HRP20110534T1 - Novi spojevi i njihova uporaba - Google Patents
Novi spojevi i njihova uporaba Download PDFInfo
- Publication number
- HRP20110534T1 HRP20110534T1 HR20110534T HRP20110534T HRP20110534T1 HR P20110534 T1 HRP20110534 T1 HR P20110534T1 HR 20110534 T HR20110534 T HR 20110534T HR P20110534 T HRP20110534 T HR P20110534T HR P20110534 T1 HRP20110534 T1 HR P20110534T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound according
- compound
- pharmaceutical composition
- formula
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 17
- 150000001450 anions Chemical class 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 241001529453 unidentified herpesvirus Species 0.000 claims 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000011877 solvent mixture Substances 0.000 claims 1
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Spoj formule (I) naznačen time, da R1 je odabran od H, F, Cl, Br, CF3, C1-C6 alkoksi i OH; R2 je odabran od H i C1-C6 alkila; n je 1-12; m je 0 ili 1; i Y je odabran od CH2, NR3, (NR3R4)+X-, O i S; R3 i R4 su neovisno odabrani od H i C1-C4 alkila; i X- je odabran od farmaceutski prihvatljivih aniona. Patent sadrži još 16 patentnih zahtjeva.
Claims (17)
1. Spoj formule (I)
[image]
naznačen time, da R1 je odabran od H, F, Cl, Br, CF3, C1-C6 alkoksi i OH;
R2 je odabran od H i C1-C6 alkila; n je 1-12; m je 0 ili 1; i
Y je odabran od CH2, NR3, (NR3R4)+X-, O i S;
R3 i R4 su neovisno odabrani od H i C1-C4 alkila; i X-je odabran od farmaceutski prihvatljivih aniona.
2. Spoj prema zahtjevu 1, naznačen time, da R1 je odabran od H, F, Cl, Br, CF3, CH3 i OH.
3. Spoj prema zahtjevu 1 ili 2, naznačen time, da R2 je odabran od H i CH3.
4. Spoj prema bilo kojem zahtjevu 1 do 3, naznačen time, da X- je odabran od Cl-, Br-, metansulfonata, toluensulfonata, acetata, citrata i maleata.
5. Spoj prema bilo kojem zahtjevu 1 do 4, naznačen time, da m je 0.
6. Spoj prema bilo kojem zahtjevu 1 do 4, naznačen time, da m je 1.
7. Spoj prema zahtjevu 6, naznačen time, da Y je O.
8. Spoj prema bilo kojem zahtjevu 1 do 7, naznačen time, da n je 4-10.
9. Spoj prema bilo kojem zahtjevu 1 do 7, naznačen time, da n je 1-3.
10. Spoj prema zahtjevu 1, naznačen time, da R1=H, R2=CH3, n=3, m=0, X-=Br-; R1=H, R2=CH3, n=5, m=0, X-=Br-; R1 = 9-Br, R2= CH3, n = 3, m= 0, X-= Br-; R1=9-Cl, R2=H, n=3, m=0, X-=Br-; R1 =H, R2=H, n= 1, m= 1, Y =CH2, X-= Br-; R1=H, R2=H, n=3, m=0, X-=Br-; R1=H, R2=CH3, n=2, Y=O, m=1, X-=Br-; ili R1 = 9-Br, R2= CH3, n =2, Y = O, m = 1, X-=Br-.
11. Postupak pripravljanja spoja prema bilo kojem zahtjevu 1 do 10, naznačen time, da obuhvaća reakciju spoja formule (II)
[image]
sa spojem formule (III)
L(CH2)n(Y)m(CH2)nL (III)
pri čemu
R1, R2, Y, m i n su kao što je određeno u bilo kojem zahtjevu 1 do 10; a L je ostavljena skupina; u otapalu ili mješavini otapala.
12. Postupak prema zahtjevu 11, naznačen time, da je ostavljena skupina odabrana od Cl, Br, metansulfonila i toluensulfonila.
13. Spoj prema bilo kojem zahtjevu 1 do 10, naznačen time, da se upotrebljava kao farmaceutsko sredstvo.
14. Farmaceutski sastav, naznačen time, da sadrži spoj prema bilo kojem zahtjevu 1 do 10 i farmaceutski prihvatljiv ekscipijent.
15. Farmaceutski sastav prema zahtjevu 14, naznačen time, da se upotrebljava kao antivirusni lijek.
16. Farmaceutski sastav prema zahtjevu 15, naznačen time, da se upotrebljava kao lijek protiv virusa herpesa.
17. Farmaceutski sastav prema zahtjevu 16, naznačen time, da virus herpesa je humani citomegalovirus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0600134A SE529777C2 (sv) | 2006-01-23 | 2006-01-23 | Nya föreningar och användning därav |
| PCT/SE2007/050033 WO2007084073A1 (en) | 2006-01-23 | 2007-01-22 | Novel compounds and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110534T1 true HRP20110534T1 (hr) | 2011-09-30 |
Family
ID=38287919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110534T HRP20110534T1 (hr) | 2006-01-23 | 2011-07-18 | Novi spojevi i njihova uporaba |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8076341B2 (hr) |
| EP (1) | EP1976853B1 (hr) |
| JP (1) | JP5190379B2 (hr) |
| CN (1) | CN101374845B (hr) |
| AR (1) | AR059149A1 (hr) |
| AT (1) | ATE506365T1 (hr) |
| AU (1) | AU2007206092B2 (hr) |
| BR (1) | BRPI0707203C1 (hr) |
| CA (1) | CA2637417C (hr) |
| CY (1) | CY1112596T1 (hr) |
| DE (1) | DE602007014008D1 (hr) |
| DK (1) | DK1976853T3 (hr) |
| ES (1) | ES2365423T3 (hr) |
| HR (1) | HRP20110534T1 (hr) |
| IL (1) | IL192820A (hr) |
| NZ (1) | NZ569840A (hr) |
| PL (1) | PL1976853T3 (hr) |
| PT (1) | PT1976853E (hr) |
| RS (1) | RS51933B (hr) |
| RU (1) | RU2437887C2 (hr) |
| SE (1) | SE529777C2 (hr) |
| SI (1) | SI1976853T1 (hr) |
| WO (1) | WO2007084073A1 (hr) |
| ZA (1) | ZA200806315B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2128160B1 (en) | 2008-04-30 | 2010-07-14 | Universität Duisburg-Essen | Indolo[2,3-b]-, Indeno[1,2-b]- and Indeno[2,1-b]pyrido[2,3-f] quinoxaline-3-carboxylic acids and esters, processes for their preparation and their use as antiviral, antibiotic and antitumor agents |
| EP2489354A1 (en) | 2011-02-18 | 2012-08-22 | Vironova AB | Pharmaceutical formulation of B220 for topical treatment of herpes |
| CN105061432B (zh) * | 2015-07-16 | 2017-09-29 | 河北大学 | 6H‑吲哚[2,3‑b]喹喔啉衍生物、药物组合物及其制备和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8600260D0 (sv) | 1986-01-21 | 1986-01-21 | Lundblad Leif | Substituerade indolokinoxaliner |
| SE8600261D0 (sv) * | 1986-01-21 | 1986-01-21 | Lundblad Leif | Indolokinoxaliner med substituenter i 6-position som innehaller cykliska grupper |
| SE527639C2 (sv) * | 2004-06-17 | 2006-05-02 | Oxypharma Ab | Alkylsubstituerade indolokinoxaliner |
-
2006
- 2006-01-23 SE SE0600134A patent/SE529777C2/sv not_active IP Right Cessation
-
2007
- 2007-01-22 ZA ZA200806315A patent/ZA200806315B/xx unknown
- 2007-01-22 WO PCT/SE2007/050033 patent/WO2007084073A1/en active Application Filing
- 2007-01-22 US US12/161,081 patent/US8076341B2/en not_active Expired - Fee Related
- 2007-01-22 PT PT07709426T patent/PT1976853E/pt unknown
- 2007-01-22 ES ES07709426T patent/ES2365423T3/es active Active
- 2007-01-22 RS RS20110304A patent/RS51933B/en unknown
- 2007-01-22 AU AU2007206092A patent/AU2007206092B2/en not_active Ceased
- 2007-01-22 RU RU2008134509/04A patent/RU2437887C2/ru active
- 2007-01-22 DK DK07709426.6T patent/DK1976853T3/da active
- 2007-01-22 AR ARP070100274A patent/AR059149A1/es not_active Application Discontinuation
- 2007-01-22 EP EP07709426A patent/EP1976853B1/en active Active
- 2007-01-22 SI SI200730657T patent/SI1976853T1/sl unknown
- 2007-01-22 CA CA2637417A patent/CA2637417C/en not_active Expired - Fee Related
- 2007-01-22 CN CN2007800028861A patent/CN101374845B/zh not_active Expired - Fee Related
- 2007-01-22 NZ NZ569840A patent/NZ569840A/en not_active IP Right Cessation
- 2007-01-22 PL PL07709426T patent/PL1976853T3/pl unknown
- 2007-01-22 AT AT07709426T patent/ATE506365T1/de active
- 2007-01-22 BR BRPI0707203A patent/BRPI0707203C1/pt not_active IP Right Cessation
- 2007-01-22 JP JP2008551228A patent/JP5190379B2/ja not_active Expired - Fee Related
- 2007-01-22 DE DE602007014008T patent/DE602007014008D1/de active Active
-
2008
- 2008-07-15 IL IL192820A patent/IL192820A/en active IP Right Grant
-
2011
- 2011-07-18 CY CY20111100698T patent/CY1112596T1/el unknown
- 2011-07-18 HR HR20110534T patent/HRP20110534T1/hr unknown
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