HRP20161376T1 - Emulzije ili mikroemulzije za uporabu u endoskopskoj mukoznoj resekciji i/ili endoskopskoj submukoznoj disekciji - Google Patents
Emulzije ili mikroemulzije za uporabu u endoskopskoj mukoznoj resekciji i/ili endoskopskoj submukoznoj disekciji Download PDFInfo
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- HRP20161376T1 HRP20161376T1 HRP20161376TT HRP20161376T HRP20161376T1 HR P20161376 T1 HRP20161376 T1 HR P20161376T1 HR P20161376T T HRP20161376T T HR P20161376TT HR P20161376 T HRP20161376 T HR P20161376T HR P20161376 T1 HRP20161376 T1 HR P20161376T1
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- emulsion
- pharmaceutical preparation
- poloxamer
- oil
- microemulsion according
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- 239000004530 micro-emulsion Substances 0.000 title claims 17
- 239000000839 emulsion Substances 0.000 title claims 16
- 238000012323 Endoscopic submucosal dissection Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 9
- 229920001983 poloxamer Polymers 0.000 claims 5
- 229960000502 poloxamer Drugs 0.000 claims 5
- 239000003921 oil Substances 0.000 claims 4
- 235000019198 oils Nutrition 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 150000002634 lipophilic molecules Chemical class 0.000 claims 3
- 239000012071 phase Substances 0.000 claims 3
- 229920001993 poloxamer 188 Polymers 0.000 claims 3
- 229940044519 poloxamer 188 Drugs 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 claims 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 claims 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 235000019489 Almond oil Nutrition 0.000 claims 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 claims 1
- 229920002507 Poloxamer 124 Polymers 0.000 claims 1
- 229920002511 Poloxamer 237 Polymers 0.000 claims 1
- 229920002517 Poloxamer 338 Polymers 0.000 claims 1
- 235000019485 Safflower oil Nutrition 0.000 claims 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 claims 1
- 239000008168 almond oil Substances 0.000 claims 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 1
- 239000000828 canola oil Substances 0.000 claims 1
- 235000019519 canola oil Nutrition 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- ALSTYHKOOCGGFT-UHFFFAOYSA-N cis-oleyl alcohol Natural products CCCCCCCCC=CCCCCCCCCO ALSTYHKOOCGGFT-UHFFFAOYSA-N 0.000 claims 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims 1
- 229940093471 ethyl oleate Drugs 0.000 claims 1
- -1 fatty acid esters Chemical class 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229940072106 hydroxystearate Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960003988 indigo carmine Drugs 0.000 claims 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 claims 1
- 235000012738 indigotine Nutrition 0.000 claims 1
- 239000004179 indigotine Substances 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 229960000907 methylthioninium chloride Drugs 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 claims 1
- 229940093448 poloxamer 124 Drugs 0.000 claims 1
- 229920001992 poloxamer 407 Polymers 0.000 claims 1
- 229940044476 poloxamer 407 Drugs 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 235000005713 safflower oil Nutrition 0.000 claims 1
- 239000003813 safflower oil Substances 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 1
- 229950003937 tolonium Drugs 0.000 claims 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
Claims (15)
1. Farmaceutski pripravak u obliku emulzije ili mikroemulzije, koji je u tekućoj fazi na temperaturi do oko 40°C in vitro, a koji sadrži:
a) vodenu fazu;
b) uljnu fazu;
c) barem jednu ne-ionsku površinski aktivnu tvar (surfaktant);
d) barem jedan poloksamer u količini između 5% i 12% težine, s obzirom na težinu pripravka;
e) po izboru barem jednu fiziološki prikladnu pomoćnu tvar;
f) barem jednu boju odabranu između Lugolove otopine, metilenskog modrila, toluidin plave, kristal violet, indigo karmin, kongo crvene i fenol crvene.
2. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje je taj pripravak emulzija ili mikroemulzija ulje-u-vodi.
3. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje taj pripravak ima viskoznost nižu od oko 0,15 Pa·s (150 cP), poželjno nižu od oko 0,1 Pa·s (100 cP), poželjnije nižu od oko 0,05 Pa·s (50 cP), još poželjnije nižu od oko 0,02 Pa·s (20 cP).
4. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 3, gdje se ta viskoznost mjeri na oko 25°C, oko 30°C i/ili oko 37°C.
5. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje je taj barem jedan poloksamer u količini između oko 5% i oko 11 % težine, s obzirom na težinu pripravka.
6. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje je taj barem jedan poloksamer u količini od oko 7%, oko 8%, oko 9% ili oko 10% težine, s obzirom na težinu pripravka.
7. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje se taj barem jedan poloksamer odabire između poloksamer 124, poloksamer 188, poloksamer 237, poloksamer 338, i poloksamer 407.
8. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 7, gdje taj barem jedan poloksamer jest poloksamer 188.
9. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 8, gdje je poloksamer 188 u količini od oko 10% težine, s obzirom na težinu pripravka.
10. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje ta uljna faza sadrži barem jedan lipofilni spoj.
11. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 10, gdje se taj barem jedan lipofilni spoj odabire između prirodnih ulja, kao što su bademovo ulje, kanola ulje, ricinusovo ulje, kukuruzno ulje, pamučno ulje, maslinovo ulje, ulje šafranike, sezamovo ulje, sojino ulje; estera masnih kiselina, kao što su izopropil palmitat, izopropil miristat, etil oleat; masnih alkohola, kao što su miristinski alkohol, oleinski alkohol; masnih kiselina, kao što su miristinska kiselina, oleinska kiselina, palmitinska kiselina; triglicerida, kao što su dugolančani i/ili srednjelančani trigliceridi; diglicerida i monoglicerida.
12. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 10, gdje je taj barem jedan lipofilni spoj srednjelančani triglicerid.
13. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 1, gdje se taj ne-ionski surfaktant odabire između polisorbata 80 i PEG-15 hidroksistearata.
14. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema bilo kojem od prethodnih zahtjeva, koji dalje sadrži barem jedan ko-surfaktant.
15. Farmaceutski pripravak u obliku emulzije ili mikroemulzije prema zahtjevu 14, gdje se taj barem jedan ko-surfaktant odabire između propilen glikola, glicerola i natrijevog oleata.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001924A ITMI20131924A1 (it) | 2013-11-20 | 2013-11-20 | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| EP14799474.3A EP2911707B1 (en) | 2013-11-20 | 2014-11-18 | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection |
| PCT/EP2014/074886 WO2015075024A1 (en) | 2013-11-20 | 2014-11-18 | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20161376T1 true HRP20161376T1 (hr) | 2016-12-02 |
Family
ID=49958555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20161376TT HRP20161376T1 (hr) | 2013-11-20 | 2016-10-21 | Emulzije ili mikroemulzije za uporabu u endoskopskoj mukoznoj resekciji i/ili endoskopskoj submukoznoj disekciji |
| HRP20210048TT HRP20210048T1 (hr) | 2013-11-20 | 2021-01-12 | Emulzije ili mikroemulzije namijenjene upotrebi u endoskopskoj resekciji sluznice i/ili endoskopskoj sekciji podsluznice |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210048TT HRP20210048T1 (hr) | 2013-11-20 | 2021-01-12 | Emulzije ili mikroemulzije namijenjene upotrebi u endoskopskoj resekciji sluznice i/ili endoskopskoj sekciji podsluznice |
Country Status (24)
| Country | Link |
|---|---|
| US (7) | US9226996B2 (hr) |
| EP (2) | EP2911707B1 (hr) |
| JP (2) | JP6675981B2 (hr) |
| KR (1) | KR102398802B1 (hr) |
| CN (2) | CN110665047B (hr) |
| AU (1) | AU2014352009B2 (hr) |
| BR (1) | BR112016011345B1 (hr) |
| CA (1) | CA2929911C (hr) |
| DK (2) | DK2911707T3 (hr) |
| ES (2) | ES2602964T3 (hr) |
| HK (1) | HK1210972A1 (hr) |
| HR (2) | HRP20161376T1 (hr) |
| HU (2) | HUE052870T2 (hr) |
| IL (1) | IL245118B (hr) |
| IT (1) | ITMI20131924A1 (hr) |
| LT (2) | LT2911707T (hr) |
| MX (2) | MX2016006581A (hr) |
| NZ (1) | NZ720148A (hr) |
| PL (2) | PL3106182T3 (hr) |
| PT (2) | PT2911707T (hr) |
| RS (2) | RS61290B1 (hr) |
| RU (1) | RU2696263C1 (hr) |
| WO (1) | WO2015075024A1 (hr) |
| ZA (1) | ZA201603313B (hr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20131924A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| ITMI20131927A1 (it) | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection. emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
| US10925978B2 (en) * | 2014-01-29 | 2021-02-23 | Cosmo Technologies Limited | Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum |
| WO2015143310A1 (en) | 2014-03-21 | 2015-09-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix |
| JP6692021B2 (ja) * | 2016-01-06 | 2020-05-13 | 国立大学法人 東京大学 | 眼科治療用ゲル材料 |
| EP3484485A1 (en) * | 2016-07-12 | 2019-05-22 | Centre National De La Recherche Scientifique | Compositions useful for mucosal healing |
| JP7007086B2 (ja) * | 2016-11-17 | 2022-01-24 | 地方独立行政法人東京都立産業技術研究センター | 粘膜下局注用コラーゲンゾル |
| CA3052489A1 (en) | 2017-03-02 | 2018-09-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Ecm hydrogel for treating esophageal inflammation |
| KR101884467B1 (ko) * | 2017-06-12 | 2018-08-02 | 한국맥널티 주식회사 | 알긴산 또는 그 약학적으로 허용되는 염과 콜로이드성 다당류를 함유하는 액상 조성물 |
| CN107281542B (zh) * | 2017-06-25 | 2020-11-13 | 长沙善道新材料科技有限公司 | 一种防色素沉积的液体创可贴及其制备方法 |
| CN111820995A (zh) * | 2017-11-10 | 2020-10-27 | 西安交通大学医学院第一附属医院 | 一种辅助内镜下粘膜剥离手术的装置 |
| WO2019246442A1 (en) * | 2018-06-21 | 2019-12-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of an extracellular matrix (ecm) hydrogel as an esophageal submucosal fluid cushion |
| CN115487364B (zh) * | 2018-06-21 | 2024-02-23 | 联邦高等教育系统匹兹堡大学 | 细胞外基质(ecm)水凝胶作为粘膜下流体垫 |
| CA3103973A1 (en) * | 2018-06-21 | 2019-12-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of a urinary bladder ecm hydrogel as an esophageal submucosal fluid cushion |
| US20220062498A1 (en) | 2018-12-21 | 2022-03-03 | Qmark Medical Inc. | Hydrogel composition for mucosal lifting procedures within lumenal anatomical structures |
| CA3130684A1 (en) | 2019-03-13 | 2020-09-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Acoustic extracellular matrix hydrogels and their use |
| KR102027311B1 (ko) * | 2019-03-27 | 2019-10-02 | 주식회사 티젤바이오 | 염증성 비정상 조직 또는 종양 조직의 선택적 염색이 가능한 나노 진단 제제의 제조 방법 |
| RU203313U1 (ru) * | 2020-11-18 | 2021-03-31 | Александр Александрович Соколов | Устройство для проведения холодовой ишемии при резекции |
| RU2756489C1 (ru) * | 2020-12-14 | 2021-09-30 | Государственное автономное учреждение здравоохранения "Межрегиональный клинико-диагностический центр", сокращенно - ГАУЗ "МКДЦ" | Способ эндоскопической подслизистой диссекции колоректальных образований |
| EP4154865A1 (en) * | 2021-09-23 | 2023-03-29 | Ovesco Endoscopy AG | Process for manufacturing an injection agent and injection agent obtainable by this process |
| KR102449537B1 (ko) * | 2022-01-27 | 2022-10-05 | 주식회사 나노메디팜 | 근적외선을 이용하여 진단 생검 또는 종양 제거 수술 중에 종양 식별과 절제면 구분을 위한 종양 표적 진단 조영제 |
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| US3740421A (en) | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
| KR19980033213A (ko) | 1996-10-31 | 1998-07-25 | 조셉제이.스위니 | 스퍼터링 챔버내의 미립자 물질 발생 감소 방법 |
| ES2261210T3 (es) * | 1999-06-21 | 2006-11-16 | Kuhnil Pharmaceutical Co., Ltd. | Comoposicion anestesica para inyeccion intravenosa que comprende propofol. |
| US8802116B2 (en) * | 2003-02-27 | 2014-08-12 | Novasel Australia Pty. Ltd. | Poloxamer emulsion preparations |
| EP1605922A4 (en) * | 2003-03-24 | 2011-03-16 | Biosphere Medical Inc | TEMPORARY EMBOLIZATION USING REVERSIBLE THERMOSENSIVE POLYMERS WITH MOMENTARY ACTION |
| US7909809B2 (en) | 2004-09-27 | 2011-03-22 | Boston Scientific Scimed, Inc. | Devices and methods for agent-assisted medical procedures |
| US8232621B2 (en) | 2006-07-28 | 2012-07-31 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device |
| EP2094169A4 (en) * | 2006-12-11 | 2016-05-04 | Pluromed Inc | HEMOSTASIS OF PERFUSED ORGANS |
| AU2008242331B2 (en) * | 2007-04-17 | 2013-11-14 | Covidien Lp | Colon polyp staging methods |
| CN107029277A (zh) | 2007-11-29 | 2017-08-11 | 健赞公司 | 使用纯化的逆向热敏聚合物的内镜粘膜切除 |
| RU2409363C9 (ru) * | 2009-09-18 | 2013-12-10 | Всеволод Иванович Киселев | Фармацевтические композиции для пероральной доставки дииндолилметана (dim) и способы применения этих композиций |
| CN102048688B (zh) * | 2009-10-29 | 2014-03-05 | 中国医学科学院药物研究所 | 以胆固醇复合物为中间载体的紫杉醇亚微乳 |
| JP2013520233A (ja) | 2010-02-19 | 2013-06-06 | クック メディカル テクノロジーズ エルエルシー | 内視鏡的粘膜下層剥離術のための装置及び方法 |
| ITMI20131924A1 (it) * | 2013-11-20 | 2015-05-21 | Cosmo Technologies Ltd | Emulsions or microemulsions for use in endoscopic mucosal resectioning and/or endoscopic submucosal dissection emulsioni o microemulsioni per uso nella resezione mucosale endoscopica e/o dissezione submucosale endoscopica |
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2013
- 2013-11-20 IT IT001924A patent/ITMI20131924A1/it unknown
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2014
- 2014-11-18 PT PT147994743T patent/PT2911707T/pt unknown
- 2014-11-18 LT LTEP14799474.3T patent/LT2911707T/lt unknown
- 2014-11-18 JP JP2016533027A patent/JP6675981B2/ja active Active
- 2014-11-18 CN CN201910950677.4A patent/CN110665047B/zh active Active
- 2014-11-18 LT LTEP16179259.3T patent/LT3106182T/lt unknown
- 2014-11-18 WO PCT/EP2014/074886 patent/WO2015075024A1/en active Application Filing
- 2014-11-18 CN CN201480063659.XA patent/CN105848689B/zh active Active
- 2014-11-18 ES ES14799474.3T patent/ES2602964T3/es active Active
- 2014-11-18 NZ NZ720148A patent/NZ720148A/en unknown
- 2014-11-18 HU HUE16179259A patent/HUE052870T2/hu unknown
- 2014-11-18 PT PT161792593T patent/PT3106182T/pt unknown
- 2014-11-18 AU AU2014352009A patent/AU2014352009B2/en active Active
- 2014-11-18 US US14/546,925 patent/US9226996B2/en active Active
- 2014-11-18 CA CA2929911A patent/CA2929911C/en active Active
- 2014-11-18 RU RU2016124105A patent/RU2696263C1/ru active
- 2014-11-18 BR BR112016011345-4A patent/BR112016011345B1/pt active IP Right Grant
- 2014-11-18 MX MX2016006581A patent/MX2016006581A/es active IP Right Grant
- 2014-11-18 MX MX2020011901A patent/MX2020011901A/es unknown
- 2014-11-18 PL PL16179259T patent/PL3106182T3/pl unknown
- 2014-11-18 PL PL14799474T patent/PL2911707T3/pl unknown
- 2014-11-18 RS RS20210029A patent/RS61290B1/sr unknown
- 2014-11-18 HU HUE14799474A patent/HUE031801T2/en unknown
- 2014-11-18 RS RS20160944A patent/RS55330B1/sr unknown
- 2014-11-18 DK DK14799474.3T patent/DK2911707T3/en active
- 2014-11-18 DK DK16179259.3T patent/DK3106182T3/da active
- 2014-11-18 KR KR1020167015648A patent/KR102398802B1/ko active IP Right Grant
- 2014-11-18 ES ES16179259T patent/ES2843521T3/es active Active
- 2014-11-18 EP EP14799474.3A patent/EP2911707B1/en active Active
- 2014-11-18 US US15/038,018 patent/US9987366B2/en active Active
- 2014-11-18 EP EP16179259.3A patent/EP3106182B1/en active Active
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2015
- 2015-11-24 US US14/950,525 patent/US9364580B2/en active Active
- 2015-12-01 HK HK15111812.6A patent/HK1210972A1/zh unknown
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2016
- 2016-04-14 IL IL245118A patent/IL245118B/en active IP Right Grant
- 2016-05-13 US US15/154,857 patent/US9522216B2/en active Active
- 2016-05-16 ZA ZA2016/03313A patent/ZA201603313B/en unknown
- 2016-10-21 HR HRP20161376TT patent/HRP20161376T1/hr unknown
- 2016-10-26 US US15/334,496 patent/US9962445B2/en active Active
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2018
- 2018-04-25 US US15/962,458 patent/US10413611B2/en active Active
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2019
- 2019-08-09 US US16/536,572 patent/US10849979B2/en active Active
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2020
- 2020-03-11 JP JP2020041957A patent/JP6978537B2/ja active Active
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2021
- 2021-01-12 HR HRP20210048TT patent/HRP20210048T1/hr unknown
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