HRP20161612T2 - Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, njihova priprava i uporaba istih - Google Patents
Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, njihova priprava i uporaba istih Download PDFInfo
- Publication number
- HRP20161612T2 HRP20161612T2 HRP20161612TT HRP20161612T HRP20161612T2 HR P20161612 T2 HRP20161612 T2 HR P20161612T2 HR P20161612T T HRP20161612T T HR P20161612TT HR P20161612 T HRP20161612 T HR P20161612T HR P20161612 T2 HRP20161612 T2 HR P20161612T2
- Authority
- HR
- Croatia
- Prior art keywords
- disease
- sulfate salt
- pharmaceutically acceptable
- propyl
- salt according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306690 | 2012-12-27 | ||
| EP13815780.5A EP2938597B1 (en) | 2012-12-27 | 2013-12-27 | Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
| PCT/EP2013/078068 WO2014102339A1 (en) | 2012-12-27 | 2013-12-27 | Sulphate salts of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine, preparation thereof and use of the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20161612T1 HRP20161612T1 (hr) | 2017-01-27 |
| HRP20161612T2 true HRP20161612T2 (hr) | 2017-02-24 |
Family
ID=47501005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161612TT HRP20161612T2 (hr) | 2012-12-27 | 2013-12-27 | Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, njihova priprava i uporaba istih |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9562018B2 (https=) |
| EP (1) | EP2938597B1 (https=) |
| JP (1) | JP6384923B2 (https=) |
| KR (1) | KR102115060B1 (https=) |
| CN (1) | CN105008333B (https=) |
| AU (2) | AU2013369288B2 (https=) |
| BR (1) | BR112015015474B1 (https=) |
| CA (1) | CA2895285C (https=) |
| DK (1) | DK2938597T3 (https=) |
| ES (1) | ES2605494T3 (https=) |
| HR (1) | HRP20161612T2 (https=) |
| HU (1) | HUE030930T2 (https=) |
| IL (1) | IL239450B (https=) |
| LT (1) | LT2938597T (https=) |
| MX (1) | MX363367B (https=) |
| NZ (1) | NZ708959A (https=) |
| PL (1) | PL2938597T3 (https=) |
| PT (1) | PT2938597T (https=) |
| RS (1) | RS55511B1 (https=) |
| RU (1) | RU2655454C2 (https=) |
| SI (1) | SI2938597T1 (https=) |
| WO (1) | WO2014102339A1 (https=) |
| ZA (1) | ZA201504521B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2938597T1 (sl) | 2012-12-27 | 2017-03-31 | Alzprotect | Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h- benzo(d)imidazol-2-amin, njihova priprava in uporaba istega |
| WO2016146655A1 (en) | 2015-03-16 | 2016-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel 1,4-bis(3-aminopropyl)piperazine derivative and its use |
| TWI744300B (zh) * | 2016-03-23 | 2021-11-01 | 里爾中央醫學中心 | 改良性熱處理的血小板顆粒裂解液在製備用於治療神經系統疾病的組合物的用途 |
| AU2021353998B2 (en) * | 2020-10-01 | 2024-02-29 | Alzprotect | Succinate salts of N-(3-(4-(3-(Diisobutylamino)Propyl)Piperazin-1-YL)Propyl)-1H-Benzo[D]Imidazol-2-Amine, Preparation Thereof And Use Of The Same |
| WO2022074093A1 (en) * | 2020-10-07 | 2022-04-14 | Alzprotect | Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine sulphate salts and solvates thereof for the treatment of motor neuron diseases and neuromuscular junction disorders |
| CA3243012A1 (en) | 2021-12-20 | 2023-06-29 | Alzprotect | USE OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[D]IMIDAZOL-2-AMINE SUCCINATE SALTS AND ASSOCIATED SOLVATES FOR THE TREATMENT OF MOTOR NERVE DISEASES AND NEUROMUSCULAR JUNCTION DISORDERS |
| US20250205226A1 (en) | 2022-03-25 | 2025-06-26 | Alzprotect | Use of n-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1h-benzo[d]imidazol-2-amine salts and solvates thereof for the treatment of sensory neuron diseases |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2674856B1 (fr) * | 1991-04-05 | 1993-07-30 | Esteve Labor Dr | Nouveaux antihistaminiques non sedatifs, derives de benzimidazole, leur procede de preparation et leur utilisation en tant que medicaments. |
| CA2263367A1 (fr) * | 1997-06-12 | 1998-12-17 | Transgene S.A. | Nouveaux complexes lipidiques pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique |
| AU6280199A (en) | 1998-09-30 | 2000-04-17 | Neurogen Corporation | 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands |
| WO2002096431A1 (en) * | 2001-05-25 | 2002-12-05 | The Regents Of The University Of California | Optically active compounds clearing malformed proteins |
| US20040116441A1 (en) * | 2002-10-30 | 2004-06-17 | Pfizer Inc | Methods of using sulfonic acid derivatives |
| JP4660199B2 (ja) * | 2002-12-23 | 2011-03-30 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換１−ピペリジン−４−イル−４−アゼチジン−３−イル−ピペラジン誘導体およびそれらのニューロキニン拮抗薬としての使用 |
| CA2585983C (en) * | 2004-11-10 | 2014-03-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of 1,4-bis (3-aminoalkyl) piperazine derivatives in the treatment of neurodegenerative diseases |
| SI2938597T1 (sl) * | 2012-12-27 | 2017-03-31 | Alzprotect | Sulfatne soli n-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h- benzo(d)imidazol-2-amin, njihova priprava in uporaba istega |
-
2013
- 2013-12-27 SI SI201330408A patent/SI2938597T1/sl unknown
- 2013-12-27 HR HRP20161612TT patent/HRP20161612T2/hr unknown
- 2013-12-27 PT PT138157805T patent/PT2938597T/pt unknown
- 2013-12-27 NZ NZ70895913A patent/NZ708959A/en unknown
- 2013-12-27 JP JP2015550088A patent/JP6384923B2/ja active Active
- 2013-12-27 LT LTEP13815780.5T patent/LT2938597T/lt unknown
- 2013-12-27 US US14/655,642 patent/US9562018B2/en active Active
- 2013-12-27 EP EP13815780.5A patent/EP2938597B1/en active Active
- 2013-12-27 AU AU2013369288A patent/AU2013369288B2/en active Active
- 2013-12-27 ES ES13815780.5T patent/ES2605494T3/es active Active
- 2013-12-27 RU RU2015130671A patent/RU2655454C2/ru active
- 2013-12-27 CN CN201380068524.8A patent/CN105008333B/zh active Active
- 2013-12-27 WO PCT/EP2013/078068 patent/WO2014102339A1/en not_active Ceased
- 2013-12-27 KR KR1020157017192A patent/KR102115060B1/ko active Active
- 2013-12-27 RS RS20161055A patent/RS55511B1/sr unknown
- 2013-12-27 HU HUE13815780A patent/HUE030930T2/hu unknown
- 2013-12-27 CA CA2895285A patent/CA2895285C/en active Active
- 2013-12-27 PL PL13815780T patent/PL2938597T3/pl unknown
- 2013-12-27 BR BR112015015474-3A patent/BR112015015474B1/pt active IP Right Grant
- 2013-12-27 DK DK13815780.5T patent/DK2938597T3/en active
- 2013-12-27 MX MX2015008502A patent/MX363367B/es unknown
-
2015
- 2015-06-16 IL IL239450A patent/IL239450B/en active IP Right Grant
- 2015-06-23 ZA ZA2015/04521A patent/ZA201504521B/en unknown
-
2016
- 2016-12-22 US US15/388,349 patent/US10537569B2/en active Active
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2018
- 2018-03-28 AU AU2018202218A patent/AU2018202218B2/en active Active
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2019
- 2019-08-27 US US16/552,436 patent/US10772884B2/en active Active
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