnika |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| EP3353204B1 (en) * | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
| BR112018013407A2 (pt) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc | anticorpos e conjugados dos mesmos |
| WO2019005754A1 (en) * | 2017-06-26 | 2019-01-03 | The Cleveland Clinic Foundation | TREATMENT AGAINST CANCER |
| EP4041312A4 (en) | 2019-10-10 | 2023-12-20 | Kodiak Sciences Inc. | METHOD FOR TREATING AN EYE DISORDER |
| CN113244388A (zh) * | 2021-07-01 | 2021-08-13 | 江苏先声药业有限公司 | 抗人vegf抗体与化药联用在制备治疗卵巢癌的药物中的应用 |
| WO2023207931A1 (zh) * | 2022-04-26 | 2023-11-02 | 石药集团中奇制药技术（石家庄）有限公司 | 米托蒽醌脂质体联合抗血管生成靶向药治疗卵巢癌的用途 |
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| WO2009149150A2 (en) * | 2008-06-03 | 2009-12-10 | Alza Corporation | Composition comprising liposome-entrapped doxorubicin and methods of administration |
| KR101807319B1 (ko) | 2008-11-22 | 2017-12-11 | 제넨테크, 인크. | 유방암의 치료를 위한, 화학요법과 조합된 항-ｖｅｇｆ 항체의 용도 |
| US20190185555A1 (en) | 2017-12-19 | 2019-06-20 | Genentech, Inc. | Anti-angiogenesis therapy for the treatment of previously treated breast cancer |
| EP2539367A2 (en) * | 2010-02-23 | 2013-01-02 | F. Hoffmann-La Roche AG | Anti-angiogenesis therapy for the treatment of ovarian cancer |
| PL2825558T3 (pl) | 2012-03-13 | 2019-11-29 | Hoffmann La Roche | Terapia skojarzona w leczeniu raka jajnika |
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