ATE484591T1 - Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression - Google Patents

Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression

Info

Publication number
ATE484591T1
ATE484591T1 AT04791263T AT04791263T ATE484591T1 AT E484591 T1 ATE484591 T1 AT E484591T1 AT 04791263 T AT04791263 T AT 04791263T AT 04791263 T AT04791263 T AT 04791263T AT E484591 T1 ATE484591 T1 AT E484591T1
Authority
AT
Austria
Prior art keywords
dna sequence
protein expression
chromatin insulator
minimal dna
sequence acting
Prior art date
Application number
AT04791263T
Other languages
English (en)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Application granted granted Critical
Publication of ATE484591T1 publication Critical patent/ATE484591T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04791263T 2003-10-21 2004-10-20 Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression ATE484591T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03103890 2003-10-21
PCT/EP2004/052591 WO2005040384A1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression

Publications (1)

Publication Number Publication Date
ATE484591T1 true ATE484591T1 (de) 2010-10-15

Family

ID=34486337

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04791263T ATE484591T1 (de) 2003-10-21 2004-10-20 Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression

Country Status (17)

Country Link
US (1) US8133699B2 (de)
EP (1) EP1675956B1 (de)
JP (1) JP4745972B2 (de)
AT (1) ATE484591T1 (de)
AU (1) AU2004284243B2 (de)
CA (1) CA2541523A1 (de)
CY (1) CY1110868T1 (de)
DE (1) DE602004029598D1 (de)
DK (1) DK1675956T3 (de)
ES (1) ES2354160T3 (de)
HR (1) HRP20100560T1 (de)
IL (1) IL175021A (de)
NO (1) NO338767B1 (de)
PL (1) PL1675956T3 (de)
PT (1) PT1675956E (de)
SI (1) SI1675956T1 (de)
WO (1) WO2005040384A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4307079B2 (ja) 2001-01-26 2009-08-05 セレキス エスアー マトリックス付着領域およびその使用方法
DK1601776T3 (da) 2003-03-11 2008-10-13 Serono Lab Ekspressionsvektorer omfattende mCmV-IE2-promotoren
ATE549353T1 (de) * 2003-05-13 2012-03-15 Merck Serono Sa Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
RU2375450C2 (ru) 2003-10-24 2009-12-10 Селексис С.А. Днк, повышающая продуцирование белка, и ее применение
ATE360647T1 (de) * 2003-11-05 2007-05-15 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
SI1720979T1 (sl) 2004-03-01 2007-12-31 Ares Trading Sa Uporaba medija za celiäśno kulturo brez seruma zaizdelavo il-18bp pri celicah sesalcev
DE602005009827D1 (de) * 2004-06-29 2008-10-30 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
PL2267024T3 (pl) * 2005-06-03 2012-10-31 Ares Trading Sa Wytwarzanie rekombinowanego białka wiążącego IL-18
RS52273B (en) 2005-06-10 2012-10-31 Ares Trading S.A. PROCESS FOR PURIFICATION OF IL-18 BINDING PROTEIN
EP1760092A1 (de) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System für Screening von Zellen mit hoher Expression von einem interessierenden Protein
FR2919616A1 (fr) * 2007-08-02 2009-02-06 Ecole Norm Superieure Lyon Polynucleotides insulateurs derives de l'element d4z4 et leurs utilisations en transgenese
KR101993938B1 (ko) 2011-04-13 2019-06-27 내셔날 리서치 카운실 오브 캐나다 IFNα2로부터의 SAR 인자를 갖는 발현 시스템
US20140342432A1 (en) * 2011-12-21 2014-11-20 Danisco Us Inc. Fungal Gene Expression Using Insulator DNA Sequences
JP6297559B2 (ja) * 2012-07-31 2018-03-20 バジル・エム・ハンタッシュＢａｓｉｌ Ｍ． ＨＡＮＴＡＳＨ Ｈｌａｇ改変された細胞および方法
KR101591823B1 (ko) 2013-12-27 2016-02-04 재단법인 목암생명공학연구소 증가된 유전자 발현능을 갖는 발현벡터
WO2017075395A1 (en) * 2015-10-28 2017-05-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
CA3002524A1 (en) * 2015-10-28 2017-05-04 Sangamo Therapeutics, Inc. Liver-specific constructs, factor viii expression cassettes and methods of use thereof
CN106754817B (zh) * 2016-11-03 2021-02-05 山西省生物研究院有限公司 一种重组自分泌运动因子的表达方法
US10947295B2 (en) 2017-08-22 2021-03-16 Sanabio, Llc Heterodimers of soluble interferon receptors and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US6432700B1 (en) * 1997-03-03 2002-08-13 Cell Genesys, Inc. Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same
US6194152B1 (en) * 1997-08-20 2001-02-27 Dendreon Corporation Prostate tumor polynucleotide compositions and methods of detection thereof
AU1128400A (en) * 1998-10-22 2000-05-08 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
CA2377929A1 (en) * 1999-06-30 2001-01-11 Adam C. Bell Dna binding protein and sequence as insulators having specific enhancer blocking activity for regulation of gene expression
DK1601776T3 (da) 2003-03-11 2008-10-13 Serono Lab Ekspressionsvektorer omfattende mCmV-IE2-promotoren
ATE549353T1 (de) 2003-05-13 2012-03-15 Merck Serono Sa Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen
ATE360647T1 (de) 2003-11-05 2007-05-15 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
SI1720979T1 (sl) 2004-03-01 2007-12-31 Ares Trading Sa Uporaba medija za celiäśno kulturo brez seruma zaizdelavo il-18bp pri celicah sesalcev
DE602005009827D1 (de) 2004-06-29 2008-10-30 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
PL2267024T3 (pl) 2005-06-03 2012-10-31 Ares Trading Sa Wytwarzanie rekombinowanego białka wiążącego IL-18
RS52273B (en) 2005-06-10 2012-10-31 Ares Trading S.A. PROCESS FOR PURIFICATION OF IL-18 BINDING PROTEIN

Also Published As

Publication number Publication date
AU2004284243B2 (en) 2010-11-04
DK1675956T3 (da) 2010-11-22
ES2354160T3 (es) 2011-03-10
CA2541523A1 (en) 2005-05-06
WO2005040384A1 (en) 2005-05-06
IL175021A0 (en) 2006-08-20
US8133699B2 (en) 2012-03-13
NO338767B1 (no) 2016-10-17
JP2007508833A (ja) 2007-04-12
EP1675956A1 (de) 2006-07-05
SI1675956T1 (sl) 2010-12-31
US20070134761A1 (en) 2007-06-14
NO20062315L (no) 2006-07-18
DE602004029598D1 (de) 2010-11-25
PT1675956E (pt) 2010-11-04
CY1110868T1 (el) 2015-06-10
PL1675956T3 (pl) 2011-06-30
IL175021A (en) 2011-07-31
JP4745972B2 (ja) 2011-08-10
HRP20100560T1 (hr) 2010-11-30
AU2004284243A1 (en) 2005-05-06
EP1675956B1 (de) 2010-10-13

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