HRP20120144T4 - Terapijske uporabe spojeva koji imaju i sert i 5-ht3 i 5-ht1a aktivnost - Google Patents
Terapijske uporabe spojeva koji imaju i sert i 5-ht3 i 5-ht1a aktivnost Download PDFInfo
- Publication number
- HRP20120144T4 HRP20120144T4 HRP20120144TT HRP20120144T HRP20120144T4 HR P20120144 T4 HRP20120144 T4 HR P20120144T4 HR P20120144T T HRP20120144T T HR P20120144TT HR P20120144 T HRP20120144 T HR P20120144T HR P20120144 T4 HRP20120144 T4 HR P20120144T4
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- disease
- compounds
- therapeutic uses
- dimethylphenylsulfanyl
- Prior art date
Links
- 230000000694 effects Effects 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- YQNWZWMKLDQSAC-UHFFFAOYSA-N vortioxetine Chemical compound CC1=CC(C)=CC=C1SC1=CC=CC=C1N1CCNCC1 YQNWZWMKLDQSAC-UHFFFAOYSA-N 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 206010012335 Dependence Diseases 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical group Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 208000020685 sleep-wake disease Diseases 0.000 claims 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (4)
1. Uporaba 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazina i njegovih farmaceutski prihvatljivih soli u proizvodnji 5 lijeka za liječenje bolesti izabrane između depresije, anksioznosti, ovisnosti ili kronične boli, pri čemu je taj lijek namijenjen uporabi kod bolesnika koji je prethodno liječen drugim lijekom za tu bolest, a čija je primjena prestala ili je smanjena zbog nuspojave povezane s poremećajem spavanja.
2. Uporaba prema zahtjevu 1, pri čemu je farmaceutski prihvatljiva sol bromovodična sol.
3. 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazin i njegove farmaceutski prihvatljive soli za uporabu u liječenju bolesti 10 izabrane između depresije, anksioznosti, ovisnosti ili kronične boli, pri čemu je navedeni lijek namijenjen uporabi kod bolesnika koji je prethodno liječen drugim lijekom za tu bolest, a čija je primjena prestala ili je smanjena zbog nuspojave povezane s poremećajem spavanja.
4. 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazin i farmaceutski prihvatljive soli za uporabu prema zahtjevu 3, pri čemu je to bromovodična sol.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98771007P | 2007-11-13 | 2007-11-13 | |
DKPA200701607 | 2007-11-13 | ||
US1372207P | 2007-12-14 | 2007-12-14 | |
DKPA200701788 | 2007-12-14 | ||
US9784008P | 2008-09-17 | 2008-09-17 | |
DKPA200801300 | 2008-09-17 | ||
PCT/DK2008/050271 WO2009062517A1 (en) | 2007-11-13 | 2008-11-12 | Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity |
EP08850935.1A EP2219647B2 (en) | 2007-11-13 | 2008-11-12 | Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20120144T1 HRP20120144T1 (hr) | 2012-04-30 |
HRP20120144T4 true HRP20120144T4 (hr) | 2020-11-13 |
Family
ID=40170671
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20120144TT HRP20120144T4 (hr) | 2007-11-13 | 2012-02-14 | Terapijske uporabe spojeva koji imaju i sert i 5-ht3 i 5-ht1a aktivnost |
HRP20161121TT HRP20161121T1 (hr) | 2007-11-13 | 2016-09-01 | Terapijska uporaba spojeva koji imaju objedinjenu sert, 5-ht3 i 5-ht1a aktivnost |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20161121TT HRP20161121T1 (hr) | 2007-11-13 | 2016-09-01 | Terapijska uporaba spojeva koji imaju objedinjenu sert, 5-ht3 i 5-ht1a aktivnost |
Country Status (30)
Country | Link |
---|---|
US (5) | US9278096B2 (hr) |
EP (3) | EP2431039B1 (hr) |
JP (2) | JP5603244B2 (hr) |
KR (1) | KR101536023B1 (hr) |
CN (1) | CN102014908A (hr) |
AR (1) | AR069260A1 (hr) |
AT (1) | ATE537829T1 (hr) |
AU (1) | AU2008323390B2 (hr) |
BR (1) | BRPI0820474B8 (hr) |
CA (1) | CA2705163C (hr) |
CL (1) | CL2008003363A1 (hr) |
CO (1) | CO6270322A2 (hr) |
CY (2) | CY1112646T1 (hr) |
DK (2) | DK2431039T3 (hr) |
EA (1) | EA027783B1 (hr) |
ES (2) | ES2591110T3 (hr) |
HR (2) | HRP20120144T4 (hr) |
HU (1) | HUE029588T2 (hr) |
IL (1) | IL205466A (hr) |
LT (1) | LT2431039T (hr) |
MX (1) | MX2010004688A (hr) |
NZ (1) | NZ585247A (hr) |
PL (2) | PL2431039T3 (hr) |
PT (2) | PT2431039T (hr) |
RS (2) | RS52256B2 (hr) |
SG (1) | SG10201405001XA (hr) |
SI (2) | SI2431039T1 (hr) |
TW (1) | TW200932233A (hr) |
WO (1) | WO2009062517A1 (hr) |
ZA (1) | ZA201003350B (hr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200932233A (en) | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
CN102639117A (zh) | 2009-08-24 | 2012-08-15 | H.隆德贝克有限公司 | 1-[2-(2,4-二甲基-苯基硫基)-苯基]哌嗪的新组合物 |
TW201212918A (en) * | 2010-08-23 | 2012-04-01 | Lundbeck & Co As H | Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine |
AU2012209466C1 (en) * | 2011-01-27 | 2016-06-23 | Neuren Pharmaceuticals Limited | Treatment of Autism Spectrum Disorders using Glycyl-L-2-Methylprolyl-L-Glutamic Acid |
JP6078466B2 (ja) | 2011-07-21 | 2017-02-08 | 学校法人 名城大学 | セロトニントランスポーター分析キット及び血中ユビキチン化セロトニントランスポーター分析キット |
CN104853755B (zh) | 2012-12-13 | 2017-08-22 | H.隆德贝克有限公司 | 包含沃替西汀和多奈哌齐的组合物 |
JP6323979B2 (ja) * | 2013-01-17 | 2018-05-16 | 学校法人 名城大学 | うつ病マーカー、アッセイ方法、測定方法、うつ病薬のスクリーニング方法及びキット |
CN105339361A (zh) * | 2013-05-31 | 2016-02-17 | 斯洛文尼亚莱柯制药股份有限公司 | 用于合成1-(2-((2,4-二甲基苯基)硫代)苯基)哌嗪的新方法 |
EP2878596A1 (en) * | 2013-11-29 | 2015-06-03 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates |
EP3082815B1 (en) * | 2013-12-20 | 2018-10-03 | H. Lundbeck A/S | Use of an opioid receptor antagonist with kappa-activity and vortioxetine for treatment of depressive disorder with melancholic features |
CN103788019B (zh) * | 2014-01-22 | 2015-10-07 | 苏州明锐医药科技有限公司 | 沃替西汀的制备方法 |
CN106103418A (zh) | 2014-01-31 | 2016-11-09 | 埃吉斯药物私人有限公司 | 沃替西汀盐的制备方法 |
EP2930171A1 (en) * | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
CN104119298B (zh) * | 2014-08-13 | 2016-08-24 | 北京蓝贝望生物医药科技股份有限公司 | 氢溴酸沃赛汀或氢溴酸沃替西汀 |
CN104119299B (zh) * | 2014-08-13 | 2016-08-17 | 北京蓝贝望生物医药科技股份有限公司 | 沃赛汀或沃替西汀的氢溴酸盐 |
CN104610195B (zh) * | 2015-01-30 | 2017-06-27 | 上虞京新药业有限公司 | 沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途 |
JO3456B1 (ar) * | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
EP3799873A1 (en) * | 2015-07-17 | 2021-04-07 | Institut Pasteur | 5-hydroxytryptamine 1b receptor-stimulating agent for use as a promoter of satellite cells self-renewal and/or differentiation |
KR20190025556A (ko) | 2016-07-01 | 2019-03-11 | 하. 룬드벡 아크티에셀스카브 | 항우울 효과의 신속한 개시를 위한 보티옥세틴 투여 요법 |
JP2023520016A (ja) | 2020-04-03 | 2023-05-15 | ハー・ルンドベック・アクチエゼルスカベット | 感情鈍麻の予防又は処置のための1-[2-(2,4-ジメチルフェニルスルファニル)-フェニル]ピペラジン |
WO2023036820A1 (en) | 2021-09-10 | 2023-03-16 | H. Lundbeck A/S | Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine |
KR20230148676A (ko) | 2022-04-18 | 2023-10-25 | 영진약품 주식회사 | 라베프라졸 및 탄산수소나트륨을 포함하는 조성물 및 이의 용도 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU163075A (en) * | 1975-07-21 | 1982-05-31 | Science Union & Cie | Process for preparing new phenoxy derivatives |
US5258387A (en) * | 1990-08-21 | 1993-11-02 | Hoffmann-La Roche Inc. | Tricyclic pyridone derivatives |
UA81749C2 (uk) | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
CN100457738C (zh) * | 2001-12-20 | 2009-02-04 | H·隆德贝克有限公司 | 芳氧基苯基和芳硫基苯基衍生物 |
AU2004226838B8 (en) | 2003-04-04 | 2009-06-11 | H. Lundbeck A/S | 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors |
US20060019938A1 (en) | 2003-12-31 | 2006-01-26 | Beer Tomasz M | Estrogen administration for treating male cognitive dysfunction or improving male cognitive function |
PL2044043T5 (pl) | 2006-06-16 | 2022-05-02 | H. Lundbeck A/S | Bromowodorek 1-[2-(2,4-dimetylofenylosulfanylo)fenylo]piperazyny jako związek o połączonym działaniu wychwytu zwrotnego serotoniny i działaniu na 5-ht3 i 5-ht1a do leczenia upośledzenia funckji poznawczych |
TW200848411A (en) * | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
TW200932233A (en) * | 2007-11-13 | 2009-08-01 | Lundbeck & Co As H | Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity |
CN102639117A (zh) | 2009-08-24 | 2012-08-15 | H.隆德贝克有限公司 | 1-[2-(2,4-二甲基-苯基硫基)-苯基]哌嗪的新组合物 |
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2008
- 2008-11-03 TW TW097142306A patent/TW200932233A/zh unknown
- 2008-11-11 AR ARP080104919A patent/AR069260A1/es unknown
- 2008-11-12 PT PT111932372T patent/PT2431039T/pt unknown
- 2008-11-12 CN CN2008801164637A patent/CN102014908A/zh active Pending
- 2008-11-12 EP EP11193237.2A patent/EP2431039B1/en active Active
- 2008-11-12 ES ES11193237.2T patent/ES2591110T3/es active Active
- 2008-11-12 SI SI200831677A patent/SI2431039T1/sl unknown
- 2008-11-12 CL CL2008003363A patent/CL2008003363A1/es unknown
- 2008-11-12 DK DK11193237.2T patent/DK2431039T3/en active
- 2008-11-12 MX MX2010004688A patent/MX2010004688A/es active IP Right Grant
- 2008-11-12 KR KR1020107010492A patent/KR101536023B1/ko active IP Right Review Request
- 2008-11-12 CA CA2705163A patent/CA2705163C/en active Active
- 2008-11-12 HU HUE11193237A patent/HUE029588T2/en unknown
- 2008-11-12 NZ NZ585247A patent/NZ585247A/en not_active IP Right Cessation
- 2008-11-12 AU AU2008323390A patent/AU2008323390B2/en active Active
- 2008-11-12 EA EA201070598A patent/EA027783B1/ru not_active IP Right Cessation
- 2008-11-12 EP EP16178423.6A patent/EP3115050A1/en not_active Withdrawn
- 2008-11-12 WO PCT/DK2008/050271 patent/WO2009062517A1/en active Application Filing
- 2008-11-12 DK DK08850935.1T patent/DK2219647T4/da active
- 2008-11-12 AT AT08850935T patent/ATE537829T1/de active
- 2008-11-12 EP EP08850935.1A patent/EP2219647B2/en active Active
- 2008-11-12 PL PL11193237.2T patent/PL2431039T3/pl unknown
- 2008-11-12 ES ES08850935T patent/ES2379419T5/es active Active
- 2008-11-12 US US12/741,780 patent/US9278096B2/en active Active
- 2008-11-12 RS RS20120087A patent/RS52256B2/sr unknown
- 2008-11-12 PL PL08850935T patent/PL2219647T3/pl unknown
- 2008-11-12 PT PT08850935T patent/PT2219647E/pt unknown
- 2008-11-12 JP JP2010533436A patent/JP5603244B2/ja active Active
- 2008-11-12 SG SG10201405001XA patent/SG10201405001XA/en unknown
- 2008-11-12 LT LTEP11193237.2T patent/LT2431039T/lt unknown
- 2008-11-12 RS RS20160756A patent/RS55147B1/sr unknown
- 2008-11-12 BR BRPI0820474A patent/BRPI0820474B8/pt active IP Right Grant
- 2008-11-12 SI SI200830548T patent/SI2219647T2/sl unknown
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2010
- 2010-04-29 IL IL205466A patent/IL205466A/en active IP Right Grant
- 2010-05-12 ZA ZA2010/03350A patent/ZA201003350B/en unknown
- 2010-05-13 CO CO10057476A patent/CO6270322A2/es not_active Application Discontinuation
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2012
- 2012-02-14 HR HRP20120144TT patent/HRP20120144T4/hr unknown
- 2012-02-24 CY CY20121100199T patent/CY1112646T1/el unknown
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2014
- 2014-05-14 JP JP2014100815A patent/JP5841636B2/ja active Active
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2016
- 2016-02-12 US US15/043,167 patent/US9744166B2/en active Active
- 2016-09-01 HR HRP20161121TT patent/HRP20161121T1/hr unknown
- 2016-09-07 CY CY20161100885T patent/CY1117978T1/el unknown
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2017
- 2017-07-27 US US15/661,392 patent/US20180161321A1/en not_active Abandoned
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2020
- 2020-05-12 US US15/930,014 patent/US11628166B2/en active Active
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2023
- 2023-04-04 US US18/130,749 patent/US20240082239A1/en active Pending
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