HRP20110896T1 - Pripravci na bazi silikonskog gela za liječenje rana i smanjenje ožiljaka - Google Patents
Pripravci na bazi silikonskog gela za liječenje rana i smanjenje ožiljaka Download PDFInfo
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- HRP20110896T1 HRP20110896T1 HR20110896T HRP20110896T HRP20110896T1 HR P20110896 T1 HRP20110896 T1 HR P20110896T1 HR 20110896 T HR20110896 T HR 20110896T HR P20110896 T HRP20110896 T HR P20110896T HR P20110896 T1 HRP20110896 T1 HR P20110896T1
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- silicone
- dimethicone
- ascorbyl
- Prior art date
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- 229920001296 polysiloxane Polymers 0.000 title claims abstract 7
- 239000000203 mixture Substances 0.000 title claims abstract 4
- 231100000241 scar Toxicity 0.000 title claims 3
- 230000029663 wound healing Effects 0.000 title abstract 2
- -1 cyclic siloxane Chemical class 0.000 claims abstract 10
- 239000000843 powder Substances 0.000 claims abstract 3
- 229920002050 silicone resin Polymers 0.000 claims abstract 3
- 239000012530 fluid Substances 0.000 claims abstract 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 11
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 11
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 11
- 229940008099 dimethicone Drugs 0.000 claims 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 235000010323 ascorbic acid Nutrition 0.000 claims 5
- 229960005070 ascorbic acid Drugs 0.000 claims 5
- 239000011668 ascorbic acid Substances 0.000 claims 5
- 229920006037 cross link polymer Polymers 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 229920002545 silicone oil Polymers 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- 208000032544 Cicatrix Diseases 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229940057874 phenyl trimethicone Drugs 0.000 claims 2
- 230000037387 scars Effects 0.000 claims 2
- 229920002379 silicone rubber Polymers 0.000 claims 2
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 claims 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
- 208000012260 Accidental injury Diseases 0.000 claims 1
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 claims 1
- 239000004261 Ascorbyl stearate Substances 0.000 claims 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- DWKSHXDVQRZSII-SUMWQHHRSA-N [(2s)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O DWKSHXDVQRZSII-SUMWQHHRSA-N 0.000 claims 1
- MSKSZMDNKAEBSG-HNAYVOBHSA-N [(2s)-2-[(2r)-3,4-dihydroxy-5-oxo-2h-furan-2-yl]-2-hydroxyethyl] tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O MSKSZMDNKAEBSG-HNAYVOBHSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims 1
- 235000019276 ascorbyl stearate Nutrition 0.000 claims 1
- 230000004888 barrier function Effects 0.000 claims 1
- 229940116224 behenate Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920003216 poly(methylphenylsiloxane) Polymers 0.000 claims 1
- 229920003217 poly(methylsilsesquioxane) Polymers 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 229920005573 silicon-containing polymer Polymers 0.000 claims 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0052—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/48—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
- C08G77/50—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms by carbon linkages
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/70—Siloxanes defined by use of the MDTQ nomenclature
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- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Pripravak za stvaranje tanke zaštitne prepreke kojoj je svrha smanjiti nastanak prevelikih ožiljaka nakon kirurških zahvata ili slučajnih ozljeda, koji sadrži: ciklički siloksan; silikonsku okluzivnu tekućinu u obliku polialkil-siloksana odabranog između sljedećeg: poli(dimetildiloksan), poli(metiletilsiloksan), poli(metilfenil-siloksan) te njihove mješavine koje imaju viskozitet u rasponu od 50 do 500 mm2.s-1 (cSt); silikonski okluzivni gel u obliku disperzije silikonskog elastomera u silikonskom ulju, naznačen time, da je silikonski elastomer odabran između sljedećeg: umreženi (crosslinked) dimetikon, stearil metil-dimetil siloksan kopolimer, polisilikon-11, cetearil dimetikon/vinil dimetikon umreženi polimer, dimetikon/fenil vinil dimetikon umreženi polimer te dimetikon/vinil dimetikon umreženi polimer, a silikonsko ulje odabrano je između sljedećeg: fenil trimetikon, fenil dimetikon, dimetikon kopoliol i alkil dimetikon kopoliolprah silikonske smole u obliku polimetil silseskvioksana. Patent sadrži još 13 patentnih zahtjeva.
Claims (14)
1. Pripravak za stvaranje tanke zaštitne prepreke kojoj je svrha smanjiti nastanak prevelikih ožiljaka nakon kirurških zahvata ili slučajnih ozljeda, koji sadrži:
- ciklički siloksan;
- silikonsku okluzivnu tekućinu u obliku polialkil-siloksana odabranog između sljedećeg: poli(dimetildiloksan), poli(metiletilsiloksan), poli(metilfenil-siloksan) te njihove mješavine koje imaju viskozitet u rasponu od 50 do 500 mm2.s-1 (cSt);
- silikonski okluzivni gel u obliku disperzije silikonskog elastomera u silikonskom ulju, naznačen time, da je silikonski elastomer odabran između sljedećeg: umreženi (crosslinked) dimetikon, stearil metil-dimetil siloksan kopolimer, polisilikon-11, cetearil dimetikon/vinil dimetikon umreženi polimer, dimetikon/fenil vinil dimetikon umreženi polimer te dimetikon/vinil dimetikon umreženi polimer, a silikonsko ulje odabrano je između sljedećeg: fenil trimetikon, fenil dimetikon, dimetikon kopoliol i alkil dimetikon kopoliol
- prah silikonske smole u obliku polimetil silseskvioksana.
2. Pripravak iz patentnog zahtjeva 1, naznačen time, da dodatno sadrži ester askorbinske kiseline ili njezina sol.
3. Pripravak iz patentnog zahtjeva 1, naznačen time, da ciklički siloksan čini 30 - 80% masenog udjela pripravka, poželjno je 45 - 65% masenog udjela pripravka, a poželjnije 55 - 65% masenog udjela pripravka.
4. Pripravak iz patentnog zahtjeva 1, naznačen time, da je viskozitet silikonske okluzivne tekućine u rasponu od 100 do 350 mm2.s-1 (cSt).
5. Pripravak iz patentnog zahtjeva 1, naznačen time, da je polialkilsiloksan polidimetilsiloksan, a viskozitet je 200 mm2.s-1 (cSt).
6. Pripravak iz patentnog zahtjeva 1, naznačen time, da silikonska okluzivna tekućina čini 1 - 15 % masenog udjela pripravka, poželjno 2 - 15% masenog udjela pripravka, poželjnije 3 - 7% masenog udjela pripravka.
7. Pripravak iz patentnog zahtjeva 1, naznačen time, da je umreženi silikonski polimer polisilikon-11.
8. Pripravak iz patentnog zahtjeva 1, naznačen time, da je silikonsko ulje fenil trimetikon.
9. Pripravak iz patentnog zahtjeva 1, naznačen time, da prah silikonske smole čini 1 - 10 % masenog udjela pripravka, poželjno 1 - 5 % masenog udjela pripravka, poželjnije 2 - 3 % masenog udjela pripravka.
10. Pripravak iz patentnog zahtjeva 2, naznačen time, da ester askorbinske kiseline ili njezina sol sadrži ester masne kiseline s 8 do 24 atoma ugljika.
11. Pripravak iz patentnog zahtjeva 2, naznačen time, da je ester askorbinske kiseline ili njezina sol odabran između sljedećeg: askorbil laurat, askorbil miristat, askorbil palmitat, askorbil izopalmitat, askorbil stearat, tetraizopalmitat askorbinske kiseline i askorbil behenat te njihove soli.
12. Pripravak iz patentnog zahtjeva 2, naznačen time, da ester askorbinske kiseline ili njezina sol čini između 0,1 i 2 % masenog udjela pripravka, poželjno je između 0,2 i 1 % masenog udjela pripravka, a poželjnije između 0,3 i 0,7 % masenog udjela pripravka.
13. Uporaba pripravka iz patentnog zahtjeva 1, naznačena time, da se pripravak koristi u proizvodnji lijeka za liječenje ozljeda s ciljem smanjivanja ožiljaka.
14. Uporaba iz patentnog zahtjeva 13, naznačena time, da pripravak iz patentnog zahtjeva 1 dodatno sadrži ester askorbinske kiseline ili njezinu sol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99716607P | 2007-09-30 | 2007-09-30 | |
| PCT/US2008/078340 WO2009046033A2 (en) | 2007-09-30 | 2008-09-30 | Silicone gel-based compositions for wound healing and scar reduction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110896T1 true HRP20110896T1 (hr) | 2011-12-31 |
Family
ID=40336388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110896T HRP20110896T1 (hr) | 2007-09-30 | 2011-11-30 | Pripravci na bazi silikonskog gela za liječenje rana i smanjenje ožiljaka |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US8563604B2 (hr) |
| EP (1) | EP2211919B1 (hr) |
| JP (2) | JP5449173B2 (hr) |
| KR (1) | KR101521669B1 (hr) |
| CN (1) | CN101854959B (hr) |
| AT (1) | ATE523210T1 (hr) |
| AU (1) | AU2008308849B2 (hr) |
| BR (1) | BRPI0817607A2 (hr) |
| CA (1) | CA2700382A1 (hr) |
| DK (1) | DK2211919T3 (hr) |
| EA (1) | EA017174B1 (hr) |
| ES (1) | ES2372127T3 (hr) |
| GE (1) | GEP20125661B (hr) |
| HR (1) | HRP20110896T1 (hr) |
| IL (1) | IL204002A (hr) |
| ME (1) | ME01258B (hr) |
| MX (1) | MX2010003503A (hr) |
| PH (1) | PH12013502430A1 (hr) |
| PL (1) | PL2211919T3 (hr) |
| PT (1) | PT2211919E (hr) |
| RS (1) | RS52070B (hr) |
| SI (1) | SI2211919T1 (hr) |
| TW (1) | TW200932292A (hr) |
| UA (1) | UA101812C2 (hr) |
| WO (1) | WO2009046033A2 (hr) |
| ZA (1) | ZA201002201B (hr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001089464A1 (en) * | 2000-05-23 | 2001-11-29 | Unilever Plc | Deodorant and/or antiperspirant compositions |
| CN1234426C (zh) * | 2001-07-24 | 2006-01-04 | 先进生物技术公司 | 局部用药物制剂 |
| IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US20100124539A1 (en) * | 2006-10-16 | 2010-05-20 | Hanson Medical, Inc. | Cosmetic preparations |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| ES2372127T3 (es) | 2007-09-30 | 2012-01-16 | Meda Ab | Composiciones de gel a base de silicona para curar heridas y reducir las cicatrices. |
| US20100322875A1 (en) | 2009-06-18 | 2010-12-23 | Advanced Bio-Technologies, Inc. | Silicone scar treatment preparation |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US10029013B2 (en) | 2009-10-02 | 2018-07-24 | Foamix Pharmaceuticals Ltd. | Surfactant-free, water-free formable composition and breakable foams and their uses |
| BE1019220A3 (nl) | 2010-06-30 | 2012-04-03 | Sylphar | Huidverzorgingsproduct voor het behandelen van littekens. |
| US8491941B1 (en) | 2011-01-25 | 2013-07-23 | Tec Laboratories, Inc. | Rash treatment with scar prevention |
| US9592243B2 (en) | 2011-04-25 | 2017-03-14 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an anabolic agent for treatment of an injury |
| US9511077B2 (en) | 2011-04-25 | 2016-12-06 | Warsaw Orthopedic, Inc. | Medical devices and methods comprising an anabolic agent for wound healing |
| CN102210886A (zh) * | 2011-06-08 | 2011-10-12 | 湖南恒邦医疗科技有限公司 | 一种祛疤凝胶组合物及其制备方法 |
| US20130144225A1 (en) * | 2011-12-06 | 2013-06-06 | Jessica Rowen | Method And Device For Scar Management |
| US9592241B2 (en) | 2011-12-27 | 2017-03-14 | Cmpd Licensing, Llc | Silicone-based composition for skin treatment |
| CN103191459B (zh) * | 2013-04-06 | 2014-08-06 | 广东泰宝医疗科技股份有限公司 | 一种复合硅凝胶护创敷料及其制备方法 |
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| CN105168045B (zh) * | 2015-09-07 | 2018-07-17 | 天津嘉氏堂科技有限公司 | 一种疤痕防晒修复硅凝胶及制备方法 |
| CH712832B1 (de) * | 2016-08-24 | 2020-04-30 | Drossapharm Ag | Zusammensetzung für die Verwendung als Wundverband. |
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| US10496949B2 (en) | 2017-01-04 | 2019-12-03 | Christopher Zoumalan | Compositions and methods for treating cutaneous conditions |
| US11559622B2 (en) | 2017-07-29 | 2023-01-24 | Edward D. Lin | Deformation resistant wound therapy apparatus and related methods of use |
| US10780201B2 (en) | 2017-07-29 | 2020-09-22 | Edward D. Lin | Control apparatus and related methods for wound therapy delivery |
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| KR102234063B1 (ko) * | 2018-11-28 | 2021-03-31 | 주식회사 현대바이오랜드 | 흉터개선용 피복 필름 형성을 위한 이액형 겔 조성물 |
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