HRP20110697T1 - Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi - Google Patents

Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi Download PDF

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Publication number
HRP20110697T1
HRP20110697T1 HR20110697T HRP20110697T HRP20110697T1 HR P20110697 T1 HRP20110697 T1 HR P20110697T1 HR 20110697 T HR20110697 T HR 20110697T HR P20110697 T HRP20110697 T HR P20110697T HR P20110697 T1 HRP20110697 T1 HR P20110697T1
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Croatia
Prior art keywords
sexual desire
menopause
acid
disorders
flibanserin
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HR20110697T
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English (en)
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Pollentier Stephane
Pyke Robert
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Boehringer Ingelheim International Gmbh
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Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of HRP20110697T1 publication Critical patent/HRP20110697T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Uporaba, naznačena time, da se koristi flibanserin, po izboru u obliku slobodne baze, farmakološki prihvatljivih kiselinskih adicijskih soli i/ili po izboru u obliku svojih hidrata i/ili solvata za izradu lijeka za liječenje poremećaja seksualne želje u pre-menopauzi kod žena, pri čemu se lijek primjenjuje jednom dnevno uzastopno tijekom određenog vremenskog razdoblja. Patent sadrži još 13 patentnih zahtjeva.

Claims (14)

1. Uporaba, naznačena time, da se koristi flibanserin, po izboru u obliku slobodne baze, farmakološki prihvatljivih kiselinskih adicijskih soli i/ili po izboru u obliku svojih hidrata i/ili solvata za izradu lijeka za liječenje poremećaja seksualne želje u pre-menopauzi kod žena, pri čemu se lijek primjenjuje jednom dnevno uzastopno tijekom određenog vremenskog razdoblja.
2. Uporaba u skladu sa zahtjevom 1, naznačena time, da je poremećaj seksualne želje u pre-menopauzi izabran iz skupine koju čine poremećaj hipoaktivne seksualne želje u pre-menopauzi, poremećaj seksualne averzije u pre-menopauzi, gubitak seksualne želje u pre-menopauzi, manjak seksualne želje u pre-menopauzi, smanjena seksualna želja u pre-menopauzi, inhibirana seksualna želja u pre-menopauzi, gubitak libida u pre-menopauzi, poremećaj libida u pre-menopauzi i frigidnost u pre-menopauzi-
3. Uporaba u skladu sa zahtjevom 1, naznačena time, da poremećaj seksualne želje u pre-menopauzi je poremećaj hipoaktivne seksualne želje u pre-menopauzi.
4. Uporaba u skladu sa zahtjevom 1, 2 ili 3, naznačena time, da poremećaji seksualne želje u pre-menopauzi su cjeloživotnog tipa.
5. Uporaba u skladu sa zahtjevom 1, 2 ili 3, naznačena time, da poremećaji seksualne želje u pre-menopauzi su stečenog tipa.
6. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su općeg subtipa.
7. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su situacijskog subtipa.
8. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su zbog psiholoških faktora.
9. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su zbog organskih faktora.
10. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da poremećaji seksualne želje u pre-menopauzi su zbog spojenih faktora.
11. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da se flibanserin primjenjuje u obliku farmaceutski prihvatljive kiselinske adicijske soli izabrane između soli formiranih pomoću kiselina izabranih iz skupine koju čine sukcinska kiselina, bromidna kiselina, octena kiselina, mravlja kiselina, maleinska kiselina, metansulfonska kiselina, mliječna kiselina, fosforna kiselina, kloridna kiselina, sumporna kiselina, vinska kiselina, limunska kiselina i njihove mješavine.
12. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da se flibanserin primjenjuje u obliku svoje slobodne baze.
13. Uporaba u skladu sa zahtjevom 12, naznačena time, da se flibanserin primjenjuje u obliku polimorfa A slobodne baze koji ima točku tališta na oko 161 °C izmjerenu uporabom DSC.
14. Uporaba u skladu s jednim ili više prethodnih zahtjeva, naznačena time, da se flibanserin primjenjuje isključivo jednom navečer (50 ili 100 mg flibanserina) uzastopno tijekom određenog vremenskog razdoblja.
HR20110697T 2005-11-08 2011-09-29 Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi HRP20110697T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73440505P 2005-11-08 2005-11-08
US83101506P 2006-07-14 2006-07-14
PCT/EP2006/068118 WO2007054476A1 (en) 2005-11-08 2006-11-06 Use of flibanserin for the treatment of pre-menopausal sexual desire disorders

Publications (1)

Publication Number Publication Date
HRP20110697T1 true HRP20110697T1 (hr) 2011-10-31

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ID=37807895

Family Applications (1)

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HR20110697T HRP20110697T1 (hr) 2005-11-08 2011-09-29 Uporaba flibanserina za liječenje poremećaja seksualne želje u pre-menopauzi

Country Status (30)

Country Link
US (4) US20070105869A1 (hr)
EP (1) EP1948177B1 (hr)
JP (2) JP5386173B2 (hr)
KR (2) KR101436793B1 (hr)
CN (1) CN103251598A (hr)
AR (1) AR059390A1 (hr)
AT (1) ATE521352T1 (hr)
AU (1) AU2006311038B2 (hr)
BR (1) BRPI0618239A8 (hr)
CA (1) CA2626797C (hr)
CY (1) CY1112067T1 (hr)
DK (1) DK1948177T3 (hr)
EA (1) EA014189B1 (hr)
EC (1) ECSP088504A (hr)
ES (1) ES2372421T3 (hr)
HR (1) HRP20110697T1 (hr)
IL (1) IL191245A0 (hr)
MY (1) MY145439A (hr)
NO (1) NO20081527L (hr)
NZ (1) NZ568822A (hr)
PE (1) PE20070800A1 (hr)
PL (1) PL1948177T3 (hr)
PT (1) PT1948177E (hr)
RS (1) RS51961B (hr)
SG (1) SG166820A1 (hr)
SI (1) SI1948177T1 (hr)
TW (1) TWI389689B (hr)
UY (1) UY29899A1 (hr)
WO (1) WO2007054476A1 (hr)
ZA (1) ZA200802542B (hr)

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