HRP20181408T4 - Pedijatrijska otopina koja sadrži beta-blokator - Google Patents
Pedijatrijska otopina koja sadrži beta-blokator Download PDFInfo
- Publication number
- HRP20181408T4 HRP20181408T4 HRP20181408TT HRP20181408T HRP20181408T4 HR P20181408 T4 HRP20181408 T4 HR P20181408T4 HR P20181408T T HRP20181408T T HR P20181408TT HR P20181408 T HRP20181408 T HR P20181408T HR P20181408 T4 HRP20181408 T4 HR P20181408T4
- Authority
- HR
- Croatia
- Prior art keywords
- amount
- aqueous solution
- solution according
- agent
- propranolol
- Prior art date
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- 239000002876 beta blocker Substances 0.000 title 1
- 229940097320 beta blocking agent Drugs 0.000 title 1
- AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims 11
- 239000007864 aqueous solution Substances 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 229960003712 propranolol Drugs 0.000 claims 5
- 235000009499 Vanilla fragrans Nutrition 0.000 claims 4
- 244000263375 Vanilla tahitensis Species 0.000 claims 4
- 235000012036 Vanilla tahitensis Nutrition 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 3
- 235000003599 food sweetener Nutrition 0.000 claims 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000003765 sweetening agent Substances 0.000 claims 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 240000009088 Fragaria x ananassa Species 0.000 claims 2
- 235000010443 alginic acid Nutrition 0.000 claims 2
- 229920000615 alginic acid Polymers 0.000 claims 2
- 229920000591 gum Polymers 0.000 claims 2
- 229920001983 poloxamer Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims 2
- 229940085605 saccharin sodium Drugs 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- MEAPRSDUXBHXGD-UHFFFAOYSA-N 3-chloro-n-(4-propan-2-ylphenyl)propanamide Chemical group CC(C)C1=CC=C(NC(=O)CCCl)C=C1 MEAPRSDUXBHXGD-UHFFFAOYSA-N 0.000 claims 1
- 244000144730 Amygdalus persica Species 0.000 claims 1
- 241000167854 Bourreria succulenta Species 0.000 claims 1
- 244000089742 Citrus aurantifolia Species 0.000 claims 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 claims 1
- 235000005979 Citrus limon Nutrition 0.000 claims 1
- 244000131522 Citrus pyriformis Species 0.000 claims 1
- 241000675108 Citrus tangerina Species 0.000 claims 1
- 240000000560 Citrus x paradisi Species 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 239000004386 Erythritol Substances 0.000 claims 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims 1
- 235000016623 Fragaria vesca Nutrition 0.000 claims 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 241001072983 Mentha Species 0.000 claims 1
- 235000014435 Mentha Nutrition 0.000 claims 1
- 101710084933 Miraculin Proteins 0.000 claims 1
- 240000008790 Musa x paradisiaca Species 0.000 claims 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 244000288157 Passiflora edulis Species 0.000 claims 1
- 235000000370 Passiflora edulis Nutrition 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 235000006040 Prunus persica var persica Nutrition 0.000 claims 1
- 244000235659 Rubus idaeus Species 0.000 claims 1
- QFVOYBUQQBFCRH-UHFFFAOYSA-N Steviol Natural products C1CC2(C3)CC(=C)C3(O)CCC2C2(C)C1C(C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-UHFFFAOYSA-N 0.000 claims 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 235000011941 Tilia x europaea Nutrition 0.000 claims 1
- 229920001615 Tragacanth Polymers 0.000 claims 1
- 241000219094 Vitaceae Species 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 235000019568 aromas Nutrition 0.000 claims 1
- 239000000305 astragalus gummifer gum Substances 0.000 claims 1
- 235000021015 bananas Nutrition 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- MQRKKLAGBPVXCD-UHFFFAOYSA-L calcium;1,1-dioxo-1,2-benzothiazol-2-id-3-one;hydrate Chemical compound O.[Ca+2].C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 MQRKKLAGBPVXCD-UHFFFAOYSA-L 0.000 claims 1
- 235000013736 caramel Nutrition 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- 235000019693 cherries Nutrition 0.000 claims 1
- 235000019219 chocolate Nutrition 0.000 claims 1
- 235000009508 confectionery Nutrition 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 235000019414 erythritol Nutrition 0.000 claims 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims 1
- 229940009714 erythritol Drugs 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 235000021021 grapes Nutrition 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000000832 lactitol Substances 0.000 claims 1
- 235000010448 lactitol Nutrition 0.000 claims 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
- 229960003451 lactitol Drugs 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229940094522 laponite Drugs 0.000 claims 1
- 239000004571 lime Substances 0.000 claims 1
- XCOBTUNSZUJCDH-UHFFFAOYSA-B lithium magnesium sodium silicate Chemical compound [Li+].[Li+].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Na+].[Na+].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3.O1[Si](O2)([O-])O[Si]3([O-])O[Si]1([O-])O[Si]2([O-])O3 XCOBTUNSZUJCDH-UHFFFAOYSA-B 0.000 claims 1
- 235000010449 maltitol Nutrition 0.000 claims 1
- 239000000845 maltitol Substances 0.000 claims 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims 1
- 229940035436 maltitol Drugs 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001855 mannitol Drugs 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 235000014569 mints Nutrition 0.000 claims 1
- 239000006174 pH buffer Substances 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 229960003975 potassium Drugs 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 229960004604 propranolol hydrochloride Drugs 0.000 claims 1
- 235000021013 raspberries Nutrition 0.000 claims 1
- 229940081974 saccharin Drugs 0.000 claims 1
- 235000019204 saccharin Nutrition 0.000 claims 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims 1
- 229940043243 saccharin calcium Drugs 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- QFVOYBUQQBFCRH-VQSWZGCSSA-N steviol Chemical compound C([C@@]1(O)C(=C)C[C@@]2(C1)CC1)C[C@H]2[C@@]2(C)[C@H]1[C@](C)(C(O)=O)CCC2 QFVOYBUQQBFCRH-VQSWZGCSSA-N 0.000 claims 1
- 229940032084 steviol Drugs 0.000 claims 1
- 229940013618 stevioside Drugs 0.000 claims 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims 1
- 235000019202 steviosides Nutrition 0.000 claims 1
- 235000021012 strawberries Nutrition 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 229960004793 sucrose Drugs 0.000 claims 1
- 239000000892 thaumatin Substances 0.000 claims 1
- 235000010436 thaumatin Nutrition 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (11)
1. Vodena pedijatrijska otopina za višestruku uporabu bez etilnog alkohola koji sadrži propranolol ili njegovu farmaceutski prihvatljivu sol, zaslađivač bez šećera i manje od 0.01 w/V% svih konzervansa pored samog propranolola ili njegove farmaceutski prihvatljive soli.
2. Vodena otopina sukladno zahtjevu 1, naznačeno time, da je propranolol ili njegova farmaceutski prihvatljiva sol, prisutan u količini od 0.01 do 5% w/V.
3. Vodena otopina sukladno bilo kojem od zahtjeva 1 do 2, naznačeno time, da nadalje sadrži najmanje jedno sredstvo za poboljšanje okusa i/ili najmanje jedno sredstvo za povećanje viskoznosti.
4. Vodena otopina sukladno zahtjevu 3, naznačeno time, što najmanje jedno sredstvo za poboljšanje okusa odabrano od bilo kojeg od slijedećih; višnje, limuna, limete, mandarine, narandže, crvene narandže, mente, jagode, banane, karamele, laktoze, marakuje, breskve, maline, tuti-frutija, grejp, vanilije, slatkog vrhnja, čokolade, grožđa ili njihove mješavine, i prisutna je u količini od 0 do 5% w/V, npr. od 0.01 do 1 % w/V i npr. od 0.01 do 0.5 % w/V.
5. Vodena otopina sukladno zahtjevu 4, naznačeno time, što je najmanje jedno sredstvo za poboljšanje okusa vanilija u količini od 0.01 do 0.5% w/V.
6. Vodena otopina sukladno bilo kojem od zahtjeva 3, naznačeno time, što je najmanje jedan sredstvo za povećanje viskoznosti odabrano između derivata celuloze, hidroksietilceluloze, hidroksipropilceluloze, hidroksipropilmetilceluloze, ili metilceluloze, poloksamera, guma, guar gume, tragakant gume, gume akacije ksantan gume, želatinske guma, alginskih derivata, alginske kiseline, natrij alginata, polivinilpirolidona, silikata, bentonita, laponita, veegume, još poželjnije između neionskih poloksamera, polivinilpirolidona i etera celuloze, u količini od 0 do 15% w/V, npr. od 0.1 do 10% w/V, npr. od 0.1 do 5 % w/V i npr. od 0.1 do 0.5% w/V.
7. Vodena otopina sukladno zahtjevu 6, naznačeno time, što je najmanje jedan sredstvo za povećanje viskoznosti hidroksietilceluloza.
8. Otopina sukladno bilo kojem od zahtjeva 1 do 7, naznačeno time, da nadalje sadrži pH pufer, i pri čemu je pH između 2 i 6.
9. Vodena otopina sukladno bilo kojem od zahtjeva 1 do 8, naznačeno time, da je najmanje jedan zaslađivač bez šećera odabran između saharina, soli saharina, natrij saharina, kalcij saharina, saharoze, kalij acetosulfama, steviozida, steviola, manitola, eritritola, laktitola, maltitola, alitama, mirakulina, monelina, taumatina, i njihove mješavine i u količini od 0.05 do 0.5% w/V.
10. Vodena otopina sukladno zahtjevu 1, naznačeno time, da je propranolol prisutan u količini od 0.250 do 1 % w/V i vanilija je prisutna u količini od 0.01 do 1 % w/V i pri čemu navedena vodena otopina ne sadrži konzervans.
11. Pripravak sukladno bilo kojem od zahtjeva 1 do 10, naznačeno time, da je propranolol ili njegova farmaceutski prihvatljiva sol propranolol hidroklorid u količini od 0.428 ili 0.57 % w/V, pri čemu je najmanje jedan zaslađivač saharin natrij u količini od 0.15% w/V, pri čemu je najmanje jedna aroma mješavina arome vanilije i jagode u količini od 0.32% w/V, a najmanje jedno sredstvo za povećanje viskoznosti je hidroksietilceluloza u količini od 0.35 % w/V.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09290298A EP2246044A1 (en) | 2009-04-21 | 2009-04-21 | Paediatric solutions comprising a beta-blocker |
| EP12155472.9A EP2497461B2 (en) | 2009-04-21 | 2010-04-12 | Paediatric solutions comprising a beta-blocker |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20181408T1 HRP20181408T1 (hr) | 2018-11-02 |
| HRP20181408T4 true HRP20181408T4 (hr) | 2022-03-04 |
Family
ID=40940328
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170610TT HRP20170610T4 (hr) | 2009-04-21 | 2010-04-12 | Pedijatrijske otopine koje sadrže propranolol |
| HRP20181408TT HRP20181408T4 (hr) | 2009-04-21 | 2018-09-03 | Pedijatrijska otopina koja sadrži beta-blokator |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170610TT HRP20170610T4 (hr) | 2009-04-21 | 2010-04-12 | Pedijatrijske otopine koje sadrže propranolol |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20120035270A1 (hr) |
| EP (4) | EP2246044A1 (hr) |
| JP (1) | JP5695029B2 (hr) |
| KR (1) | KR101713866B1 (hr) |
| CN (1) | CN102405041A (hr) |
| AR (2) | AR076338A1 (hr) |
| AU (1) | AU2010240551B2 (hr) |
| BR (1) | BRPI1015447B1 (hr) |
| CA (1) | CA2755175C (hr) |
| CL (1) | CL2011002634A1 (hr) |
| CO (1) | CO6410278A2 (hr) |
| CY (2) | CY1119390T1 (hr) |
| DK (2) | DK2421504T4 (hr) |
| ES (2) | ES2685178T5 (hr) |
| GE (1) | GEP20146087B (hr) |
| HR (2) | HRP20170610T4 (hr) |
| HU (2) | HUE039937T2 (hr) |
| IL (1) | IL214674A (hr) |
| LT (2) | LT2497461T (hr) |
| MA (1) | MA33003B1 (hr) |
| MX (1) | MX337463B (hr) |
| NZ (1) | NZ594592A (hr) |
| PL (2) | PL2421504T5 (hr) |
| PT (2) | PT2497461T (hr) |
| RS (2) | RS57668B2 (hr) |
| RU (1) | RU2011139233A (hr) |
| SG (1) | SG172960A1 (hr) |
| SI (2) | SI2497461T2 (hr) |
| TN (1) | TN2011000350A1 (hr) |
| TW (1) | TWI429459B (hr) |
| UA (1) | UA107570C2 (hr) |
| WO (1) | WO2010122442A1 (hr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2246044A1 (en) | 2009-04-21 | 2010-11-03 | Pierre Fabre Dermo-Cosmétique | Paediatric solutions comprising a beta-blocker |
| MX351584B (es) | 2011-03-04 | 2017-10-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral. |
| JP2019142972A (ja) * | 2011-03-04 | 2019-08-29 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口的投与 |
| US20120225951A1 (en) * | 2011-03-04 | 2012-09-06 | Gruenenthal Gmbh | Parenteral Administration of Tapentadol |
| US9724297B2 (en) | 2014-04-01 | 2017-08-08 | Arbor Pharmaceuticals, Inc. | Sotalol compositions and uses of the same |
| LT3273953T (lt) | 2015-03-27 | 2019-02-25 | Grünenthal GmbH | Stabili kompozicija, skirta tapentadolio skyrimui parenteriniu būdu |
| EP3515412A1 (en) | 2016-09-23 | 2019-07-31 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| CN108261411B (zh) * | 2016-12-30 | 2021-04-30 | 武汉科福新药有限责任公司 | 用于婴幼儿血管瘤治疗的口腔膜剂及其制备方法 |
| CN107320467A (zh) * | 2017-07-21 | 2017-11-07 | 江苏云阳集团药业有限公司 | 一种盐酸普萘洛尔药用组合物及其制备方法 |
| CN108299279B (zh) * | 2018-02-09 | 2021-03-23 | 北京梅尔森医药技术开发有限公司 | 取代芳基胺醇化合物及其制备方法和用途 |
| US11547123B2 (en) * | 2019-08-16 | 2023-01-10 | The Folger Coffee Company | Methods for reducing negative flavor attributes in coffee and compositions therefrom |
| US20230364242A1 (en) | 2020-09-30 | 2023-11-16 | Nissan Chemical Corporation | Water-soluble complex containing beta blocker and lecithin |
| GB2628566A (en) | 2023-03-29 | 2024-10-02 | Novumgen Ltd | An orally rapidly disintegrating tablet of propranolol and its process of preparation |
| CN118021718B (zh) * | 2024-04-12 | 2024-07-02 | 成都瑞尔医药科技有限公司 | 一种盐酸普罗帕酮注射液及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4600708A (en) | 1985-07-19 | 1986-07-15 | American Home Products Corporation | Propranolol hydrochloride liquid formulations |
| HU209251B (en) * | 1992-03-13 | 1994-04-28 | Synepos Ag | Process for producing stable, peroral solution drug forms with controlled release of active ingredient and comprising beta-blocking pharmacons |
| DE69613164T2 (de) | 1995-03-15 | 2001-09-27 | Kao Corp | Verwendung eines Zusatzstoffes zur Verminderung von Bittergeschmack |
| JPH1025253A (ja) * | 1996-07-12 | 1998-01-27 | Kao Corp | 苦味低減化剤及び苦味低減化法 |
| JPH11349492A (ja) * | 1998-06-03 | 1999-12-21 | Yamanouchi Pharmaceut Co Ltd | 苦味を低減した経口用医薬組成物および苦味低減化方法 |
| JP2001342151A (ja) * | 2000-03-31 | 2001-12-11 | Eisai Co Ltd | 甘味を有する薬剤組成物 |
| NZ529173A (en) * | 2001-05-25 | 2005-07-29 | Warner Lambert Co | Stable liquid pharmaceutical composition comprising a GABA analog i.e. gabapentin or pregabalin, and a polyhydric alcohol e.g. glycerol, xylitol, sorbitol, mannitol |
| EP1543831A1 (en) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Pregabalin composition |
| JP2008531556A (ja) * | 2005-02-25 | 2008-08-14 | バイオマリン ファーマシューティカル インコーポレイテッド | 室温で安定な水性の液状薬学的組成物 |
| BRPI0610210A2 (pt) * | 2005-05-25 | 2010-06-01 | Janssen Pharmaceutica Nv | composições pediátricas de topiramato, uso das mesmas e recipiente |
| DE102006020604A1 (de) * | 2006-05-02 | 2007-11-08 | Bayer Healthcare Ag | Flüssige Arzneimittelformulierung |
| EP2050441A1 (en) | 2007-10-19 | 2009-04-22 | Université Victor Segalen Bordeaux 2 | Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas |
| US8703156B2 (en) * | 2008-04-25 | 2014-04-22 | Apotex Technologies Inc. | Liquid formulation for deferiprone with palatable taste |
| EP2246044A1 (en) | 2009-04-21 | 2010-11-03 | Pierre Fabre Dermo-Cosmétique | Paediatric solutions comprising a beta-blocker |
-
2009
- 2009-04-21 EP EP09290298A patent/EP2246044A1/en not_active Withdrawn
-
2010
- 2010-04-12 AU AU2010240551A patent/AU2010240551B2/en active Active
- 2010-04-12 HR HRP20170610TT patent/HRP20170610T4/hr unknown
- 2010-04-12 LT LTEP12155472.9T patent/LT2497461T/lt unknown
- 2010-04-12 PL PL10717263.7T patent/PL2421504T5/pl unknown
- 2010-04-12 PL PL12155472T patent/PL2497461T5/pl unknown
- 2010-04-12 KR KR1020117024721A patent/KR101713866B1/ko active IP Right Grant
- 2010-04-12 GE GEAP201012468A patent/GEP20146087B/en unknown
- 2010-04-12 MA MA34064A patent/MA33003B1/fr unknown
- 2010-04-12 RS RS20181036A patent/RS57668B2/sr unknown
- 2010-04-12 RS RS20170358A patent/RS55862B2/sr unknown
- 2010-04-12 BR BRPI1015447A patent/BRPI1015447B1/pt active IP Right Grant
- 2010-04-12 LT LTEP10717263.7T patent/LT2421504T/lt unknown
- 2010-04-12 HU HUE12155472A patent/HUE039937T2/hu unknown
- 2010-04-12 MX MX2011010766A patent/MX337463B/es active IP Right Grant
- 2010-04-12 CN CN2010800174060A patent/CN102405041A/zh active Pending
- 2010-04-12 SI SI201031741T patent/SI2497461T2/sl unknown
- 2010-04-12 ES ES12155472T patent/ES2685178T5/es active Active
- 2010-04-12 EP EP10717263.7A patent/EP2421504B2/en active Active
- 2010-04-12 NZ NZ594592A patent/NZ594592A/xx unknown
- 2010-04-12 SG SG2011050663A patent/SG172960A1/en unknown
- 2010-04-12 DK DK10717263.7T patent/DK2421504T4/da active
- 2010-04-12 EP EP18174428.5A patent/EP3384899A1/en active Pending
- 2010-04-12 WO PCT/IB2010/051573 patent/WO2010122442A1/en active Application Filing
- 2010-04-12 EP EP12155472.9A patent/EP2497461B2/en active Active
- 2010-04-12 JP JP2012506607A patent/JP5695029B2/ja active Active
- 2010-04-12 DK DK12155472.9T patent/DK2497461T4/da active
- 2010-04-12 PT PT12155472T patent/PT2497461T/pt unknown
- 2010-04-12 SI SI201031439A patent/SI2421504T1/sl unknown
- 2010-04-12 CA CA2755175A patent/CA2755175C/en active Active
- 2010-04-12 PT PT107172637T patent/PT2421504T/pt unknown
- 2010-04-12 US US13/265,739 patent/US20120035270A1/en not_active Abandoned
- 2010-04-12 RU RU2011139233/15A patent/RU2011139233A/ru unknown
- 2010-04-12 HU HUE10717263A patent/HUE034581T2/en unknown
- 2010-04-12 ES ES10717263T patent/ES2623936T5/es active Active
- 2010-04-20 TW TW099112270A patent/TWI429459B/zh active
- 2010-04-20 AR ARP100101299A patent/AR076338A1/es not_active Application Discontinuation
- 2010-12-04 UA UAA201112317A patent/UA107570C2/ru unknown
-
2011
- 2011-07-15 TN TN2011000350A patent/TN2011000350A1/fr unknown
- 2011-07-28 CO CO11095137A patent/CO6410278A2/es not_active Application Discontinuation
- 2011-08-15 IL IL214674A patent/IL214674A/en active IP Right Grant
- 2011-10-21 CL CL2011002634A patent/CL2011002634A1/es unknown
-
2014
- 2014-12-01 US US14/556,861 patent/US20150087719A1/en not_active Abandoned
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2017
- 2017-05-31 CY CY20171100562T patent/CY1119390T1/el unknown
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2018
- 2018-09-03 HR HRP20181408TT patent/HRP20181408T4/hr unknown
- 2018-09-07 CY CY181100939T patent/CY1120667T1/el unknown
-
2019
- 2019-07-25 AR ARP190102095A patent/AR117621A2/es unknown
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