AR090313A1 - Terapia combinada para el tratamiento del cancer de ovario - Google Patents
Terapia combinada para el tratamiento del cancer de ovarioInfo
- Publication number
- AR090313A1 AR090313A1 ARP130100793A AR090313A1 AR 090313 A1 AR090313 A1 AR 090313A1 AR P130100793 A ARP130100793 A AR P130100793A AR 090313 A1 AR090313 A1 AR 090313A1
- Authority
- AR
- Argentina
- Prior art keywords
- patient
- vegf antibody
- chemotherapeutic
- sec
- amino acid
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q30/00—Commerce
- G06Q30/02—Marketing; Price estimation or determination; Fundraising
- G06Q30/0241—Advertisements
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
- G06Q90/00—Systems or methods specially adapted for administrative, commercial, financial, managerial or supervisory purposes, not involving significant data processing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Abstract
Reivindicación 1: Un método de tratamiento de una paciente diagnosticada de cáncer ovárico resistente al platino que incluye la administración a dicha paciente de una cantidad efectiva de un anticuerpo anti-VEGF y un quimioterapéutico, en el que dicha paciente recibió dos o menos regímenes anticáncer previos, en el que dicho tratamiento prolonga el tiempo de supervivencia libre de progresión media de la paciente en comparación con una paciente con cáncer ovárico resistente al platino que sólo recibe dicho quimioterapéutico. Reivindicación 7: El método de la reivindicación 1, en el que dicho quimioterapéutico se selecciona a partir de un grupo que incluye de paclitaxel, topotecán o una doxorrubicina liposomal pegilada (PLD). Reivindicación 13: El método de la reivindicación 1, en el que dicho anticuerpo anti-VEGF es bevacizumab. Reivindicación 14: El método de la reivindicación 1, en el que dicho anticuerpo anti-VEGF incluye una cadena pesada variable (VH) y una cadena ligera variable (VL), en el que dicha VH tiene una secuencia de aminoácidos con el Id. de Sec. Nº 2 y dicha VL tiene una secuencia de aminoácidos con el Id. de Sec. Nº 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610128P | 2012-03-13 | 2012-03-13 | |
| US201261653598P | 2012-05-31 | 2012-05-31 | |
| US201261672987P | 2012-07-18 | 2012-07-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR090313A1 true AR090313A1 (es) | 2014-11-05 |
Family
ID=47844333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130100793 AR090313A1 (es) | 2012-03-13 | 2013-03-12 | Terapia combinada para el tratamiento del cancer de ovario |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20150098988A1 (es) |
| EP (2) | EP2825558B1 (es) |
| JP (2) | JP6563197B2 (es) |
| KR (1) | KR102082363B1 (es) |
| CN (1) | CN104334577A (es) |
| AR (1) | AR090313A1 (es) |
| AU (2) | AU2013231410B2 (es) |
| BR (1) | BR112014018964A2 (es) |
| CA (2) | CA3056813A1 (es) |
| CO (1) | CO7000770A2 (es) |
| CR (1) | CR20140400A (es) |
| CY (1) | CY1121821T1 (es) |
| DK (1) | DK2825558T3 (es) |
| EA (1) | EA201400996A1 (es) |
| ES (1) | ES2736030T3 (es) |
| HK (1) | HK1202122A1 (es) |
| HR (1) | HRP20191248T1 (es) |
| HU (1) | HUE045445T2 (es) |
| IL (2) | IL234174B (es) |
| LT (1) | LT2825558T (es) |
| MX (1) | MX365139B (es) |
| PE (1) | PE20141909A1 (es) |
| PH (1) | PH12014501543A1 (es) |
| PL (1) | PL2825558T3 (es) |
| PT (1) | PT2825558T (es) |
| RS (1) | RS58964B1 (es) |
| SG (1) | SG11201404417PA (es) |
| SI (1) | SI2825558T1 (es) |
| TW (1) | TW201343178A (es) |
| WO (1) | WO2013135602A2 (es) |
| ZA (1) | ZA201404843B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3485903T (lt) | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
| PT2825558T (pt) | 2012-03-13 | 2019-07-11 | Hoffmann La Roche | Terapêutica combinada para o tratamento do cancro do ovário |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| EP3353204B1 (en) * | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
| RU2744860C2 (ru) | 2015-12-30 | 2021-03-16 | Кодиак Сайенсиз Инк. | Антитела и их конъюгаты |
| WO2019005754A1 (en) * | 2017-06-26 | 2019-01-03 | The Cleveland Clinic Foundation | TREATMENT AGAINST CANCER |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN113244388A (zh) * | 2021-07-01 | 2021-08-13 | 江苏先声药业有限公司 | 抗人vegf抗体与化药联用在制备治疗卵巢癌的药物中的应用 |
| WO2023207931A1 (zh) * | 2022-04-26 | 2023-11-02 | 石药集团中奇制药技术（石家庄）有限公司 | 米托蒽醌脂质体联合抗血管生成靶向药治疗卵巢癌的用途 |
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| PT2825558T (pt) | 2012-03-13 | 2019-07-11 | Hoffmann La Roche | Terapêutica combinada para o tratamento do cancro do ovário |
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2013
- 2013-03-11 PT PT13708435T patent/PT2825558T/pt unknown
- 2013-03-11 PL PL13708435T patent/PL2825558T3/pl unknown
- 2013-03-11 US US14/384,863 patent/US20150098988A1/en not_active Abandoned
- 2013-03-11 RS RS20190846A patent/RS58964B1/sr unknown
- 2013-03-11 KR KR1020147024773A patent/KR102082363B1/ko active IP Right Review Request
- 2013-03-11 EA EA201400996A patent/EA201400996A1/ru unknown
- 2013-03-11 CN CN201380024869.3A patent/CN104334577A/zh active Pending
- 2013-03-11 AU AU2013231410A patent/AU2013231410B2/en active Active
- 2013-03-11 EP EP13708435.6A patent/EP2825558B1/en active Active
- 2013-03-11 CA CA3056813A patent/CA3056813A1/en not_active Abandoned
- 2013-03-11 MX MX2014010591A patent/MX365139B/es active IP Right Grant
- 2013-03-11 WO PCT/EP2013/054818 patent/WO2013135602A2/en active Application Filing
- 2013-03-11 EP EP19174209.7A patent/EP3553083A1/en active Pending
- 2013-03-11 BR BR112014018964-1A patent/BR112014018964A2/pt not_active Application Discontinuation
- 2013-03-11 HU HUE13708435A patent/HUE045445T2/hu unknown
- 2013-03-11 ES ES13708435T patent/ES2736030T3/es active Active
- 2013-03-11 SG SG11201404417PA patent/SG11201404417PA/en unknown
- 2013-03-11 SI SI201331522T patent/SI2825558T1/sl unknown
- 2013-03-11 PE PE2014001409A patent/PE20141909A1/es not_active Application Discontinuation
- 2013-03-11 LT LTEP13708435.6T patent/LT2825558T/lt unknown
- 2013-03-11 DK DK13708435.6T patent/DK2825558T3/da active
- 2013-03-11 CA CA2860941A patent/CA2860941C/en active Active
- 2013-03-11 JP JP2014561385A patent/JP6563197B2/ja active Active
- 2013-03-12 TW TW102108775A patent/TW201343178A/zh unknown
- 2013-03-12 AR ARP130100793 patent/AR090313A1/es unknown
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2014
- 2014-06-27 CO CO14139058A patent/CO7000770A2/es not_active Application Discontinuation
- 2014-06-30 ZA ZA2014/04843A patent/ZA201404843B/en unknown
- 2014-07-03 PH PH12014501543A patent/PH12014501543A1/en unknown
- 2014-08-18 IL IL234174A patent/IL234174B/en active IP Right Grant
- 2014-08-26 CR CR20140400A patent/CR20140400A/es unknown
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2015
- 2015-03-11 HK HK15102494.0A patent/HK1202122A1/xx unknown
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2016
- 2016-05-12 US US15/153,637 patent/US11384142B2/en active Active
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2017
- 2017-11-10 AU AU2017258927A patent/AU2017258927A1/en not_active Abandoned
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2018
- 2018-07-13 JP JP2018132869A patent/JP6640288B2/ja active Active
- 2018-12-18 IL IL263781A patent/IL263781A/en unknown
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2019
- 2019-07-11 HR HRP20191248TT patent/HRP20191248T1/hr unknown
- 2019-07-16 CY CY20191100758T patent/CY1121821T1/el unknown
Also Published As
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