HRP20190747T1 - Uređaj za inhalaciju - Google Patents
Uređaj za inhalaciju Download PDFInfo
- Publication number
- HRP20190747T1 HRP20190747T1 HRP20190747TT HRP20190747T HRP20190747T1 HR P20190747 T1 HRP20190747 T1 HR P20190747T1 HR P20190747T T HRP20190747T T HR P20190747TT HR P20190747 T HRP20190747 T HR P20190747T HR P20190747 T1 HRP20190747 T1 HR P20190747T1
- Authority
- HR
- Croatia
- Prior art keywords
- aqueous solution
- use according
- colistimethate
- sodium
- solution
- Prior art date
Links
- 239000007864 aqueous solution Substances 0.000 claims 18
- 108010040201 Polymyxins Proteins 0.000 claims 6
- 239000000243 solution Substances 0.000 claims 6
- 229960004531 colistimethate sodium Drugs 0.000 claims 4
- IQWHCHZFYPIVRV-VLLYEMIKSA-I colistin A sodium methanesulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].CC[C@@H](C)CCCCC(=O)N[C@@H](CCNCS([O-])(=O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCNCS([O-])(=O)=O)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCNCS([O-])(=O)=O)NC(=O)[C@H](CCNCS([O-])(=O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCNCS([O-])(=O)=O)NC1=O IQWHCHZFYPIVRV-VLLYEMIKSA-I 0.000 claims 4
- 108700028201 colistinmethanesulfonic acid Proteins 0.000 claims 4
- IQWHCHZFYPIVRV-UHFFFAOYSA-I pentasodium;[2-[17-(1-hydroxyethyl)-22-[[2-[[3-hydroxy-2-[[2-(6-methyloctanoylamino)-4-(sulfonatomethylamino)butanoyl]amino]butanoyl]amino]-4-(sulfonatomethylamino)butanoyl]amino]-5,8-bis(2-methylpropyl)-3,6,9,12,15,18,23-heptaoxo-11,14-bis[2-(sulfonatome Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].CCC(C)CCCCC(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC(C(C)O)C(=O)NC(CCNCS([O-])(=O)=O)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CCNCS([O-])(=O)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCNCS([O-])(=O)=O)NC1=O IQWHCHZFYPIVRV-UHFFFAOYSA-I 0.000 claims 4
- 239000007921 spray Substances 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 2
- 208000035143 Bacterial infection Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000588915 Klebsiella aerogenes Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000009267 bronchiectasis Diseases 0.000 claims 1
- 229940092559 enterobacter aerogenes Drugs 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 208000035474 group of disease Diseases 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/003—Particle size control by passing the aerosol trough sieves or filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manipulator (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (22)
1. Uređaj za plućnu primjenu, koji sadrži jedinicu mlaznice
jedinicu mlaznice za raspršivanje i
patronu koja sadrži vodenu otopinu sastavljenu od 80 do 400 mg A/mL sulfometiliranog polimiksina.
2. Uređaj sukladno patentnom zahtjevu 1, pri čemu je sulfometilizirani polimiksin kolistimetat natrij.
3. Uređaj sukladno patentnom zahtjevu 1 ili 2, pri čemu je koncentracija sulfometiliziranog polimiksina u rasponu od 80 do 200 mg A/mL.
4. Uređaj sukladno patentnom zahtjevu 2 , pri čemu koncentracija kolistimetat natrij u rasponu od 80 do 120 mg A/mL.
5. Uređaj sukladno patentnom zahtjevu 2, pri čemu koncentracija kolistimetat natrija u rasponu od 85 do 113 mg A/mL.
6. Uređaj sukladno patentnom zahtjevu 2-5, pri čemu ta patrona ima nominalnu vrijednost od 0,5-1,5 mL.
7. Vodeni rastvor koji obuhvata od 80 do 400 mg A/mL sulfometilisanog polimiksina za upotrebu u terapijskom ili profilaktičkom liječenju bakterijske infekcije u plućnom sistemu, pri čemu je ta supstanca/ otopina za isporuku u pluća.
8. Otopina za uporabu sukladno patentnom zahtjevu 7, pri čemu je sulfometilizirani polimiksin kolistimetat natrij.
9. Otopina za uporabu sukladno patentnom zahtjevu 7 ili 8, pri čemu je koncentracija sulfometiliziranog polimiksina u rasponu od 90 do 150 mg A/mL.
10. Otopina za uporabu sukladno patentnom zahtjevu 8, pri čemu je koncentracija kolistimetat natrija u rasponu od 90 do 110 mg A/mL.
11. Otopina za uporabu sukladno patentnom zahtjevu 8, pri čemu je koncentracija kolistimetat natrija u rasponu od 90 do 100 mg A/mL.
12. Otopina za uporabu sukladno patentnom zahtjevu 7-11, pri čemu ta patrona ima nominalni volumen od 0,5-1,5 mL.
13. Vodena otopina za uporabu sukladno patentnom zahtjevu 7-12 pri čemu isporuka pacijentu, sadrži:
pokretanje inhalatora koji sadrži jedinicu s mlaznicom za raspršivanje i patronu koja sadrži vodenu otopinu i
davanje vodene otopine pacijentu u obliku kapiljica koje imaju srednju aerodinamičku masu promjera od 4 do 8 µm.
14. Vodena otopina za uporabu sukladno patentnom zahtjevu 13 pri čemu je srednja aerodinamička masa kapiljica promjera od 5,5 do 7,5 µm.
15. Vodena otopina za uporabu sukladno patentnom zahtjevu 13-14, naznačena time, da jedinica mlaznice za raspršivanje ima otvore promjera od 1,5 do 2,2 mm.
16. Vodena otopina za uporabu sukladno patentnom zahtjevu 7-14, pri čemu je bakterijska infekcija prouzročena gram negativnim bakterijama.
17. Vodena otopina za uporabu sukladno bilo kojem patentnom zahtjevu 7-8 i 12-16, pri čemu vodena otopina sadrži od 80 do 120 mg A/mL kolistimetat natrija.
18. Vodena otopina za uporabu sukladno patentnom zahtjevu 17, pri čemu vodena otopina sadrži od 85 do 113 mg A/mL kolistimetat natrija.
19. Vodena otopina za uporabu sukladno patentnom zahtjevu 16, pri čemu su te gram negativne bakterije Enterobacter aerogenes, Escherichia coli, Klebsiella pneumonaiae, Pseudomonas aeruginosa, ili njihova kombinacija.
20. Vodena otopina za uporabu sukladno patentnom zahtjevu 13, pri čemu pacijent pati od kroničnog poremećaja pluća.
21. Vodena otopina za uporabu sukladno patentnom zahtjevu 20, pri čemu se kronični poremećaj pluća odabire iz skupine bolesti kao što je astma, cistična fibroza (CF), necistična fizbrozna bronhiektazija, kronične opstruktivna bolest pluća, ili njihova kombinacija.
22. Vodena otopina za uporabu sukladno patentnom zahtjevu 11, pri čemu isporuka pacijentu sadrži:
aktiviranje inhalatora sadrži jedinicu mlaznice za raspršivanje koja s presjekom otvora od 1,7-2,0 µm i patronu koja sadrži vodenu otopinu; i
isporuku vodene otopine pacijentu u obliku kapiljica srednjeg aerodinamičke mase presjeka od 4 do 8 µm s protokom zraka od 15-20 L/min.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462059748P | 2014-10-03 | 2014-10-03 | |
| PCT/EP2015/072736 WO2016050933A1 (en) | 2014-10-03 | 2015-10-01 | Inhalation device |
| EP15774606.6A EP3200762B1 (en) | 2014-10-03 | 2015-10-01 | Inhalation device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190747T1 true HRP20190747T1 (hr) | 2019-07-12 |
Family
ID=54249495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190747TT HRP20190747T1 (hr) | 2014-10-03 | 2019-04-23 | Uređaj za inhalaciju |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US11033602B2 (hr) |
| EP (2) | EP3200762B1 (hr) |
| JP (1) | JP6626890B2 (hr) |
| KR (1) | KR102494511B1 (hr) |
| CN (1) | CN106999542B (hr) |
| AU (1) | AU2015326847B2 (hr) |
| BR (1) | BR112017006816A2 (hr) |
| CA (1) | CA2962120C (hr) |
| CO (1) | CO2017004442A2 (hr) |
| CY (1) | CY1121803T1 (hr) |
| DK (1) | DK3200762T3 (hr) |
| ES (1) | ES2721401T3 (hr) |
| HR (1) | HRP20190747T1 (hr) |
| HU (1) | HUE044289T2 (hr) |
| IL (1) | IL251480B (hr) |
| LT (1) | LT3200762T (hr) |
| MX (1) | MX2017004175A (hr) |
| PH (1) | PH12017500538A1 (hr) |
| PL (1) | PL3200762T3 (hr) |
| PT (1) | PT3200762T (hr) |
| RS (1) | RS58792B1 (hr) |
| RU (1) | RU2702335C2 (hr) |
| SG (1) | SG11201702666SA (hr) |
| SI (1) | SI3200762T1 (hr) |
| TR (1) | TR201906108T4 (hr) |
| WO (1) | WO2016050933A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3200827T3 (pl) | 2014-10-03 | 2020-12-14 | Xellia Pharmaceuticals Aps | Kompozycje |
| CN112546030A (zh) * | 2019-09-26 | 2021-03-26 | 盈科瑞（天津）创新医药研究有限公司 | 一种吸入用多粘菌素e甲磺酸钠溶液及其制备方法 |
| US20230052317A1 (en) * | 2021-08-05 | 2023-02-16 | Zambon S.P.A. | Treatment of non-cystic fibrosis bronchiectasis |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1062895A (en) | 1962-12-13 | 1967-03-22 | Wellcome Found | Sulphomethyl derivatives of polymxin |
| DE1906699A1 (de) | 1968-02-12 | 1970-02-05 | Pfizer | Neue Polymyxinderivate und Verfahren zu deren Herstellung |
| FR1586834A (hr) | 1968-02-12 | 1970-03-06 | ||
| AU611030B2 (en) | 1988-04-07 | 1991-05-30 | Edward Shanbrom | Non-thrombogenic intravascular time release catheter |
| SE9201246D0 (sv) | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | Injection cartridge arrangement |
| NL9401260A (nl) | 1993-11-12 | 1995-06-01 | Cornelis Johannes Maria Van Ri | Membraan voor microfiltratie, ultrafiltratie, gasscheiding en katalyse, werkwijze ter vervaardiging van een dergelijk membraan, mal ter vervaardiging van een dergelijk membraan, alsmede diverse scheidingssystemen omvattende een dergelijk membraan. |
| EP0920324B1 (en) * | 1996-11-15 | 2001-06-27 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| US5767068A (en) * | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| ATE322249T1 (de) | 2001-05-18 | 2006-04-15 | Chiron Corp | System zur abgabe einer tobramycin-formulierung |
| US20040022740A1 (en) | 2001-07-10 | 2004-02-05 | Baker William R. | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
| ATE349223T1 (de) | 2002-03-01 | 2007-01-15 | Chiesi Farma Spa | Pharmazeutische zubereitungen mit verbesserten oberflächeneigenschaften welche ein lungen surfactant und ein polymyxin enthalten |
| WO2008025560A1 (en) * | 2006-09-01 | 2008-03-06 | Pari Pharma Gmbh | Methods for taste masking of nebulised compositions for nasal and pulmonary inhalation therapy |
| US20080066739A1 (en) * | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| US8329645B2 (en) * | 2008-02-08 | 2012-12-11 | Northern Antibiotics Ltd. | Polymyxin derivatives and uses thereof |
| DE102008030267B3 (de) | 2008-06-19 | 2010-01-28 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | Verfahren zum Befüllen von Doppelkammersystemen in vorsterilisierbaren Trägersystemen und vorsterilisierbares Trägersystem |
| RU2492878C1 (ru) | 2009-10-08 | 2013-09-20 | Схл Груп Аб | Ингалятор отмеренных жидкокапельных доз |
| WO2011051070A1 (en) | 2009-10-30 | 2011-05-05 | Xellia Pharmaceuticals Aps | Method for purification of colistin and purified colistin components |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| CN102531955B (zh) | 2011-09-16 | 2014-02-19 | 浙江众益制药股份有限公司 | 奥沙拉秦钠的制备方法和甲磺化反应的后处理方法 |
| CA2895910C (en) | 2013-01-11 | 2021-12-21 | Xellia Pharmaceuticals Aps | Polymyxins, compositions, methods of making and methods of use |
| TW201522364A (zh) | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| PT3166960T (pt) | 2014-07-09 | 2019-10-25 | Xellia Pharmaceuticals Aps | Polimixinas de baixa substituição e composições das mesmas. |
| PL3200827T3 (pl) | 2014-10-03 | 2020-12-14 | Xellia Pharmaceuticals Aps | Kompozycje |
-
2015
- 2015-10-01 EP EP15774606.6A patent/EP3200762B1/en active Active
- 2015-10-01 WO PCT/EP2015/072736 patent/WO2016050933A1/en active Application Filing
- 2015-10-01 DK DK15774606.6T patent/DK3200762T3/da active
- 2015-10-01 RS RS20190509A patent/RS58792B1/sr unknown
- 2015-10-01 HU HUE15774606 patent/HUE044289T2/hu unknown
- 2015-10-01 LT LTEP15774606.6T patent/LT3200762T/lt unknown
- 2015-10-01 TR TR2019/06108T patent/TR201906108T4/tr unknown
- 2015-10-01 CN CN201580065903.0A patent/CN106999542B/zh active Active
- 2015-10-01 PL PL15774606T patent/PL3200762T3/pl unknown
- 2015-10-01 AU AU2015326847A patent/AU2015326847B2/en active Active
- 2015-10-01 JP JP2017517048A patent/JP6626890B2/ja active Active
- 2015-10-01 ES ES15774606T patent/ES2721401T3/es active Active
- 2015-10-01 CA CA2962120A patent/CA2962120C/en active Active
- 2015-10-01 PT PT15774606T patent/PT3200762T/pt unknown
- 2015-10-01 SG SG11201702666SA patent/SG11201702666SA/en unknown
- 2015-10-01 MX MX2017004175A patent/MX2017004175A/es active IP Right Grant
- 2015-10-01 EP EP19163697.6A patent/EP3520777B1/en active Active
- 2015-10-01 BR BR112017006816A patent/BR112017006816A2/pt not_active Application Discontinuation
- 2015-10-01 US US15/516,286 patent/US11033602B2/en active Active
- 2015-10-01 SI SI201530718T patent/SI3200762T1/sl unknown
- 2015-10-01 RU RU2017114144A patent/RU2702335C2/ru active
- 2015-10-01 KR KR1020177011791A patent/KR102494511B1/ko active IP Right Grant
-
2017
- 2017-03-23 PH PH12017500538A patent/PH12017500538A1/en unknown
- 2017-03-30 IL IL251480A patent/IL251480B/en active IP Right Grant
- 2017-05-02 CO CONC2017/0004442A patent/CO2017004442A2/es unknown
-
2019
- 2019-04-22 CY CY20191100440T patent/CY1121803T1/el unknown
- 2019-04-23 HR HRP20190747TT patent/HRP20190747T1/hr unknown
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