HRP20100343T1 - Intranazalne kompozicije - Google Patents
Intranazalne kompozicije Download PDFInfo
- Publication number
- HRP20100343T1 HRP20100343T1 HR20100343T HRP20100343T HRP20100343T1 HR P20100343 T1 HRP20100343 T1 HR P20100343T1 HR 20100343 T HR20100343 T HR 20100343T HR P20100343 T HRP20100343 T HR P20100343T HR P20100343 T1 HRP20100343 T1 HR P20100343T1
- Authority
- HR
- Croatia
- Prior art keywords
- composition according
- salt
- granisetron
- derivative
- chitosan
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 24
- 150000003839 salts Chemical class 0.000 claims abstract 11
- MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 claims abstract 7
- 229960003727 granisetron Drugs 0.000 claims abstract 7
- 229920001661 Chitosan Polymers 0.000 claims abstract 6
- 206010028813 Nausea Diseases 0.000 claims abstract 3
- 206010047700 Vomiting Diseases 0.000 claims abstract 3
- 239000007864 aqueous solution Substances 0.000 claims abstract 3
- 230000008693 nausea Effects 0.000 claims abstract 3
- 230000002265 prevention Effects 0.000 claims abstract 3
- 230000008673 vomiting Effects 0.000 claims abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical class CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 239000012458 free base Substances 0.000 claims 3
- 239000000843 powder Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical class C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical class OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Chemical class 0.000 claims 1
- 239000002202 Polyethylene glycol Chemical class 0.000 claims 1
- 229960002903 benzyl benzoate Drugs 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229960003607 granisetron hydrochloride Drugs 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- QYZRTBKYBJRGJB-UHFFFAOYSA-N hydron;1-methyl-n-(9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)indazole-3-carboxamide;chloride Chemical compound Cl.C1=CC=C2C(C(=O)NC3CC4CCCC(C3)N4C)=NN(C)C2=C1 QYZRTBKYBJRGJB-UHFFFAOYSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 239000012457 nonaqueous media Substances 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 229920001223 polyethylene glycol Chemical class 0.000 claims 1
- -1 polyoxyethylene Chemical class 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Kompozicija za nazalno davanje, koja se sastoji od granisetrona ili njegove faramceutski prihvatljive soli i hitosana, njegove soli, derivata ili soli njegovog derivata. Patent sadrži još 20 patentnih zahtjeva.
Claims (21)
1. Kompozicija za nazalno davanje, koja se sastoji od granisetrona ili njegove faramceutski prihvatljive soli i hitosana, njegove soli, derivata ili soli njegovog derivata.
2. Kompozicija prema zahtjevu 1, u obliku otopine ili praha.
3. Kompozicija prema zahtjevu 2, u obliku vodene otopine.
4. Kompozicija prema bilo kojem od prethodnih zahtjeva, koja sadrži sol granisetrona izabranu od hidrokloridne, mezilatne, citratne, nitratne, laktatne, maleatne, tartaratne, fosfatne, sukcinatne, fumaratne i glukonatne soli.
5. Kompozicija prema zahtjevu 4, naznačena time, što je sol hidrokloridna.
6. Kompozicija prema bilo kojem od prethodnih zahtjeva, koja je u obliku otopine i sadrži od 0.2 do 150 mg/ml granisetrona (izraženih kao slobodna baza).
7. Kompozicija prema zahtjevu 6, koja sadrži od 1 do 100 mg/ml granisetrona (izraženog kao slobodna baza).
8. Kompozicija prema bilo kojem od prethodnih zahtjeva koja ima osmolalnost od 0.15 do 0.45 osmol/kg.
9. Kompozicija prema bilo kojem od prethodnih zahtjeva koja ima pH od 4.0 do 7.0.
10. Kompozicija prema bilo kojem od prethodnih zahtjeva, koja sadrži od 0.5 do 50 mg/ml hitosana.
11. Kompozicija prema zahtjevu 10, koja je vodena otopina i sadrži od 1 do 112 mg/ml granisetron hidroklorida i 2 do 10 mg/ml hitosan glutamata.
12. Kompozicija prema bilo kojem od zahtjeva 1, 2 i 4 do 10, u obliku nevodenih otopina.
13. Kompozicija prema zahtjevu 12, koja sadrži bar jedan etanol, propilen glikol, polietilen glikol, glikofurol, benzil benzoat i polioksietilenski derivat ricinusovog ulja.
14. Kompozicija prema bilo kojem od zahtjeva 1, 2 i 4 do 10 u obliku praha.
15. Kompozicija prema zahtjevu 14, naznačena time, što prah sadrži granule ili mikrosfere.
16. Kompozicija prema zahtjevu 14 ili 15, koja sadrži 30 do 70% težinskih granisetrona (izraženog kao slobodna baza).
17. Kompozicija prema bilo kojem od zahtjeva 1 do 16, za nazalno davanje pacijentu kojem je to potrebno.
18. Kompozicija prema bilo kojem od zahtjeva 1 do 16, je za upotrebu u liječenju ili prevenciji mučnine i/ili povraćanja.
19. Upotreba granisetrona ili njegove farmaceutski prihvatljive soli i hitosana, njegove soli, derivata ili soli derivata u proizvodnju lijeka za nazalno davanje pacijentu kojem je to potrebno.
20. Upotreba prema zahtjevu 19, u proizvodnju lijeka za liječenje ili prevenciju mučnine i/ili povraćanja.
21. Uređaj za nazalno davanje lijeka ili dozni kartridž za upotrebu u uređaju za nazalno davanje lijeka koji se sastoji od kompozicije u bilo kojem od zahtjeva 1 do 18.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0328186.2A GB0328186D0 (en) | 2003-12-05 | 2003-12-05 | Intranasal compositions |
| PCT/GB2004/005043 WO2005056008A1 (en) | 2003-12-05 | 2004-11-30 | Intranasal compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100343T1 true HRP20100343T1 (hr) | 2010-11-30 |
Family
ID=29764615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100343T HRP20100343T1 (hr) | 2003-12-05 | 2010-06-17 | Intranazalne kompozicije |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US7947257B2 (hr) |
| EP (1) | EP1696911B1 (hr) |
| JP (1) | JP5103018B2 (hr) |
| KR (1) | KR101194593B1 (hr) |
| CN (2) | CN102389422A (hr) |
| AT (1) | ATE460932T1 (hr) |
| AU (1) | AU2004296586B2 (hr) |
| BR (1) | BRPI0417350A2 (hr) |
| CA (1) | CA2548559C (hr) |
| CY (1) | CY1110664T1 (hr) |
| DE (1) | DE602004026107D1 (hr) |
| DK (1) | DK1696911T3 (hr) |
| ES (1) | ES2357607T3 (hr) |
| GB (1) | GB0328186D0 (hr) |
| HR (1) | HRP20100343T1 (hr) |
| IL (1) | IL176132A (hr) |
| ME (1) | ME01070B (hr) |
| MX (1) | MXPA06006239A (hr) |
| NO (1) | NO335348B1 (hr) |
| NZ (1) | NZ547848A (hr) |
| PL (1) | PL1696911T3 (hr) |
| PT (1) | PT1696911E (hr) |
| RS (1) | RS51251B (hr) |
| SI (1) | SI1696911T1 (hr) |
| WO (1) | WO2005056008A1 (hr) |
| ZA (1) | ZA200604553B (hr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| CA2519287A1 (en) | 2003-03-27 | 2004-10-14 | Bioactis Limited | Powder medicine applicator for nasal cavity |
| US8673360B2 (en) | 2004-08-10 | 2014-03-18 | Shin Nippon Biomedical Laboratories, Ltd. | Compositions that enable rapid-acting and highly absorptive intranasal administration |
| US7868016B2 (en) | 2005-07-13 | 2011-01-11 | Baxter International Inc. | Pharmaceutical formulations of endo-N-(9-methyl-9-azabicyclo[3,3.1]non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride |
| DE112005003703T5 (de) * | 2005-09-23 | 2008-07-10 | Amphenol Phoenix Co., Ltd., Hwaseong | Öffnungs- und Schließvorrichtung in Gleitbauweise zur Verwendung in Mobiltelefonen |
| JP5362360B2 (ja) * | 2005-10-11 | 2013-12-11 | イッサム リサーチ ディヴェロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 経鼻投与用組成物 |
| CN101668544B (zh) | 2006-12-26 | 2013-04-24 | 株式会社新日本科学 | 经鼻投用制剂 |
| EP2429495A4 (en) * | 2009-05-15 | 2014-01-22 | Shin Nippon Biomedical Lab Ltd | INTRANASAL PHARMACEUTICAL COMPOSITIONS WITH ENHANCED PHARMACOKINETICS |
| WO2011013003A2 (en) * | 2009-07-31 | 2011-02-03 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal granisetron and nasal applicator |
| KR101368587B1 (ko) | 2010-12-27 | 2014-03-05 | 주식회사 삼양바이오팜 | 오심 또는 구토 방지용 조성물 |
| JP6081102B2 (ja) * | 2012-08-10 | 2017-02-15 | テルモ株式会社 | 安定なグラニセトロン含有水性製剤 |
| US10335398B2 (en) | 2015-04-08 | 2019-07-02 | Maxinase Life Sciences Limited | Bioadhesive compositions for intranasal administration of granisetron |
| WO2017123744A1 (en) * | 2016-01-12 | 2017-07-20 | Grace Therapeutics Llc | Betamethasone oral spray formulation and method of use to treat ataxia |
| US11744967B2 (en) | 2017-09-26 | 2023-09-05 | Shin Nippon Biomedical Laboratories, Ltd. | Intranasal delivery devices |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2004270A1 (en) | 1988-12-29 | 1990-06-29 | William R. Michael | Perfume microcapsules for use in granular detergent compositions |
| CA2042529C (en) | 1990-08-10 | 2002-07-30 | Chokyun Rha | Polysaccharide article and uses therefor |
| US5929059A (en) | 1991-01-19 | 1999-07-27 | Smithkline Beecham P.L.C. | Pharmaceutical compositions containing granisetron and dexamethasone |
| GB9305593D0 (en) | 1993-03-18 | 1993-05-05 | Smithkline Beecham Plc | Pharmaceuticals |
| US5897858A (en) * | 1994-02-03 | 1999-04-27 | Schering-Plough Healthcare Products, Inc. | Nasal spray compositions exhibiting increased retention in the nasal cavity |
| GB9406171D0 (en) | 1994-03-29 | 1994-05-18 | Electrosols Ltd | Dispensing device |
| HRP950149A2 (en) | 1994-04-13 | 1997-06-30 | Janssen Pharmaceutica Nv | Intranasal antimigrene composition |
| GB9414966D0 (en) | 1994-07-26 | 1994-09-14 | Danbiosyst Uk | Pharmaceutical compositions for the nasal administration of antiviral agents |
| GB9700624D0 (en) | 1997-01-14 | 1997-03-05 | Danbiosyst Uk | Drug delivery composition |
| GB9713980D0 (en) | 1997-07-03 | 1997-09-10 | Danbiosyst Uk | New conjugates |
| US20020132803A1 (en) * | 2001-01-05 | 2002-09-19 | Mahendra Dedhiya | Fluticasone suspension formulation, spray pattern method, and nasal spray apparatus |
| JP2002255795A (ja) * | 2001-02-26 | 2002-09-11 | Teijin Ltd | 経鼻投与用組成物 |
| US20030044356A1 (en) * | 2001-04-20 | 2003-03-06 | Jin Auh | Composition for nasal solution sprays having effective component of 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one) |
| US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| CN1289085C (zh) * | 2002-04-26 | 2006-12-13 | 中国人民解放军军事医学科学院毒物药物研究所 | 鼻腔喷雾剂 |
| CN1332664C (zh) * | 2002-04-26 | 2007-08-22 | 中国人民解放军军事医学科学院毒物药物研究所 | 鼻粉剂 |
| GB0329918D0 (en) | 2003-12-24 | 2004-01-28 | West Pharm Serv Drug Res Ltd | Intranasal compositions |
-
2003
- 2003-12-05 GB GBGB0328186.2A patent/GB0328186D0/en not_active Ceased
-
2004
- 2004-11-30 SI SI200431395T patent/SI1696911T1/sl unknown
- 2004-11-30 KR KR1020067013467A patent/KR101194593B1/ko not_active IP Right Cessation
- 2004-11-30 CN CN2011102427243A patent/CN102389422A/zh active Pending
- 2004-11-30 RS RSP-2010/0211A patent/RS51251B/sr unknown
- 2004-11-30 CN CNA2004800398583A patent/CN1901905A/zh active Pending
- 2004-11-30 CA CA2548559A patent/CA2548559C/en not_active Expired - Fee Related
- 2004-11-30 AT AT04798713T patent/ATE460932T1/de active
- 2004-11-30 BR BRPI0417350-3A patent/BRPI0417350A2/pt not_active Application Discontinuation
- 2004-11-30 WO PCT/GB2004/005043 patent/WO2005056008A1/en active Application Filing
- 2004-11-30 JP JP2006542003A patent/JP5103018B2/ja not_active Expired - Fee Related
- 2004-11-30 DE DE602004026107T patent/DE602004026107D1/de active Active
- 2004-11-30 NZ NZ547848A patent/NZ547848A/en not_active IP Right Cessation
- 2004-11-30 ES ES04798713T patent/ES2357607T3/es active Active
- 2004-11-30 DK DK04798713.6T patent/DK1696911T3/da active
- 2004-11-30 EP EP04798713A patent/EP1696911B1/en active Active
- 2004-11-30 MX MXPA06006239A patent/MXPA06006239A/es active IP Right Grant
- 2004-11-30 PL PL04798713T patent/PL1696911T3/pl unknown
- 2004-11-30 AU AU2004296586A patent/AU2004296586B2/en not_active Ceased
- 2004-11-30 ME MEP-2010-80A patent/ME01070B/me unknown
- 2004-11-30 PT PT04798713T patent/PT1696911E/pt unknown
- 2004-12-03 US US11/004,556 patent/US7947257B2/en not_active Expired - Fee Related
-
2006
- 2006-06-02 NO NO20062548A patent/NO335348B1/no not_active IP Right Cessation
- 2006-06-02 ZA ZA200604553A patent/ZA200604553B/xx unknown
- 2006-06-05 IL IL176132A patent/IL176132A/en not_active IP Right Cessation
-
2010
- 2010-06-11 CY CY20101100528T patent/CY1110664T1/el unknown
- 2010-06-17 HR HR20100343T patent/HRP20100343T1/hr unknown
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