HRP20120202T1 - AMIDOFENOKSIINDAZOLI, KORISNI KAO INHIBITORI c-MET - Google Patents
AMIDOFENOKSIINDAZOLI, KORISNI KAO INHIBITORI c-MET Download PDFInfo
- Publication number
- HRP20120202T1 HRP20120202T1 HR20120202T HRP20120202T HRP20120202T1 HR P20120202 T1 HRP20120202 T1 HR P20120202T1 HR 20120202 T HR20120202 T HR 20120202T HR P20120202 T HRP20120202 T HR P20120202T HR P20120202 T1 HRP20120202 T1 HR P20120202T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- methyl
- compound according
- cancer
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- -1 2-methoxypyrimidin-5-yl Chemical group 0.000 claims abstract 22
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 17
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 150000003839 salts Chemical class 0.000 claims abstract 15
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 4
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000011654 childhood malignant neoplasm Diseases 0.000 claims 1
- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical group CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000026037 malignant tumor of neck Diseases 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- QHADVLVFMKEIIP-UHFFFAOYSA-N n-[3-fluoro-4-[1-methyl-6-(1h-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxamide Chemical compound O=C1N(C=2C=CC(F)=CC=2)C(C)=CC=C1C(=O)NC(C=C1F)=CC=C1OC1=CC=2C=NN(C)C=2C=C1C=1C=NNC=1 QHADVLVFMKEIIP-UHFFFAOYSA-N 0.000 claims 1
- XCPSZMLNENDLKG-UHFFFAOYSA-N n-[3-fluoro-4-[1-methyl-6-(1h-pyrazol-4-yl)indazol-5-yl]oxyphenyl]-6-methyl-2-oxo-1-phenylpyridine-3-carboxamide Chemical compound O=C1N(C=2C=CC=CC=2)C(C)=CC=C1C(=O)NC(C=C1F)=CC=C1OC1=CC=2C=NN(C)C=2C=C1C=1C=NNC=1 XCPSZMLNENDLKG-UHFFFAOYSA-N 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- IWUCHFKAVLZIBD-UHFFFAOYSA-N NCN(C)F Chemical compound NCN(C)F IWUCHFKAVLZIBD-UHFFFAOYSA-N 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8329408P | 2008-07-24 | 2008-07-24 | |
US8508208P | 2008-07-31 | 2008-07-31 | |
US10865908P | 2008-10-27 | 2008-10-27 | |
PCT/US2009/050640 WO2010011538A1 (en) | 2008-07-24 | 2009-07-15 | Amidophenoxyindazoles useful as inhibitors of c-met |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120202T1 true HRP20120202T1 (hr) | 2012-03-31 |
Family
ID=41010247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120202T HRP20120202T1 (hr) | 2008-07-24 | 2012-03-01 | AMIDOFENOKSIINDAZOLI, KORISNI KAO INHIBITORI c-MET |
Country Status (36)
Country | Link |
---|---|
US (2) | US8030302B2 (de) |
EP (1) | EP2310382B1 (de) |
JP (1) | JP5414794B2 (de) |
KR (1) | KR101334456B1 (de) |
CN (1) | CN102105462B (de) |
AR (1) | AR074632A1 (de) |
AT (1) | ATE546444T1 (de) |
AU (1) | AU2009274256B2 (de) |
BR (1) | BRPI0916286B8 (de) |
CA (1) | CA2731773C (de) |
CL (1) | CL2011000134A1 (de) |
CO (1) | CO6351737A2 (de) |
CR (1) | CR20110046A (de) |
CY (1) | CY1112595T1 (de) |
DK (1) | DK2310382T3 (de) |
DO (1) | DOP2011000009A (de) |
EA (1) | EA018385B1 (de) |
EC (1) | ECSP11010778A (de) |
ES (1) | ES2379587T3 (de) |
HK (1) | HK1155172A1 (de) |
HR (1) | HRP20120202T1 (de) |
IL (1) | IL210490A (de) |
JO (1) | JO2788B1 (de) |
MA (1) | MA32594B1 (de) |
MX (1) | MX2011000925A (de) |
MY (1) | MY163852A (de) |
NZ (1) | NZ590013A (de) |
PE (1) | PE20110150A1 (de) |
PL (1) | PL2310382T3 (de) |
PT (1) | PT2310382E (de) |
RS (1) | RS52261B (de) |
SI (1) | SI2310382T1 (de) |
SV (1) | SV2011003816A (de) |
TW (1) | TWI365185B (de) |
WO (1) | WO2010011538A1 (de) |
ZA (1) | ZA201100219B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2011004018A (es) | 2008-10-14 | 2011-06-24 | Ning Xi | Compuestos y metodos de uso. |
EP2408300B1 (de) | 2009-03-21 | 2016-05-11 | Sunshine Lake Pharma Co., Ltd. | Aminoesterderivate, salze daraus und verfahren zu ihrer verwendung |
AU2012223639B2 (en) | 2011-02-28 | 2015-03-19 | Sunshine Lake Pharma Co., Ltd. | Substituted quinoline compounds and methods of use |
JP5970003B2 (ja) * | 2011-03-04 | 2016-08-17 | ローカス ファーマシューティカルズ インコーポレイテッド | アミノピラジン化合物 |
KR20130118612A (ko) * | 2012-04-20 | 2013-10-30 | (주)네오믹스 | 신규한 아미노피리딘 유도체 및 이의 용도 |
CN104334581B (zh) * | 2012-05-09 | 2018-02-02 | 伊莱利利公司 | 抗‑c‑Met抗体 |
US9790206B2 (en) * | 2013-02-27 | 2017-10-17 | Array Biopharma Inc. | Intermediates for use in the preparation of indazole derivatives and processes for the preparation thereof |
CN104140393B (zh) * | 2013-12-10 | 2016-09-21 | 郑州泰基鸿诺医药股份有限公司 | 一种芳环/芳杂环叔丁醇酯类化合物的制备方法 |
US20150299219A1 (en) | 2014-04-22 | 2015-10-22 | Calitor Sciences, Llc | Bicyclic pyrazolone compounds and methods of use |
TW201716085A (zh) * | 2015-08-12 | 2017-05-16 | 應克隆公司 | 癌症之組合療法 |
JP2019511541A (ja) * | 2016-04-15 | 2019-04-25 | イーライ リリー アンド カンパニー | 結腸直腸癌の処置における使用のためのラムシルマブとメレスチニブとの組み合わせ |
EP3464380A1 (de) | 2016-06-02 | 2019-04-10 | Immunocore Limited | Dosierschema für gp100-spezifisches tcr-anti-cd3-scfv-fusionsprotein |
EP3490676A1 (de) * | 2016-07-29 | 2019-06-05 | Eli Lilly and Company | Kombinationstherapie mit merestinib und anti-pd-l1- oder anti-pd-1-inhibitoren zur behandlung von krebs |
CN108069938A (zh) * | 2016-11-15 | 2018-05-25 | 中国药科大学 | 2,4-二取代吡啶类化合物及其制备方法和应用 |
ES2866348T3 (es) | 2016-11-16 | 2021-10-19 | Lilly Co Eli | Terapia de combinación para el cáncer con mutación o mutaciones de omisión del exón 14 o fenotipo de omisión del exón 14 |
US20200054616A1 (en) | 2016-11-16 | 2020-02-20 | Eli Lilly And Company | Treatment of cancer with exon 14 skipping mutation(s) or exon 14 skipping phenotype |
CN107311983A (zh) * | 2017-07-06 | 2017-11-03 | 北京万全德众医药生物技术有限公司 | 吲哚类小分子c‑met抑制剂 |
CN107382968A (zh) * | 2017-07-06 | 2017-11-24 | 北京万全德众医药生物技术有限公司 | 一种吲哚类c‑Met抑制剂的制备方法 |
US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
EP3480201A1 (de) | 2017-11-06 | 2019-05-08 | Oncostellae, S.L. | Neue analoga als androgen-rezeptor und glucocorticoid-rezeptor-modulatoren |
US11623923B2 (en) | 2017-11-24 | 2023-04-11 | Medshine Discovery, Inc. | Uracil compound as c-MET/AXL inhibitor |
CN110041316B (zh) * | 2018-01-17 | 2022-04-19 | 药捷安康(南京)科技股份有限公司 | Tam家族激酶/和csf1r激酶抑制剂及其用途 |
JP6955630B2 (ja) | 2018-03-08 | 2021-10-27 | ウェルマーカー・バイオ・カンパニー・リミテッドWellmarker Bio CO., Ltd. | チエノピリジン誘導体およびそれを含む医薬組成物 |
CN110857293B (zh) * | 2018-08-24 | 2023-01-10 | 药捷安康(南京)科技股份有限公司 | 一种新型的喹啉衍生物抑制剂 |
WO2020048455A1 (zh) | 2018-09-03 | 2020-03-12 | 泰励生物科技(上海)有限公司 | 用作抗癌药的trk抑制剂 |
JP2022554042A (ja) | 2019-09-06 | 2022-12-28 | ウェルマーカー・バイオ・カンパニー・リミテッド | バイオマーカー型治療用組成物 |
WO2022270881A1 (ko) * | 2021-06-22 | 2022-12-29 | 주식회사 엘지화학 | 단백질 키나아제 억제제로서의 신규한 화합물 |
WO2023110936A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Reversible macrocyclic kinase inhibitors |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
US5484681A (en) * | 1994-10-31 | 1996-01-16 | Xerox Corporation | Conductive composite particles and processes for the preparation thereof |
IL114149A0 (en) * | 1995-06-14 | 1995-10-31 | Yeda Res & Dev | Modified avidin and streptavidin molecules and use thereof |
US5747577A (en) * | 1995-12-27 | 1998-05-05 | Xerox Corporation | Conductive particles containing carbon black and processes for the preparation thereof |
DE10046029A1 (de) | 2000-09-18 | 2002-03-28 | Bayer Ag | Indazole |
DE60212840T2 (de) * | 2001-05-18 | 2007-02-01 | SRL, Inc., Tachikawa | Immunassayverfahren |
US6956084B2 (en) * | 2001-10-04 | 2005-10-18 | Bridgestone Corporation | Nano-particle preparation and applications |
JP2004067703A (ja) * | 2002-04-24 | 2004-03-04 | Japan Science & Technology Corp | 架橋ポリマー、微粒子および製造方法 |
US7192780B2 (en) * | 2002-10-23 | 2007-03-20 | Evident Technologies | Fluorescent lifetime biological detection and imaging using water-stable semiconductor nanocrystals |
ES2273047T3 (es) | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
AU2004264038B2 (en) * | 2003-07-17 | 2010-09-23 | Life Technologies As | Process for preparing coated magnetic particles |
US7163998B2 (en) * | 2003-09-09 | 2007-01-16 | Eastman Kodak Company | Stabilized polymer beads and method of preparation |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
JO2787B1 (en) | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
US8030305B2 (en) | 2005-12-21 | 2011-10-04 | Janssen Pharmaceutica N.V. | Triazolopyridazines as kinase modulators |
BRPI0708615A2 (pt) | 2006-03-07 | 2011-06-07 | Array Biopharma Inc | compostos de pirazol heterobicìclicos e métodos de uso |
WO2008003099A1 (en) * | 2006-06-29 | 2008-01-03 | Invitrogen, Dynal As | Particles containing multi- block polymers |
PE20121506A1 (es) | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
AU2007309149C1 (en) | 2006-10-23 | 2013-04-04 | Sgx Pharmaceuticals, Inc. | Bicyclic triazoles as protein kinase modulators |
US8076521B2 (en) | 2007-06-27 | 2011-12-13 | Arkema Inc. | Process for the manufacture of hydrofluoroolefins |
-
2009
- 2009-07-10 TW TW098123519A patent/TWI365185B/zh not_active IP Right Cessation
- 2009-07-12 JO JO2009256A patent/JO2788B1/en active
- 2009-07-13 AR ARP090102636A patent/AR074632A1/es active IP Right Grant
- 2009-07-15 CA CA2731773A patent/CA2731773C/en not_active Expired - Fee Related
- 2009-07-15 PT PT09790440T patent/PT2310382E/pt unknown
- 2009-07-15 AT AT09790440T patent/ATE546444T1/de active
- 2009-07-15 KR KR1020117001628A patent/KR101334456B1/ko active IP Right Grant
- 2009-07-15 JP JP2011520095A patent/JP5414794B2/ja not_active Expired - Fee Related
- 2009-07-15 NZ NZ590013A patent/NZ590013A/en not_active IP Right Cessation
- 2009-07-15 ES ES09790440T patent/ES2379587T3/es active Active
- 2009-07-15 SI SI200930193T patent/SI2310382T1/sl unknown
- 2009-07-15 WO PCT/US2009/050640 patent/WO2010011538A1/en active Application Filing
- 2009-07-15 US US12/503,223 patent/US8030302B2/en not_active Ceased
- 2009-07-15 DK DK09790440.3T patent/DK2310382T3/da active
- 2009-07-15 PL PL09790440T patent/PL2310382T3/pl unknown
- 2009-07-15 AU AU2009274256A patent/AU2009274256B2/en not_active Ceased
- 2009-07-15 MX MX2011000925A patent/MX2011000925A/es active IP Right Grant
- 2009-07-15 PE PE2011000061A patent/PE20110150A1/es active IP Right Grant
- 2009-07-15 RS RS20120176A patent/RS52261B/en unknown
- 2009-07-15 EA EA201170252A patent/EA018385B1/ru not_active IP Right Cessation
- 2009-07-15 EP EP09790440A patent/EP2310382B1/de active Active
- 2009-07-15 MY MYPI2011000343A patent/MY163852A/en unknown
- 2009-07-15 CN CN200980128694.4A patent/CN102105462B/zh not_active Expired - Fee Related
- 2009-07-15 BR BRPI0916286A patent/BRPI0916286B8/pt not_active IP Right Cessation
-
2011
- 2011-01-06 IL IL210490A patent/IL210490A/en active IP Right Grant
- 2011-01-07 DO DO2011000009A patent/DOP2011000009A/es unknown
- 2011-01-07 ZA ZA2011/00219A patent/ZA201100219B/en unknown
- 2011-01-19 CO CO11005437A patent/CO6351737A2/es not_active Application Discontinuation
- 2011-01-21 SV SV2011003816A patent/SV2011003816A/es active IP Right Grant
- 2011-01-21 EC EC2011010778A patent/ECSP11010778A/es unknown
- 2011-01-21 CL CL2011000134A patent/CL2011000134A1/es unknown
- 2011-01-24 MA MA33555A patent/MA32594B1/fr unknown
- 2011-01-24 CR CR20110046A patent/CR20110046A/es unknown
- 2011-09-08 HK HK11109520.7A patent/HK1155172A1/xx not_active IP Right Cessation
- 2011-12-08 US US13/374,053 patent/USRE43878E1/en not_active Expired - Fee Related
-
2012
- 2012-03-01 HR HR20120202T patent/HRP20120202T1/hr unknown
- 2012-04-04 CY CY20121100337T patent/CY1112595T1/el unknown
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