BRPI0707203C1 - compostos derivados de indoloquinoxalina úteis para o tratamento de infecções virais, método para preparar os compostos, e, composição farmacêutica - Google Patents

compostos derivados de indoloquinoxalina úteis para o tratamento de infecções virais, método para preparar os compostos, e, composição farmacêutica

Info

Publication number
BRPI0707203C1
BRPI0707203C1 BRPI0707203A BRPI0707203A BRPI0707203C1 BR PI0707203 C1 BRPI0707203 C1 BR PI0707203C1 BR PI0707203 A BRPI0707203 A BR PI0707203A BR PI0707203 A BRPI0707203 A BR PI0707203A BR PI0707203 C1 BRPI0707203 C1 BR PI0707203C1
Authority
BR
Brazil
Prior art keywords
preparing
treatment
pharmaceutical composition
compounds
indoloquinoxaline
Prior art date
Application number
BRPI0707203A
Other languages
English (en)
Inventor
Söderberg-Nauclér Cecilia
Bergman Jan
Homman Mohammed
Engqvist Robert
Original Assignee
Vironova Ab
Vironova Herpes Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vironova Ab, Vironova Herpes Ab filed Critical Vironova Ab
Publication of BRPI0707203A2 publication Critical patent/BRPI0707203A2/pt
Publication of BRPI0707203B1 publication Critical patent/BRPI0707203B1/pt
Publication of BRPI0707203B8 publication Critical patent/BRPI0707203B8/pt
Publication of BRPI0707203C1 publication Critical patent/BRPI0707203C1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

composto, método para preparar um composto, composição farmacêutica, e, método para tratar um animal vertebrado. um composto de fórmula (i) (i) na qual r1 é selecionado de h, f, cl, br, cf3, c1-c6 alcóxi e oh; r2 é selecionado de h e c1-c6 alquila; n é 1-12; m é 0 ou 1; y é selecionado de ch2, nr3, (nr3r4)+x, o e s; r3 e r4 são independentemente selecionados de h e c1-c4 alquila; e x- é selecionado de ânions farmaceuticamente aceitáveis. um método de preparar o composto, seu uso como um fármaco, e um método de tratamento.
BRPI0707203A 2006-01-23 2007-01-22 compostos derivados de indoloquinoxalina úteis para o tratamento de infecções virais, método para preparar os compostos, e, composição farmacêutica BRPI0707203C1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0600134-1 2006-01-23
SE0600134A SE529777C2 (sv) 2006-01-23 2006-01-23 Nya föreningar och användning därav
PCT/SE2007/050033 WO2007084073A1 (en) 2006-01-23 2007-01-22 Novel compounds and use thereof

Publications (4)

Publication Number Publication Date
BRPI0707203A2 BRPI0707203A2 (pt) 2011-04-26
BRPI0707203B1 BRPI0707203B1 (pt) 2020-11-10
BRPI0707203B8 BRPI0707203B8 (pt) 2020-12-08
BRPI0707203C1 true BRPI0707203C1 (pt) 2021-05-25

Family

ID=38287919

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0707203A BRPI0707203C1 (pt) 2006-01-23 2007-01-22 compostos derivados de indoloquinoxalina úteis para o tratamento de infecções virais, método para preparar os compostos, e, composição farmacêutica

Country Status (24)

Country Link
US (1) US8076341B2 (pt)
EP (1) EP1976853B1 (pt)
JP (1) JP5190379B2 (pt)
CN (1) CN101374845B (pt)
AR (1) AR059149A1 (pt)
AT (1) ATE506365T1 (pt)
AU (1) AU2007206092B2 (pt)
BR (1) BRPI0707203C1 (pt)
CA (1) CA2637417C (pt)
CY (1) CY1112596T1 (pt)
DE (1) DE602007014008D1 (pt)
DK (1) DK1976853T3 (pt)
ES (1) ES2365423T3 (pt)
HR (1) HRP20110534T1 (pt)
IL (1) IL192820A (pt)
NZ (1) NZ569840A (pt)
PL (1) PL1976853T3 (pt)
PT (1) PT1976853E (pt)
RS (1) RS51933B (pt)
RU (1) RU2437887C2 (pt)
SE (1) SE529777C2 (pt)
SI (1) SI1976853T1 (pt)
WO (1) WO2007084073A1 (pt)
ZA (1) ZA200806315B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602008001795D1 (de) 2008-04-30 2010-08-26 Univ Duisburg Essen IndolÄ2,3-bÜ-, IndenÄ1,2-bÜ- und IndenÄ2,1-bÜpyridoÄ2,3-fÜ Quinoxalin-3-Carboxylsäuren und Ester, Verfahren zu ihrer Herstellung und ihre Verwendung als Antivirus- und Antitumormittel
EP2489354A1 (en) 2011-02-18 2012-08-22 Vironova AB Pharmaceutical formulation of B220 for topical treatment of herpes
CN105061432B (zh) * 2015-07-16 2017-09-29 河北大学 6H‑吲哚[2,3‑b]喹喔啉衍生物、药物组合物及其制备和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8600260D0 (sv) * 1986-01-21 1986-01-21 Lundblad Leif Substituerade indolokinoxaliner
SE8600261D0 (sv) * 1986-01-21 1986-01-21 Lundblad Leif Indolokinoxaliner med substituenter i 6-position som innehaller cykliska grupper
SE527639C2 (sv) * 2004-06-17 2006-05-02 Oxypharma Ab Alkylsubstituerade indolokinoxaliner

Also Published As

Publication number Publication date
ES2365423T3 (es) 2011-10-04
RU2008134509A (ru) 2010-02-27
SE0600134L (sv) 2007-07-24
US8076341B2 (en) 2011-12-13
WO2007084073A1 (en) 2007-07-26
CN101374845A (zh) 2009-02-25
EP1976853B1 (en) 2011-04-20
BRPI0707203B8 (pt) 2020-12-08
US20090318458A1 (en) 2009-12-24
AU2007206092A1 (en) 2007-07-26
EP1976853A4 (en) 2010-04-21
HRP20110534T1 (hr) 2011-09-30
CN101374845B (zh) 2012-07-18
CY1112596T1 (el) 2016-02-10
PL1976853T3 (pl) 2011-09-30
AU2007206092B2 (en) 2012-05-17
ZA200806315B (en) 2010-04-28
ATE506365T1 (de) 2011-05-15
JP2009523792A (ja) 2009-06-25
PT1976853E (pt) 2011-07-20
CA2637417C (en) 2014-08-05
RS51933B (en) 2012-02-29
AR059149A1 (es) 2008-03-12
RU2437887C2 (ru) 2011-12-27
JP5190379B2 (ja) 2013-04-24
NZ569840A (en) 2011-06-30
BRPI0707203B1 (pt) 2020-11-10
CA2637417A1 (en) 2007-07-26
IL192820A0 (en) 2009-02-11
SI1976853T1 (sl) 2011-09-30
SE529777C2 (sv) 2007-11-20
DK1976853T3 (da) 2011-08-08
EP1976853A1 (en) 2008-10-08
DE602007014008D1 (de) 2011-06-01
IL192820A (en) 2012-08-30
BRPI0707203A2 (pt) 2011-04-26

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Legal Events

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B25A Requested transfer of rights approved

Owner name: VIRONOVA HERPES AB (SE)

B25G Requested change of headquarter approved

Owner name: VIRONOVA HERPES AB (SE)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 10/11/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2706 DE 16-11-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.