HRP20160609T1 - Postupci liječenja hepatocelularnog karcinoma - Google Patents
Postupci liječenja hepatocelularnog karcinoma Download PDFInfo
- Publication number
- HRP20160609T1 HRP20160609T1 HRP20160609TT HRP20160609T HRP20160609T1 HR P20160609 T1 HRP20160609 T1 HR P20160609T1 HR P20160609T T HRP20160609T T HR P20160609TT HR P20160609 T HRP20160609 T HR P20160609T HR P20160609 T1 HRP20160609 T1 HR P20160609T1
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- Prior art keywords
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- combination
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- agent
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Links
- 206010073071 hepatocellular carcinoma Diseases 0.000 title claims 16
- 231100000844 hepatocellular carcinoma Toxicity 0.000 title claims 16
- 238000000034 method Methods 0.000 title claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000002105 nanoparticle Substances 0.000 claims 6
- 229940123237 Taxane Drugs 0.000 claims 5
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 5
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- -1 RUNXITI Proteins 0.000 claims 4
- 101000831940 Homo sapiens Stathmin Proteins 0.000 claims 3
- 102100024237 Stathmin Human genes 0.000 claims 3
- 230000025090 microtubule depolymerization Effects 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 2
- 102100028247 Abl interactor 1 Human genes 0.000 claims 1
- 108010040168 Bcl-2-Like Protein 11 Proteins 0.000 claims 1
- 102000001765 Bcl-2-Like Protein 11 Human genes 0.000 claims 1
- 102000017925 CHRM3 Human genes 0.000 claims 1
- 102100033592 Calponin-3 Human genes 0.000 claims 1
- 102000011068 Cdc42 Human genes 0.000 claims 1
- 102100028633 Cdc42-interacting protein 4 Human genes 0.000 claims 1
- 102100024351 Dedicator of cytokinesis protein 7 Human genes 0.000 claims 1
- 102100031477 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit Human genes 0.000 claims 1
- 101710167313 Drebrin-like protein Proteins 0.000 claims 1
- 102100028570 Drebrin-like protein Human genes 0.000 claims 1
- 102100036825 Erythroid membrane-associated protein Human genes 0.000 claims 1
- 241000598860 Garcinia hanburyi Species 0.000 claims 1
- 102100027421 Heat shock cognate 71 kDa protein Human genes 0.000 claims 1
- 102100021453 Histone deacetylase 5 Human genes 0.000 claims 1
- 102100035042 Histone-lysine N-methyltransferase EHMT2 Human genes 0.000 claims 1
- 101000724225 Homo sapiens Abl interactor 1 Proteins 0.000 claims 1
- 101000945410 Homo sapiens Calponin-3 Proteins 0.000 claims 1
- 101000766830 Homo sapiens Cdc42-interacting protein 4 Proteins 0.000 claims 1
- 101001052952 Homo sapiens Dedicator of cytokinesis protein 7 Proteins 0.000 claims 1
- 101001130785 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48 kDa subunit Proteins 0.000 claims 1
- 101000851733 Homo sapiens Erythroid membrane-associated protein Proteins 0.000 claims 1
- 101001080568 Homo sapiens Heat shock cognate 71 kDa protein Proteins 0.000 claims 1
- 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 claims 1
- 101000877312 Homo sapiens Histone-lysine N-methyltransferase EHMT2 Proteins 0.000 claims 1
- 101000928919 Homo sapiens Muscarinic acetylcholine receptor M3 Proteins 0.000 claims 1
- 101000597499 Homo sapiens Obg-like ATPase 1 Proteins 0.000 claims 1
- 101000596046 Homo sapiens Plastin-2 Proteins 0.000 claims 1
- 101000877404 Homo sapiens Protein enabled homolog Proteins 0.000 claims 1
- 101000983130 Homo sapiens Protein kinase C and casein kinase substrate in neurons protein 2 Proteins 0.000 claims 1
- 101000615238 Homo sapiens Proto-oncogene DBL Proteins 0.000 claims 1
- 101001130509 Homo sapiens Ras GTPase-activating protein 1 Proteins 0.000 claims 1
- 101001106403 Homo sapiens Rho GTPase-activating protein 4 Proteins 0.000 claims 1
- 101000697510 Homo sapiens Stathmin-2 Proteins 0.000 claims 1
- 101000762938 Homo sapiens TOX high mobility group box family member 4 Proteins 0.000 claims 1
- 101000713585 Homo sapiens Tubulin beta-4A chain Proteins 0.000 claims 1
- 108091022875 Microtubule Proteins 0.000 claims 1
- 102000029749 Microtubule Human genes 0.000 claims 1
- 206010027761 Mixed hepatocellular cholangiocarcinoma Diseases 0.000 claims 1
- 102100035415 Obg-like ATPase 1 Human genes 0.000 claims 1
- 229930012538 Paclitaxel Natural products 0.000 claims 1
- 102100035182 Plastin-2 Human genes 0.000 claims 1
- 102100035093 Protein enabled homolog Human genes 0.000 claims 1
- 102100026843 Protein kinase C and casein kinase substrate in neurons protein 2 Human genes 0.000 claims 1
- 102100021384 Proto-oncogene DBL Human genes 0.000 claims 1
- 102100031426 Ras GTPase-activating protein 1 Human genes 0.000 claims 1
- 102100021431 Rho GTPase-activating protein 4 Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 102100028051 Stathmin-2 Human genes 0.000 claims 1
- 108010040632 Transforming Protein 2 Src Homology 2 Domain-Containing Proteins 0.000 claims 1
- 102000002016 Transforming Protein 2 Src Homology 2 Domain-Containing Human genes 0.000 claims 1
- 102000004243 Tubulin Human genes 0.000 claims 1
- 108090000704 Tubulin Proteins 0.000 claims 1
- 102100036788 Tubulin beta-4A chain Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 108010051348 cdc42 GTP-Binding Protein Proteins 0.000 claims 1
- 208000011588 combined hepatocellular carcinoma and cholangiocarcinoma Diseases 0.000 claims 1
- 201000004098 fibrolamellar carcinoma Diseases 0.000 claims 1
- 229940117709 gamboge Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 210000004688 microtubule Anatomy 0.000 claims 1
- 230000000683 nonmetastatic effect Effects 0.000 claims 1
- 229960001592 paclitaxel Drugs 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31815310P | 2010-03-26 | 2010-03-26 | |
PCT/US2011/030037 WO2011119988A1 (en) | 2010-03-26 | 2011-03-25 | Methods of treatment of hepatocellular carcinoma |
EP11760333.2A EP2552438B1 (en) | 2010-03-26 | 2011-03-25 | Methods of treatment of hepatocellular carcinoma |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20160609T1 true HRP20160609T1 (hr) | 2016-09-23 |
Family
ID=44673662
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20160609TT HRP20160609T1 (hr) | 2010-03-26 | 2016-06-06 | Postupci liječenja hepatocelularnog karcinoma |
Country Status (21)
Country | Link |
---|---|
US (3) | US9370494B2 (pl) |
EP (2) | EP2898884B1 (pl) |
JP (2) | JP5847156B2 (pl) |
KR (1) | KR101786142B1 (pl) |
CN (2) | CN103052385B (pl) |
AU (1) | AU2011230512B2 (pl) |
BR (1) | BR112012024349A2 (pl) |
CA (2) | CA3051495A1 (pl) |
DK (1) | DK2552438T3 (pl) |
ES (2) | ES2675212T3 (pl) |
HK (2) | HK1181665A1 (pl) |
HR (1) | HRP20160609T1 (pl) |
HU (1) | HUE027749T2 (pl) |
IL (2) | IL221886A (pl) |
LT (1) | LT2552438T (pl) |
MX (2) | MX359413B (pl) |
NZ (1) | NZ602382A (pl) |
PL (1) | PL2552438T3 (pl) |
PT (1) | PT2552438T (pl) |
TW (1) | TWI495467B (pl) |
WO (1) | WO2011119988A1 (pl) |
Families Citing this family (37)
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US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
AU2003299590B8 (en) | 2002-12-09 | 2010-04-08 | Abraxis Bioscience, Llc | Compositions and methods of delivery of pharmacological agents |
PL3248600T3 (pl) | 2005-02-18 | 2020-09-07 | Abraxis Bioscience, Llc | Połączenia i sposoby podawania środków terapeutycznych i terapia skojarzona |
US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
BRPI0615265A8 (pt) | 2005-08-31 | 2018-03-06 | Abraxis Bioscience Llc | composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos |
ES2700074T3 (es) | 2006-12-14 | 2019-02-13 | Abraxis Bioscience Llc | Terapia para el cáncer de mama sobre la base del estado de los receptores hormonales con nanopartículas que comprenden taxano |
PL2481402T3 (pl) * | 2007-03-07 | 2018-11-30 | Abraxis Bioscience, Llc | Nanocząstka zawierająca rapamycynę i albuminę jako środek przeciwnowotworowy |
JP5579057B2 (ja) * | 2007-06-01 | 2014-08-27 | アブラクシス バイオサイエンス, エルエルシー | 再発性癌の処置のための方法および組成物 |
HUE047376T2 (hu) | 2009-04-15 | 2020-04-28 | Abraxis Bioscience Llc | Prionmentes nanorészecske-készítmények és elõállításuk |
LT2552438T (lt) | 2010-03-26 | 2016-09-26 | Abraxis Bioscience, Llc | Hepatoceliulinės karcinomos gydymo būdai |
NZ628423A (en) | 2010-03-29 | 2016-03-31 | Abraxis Bioscience Llc | Methods of treating cancer |
KR20130028727A (ko) | 2010-03-29 | 2013-03-19 | 아브락시스 바이오사이언스, 엘엘씨 | 치료제의 약물 전달 및 유효성 향상 방법 |
SG186112A1 (en) | 2010-06-04 | 2013-01-30 | Abraxis Bioscience Llc | Methods of treatment of pancreatic cancer |
CN103648521A (zh) | 2011-04-28 | 2014-03-19 | 阿布拉科斯生物科学有限公司 | 纳米颗粒组合物的血管内递送及其应用 |
RU2705998C2 (ru) | 2011-12-14 | 2019-11-13 | АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи | Применение полимерных эксципиентов для лиофилизации или заморозки частиц |
US9149455B2 (en) | 2012-11-09 | 2015-10-06 | Abraxis Bioscience, Llc | Methods of treating melanoma |
US20140186447A1 (en) * | 2012-12-28 | 2014-07-03 | Abraxis Bioscience, Llc | Nanoparticle compositions of albumin and paclitaxel |
US9511046B2 (en) | 2013-01-11 | 2016-12-06 | Abraxis Bioscience, Llc | Methods of treating pancreatic cancer |
EP2968254B1 (en) | 2013-03-12 | 2020-04-22 | Abraxis BioScience, LLC | Methods of treating lung cancer |
KR20150127187A (ko) | 2013-03-14 | 2015-11-16 | 아브락시스 바이오사이언스, 엘엘씨 | 방광암의 치료 방법 |
BR112015029853A2 (pt) | 2013-05-30 | 2017-07-25 | Nanobiotix | uso de uma composição farmacêutica |
US20150247204A1 (en) * | 2014-02-07 | 2015-09-03 | The General Hopital Corporation | Differential diagnosis of hepatic neoplasms |
AR102778A1 (es) | 2014-11-25 | 2017-03-22 | Nanobiotix | Composición farmacéutica, su preparación y sus usos |
EP3229776B1 (en) | 2014-11-25 | 2023-06-28 | Curadigm Sas | Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof |
US11304902B2 (en) | 2014-11-25 | 2022-04-19 | Curadigm Sas | Pharmaceutical compositions, preparation and uses thereof |
JP6789960B2 (ja) | 2014-11-25 | 2020-11-25 | キュラディグム・エスアエスCuradigm Sas | 医薬組成物、その調製及び使用 |
US10705070B1 (en) | 2015-03-05 | 2020-07-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug |
US10527604B1 (en) | 2015-03-05 | 2020-01-07 | Abraxis Bioscience, Llc | Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel |
AR104806A1 (es) | 2015-05-28 | 2017-08-16 | Nanobiotix | Nanopartículas para uso como vacuna terapéutica |
AU2016285720C1 (en) | 2015-06-29 | 2022-02-03 | Abraxis Bioscience, Llc | Methods of treating epithelioid cell tumors |
MX2019003694A (es) * | 2016-10-07 | 2019-06-24 | Abraxis Bioscience Llc | Metodos para tratar cancer del tracto biliar. |
US11419842B2 (en) * | 2016-10-27 | 2022-08-23 | Zhuhai Beihai Biotech Co., Ltd. | Neutral pH compositions of Docetaxel and human serum albumin |
US10896749B2 (en) * | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
CN107828887A (zh) * | 2017-10-12 | 2018-03-23 | 上海市东方医院 | Stmn1基因的用途 |
SG11202009145PA (en) | 2018-03-20 | 2020-10-29 | Abraxis Bioscience Llc | Methods of treating central nervous system disorders via administration of nanoparticles of an mtor inhibitor and an albumin |
MX2022004989A (es) | 2019-10-28 | 2022-07-21 | Abraxis Bioscience Llc | Composiciones farmaceuticas de albumina y rapamicina. |
WO2023072755A1 (en) * | 2021-10-26 | 2023-05-04 | Lipogems International S.P.A. | Microfragmented fat tissue as drug delivery system in liver cancer therapy |
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US8735394B2 (en) | 2005-02-18 | 2014-05-27 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
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