HRP20100560T1 - Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina - Google Patents
Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina Download PDFInfo
- Publication number
- HRP20100560T1 HRP20100560T1 HR20100560T HRP20100560T HRP20100560T1 HR P20100560 T1 HRP20100560 T1 HR P20100560T1 HR 20100560 T HR20100560 T HR 20100560T HR P20100560 T HRP20100560 T HR P20100560T HR P20100560 T1 HRP20100560 T1 HR P20100560T1
- Authority
- HR
- Croatia
- Prior art keywords
- use according
- interest
- polypeptide
- human
- subunit
- Prior art date
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 title claims abstract 7
- 239000012212 insulator Substances 0.000 title claims abstract 7
- 108010077544 Chromatin Proteins 0.000 title claims abstract 3
- 210000003483 chromatin Anatomy 0.000 title claims abstract 3
- 230000014509 gene expression Effects 0.000 title claims 6
- 108090000623 proteins and genes Proteins 0.000 title claims 5
- 102000004169 proteins and genes Human genes 0.000 title claims 2
- 229920001184 polypeptide Polymers 0.000 claims abstract 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 12
- 239000013598 vector Substances 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 5
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 108020004414 DNA Proteins 0.000 claims 4
- -1 intron Proteins 0.000 claims 3
- 101710169336 5'-deoxyadenosine deaminase Proteins 0.000 claims 2
- 102000055025 Adenosine deaminases Human genes 0.000 claims 2
- 101001091269 Escherichia coli Hygromycin-B 4-O-kinase Proteins 0.000 claims 2
- 102000003864 Human Follicle Stimulating Hormone Human genes 0.000 claims 2
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 claims 2
- 102000052812 Ornithine decarboxylases Human genes 0.000 claims 2
- 108700005126 Ornithine decarboxylases Proteins 0.000 claims 2
- 101001091268 Streptomyces hygroscopicus Hygromycin-B 7''-O-kinase Proteins 0.000 claims 2
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 claims 2
- 238000001890 transfection Methods 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- 108020003589 5' Untranslated Regions Proteins 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 claims 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108010092408 Eosinophil Peroxidase Proteins 0.000 claims 1
- 102100028471 Eosinophil peroxidase Human genes 0.000 claims 1
- 108010008165 Etanercept Proteins 0.000 claims 1
- 102000048120 Galactokinases Human genes 0.000 claims 1
- 108700023157 Galactokinases Proteins 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 claims 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 claims 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 101710205006 Interleukin-18-binding protein Proteins 0.000 claims 1
- 102100035017 Interleukin-18-binding protein Human genes 0.000 claims 1
- 108010025815 Kanamycin Kinase Proteins 0.000 claims 1
- 108060001084 Luciferase Proteins 0.000 claims 1
- 239000005089 Luciferase Substances 0.000 claims 1
- 206010048723 Multiple-drug resistance Diseases 0.000 claims 1
- 108010022394 Threonine synthase Proteins 0.000 claims 1
- 102000006601 Thymidine Kinase Human genes 0.000 claims 1
- 108020004440 Thymidine kinase Proteins 0.000 claims 1
- 108010027570 Xanthine phosphoribosyltransferase Proteins 0.000 claims 1
- 102000006646 aminoglycoside phosphotransferase Human genes 0.000 claims 1
- 239000003114 blood coagulation factor Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 102000004419 dihydrofolate reductase Human genes 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 229960000403 etanercept Drugs 0.000 claims 1
- 229940014144 folate Drugs 0.000 claims 1
- 102000006815 folate receptor Human genes 0.000 claims 1
- 108020005243 folate receptor Proteins 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 239000005090 green fluorescent protein Substances 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 230000008488 polyadenylation Effects 0.000 claims 1
- 229950010131 puromycin Drugs 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 210000003705 ribosome Anatomy 0.000 claims 1
- 238000003153 stable transfection Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03103890 | 2003-10-21 | ||
| PCT/EP2004/052591 WO2005040384A1 (fr) | 2003-10-21 | 2004-10-20 | Sequence d'adn minime isolant la chromatine et son utilisation dans l'expression de proteine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100560T1 true HRP20100560T1 (hr) | 2010-11-30 |
Family
ID=34486337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100560T HRP20100560T1 (hr) | 2003-10-21 | 2010-10-14 | Minimalna dnk sekvenca koja djeluje kao izolator kromatina i njena upotreba u ekspresiji proteina |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8133699B2 (fr) |
| EP (1) | EP1675956B1 (fr) |
| JP (1) | JP4745972B2 (fr) |
| AT (1) | ATE484591T1 (fr) |
| AU (1) | AU2004284243B2 (fr) |
| CA (1) | CA2541523A1 (fr) |
| CY (1) | CY1110868T1 (fr) |
| DE (1) | DE602004029598D1 (fr) |
| DK (1) | DK1675956T3 (fr) |
| ES (1) | ES2354160T3 (fr) |
| HR (1) | HRP20100560T1 (fr) |
| IL (1) | IL175021A (fr) |
| NO (1) | NO338767B1 (fr) |
| PL (1) | PL1675956T3 (fr) |
| PT (1) | PT1675956E (fr) |
| SI (1) | SI1675956T1 (fr) |
| WO (1) | WO2005040384A1 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4307079B2 (ja) | 2001-01-26 | 2009-08-05 | セレキス エスアー | マトリックス付着領域およびその使用方法 |
| DK1601776T3 (da) | 2003-03-11 | 2008-10-13 | Serono Lab | Ekspressionsvektorer omfattende mCmV-IE2-promotoren |
| ATE549353T1 (de) * | 2003-05-13 | 2012-03-15 | Merck Serono Sa | Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen |
| RU2375450C2 (ru) | 2003-10-24 | 2009-12-10 | Селексис С.А. | Днк, повышающая продуцирование белка, и ее применение |
| ATE360647T1 (de) * | 2003-11-05 | 2007-05-15 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
| SI1720979T1 (sl) | 2004-03-01 | 2007-12-31 | Ares Trading Sa | Uporaba medija za celiäśno kulturo brez seruma zaizdelavo il-18bp pri celicah sesalcev |
| DE602005009827D1 (de) * | 2004-06-29 | 2008-10-30 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
| PL2267024T3 (pl) * | 2005-06-03 | 2012-10-31 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| RS52273B (en) | 2005-06-10 | 2012-10-31 | Ares Trading S.A. | PROCESS FOR PURIFICATION OF IL-18 BINDING PROTEIN |
| EP1760092A1 (fr) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | Système pour le criblage des cellules à haute expression d'une protéine d'intérêt |
| FR2919616A1 (fr) * | 2007-08-02 | 2009-02-06 | Ecole Norm Superieure Lyon | Polynucleotides insulateurs derives de l'element d4z4 et leurs utilisations en transgenese |
| KR101993938B1 (ko) | 2011-04-13 | 2019-06-27 | 내셔날 리서치 카운실 오브 캐나다 | IFNα2로부터의 SAR 인자를 갖는 발현 시스템 |
| US20140342432A1 (en) * | 2011-12-21 | 2014-11-20 | Danisco Us Inc. | Fungal Gene Expression Using Insulator DNA Sequences |
| JP6297559B2 (ja) * | 2012-07-31 | 2018-03-20 | バジル・エム・ハンタッシュＢａｓｉｌ Ｍ． ＨＡＮＴＡＳＨ | Ｈｌａｇ改変された細胞および方法 |
| KR101591823B1 (ko) | 2013-12-27 | 2016-02-04 | 재단법인 목암생명공학연구소 | 증가된 유전자 발현능을 갖는 발현벡터 |
| WO2017075395A1 (fr) * | 2015-10-28 | 2017-05-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Vecteurs adénoviraux à spécificité tumorale et leurs utilisations thérapeutiques |
| CA3002524A1 (fr) * | 2015-10-28 | 2017-05-04 | Sangamo Therapeutics, Inc. | Constructions specifiques au foie, cassettes d'expression du facteur viii et leurs methodes d'utilisation |
| CN106754817B (zh) * | 2016-11-03 | 2021-02-05 | 山西省生物研究院有限公司 | 一种重组自分泌运动因子的表达方法 |
| US10947295B2 (en) | 2017-08-22 | 2021-03-16 | Sanabio, Llc | Heterodimers of soluble interferon receptors and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
| US6432700B1 (en) * | 1997-03-03 | 2002-08-13 | Cell Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
| US6194152B1 (en) * | 1997-08-20 | 2001-02-27 | Dendreon Corporation | Prostate tumor polynucleotide compositions and methods of detection thereof |
| AU1128400A (en) * | 1998-10-22 | 2000-05-08 | Medical College Of Georgia Institute, Inc. | Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors |
| CA2377929A1 (fr) * | 1999-06-30 | 2001-01-11 | Adam C. Bell | Sequence et proteine de liaison a l'adn utilisees en tant qu'isolants dotes d'une activite de blocage d'amplificateurs specifiques pour la regulation d'une expression genique |
| DK1601776T3 (da) | 2003-03-11 | 2008-10-13 | Serono Lab | Ekspressionsvektorer omfattende mCmV-IE2-promotoren |
| ATE549353T1 (de) | 2003-05-13 | 2012-03-15 | Merck Serono Sa | Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen |
| ATE360647T1 (de) | 2003-11-05 | 2007-05-15 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
| SI1720979T1 (sl) | 2004-03-01 | 2007-12-31 | Ares Trading Sa | Uporaba medija za celiäśno kulturo brez seruma zaizdelavo il-18bp pri celicah sesalcev |
| DE602005009827D1 (de) | 2004-06-29 | 2008-10-30 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
| PL2267024T3 (pl) | 2005-06-03 | 2012-10-31 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| RS52273B (en) | 2005-06-10 | 2012-10-31 | Ares Trading S.A. | PROCESS FOR PURIFICATION OF IL-18 BINDING PROTEIN |
-
2004
- 2004-10-20 EP EP04791263A patent/EP1675956B1/fr active Active
- 2004-10-20 ES ES04791263T patent/ES2354160T3/es active Active
- 2004-10-20 SI SI200431541T patent/SI1675956T1/sl unknown
- 2004-10-20 DK DK04791263.9T patent/DK1675956T3/da active
- 2004-10-20 JP JP2006536087A patent/JP4745972B2/ja active Active
- 2004-10-20 CA CA002541523A patent/CA2541523A1/fr not_active Abandoned
- 2004-10-20 AT AT04791263T patent/ATE484591T1/de active
- 2004-10-20 PL PL04791263T patent/PL1675956T3/pl unknown
- 2004-10-20 PT PT04791263T patent/PT1675956E/pt unknown
- 2004-10-20 AU AU2004284243A patent/AU2004284243B2/en active Active
- 2004-10-20 DE DE602004029598T patent/DE602004029598D1/de active Active
- 2004-10-20 US US10/576,509 patent/US8133699B2/en active Active
- 2004-10-20 WO PCT/EP2004/052591 patent/WO2005040384A1/fr active Application Filing
-
2006
- 2006-04-20 IL IL175021A patent/IL175021A/en active IP Right Grant
- 2006-05-22 NO NO20062315A patent/NO338767B1/no unknown
-
2010
- 2010-10-14 HR HR20100560T patent/HRP20100560T1/hr unknown
- 2010-10-29 CY CY20101100982T patent/CY1110868T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004284243B2 (en) | 2010-11-04 |
| DK1675956T3 (da) | 2010-11-22 |
| ES2354160T3 (es) | 2011-03-10 |
| CA2541523A1 (fr) | 2005-05-06 |
| WO2005040384A1 (fr) | 2005-05-06 |
| ATE484591T1 (de) | 2010-10-15 |
| IL175021A0 (en) | 2006-08-20 |
| US8133699B2 (en) | 2012-03-13 |
| NO338767B1 (no) | 2016-10-17 |
| JP2007508833A (ja) | 2007-04-12 |
| EP1675956A1 (fr) | 2006-07-05 |
| SI1675956T1 (sl) | 2010-12-31 |
| US20070134761A1 (en) | 2007-06-14 |
| NO20062315L (no) | 2006-07-18 |
| DE602004029598D1 (de) | 2010-11-25 |
| PT1675956E (pt) | 2010-11-04 |
| CY1110868T1 (el) | 2015-06-10 |
| PL1675956T3 (pl) | 2011-06-30 |
| IL175021A (en) | 2011-07-31 |
| JP4745972B2 (ja) | 2011-08-10 |
| AU2004284243A1 (en) | 2005-05-06 |
| EP1675956B1 (fr) | 2010-10-13 |
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