HRP20120526T1 - Radiofarmaceutski pripravci koji sadrže polisaharide vezane na poliamine - Google Patents
Radiofarmaceutski pripravci koji sadrže polisaharide vezane na poliamine Download PDFInfo
- Publication number
- HRP20120526T1 HRP20120526T1 HRP20120526AT HRP20120526T HRP20120526T1 HR P20120526 T1 HRP20120526 T1 HR P20120526T1 HR P20120526A T HRP20120526A T HR P20120526AT HR P20120526 T HRP20120526 T HR P20120526T HR P20120526 T1 HRP20120526 T1 HR P20120526T1
- Authority
- HR
- Croatia
- Prior art keywords
- polysaccharide
- preparation
- bringing
- contact
- polyvalent metal
- Prior art date
Links
- 150000004676 glycans Chemical class 0.000 title claims abstract 21
- 229920001282 polysaccharide Polymers 0.000 title claims abstract 21
- 239000005017 polysaccharide Substances 0.000 title claims abstract 21
- 239000000203 mixture Substances 0.000 title claims abstract 3
- 229920000768 polyamine Polymers 0.000 title 1
- 229940121896 radiopharmaceutical Drugs 0.000 title 1
- 239000012217 radiopharmaceutical Substances 0.000 title 1
- 230000002799 radiopharmaceutical effect Effects 0.000 title 1
- VHRGRCVQAFMJIZ-UHFFFAOYSA-N cadaverine Chemical compound NCCCCCN VHRGRCVQAFMJIZ-UHFFFAOYSA-N 0.000 claims abstract 12
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims abstract 12
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims abstract 12
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims abstract 10
- 230000000536 complexating effect Effects 0.000 claims abstract 9
- 229910052751 metal Inorganic materials 0.000 claims abstract 9
- 239000002184 metal Substances 0.000 claims abstract 9
- 239000005700 Putrescine Substances 0.000 claims abstract 6
- 229940063673 spermidine Drugs 0.000 claims abstract 6
- 229940063675 spermine Drugs 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 239000003638 chemical reducing agent Substances 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 238000004519 manufacturing process Methods 0.000 claims abstract 3
- 239000007800 oxidant agent Substances 0.000 claims abstract 3
- 230000003647 oxidation Effects 0.000 claims abstract 3
- 238000007254 oxidation reaction Methods 0.000 claims abstract 3
- 230000001590 oxidative effect Effects 0.000 claims abstract 3
- 238000012800 visualization Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 210000000952 spleen Anatomy 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- 229910052718 tin Inorganic materials 0.000 claims 2
- 229920000936 Agarose Polymers 0.000 claims 1
- 229920000945 Amylopectin Polymers 0.000 claims 1
- 229920000856 Amylose Polymers 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- GYHNNYVSQQEPJS-UHFFFAOYSA-N Gallium Chemical compound [Ga] GYHNNYVSQQEPJS-UHFFFAOYSA-N 0.000 claims 1
- 229910052765 Lutetium Inorganic materials 0.000 claims 1
- 229920001218 Pullulan Polymers 0.000 claims 1
- 239000004373 Pullulan Substances 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 229910052772 Samarium Inorganic materials 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 1
- 229910052733 gallium Inorganic materials 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- OHSVLFRHMCKCQY-UHFFFAOYSA-N lutetium atom Chemical compound [Lu] OHSVLFRHMCKCQY-UHFFFAOYSA-N 0.000 claims 1
- 238000011271 lymphoscintigraphy Methods 0.000 claims 1
- 230000002906 microbiologic effect Effects 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229910052702 rhenium Inorganic materials 0.000 claims 1
- WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 claims 1
- KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 claims 1
- 229910052706 scandium Inorganic materials 0.000 claims 1
- SIXSYDAISGFNSX-UHFFFAOYSA-N scandium atom Chemical compound [Sc] SIXSYDAISGFNSX-UHFFFAOYSA-N 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 229910052712 strontium Inorganic materials 0.000 claims 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229910052713 technetium Inorganic materials 0.000 claims 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 1
- 229910052727 yttrium Inorganic materials 0.000 claims 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
- A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95209407P | 2007-07-26 | 2007-07-26 | |
| FR0756750A FR2919189A1 (fr) | 2007-07-26 | 2007-07-26 | Nouvelles compositions a base de polyosides greffes par des composes polyamines ou polysoufres. |
| PCT/EP2008/059825 WO2009013358A2 (en) | 2007-07-26 | 2008-07-25 | New compositions based on polysaccharides grafted by polyamine or polysulphurised compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120526T1 true HRP20120526T1 (hr) | 2012-07-31 |
Family
ID=38896852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120526AT HRP20120526T1 (hr) | 2007-07-26 | 2012-06-21 | Radiofarmaceutski pripravci koji sadrže polisaharide vezane na poliamine |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9023396B2 (pt) |
| EP (1) | EP2175888B1 (pt) |
| JP (1) | JP5946241B2 (pt) |
| KR (1) | KR101562817B1 (pt) |
| CN (1) | CN101861171B (pt) |
| AU (1) | AU2008278976B2 (pt) |
| BR (1) | BRPI0814470B1 (pt) |
| CA (1) | CA2694582C (pt) |
| CY (1) | CY1113022T1 (pt) |
| DK (1) | DK2175888T3 (pt) |
| ES (1) | ES2386849T3 (pt) |
| FR (1) | FR2919189A1 (pt) |
| HK (1) | HK1149211A1 (pt) |
| HR (1) | HRP20120526T1 (pt) |
| IL (1) | IL203512A (pt) |
| MX (1) | MX2010001013A (pt) |
| PL (1) | PL2175888T3 (pt) |
| PT (1) | PT2175888E (pt) |
| RS (1) | RS52405B (pt) |
| RU (1) | RU2481856C2 (pt) |
| SI (1) | SI2175888T1 (pt) |
| WO (1) | WO2009013358A2 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101664444B1 (ko) * | 2013-12-13 | 2016-10-12 | 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 | 생분해성 의료용 접착제 또는 실란트 조성물 |
| RU2570114C1 (ru) * | 2014-09-17 | 2015-12-10 | Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук | Способ получения водорастворимых полимерных комплексов радиоизотопов |
| JP7025021B2 (ja) * | 2015-10-26 | 2022-02-24 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 還元多糖および酸化多糖ならびにそれらの使用の方法 |
| PL240772B1 (pl) * | 2018-06-11 | 2022-06-06 | Nanothea Spolka Akcyjna | Sposób wytwarzania nanocząstek polimerowych chelatujących izotopy promieniotwórcze do zastosowania w diagnostyce i terapii |
| CN108785323B (zh) * | 2018-06-26 | 2020-09-18 | 中国医学科学院基础医学研究所 | 作为免疫增强剂的精胺修饰的普鲁兰多糖 |
| CN115490774A (zh) * | 2022-08-16 | 2022-12-20 | 湖北第二师范学院 | 一种精胺修饰羟乙基直链淀粉基因转染材料及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7412164L (sv) | 1974-09-27 | 1976-03-29 | Pharmacia Ab | Medel for intravaskuler administrering |
| SE9803482D0 (sv) * | 1998-10-13 | 1998-10-13 | Anders Holmberg | Ion exchange tumor targeting (IETT) |
| FR2797769B1 (fr) * | 1999-09-01 | 2003-07-25 | Cis Bio Int | Produits radiopharmaceutiques et leur procede de preparation |
| US6756363B1 (en) * | 2000-11-17 | 2004-06-29 | Wound Healing Of Oklahoma, Inc. | Solutions and films of glycated chitosan |
| GB0028879D0 (en) * | 2000-11-27 | 2001-01-10 | Prometic Biosciences Ltd | Adsorbents and their use |
| JP2003104914A (ja) * | 2001-09-28 | 2003-04-09 | Yasuhiko Tabata | Ｄｎａ−金属−水溶性高分子複合体 |
| WO2006088473A2 (en) | 2004-04-23 | 2006-08-24 | Panduranga Rao Koritala | Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents |
| CN1308339C (zh) | 2005-02-28 | 2007-04-04 | 潘尚仁 | 99m锝标记的多胺类络合物肿瘤诊断显像剂及其制备 |
-
2007
- 2007-07-26 FR FR0756750A patent/FR2919189A1/fr not_active Withdrawn
-
2008
- 2008-07-25 US US12/670,811 patent/US9023396B2/en active Active
- 2008-07-25 RU RU2010107029/15A patent/RU2481856C2/ru active
- 2008-07-25 ES ES08775355T patent/ES2386849T3/es active Active
- 2008-07-25 WO PCT/EP2008/059825 patent/WO2009013358A2/en active Application Filing
- 2008-07-25 JP JP2010517415A patent/JP5946241B2/ja active Active
- 2008-07-25 CA CA2694582A patent/CA2694582C/en active Active
- 2008-07-25 PL PL08775355T patent/PL2175888T3/pl unknown
- 2008-07-25 BR BRPI0814470-2A patent/BRPI0814470B1/pt active IP Right Grant
- 2008-07-25 MX MX2010001013A patent/MX2010001013A/es active IP Right Grant
- 2008-07-25 PT PT08775355T patent/PT2175888E/pt unknown
- 2008-07-25 RS RS20120299A patent/RS52405B/en unknown
- 2008-07-25 SI SI200830730T patent/SI2175888T1/sl unknown
- 2008-07-25 DK DK08775355.4T patent/DK2175888T3/da active
- 2008-07-25 AU AU2008278976A patent/AU2008278976B2/en active Active
- 2008-07-25 EP EP08775355A patent/EP2175888B1/en active Active
- 2008-07-25 CN CN2008801043115A patent/CN101861171B/zh active Active
- 2008-07-25 KR KR1020107004356A patent/KR101562817B1/ko active IP Right Grant
-
2010
- 2010-01-26 IL IL203512A patent/IL203512A/en active IP Right Grant
-
2011
- 2011-04-11 HK HK11103631.6A patent/HK1149211A1/xx unknown
-
2012
- 2012-06-21 HR HRP20120526AT patent/HRP20120526T1/hr unknown
- 2012-08-07 CY CY20121100708T patent/CY1113022T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2694582A1 (en) | 2009-01-29 |
| RU2010107029A (ru) | 2011-09-10 |
| IL203512A (en) | 2015-01-29 |
| DK2175888T3 (da) | 2012-07-09 |
| FR2919189A1 (fr) | 2009-01-30 |
| WO2009013358A3 (en) | 2009-10-22 |
| US20100254906A1 (en) | 2010-10-07 |
| AU2008278976B2 (en) | 2014-04-17 |
| PT2175888E (pt) | 2012-07-23 |
| KR20100089059A (ko) | 2010-08-11 |
| CN101861171A (zh) | 2010-10-13 |
| MX2010001013A (es) | 2010-08-02 |
| HK1149211A1 (en) | 2011-09-30 |
| ES2386849T3 (es) | 2012-09-03 |
| CY1113022T1 (el) | 2016-04-13 |
| RU2481856C2 (ru) | 2013-05-20 |
| EP2175888B1 (en) | 2012-06-13 |
| CA2694582C (en) | 2016-02-16 |
| AU2008278976A1 (en) | 2009-01-29 |
| RS52405B (en) | 2013-02-28 |
| WO2009013358A2 (en) | 2009-01-29 |
| CN101861171B (zh) | 2013-07-17 |
| US9023396B2 (en) | 2015-05-05 |
| JP2010534732A (ja) | 2010-11-11 |
| BRPI0814470B1 (pt) | 2022-03-08 |
| PL2175888T3 (pl) | 2012-10-31 |
| KR101562817B1 (ko) | 2015-10-26 |
| SI2175888T1 (sl) | 2012-10-30 |
| JP5946241B2 (ja) | 2016-07-06 |
| BRPI0814470A2 (pt) | 2017-05-16 |
| EP2175888A2 (en) | 2010-04-21 |
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