HRP20110106T1 - Bifenil i naftil-fenil derivati hidroksamske kiseline - Google Patents
Bifenil i naftil-fenil derivati hidroksamske kiseline Download PDFInfo
- Publication number
- HRP20110106T1 HRP20110106T1 HR20110106T HRP20110106T HRP20110106T1 HR P20110106 T1 HRP20110106 T1 HR P20110106T1 HR 20110106 T HR20110106 T HR 20110106T HR P20110106 T HRP20110106 T HR P20110106T HR P20110106 T1 HRP20110106 T1 HR P20110106T1
- Authority
- HR
- Croatia
- Prior art keywords
- hydroxy
- tumor
- leukemia
- biphenyl
- compound
- Prior art date
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 2
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 17
- -1 ethylene-dioxy Chemical class 0.000 claims abstract 4
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims abstract 2
- 125000001624 naphthyl group Chemical group 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 239000002246 antineoplastic agent Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 5
- 230000007170 pathology Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 3
- 206010000871 Acute monocytic leukaemia Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 3
- 208000018084 Bone neoplasm Diseases 0.000 claims 3
- 201000009030 Carcinoma Diseases 0.000 claims 3
- 208000017604 Hodgkin disease Diseases 0.000 claims 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
- 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 3
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 3
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 3
- 206010052399 Neuroendocrine tumour Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 claims 3
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 3
- 229940041181 antineoplastic drug Drugs 0.000 claims 3
- 208000002458 carcinoid tumor Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000016065 neuroendocrine neoplasm Diseases 0.000 claims 3
- 201000011519 neuroendocrine tumor Diseases 0.000 claims 3
- 229930002330 retinoic acid Natural products 0.000 claims 3
- SHGAZHPCJJPHSC-YCNIQYBTSA-N retinoic acid group Chemical group C\C(=C/C(=O)O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 3
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 claims 2
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 2
- ZXKINMCYCKHYFR-UHFFFAOYSA-N aminooxidanide Chemical compound [O-]N ZXKINMCYCKHYFR-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 230000002492 cytodifferentiating effect Effects 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- GBZPSEMNRBQROD-XCVCLJGOSA-N (e)-3-[4-(4-chlorophenyl)phenyl]-n-hydroxyprop-2-enamide Chemical compound C1=CC(/C=C/C(=O)NO)=CC=C1C1=CC=C(Cl)C=C1 GBZPSEMNRBQROD-XCVCLJGOSA-N 0.000 claims 1
- NJUOLWKIAIFTKT-BJMVGYQFSA-N (e)-3-[4-(4-cyanophenyl)phenyl]-n-hydroxyprop-2-enamide Chemical compound C1=CC(/C=C/C(=O)NO)=CC=C1C1=CC=C(C#N)C=C1 NJUOLWKIAIFTKT-BJMVGYQFSA-N 0.000 claims 1
- IYNCGZPHMORBFM-QHHAFSJGSA-N (e)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorophenyl]-n-hydroxyprop-2-enamide Chemical compound ClC1=CC(/C=C/C(=O)NO)=CC=C1C1=CC=C(O)C(C23CC4CC(CC(C4)C2)C3)=C1 IYNCGZPHMORBFM-QHHAFSJGSA-N 0.000 claims 1
- UGGXMNLTFKYUMB-FPYGCLRLSA-N (e)-3-[4-[3-(1-adamantyl)-4-hydroxyphenyl]phenyl]-n-hydroxyprop-2-enamide Chemical compound C1=CC(/C=C/C(=O)NO)=CC=C1C1=CC=C(O)C(C23CC4CC(CC(C4)C2)C3)=C1 UGGXMNLTFKYUMB-FPYGCLRLSA-N 0.000 claims 1
- XQHSUPFWQCTNGV-RUDMXATFSA-N (e)-3-[4-[3-(1-adamantyl)-4-methoxyphenyl]phenyl]-n-hydroxyprop-2-enamide Chemical compound C1=C(C23CC4CC(CC(C4)C2)C3)C(OC)=CC=C1C1=CC=C(\C=C\C(=O)NO)C=C1 XQHSUPFWQCTNGV-RUDMXATFSA-N 0.000 claims 1
- MGGQEULGVBEMAL-XCVCLJGOSA-N (e)-n-hydroxy-3-[4-(4-hydroxyphenyl)phenyl]prop-2-enamide Chemical compound C1=CC(/C=C/C(=O)NO)=CC=C1C1=CC=C(O)C=C1 MGGQEULGVBEMAL-XCVCLJGOSA-N 0.000 claims 1
- WKQPXLKFQLGQSM-NYYWCZLTSA-N (e)-n-hydroxy-3-[4-(4-methoxyphenyl)phenyl]prop-2-enamide Chemical compound C1=CC(OC)=CC=C1C1=CC=C(\C=C\C(=O)NO)C=C1 WKQPXLKFQLGQSM-NYYWCZLTSA-N 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229940123237 Taxane Drugs 0.000 claims 1
- 229940122803 Vinca alkaloid Drugs 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 238000009830 intercalation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229930014626 natural product Natural products 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05013953 | 2005-06-28 | ||
| PCT/EP2006/062799 WO2007000383A1 (en) | 2005-06-28 | 2006-05-31 | Biphenyl and naphthyl-phenyl hydroxamic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110106T1 true HRP20110106T1 (hr) | 2011-03-31 |
Family
ID=35708385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110106T HRP20110106T1 (hr) | 2005-06-28 | 2011-02-14 | Bifenil i naftil-fenil derivati hidroksamske kiseline |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7728039B2 (ru) |
| EP (1) | EP1896399B1 (ru) |
| JP (1) | JP5080462B2 (ru) |
| KR (1) | KR101288376B1 (ru) |
| CN (2) | CN102993051A (ru) |
| AR (1) | AR057407A1 (ru) |
| AT (1) | ATE488493T1 (ru) |
| AU (1) | AU2006263915B2 (ru) |
| BR (1) | BRPI0612492A2 (ru) |
| CA (1) | CA2607207C (ru) |
| CY (1) | CY1111451T1 (ru) |
| DE (1) | DE602006018298D1 (ru) |
| DK (1) | DK1896399T3 (ru) |
| EA (1) | EA012729B1 (ru) |
| ES (1) | ES2356129T3 (ru) |
| HR (1) | HRP20110106T1 (ru) |
| MX (1) | MX2007014647A (ru) |
| PL (1) | PL1896399T3 (ru) |
| PT (1) | PT1896399E (ru) |
| RS (1) | RS51576B (ru) |
| SI (1) | SI1896399T1 (ru) |
| TW (1) | TWI383969B (ru) |
| WO (1) | WO2007000383A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201031402A (en) * | 2008-12-24 | 2010-09-01 | Sigma Tau Ind Farmaceuti | New retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties |
| WO2010106135A1 (en) | 2009-03-20 | 2010-09-23 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Combined use for the treatment of ovarian carcinoma |
| WO2013101600A1 (en) * | 2011-12-29 | 2013-07-04 | Pharmacyclics, Inc. | Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8 |
| CN105476980B (zh) * | 2014-09-28 | 2018-07-24 | 复旦大学 | 联苯类化合物4-(3’,4’-二羟苯基)肉桂酸在制药中的用途 |
| EP3301085A1 (en) | 2016-09-29 | 2018-04-04 | Biogem S.Ca.R.L. | Retinoid derivatives with antitumor activity |
| WO2019134087A1 (zh) * | 2018-01-04 | 2019-07-11 | 北京大学深圳研究生院 | 同时抑制lsd1和hdac靶点的化合物及其应用 |
| CN108314630B (zh) * | 2018-02-08 | 2020-11-06 | 广西民族大学 | 一种肟醚类衍生物及其制备方法与应用 |
| WO2022229017A1 (en) | 2021-04-27 | 2022-11-03 | Biogem S.C.A R.L. | Adamantyl retinoid derivative with anticancer activity |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10182583A (ja) * | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | 新規ヒドロキサム酸誘導体 |
| JP2004359546A (ja) * | 2001-03-15 | 2004-12-24 | Ono Pharmaceut Co Ltd | ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および／または治療剤 |
| ITRM20010464A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati retinoidi ad attivita' antiangiogenica, antitumorale e pro-apoptotica. |
-
2006
- 2006-05-31 MX MX2007014647A patent/MX2007014647A/es active IP Right Grant
- 2006-05-31 BR BRPI0612492-5A patent/BRPI0612492A2/pt not_active IP Right Cessation
- 2006-05-31 EP EP06763427A patent/EP1896399B1/en active Active
- 2006-05-31 CA CA2607207A patent/CA2607207C/en not_active Expired - Fee Related
- 2006-05-31 DE DE602006018298T patent/DE602006018298D1/de active Active
- 2006-05-31 AT AT06763427T patent/ATE488493T1/de active
- 2006-05-31 DK DK06763427.9T patent/DK1896399T3/da active
- 2006-05-31 US US11/993,184 patent/US7728039B2/en not_active Expired - Fee Related
- 2006-05-31 SI SI200630925T patent/SI1896399T1/sl unknown
- 2006-05-31 PL PL06763427T patent/PL1896399T3/pl unknown
- 2006-05-31 RS RS20110074A patent/RS51576B/en unknown
- 2006-05-31 CN CN2012102945853A patent/CN102993051A/zh active Pending
- 2006-05-31 EA EA200800156A patent/EA012729B1/ru not_active IP Right Cessation
- 2006-05-31 AU AU2006263915A patent/AU2006263915B2/en not_active Ceased
- 2006-05-31 CN CNA200680021008XA patent/CN101198586A/zh active Pending
- 2006-05-31 PT PT06763427T patent/PT1896399E/pt unknown
- 2006-05-31 ES ES06763427T patent/ES2356129T3/es active Active
- 2006-05-31 JP JP2008518775A patent/JP5080462B2/ja not_active Expired - Fee Related
- 2006-05-31 WO PCT/EP2006/062799 patent/WO2007000383A1/en active Application Filing
- 2006-05-31 KR KR1020077029094A patent/KR101288376B1/ko not_active IP Right Cessation
- 2006-06-12 TW TW095120842A patent/TWI383969B/zh not_active IP Right Cessation
- 2006-06-26 AR ARP060102734A patent/AR057407A1/es unknown
-
2011
- 2011-02-14 HR HR20110106T patent/HRP20110106T1/hr unknown
- 2011-02-16 CY CY20111100190T patent/CY1111451T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2607207C (en) | 2015-01-20 |
| AR057407A1 (es) | 2007-12-05 |
| KR101288376B1 (ko) | 2013-07-22 |
| TW200740728A (en) | 2007-11-01 |
| RS51576B (en) | 2011-08-31 |
| MX2007014647A (es) | 2008-02-11 |
| KR20080017028A (ko) | 2008-02-25 |
| AU2006263915B2 (en) | 2011-12-01 |
| EP1896399A1 (en) | 2008-03-12 |
| TWI383969B (zh) | 2013-02-01 |
| EA012729B1 (ru) | 2009-12-30 |
| CA2607207A1 (en) | 2007-01-04 |
| EA200800156A1 (ru) | 2008-04-28 |
| JP2008546822A (ja) | 2008-12-25 |
| CN102993051A (zh) | 2013-03-27 |
| WO2007000383A1 (en) | 2007-01-04 |
| AU2006263915A1 (en) | 2007-01-04 |
| PL1896399T3 (pl) | 2011-04-29 |
| US7728039B2 (en) | 2010-06-01 |
| ATE488493T1 (de) | 2010-12-15 |
| BRPI0612492A2 (pt) | 2010-11-23 |
| ES2356129T3 (es) | 2011-04-05 |
| DK1896399T3 (da) | 2011-02-21 |
| JP5080462B2 (ja) | 2012-11-21 |
| EP1896399B1 (en) | 2010-11-17 |
| CN101198586A (zh) | 2008-06-11 |
| PT1896399E (pt) | 2011-02-16 |
| DE602006018298D1 (ru) | 2010-12-30 |
| SI1896399T1 (sl) | 2011-08-31 |
| CY1111451T1 (el) | 2015-08-05 |
| US20080319082A1 (en) | 2008-12-25 |
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