HRP20170618T1 - Kondenzirani piroldikarboksamidi i njihova uporaba kao farmaceutskih proizvoda - Google Patents
Kondenzirani piroldikarboksamidi i njihova uporaba kao farmaceutskih proizvoda Download PDFInfo
- Publication number
- HRP20170618T1 HRP20170618T1 HRP20170618TT HRP20170618T HRP20170618T1 HR P20170618 T1 HRP20170618 T1 HR P20170618T1 HR P20170618T T HRP20170618T T HR P20170618TT HR P20170618 T HRP20170618 T HR P20170618T HR P20170618 T1 HRP20170618 T1 HR P20170618T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- group
- phenyl
- amide
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305129 | 2012-02-03 | ||
| PCT/EP2013/051996 WO2013113860A1 (en) | 2012-02-03 | 2013-02-01 | Fused pyrroledicarboxamides and their use as pharmaceuticals |
| EP13702225.7A EP2809669B1 (en) | 2012-02-03 | 2013-02-01 | Fused pyrroledicarboxamides and their use as pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170618T1 true HRP20170618T1 (hr) | 2017-06-30 |
Family
ID=47631438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170618TT HRP20170618T1 (hr) | 2012-02-03 | 2013-02-01 | Kondenzirani piroldikarboksamidi i njihova uporaba kao farmaceutskih proizvoda |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US9284333B2 (https=) |
| EP (1) | EP2809669B1 (https=) |
| JP (1) | JP6126135B2 (https=) |
| KR (1) | KR102017362B1 (https=) |
| CN (1) | CN104169281B (https=) |
| AR (1) | AR089863A1 (https=) |
| AU (1) | AU2013214226B2 (https=) |
| BR (1) | BR112014018767B1 (https=) |
| CA (1) | CA2860933C (https=) |
| CY (1) | CY1119108T1 (https=) |
| DK (1) | DK2809669T3 (https=) |
| ES (1) | ES2623167T3 (https=) |
| HR (1) | HRP20170618T1 (https=) |
| HU (1) | HUE031729T2 (https=) |
| LT (1) | LT2809669T (https=) |
| MX (1) | MX350793B (https=) |
| PL (1) | PL2809669T3 (https=) |
| PT (1) | PT2809669T (https=) |
| RU (1) | RU2650111C2 (https=) |
| SG (1) | SG11201403852UA (https=) |
| SI (1) | SI2809669T1 (https=) |
| UY (1) | UY34610A (https=) |
| WO (1) | WO2013113860A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10414765B2 (en) | 2015-12-10 | 2019-09-17 | Bayer Pharma Aktiengesellschaft | Substituted perhydropyrrolo[3,4-c]pyrrole derivatives and the use of same |
| WO2017097792A1 (de) | 2015-12-10 | 2017-06-15 | Bayer Pharma Aktiengesellschaft | 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridin-derivate als blocker der task-1 und task-2 kanäle zur behandlung von schlafbedingten atemstörungen |
| CN108601784A (zh) | 2015-12-25 | 2018-09-28 | 武田药品工业株式会社 | 药物 |
| WO2017170354A1 (ja) | 2016-03-28 | 2017-10-05 | 武田薬品工業株式会社 | 医薬 |
| JOP20190005A1 (ar) * | 2016-07-20 | 2019-01-20 | Bayer Ag | مركبات ديازاهيترو ثنائية الحلقة مستبدلة واستخداماتها |
| CA3043325A1 (en) | 2016-11-10 | 2018-05-17 | The Research Foundation For The State University Of New York | System, method and biomarkers for airway obstruction |
| CA3061600A1 (en) * | 2017-04-27 | 2019-10-25 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| AU2018257332B2 (en) | 2017-04-27 | 2021-11-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JOP20190284A1 (ar) | 2017-06-14 | 2019-12-11 | Bayer Pharma AG | مركبات إيميدازوبيريميدين مستبدلة بديازا ثنائي الحلقة واستخدامها للمعالجة من اضطرابات التنفس |
| EP3836918B1 (en) | 2018-08-15 | 2026-04-08 | Universität Heidelberg | Task-1 inhibitors for use in the treatment of atrial arrhythmias |
| KR20230144065A (ko) * | 2021-02-08 | 2023-10-13 | 우한 휴먼웰 이노베이티브 드러그 리서치 앤드 디벨롭먼트 센터 리미티드 컴퍼니 | 피리도피리미디논계 유도체 및 이의 제조 방법과 용도 |
| WO2023225177A1 (en) * | 2022-05-19 | 2023-11-23 | Enalare Therapeutics Inc. | Methods and pharmaceutical compositions to treat respiratory depression in patients |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU83327A1 (fr) | 1981-04-29 | 1983-03-24 | Midit | Procede de preparation de derives de 1,4-thiazine,leur utilisation ainsi que compositions contenant ces derives |
| EP0447704A1 (en) | 1990-03-21 | 1991-09-25 | Smithkline Beecham Farmaceutici S.p.A. | N-Acylated azacyclic compounds, processes for their preparations and their use as medications |
| US7030112B2 (en) | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
| DE10332685A1 (de) | 2003-07-18 | 2005-02-17 | Bayer Healthcare Ag | Vorhof-selektiv exprimierte Kaliumkanäle |
| DE102005028845A1 (de) * | 2005-06-22 | 2006-12-28 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| DE102005028862A1 (de) * | 2005-06-22 | 2007-01-11 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| RU2436577C2 (ru) * | 2006-04-27 | 2011-12-20 | Санофи-Авентис Дойчланд Гмбх | Ингибиторы ионных task-1 и task-3 каналов |
| WO2008053319A1 (en) | 2006-10-30 | 2008-05-08 | Pfizer Products Inc. | Amide resorcinol compounds |
| PT2185561E (pt) | 2007-07-27 | 2011-09-07 | Sanofi Aventis | Derivados de 1,2,3,4-tetra-hidropirrolo(1,2-a)pirazina-6- carboxamidas e de 2,3,4,5-tetra-hidropirrolo(1,2-a)-diazepina-7- carboxamidas, sua preparação e sua aplicação em terapia |
-
2013
- 2013-02-01 UY UY0001034610A patent/UY34610A/es not_active Application Discontinuation
- 2013-02-01 HR HRP20170618TT patent/HRP20170618T1/hr unknown
- 2013-02-01 SI SI201330622A patent/SI2809669T1/sl unknown
- 2013-02-01 US US14/375,273 patent/US9284333B2/en active Active
- 2013-02-01 DK DK13702225.7T patent/DK2809669T3/da active
- 2013-02-01 AU AU2013214226A patent/AU2013214226B2/en active Active
- 2013-02-01 WO PCT/EP2013/051996 patent/WO2013113860A1/en not_active Ceased
- 2013-02-01 RU RU2014135759A patent/RU2650111C2/ru active
- 2013-02-01 LT LTEP13702225.7T patent/LT2809669T/lt unknown
- 2013-02-01 HU HUE13702225A patent/HUE031729T2/en unknown
- 2013-02-01 ES ES13702225T patent/ES2623167T3/es active Active
- 2013-02-01 SG SG11201403852UA patent/SG11201403852UA/en unknown
- 2013-02-01 JP JP2014555214A patent/JP6126135B2/ja active Active
- 2013-02-01 KR KR1020147024134A patent/KR102017362B1/ko active Active
- 2013-02-01 EP EP13702225.7A patent/EP2809669B1/en active Active
- 2013-02-01 CA CA2860933A patent/CA2860933C/en active Active
- 2013-02-01 BR BR112014018767-3A patent/BR112014018767B1/pt active IP Right Grant
- 2013-02-01 AR ARP130100297A patent/AR089863A1/es unknown
- 2013-02-01 MX MX2014009356A patent/MX350793B/es active IP Right Grant
- 2013-02-01 CN CN201380007669.7A patent/CN104169281B/zh active Active
- 2013-02-01 PL PL13702225T patent/PL2809669T3/pl unknown
- 2013-02-01 PT PT137022257T patent/PT2809669T/pt unknown
-
2016
- 2016-02-11 US US15/041,541 patent/US9884860B2/en active Active
-
2017
- 2017-04-25 CY CY20171100459T patent/CY1119108T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20170618T1 (hr) | Kondenzirani piroldikarboksamidi i njihova uporaba kao farmaceutskih proizvoda | |
| CN106715430B (zh) | 抑制瞬时型感受器电位a1离子通道 | |
| CN110183440B (zh) | 杂芳基syk抑制剂 | |
| ES2312051T3 (es) | Compuestos que ejercen efecto sobre la glucoquinasa. | |
| ES2274047T3 (es) | Derivados de vinilfenilo como activadores de glk. | |
| US8383827B2 (en) | Aryl pyridine as aldosterone synthase inhibitors | |
| US8778972B2 (en) | 5-pyridin-3-yl-1, 3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1 | |
| JP6461121B2 (ja) | 新規の二環式ブロモドメイン阻害剤 | |
| RU2440992C2 (ru) | Бензоиламиногетероциклильные соединения в качестве активаторов глюкокиназы (glk) | |
| EP2993169B1 (en) | Aryl-pyridine derivatives as aldosterone synthase inhibitors | |
| US20090105263A1 (en) | Heterobicyclic compounds as glucokinase activators | |
| US20070255062A1 (en) | Benzoyl Amino Pyridyl Carboxylic Acid Derivatives Useful as Glucokinase (Glk) Activators | |
| JP2008516936A (ja) | ２型糖尿病および肥満の処置において有用であるフェノキシベンズアミド化合物 | |
| TWI690506B (zh) | 阻斷疾病之泛素化－蛋白酶體系統之胺萘醌化合物及醫藥組合物 | |
| EP1682509A1 (en) | Pyridine carboxylic acid derivatives as glucokinase modulators | |
| US20080234273A1 (en) | Heteroaryl Benzamide Derivatives for Use as Glk Activators in the Treatment of Diabetes | |
| ES2299886T3 (es) | Derivados de acidos benzoilaminopiridilcarboxilicos como activadores de glucoquinasa. | |
| US20070287693A1 (en) | Benzamide Derivatives That Act Upon The Glucokinase Enzyme | |
| WO2018214796A1 (zh) | 一类异吲哚酮-酰亚胺环-1,3-二酮-2-烯化合物、其组合物和用途 | |
| Kumar et al. | The synthesis and anticancer potentials of quinoline analogues: a review of literature | |
| JP2016508968A5 (https=) | ||
| TWI313601B (en) | Benzamide compounds, process for preparation thereof, and pharmaceutical compositions for treating or prevevting a disease or medical condition mediated through glucokinaswe (glk) comprising same | |
| CN101018773A (zh) | 在糖尿病治疗中用作glk激活剂的杂芳基苯甲酰胺衍生物 | |
| MXPA06004779A (en) | Pyridine carboxylic acid derivatives as glucokinase modulators |