HRP20171627T1 - Estrogenski derivati za upotrebu u liječenju neuroloških poremećaja - Google Patents
Estrogenski derivati za upotrebu u liječenju neuroloških poremećaja Download PDFInfo
- Publication number
- HRP20171627T1 HRP20171627T1 HRP20171627TT HRP20171627T HRP20171627T1 HR P20171627 T1 HRP20171627 T1 HR P20171627T1 HR P20171627T T HRP20171627T T HR P20171627TT HR P20171627 T HRP20171627 T HR P20171627T HR P20171627 T1 HRP20171627 T1 HR P20171627T1
- Authority
- HR
- Croatia
- Prior art keywords
- treatment
- estetrol
- brain injury
- neurological disorders
- use according
- Prior art date
Links
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 230000001076 estrogenic effect Effects 0.000 title 1
- AJIPIJNNOJSSQC-NYLIRDPKSA-N estetrol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)[C@@H]4O)O)[C@@H]4[C@@H]3CCC2=C1 AJIPIJNNOJSSQC-NYLIRDPKSA-N 0.000 claims 5
- 229950009589 estetrol Drugs 0.000 claims 5
- 206010070511 Hypoxic-ischaemic encephalopathy Diseases 0.000 claims 4
- 208000037212 Neonatal hypoxic and ischemic brain injury Diseases 0.000 claims 4
- 208000009973 brain hypoxia - ischemia Diseases 0.000 claims 4
- 208000033300 perinatal asphyxia Diseases 0.000 claims 4
- 208000029028 brain injury Diseases 0.000 claims 3
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 230000009517 anoxic brain damage Effects 0.000 claims 1
- 210000001320 hippocampus Anatomy 0.000 claims 1
- 230000009524 hypoxic brain injury Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (5)
1. 1,3,5(10)-estratrien-3,15α,16α,17β-tetrol (Estetrol) naznačen time da se koristi za upotrebu u liječenju ozljeda mozga u području hipokampusa.
2. Estetrol za upotrebu prema zahtjevu 1, naznačen time da je liječenje ozljede mozga terapijsko.
3. Estetrol za upotrebu prema zahtjevu 1 ili 2, naznačen time da je ozljeda mozga odabrana iz skupine koja sadrži hipoksičku ozljedu mozga, anoksičnu ozljedu mozga, traumatsku ozljedu mozga.
4. Estetrol za upotrebu prema bilo kojem od zahtjeva od 1 do 3, naznačen time da se koristi za upotrebu u liječenju hipoksične ishemijske encefalopatije (HIE).
5. Estetrol za upotrebu prema bilo kojem od zahtjeva od 1 do 4, naznačen time da se koristi za upotrebu u liječenju neonatalne hipoksične ishemijske encefalopatije (HIE).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12164741.6A EP2653163A1 (en) | 2012-04-19 | 2012-04-19 | Estrogenic components for use in the treatment of neurological disorders |
| EP13714917.5A EP2838539B1 (en) | 2012-04-19 | 2013-04-08 | Estrogenic derivatives for use in the treatment of neurological disorders. |
| PCT/EP2013/057279 WO2013156329A1 (en) | 2012-04-19 | 2013-04-08 | Estrogenic components for use in the treatment of neurological disorders. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20171627T1 true HRP20171627T1 (hr) | 2017-12-01 |
Family
ID=48050711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20171627TT HRP20171627T1 (hr) | 2012-04-19 | 2017-10-25 | Estrogenski derivati za upotrebu u liječenju neuroloških poremećaja |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9238035B2 (hr) |
| EP (2) | EP2653163A1 (hr) |
| JP (1) | JP6139662B2 (hr) |
| CN (1) | CN104379148B (hr) |
| AU (1) | AU2013248481B2 (hr) |
| CA (1) | CA2869902C (hr) |
| CY (1) | CY1119603T1 (hr) |
| DK (1) | DK2838539T3 (hr) |
| ES (1) | ES2647111T3 (hr) |
| HR (1) | HRP20171627T1 (hr) |
| HU (1) | HUE034902T2 (hr) |
| LT (1) | LT2838539T (hr) |
| NO (1) | NO2838539T3 (hr) |
| PL (1) | PL2838539T3 (hr) |
| PT (1) | PT2838539T (hr) |
| RS (1) | RS56595B1 (hr) |
| RU (1) | RU2627846C2 (hr) |
| SI (1) | SI2838539T1 (hr) |
| WO (1) | WO2013156329A1 (hr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2714710T3 (pl) | 2011-06-01 | 2017-03-31 | Estetra S.P.R.L. | Sposób wytwarzania estetrolowych związków pośrednich |
| CA2835979C (en) | 2011-06-01 | 2018-05-01 | Estetra S.A. | Process for the production of estetrol intermediates |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| WO2016187558A2 (en) * | 2015-05-20 | 2016-11-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Method to improve neurologic outcomes in temperature managed patients |
| SI3310345T1 (sl) | 2015-06-18 | 2021-05-31 | Estetra Sprl | Orodisperzibilna tableta, ki vsebuje estetrol |
| RS61777B1 (sr) * | 2015-06-18 | 2021-06-30 | Estetra Sprl | Oralno-disperzibilna tableta koja sadrži estetrol |
| MY195019A (en) * | 2015-06-18 | 2023-01-03 | Estetra Sprl | Orodispersible dosage unit containing an estetrol component |
| ME03728B (me) | 2015-06-18 | 2021-01-20 | Estetra Sprl | Orodisperzibilna dozna jedinica koja sadrži komponentu estetrola |
| KR20220144885A (ko) | 2016-08-05 | 2022-10-27 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| CN107260712A (zh) * | 2017-06-22 | 2017-10-20 | 中国人民解放军第三军医大学 | 奥培米芬在制备促进髓鞘形成和再生的药物中的应用 |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| CN113243332B (zh) * | 2020-02-07 | 2023-07-28 | 上海市东方医院（同济大学附属东方医院） | 一种广泛脑区神经元树突发育障碍动物模型的制备与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2378898A (en) * | 2001-08-14 | 2003-02-26 | Hunter Fleming Ltd | Prophylactic and therapeutic use of hydroxysteroids |
| AU2003274943A1 (en) | 2002-06-11 | 2003-12-22 | Pantarhei Bioscience B.V. | Use of estetrol and analogues for treating or preventing cardiovascular pathologies, in particular atherosclerosis |
| WO2003103684A1 (en) * | 2002-06-11 | 2003-12-18 | Pantarhei Bioscience B.V. | Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein |
| EP3045177A1 (en) * | 2005-09-26 | 2016-07-20 | The Regents of The University of California | Estriol therapy for autoimmune and neurodegenerative diseases and disorders |
| US20090221540A1 (en) * | 2006-01-09 | 2009-09-03 | Pantarhei Bioscience B.V. | Method of Treating An Acute Vascular Disorder |
| EP2155205B1 (en) * | 2007-06-21 | 2011-12-21 | Pantarhei Bioscience B.V. | Treatment of meconium aspiration syndrome with estrogens |
| CA2704921C (en) * | 2007-11-06 | 2015-11-24 | Ellis L. Kline | Compositions and methods for treating parkinson's disease and related disorders |
| CN101884638B (zh) * | 2010-07-09 | 2011-11-09 | 中山大学 | 5α-雄甾(烷)-3β,5,6β-三醇在制备神经元保护药物中的应用 |
-
2012
- 2012-04-19 EP EP12164741.6A patent/EP2653163A1/en not_active Withdrawn
-
2013
- 2013-04-08 EP EP13714917.5A patent/EP2838539B1/en active Active
- 2013-04-08 NO NO13714917A patent/NO2838539T3/no unknown
- 2013-04-08 SI SI201330825T patent/SI2838539T1/sl unknown
- 2013-04-08 RS RS20171122A patent/RS56595B1/sr unknown
- 2013-04-08 HU HUE13714917A patent/HUE034902T2/hu unknown
- 2013-04-08 PL PL13714917T patent/PL2838539T3/pl unknown
- 2013-04-08 LT LTEP13714917.5T patent/LT2838539T/lt unknown
- 2013-04-08 JP JP2015506173A patent/JP6139662B2/ja active Active
- 2013-04-08 ES ES13714917.5T patent/ES2647111T3/es active Active
- 2013-04-08 PT PT137149175T patent/PT2838539T/pt unknown
- 2013-04-08 DK DK13714917.5T patent/DK2838539T3/da active
- 2013-04-08 CN CN201380020555.6A patent/CN104379148B/zh active Active
- 2013-04-08 CA CA2869902A patent/CA2869902C/en active Active
- 2013-04-08 RU RU2014145800A patent/RU2627846C2/ru active
- 2013-04-08 WO PCT/EP2013/057279 patent/WO2013156329A1/en active Application Filing
- 2013-04-08 AU AU2013248481A patent/AU2013248481B2/en active Active
- 2013-04-08 US US14/395,465 patent/US9238035B2/en active Active
-
2017
- 2017-10-25 HR HRP20171627TT patent/HRP20171627T1/hr unknown
- 2017-11-14 CY CY20171101193T patent/CY1119603T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2838539T3 (pl) | 2018-01-31 |
| CN104379148B (zh) | 2017-08-25 |
| EP2838539A1 (en) | 2015-02-25 |
| CA2869902C (en) | 2019-07-02 |
| US20150133419A1 (en) | 2015-05-14 |
| EP2653163A1 (en) | 2013-10-23 |
| EP2838539B1 (en) | 2017-08-16 |
| WO2013156329A1 (en) | 2013-10-24 |
| RU2627846C2 (ru) | 2017-08-14 |
| US9238035B2 (en) | 2016-01-19 |
| PT2838539T (pt) | 2017-11-15 |
| CY1119603T1 (el) | 2018-04-04 |
| HUE034902T2 (hu) | 2018-03-28 |
| NO2838539T3 (hr) | 2018-01-13 |
| JP2015514731A (ja) | 2015-05-21 |
| AU2013248481B2 (en) | 2017-02-16 |
| AU2013248481A1 (en) | 2014-10-30 |
| RU2014145800A (ru) | 2016-06-10 |
| JP6139662B2 (ja) | 2017-05-31 |
| RS56595B1 (sr) | 2018-02-28 |
| LT2838539T (lt) | 2017-11-27 |
| CN104379148A (zh) | 2015-02-25 |
| CA2869902A1 (en) | 2013-10-24 |
| SI2838539T1 (sl) | 2017-12-29 |
| ES2647111T3 (es) | 2017-12-19 |
| DK2838539T3 (da) | 2017-11-27 |
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