HRP20100276T1 - Gaboksadol za liječenje depresije i drugih afektivnih poremećaja - Google Patents
Gaboksadol za liječenje depresije i drugih afektivnih poremećaja Download PDFInfo
- Publication number
- HRP20100276T1 HRP20100276T1 HR20100276T HRP20100276T HRP20100276T1 HR P20100276 T1 HRP20100276 T1 HR P20100276T1 HR 20100276 T HR20100276 T HR 20100276T HR P20100276 T HRP20100276 T HR P20100276T HR P20100276 T1 HRP20100276 T1 HR P20100276T1
- Authority
- HR
- Croatia
- Prior art keywords
- gaboxadol
- treating depression
- pharmaceutical composition
- oral dose
- affective disorders
- Prior art date
Links
- ZXRVKCBLGJOCEE-UHFFFAOYSA-N Gaboxadol Chemical compound C1NCCC2=C1ONC2=O ZXRVKCBLGJOCEE-UHFFFAOYSA-N 0.000 title claims abstract 10
- 229950004346 gaboxadol Drugs 0.000 title claims abstract 10
- 208000019022 Mood disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 208000020401 Depressive disease Diseases 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 150000004682 monohydrates Chemical class 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48301903P | 2003-06-25 | 2003-06-25 | |
DKPA200300956 | 2003-06-25 | ||
US53512304P | 2004-01-07 | 2004-01-07 | |
DKPA200400016 | 2004-01-07 | ||
PCT/DK2004/000459 WO2004112786A2 (en) | 2003-06-25 | 2004-06-25 | Gaboxadol for treating depression and other affective disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20100276T1 true HRP20100276T1 (hr) | 2010-06-30 |
Family
ID=33545397
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20100276T HRP20100276T1 (hr) | 2003-06-25 | 2010-05-18 | Gaboksadol za liječenje depresije i drugih afektivnih poremećaja |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP2145620A3 (de) |
JP (1) | JP2007508236A (de) |
AT (1) | ATE459353T1 (de) |
AU (1) | AU2004248890A1 (de) |
BR (1) | BRPI0410857A (de) |
CY (1) | CY1110046T1 (de) |
DE (1) | DE602004025808D1 (de) |
DK (1) | DK1641456T3 (de) |
ES (1) | ES2341004T3 (de) |
HR (1) | HRP20100276T1 (de) |
IL (2) | IL172631A0 (de) |
MX (1) | MXPA05013016A (de) |
NZ (1) | NZ543586A (de) |
PL (1) | PL1641456T3 (de) |
PT (1) | PT1641456E (de) |
SI (1) | SI1641456T1 (de) |
WO (1) | WO2004112786A2 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070032553A1 (en) * | 2003-09-10 | 2007-02-08 | Mckernan Ruth | Use of gabaa receptor agonists for the treatment of hearing, vestibular and attention disorders, intention tremor and restless leg syndrome |
PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
GB0402118D0 (en) * | 2004-01-30 | 2004-03-03 | Merck Sharp & Dohme | Polymorphic forms of a GABAA agonist |
DE602005018763D1 (de) | 2004-02-18 | 2010-02-25 | Sepracor Inc | Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität |
GB0417558D0 (en) * | 2004-08-06 | 2004-09-08 | Merck Sharp & Dohme | Novel combination therapy |
EP2292222A1 (de) | 2005-01-28 | 2011-03-09 | H. Lundbeck A/S | Polymorphe Formen eines GABAA-Agonisten |
EP1906953A4 (de) * | 2005-04-29 | 2009-05-20 | Lundbeck & Co As H | Säure- und basensalzformen von gaboxadol |
TW200920358A (en) * | 2007-08-13 | 2009-05-16 | Lundbeck & Co As H | Method of treating stress-mediated depression |
US20090143335A1 (en) * | 2007-10-29 | 2009-06-04 | H. Lundbeck A/S | Modified absorption formulation of gaboxadol |
CA2732636A1 (en) * | 2008-09-01 | 2009-05-07 | H. Lundbeck A/S | Pharmaceutical composition comprising gaboxadol and an inhibitor of pat1 or oat |
EP3274331B1 (de) | 2015-03-24 | 2020-02-26 | H. Lundbeck A/S | Herstellung von 4,5,6,7-tetrahydroisozaxolo[5,4-c]pyridin-3-ol |
AU2017363598A1 (en) * | 2016-11-22 | 2019-05-23 | Ovid Therapeutics Inc. | Methods of treating developmental disorders and/or seizure disorders with flupirtine |
US20180338959A1 (en) * | 2017-05-24 | 2018-11-29 | Ovid Therapeutics Inc. | Treatment of depressive disorders |
KR20210039324A (ko) * | 2018-04-06 | 2021-04-09 | 오비드 테라퓨틱스 인크. | 물질 사용 장애들의 치료에서 가복사돌의 사용 |
MX2021003302A (es) | 2018-09-20 | 2021-05-13 | Ovid Therapeutics Inc | Uso de gaboxadol para el tratamiento del sindrome de tourette, los tics y la tartamudez. |
CN114072154B (zh) * | 2018-11-21 | 2024-03-08 | 塞迪戈Abc有限责任公司 | 用于治疗精神障碍的加波沙朵和锂的组合物 |
KR20210110585A (ko) | 2018-11-21 | 2021-09-08 | 썰테고 테라퓨틱스 아이엔씨. | 자살의 위험을 감소시키고 우울증의 신속한 완화를 위한 가복사돌 |
KR20210105387A (ko) | 2018-12-17 | 2021-08-26 | 오비드 테라퓨틱스 인크. | 비-24 시간 수면-각성 장애의 치료를 위한 가복사돌의 사용 |
AU2020405060A1 (en) | 2019-12-18 | 2022-06-09 | Ovid Therapeutics Inc. | Gaboxadol for therapeutic treatment of 1p36 deletion syndrome |
EP4153549A2 (de) | 2020-05-20 | 2023-03-29 | Certego Therapeutics Inc. | Ringdeuteriertes gaboxadol und seine verwendung zur behandlung von psychiatrischen erkrankungen |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK270278A (da) | 1977-06-20 | 1978-12-21 | Krogsgaard Larsen P | Cycliske aminosyrer |
DE19525598C2 (de) | 1995-07-13 | 1997-09-25 | Max Planck Gesellschaft | Schlafmittel |
AR031473A1 (es) * | 2000-11-20 | 2003-09-24 | Lundbeck & Co As H | Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide |
US20020165217A1 (en) * | 2001-05-01 | 2002-11-07 | Pfizer Inc. | Combination treatment for anxiety and depression |
CA2447603A1 (en) | 2001-05-21 | 2002-11-28 | H. Lundbeck A/S | Granular preparations of gaboxadol |
-
2004
- 2004-06-25 PL PL04738956T patent/PL1641456T3/pl unknown
- 2004-06-25 EP EP09173892A patent/EP2145620A3/de not_active Withdrawn
- 2004-06-25 BR BRPI0410857-4A patent/BRPI0410857A/pt not_active IP Right Cessation
- 2004-06-25 ES ES04738956T patent/ES2341004T3/es not_active Expired - Lifetime
- 2004-06-25 EP EP04738956A patent/EP1641456B1/de not_active Expired - Lifetime
- 2004-06-25 WO PCT/DK2004/000459 patent/WO2004112786A2/en active Application Filing
- 2004-06-25 DK DK04738956.4T patent/DK1641456T3/da active
- 2004-06-25 AT AT04738956T patent/ATE459353T1/de not_active IP Right Cessation
- 2004-06-25 SI SI200431414T patent/SI1641456T1/sl unknown
- 2004-06-25 DE DE602004025808T patent/DE602004025808D1/de not_active Expired - Lifetime
- 2004-06-25 AU AU2004248890A patent/AU2004248890A1/en not_active Abandoned
- 2004-06-25 PT PT04738956T patent/PT1641456E/pt unknown
- 2004-06-25 MX MXPA05013016A patent/MXPA05013016A/es active IP Right Grant
- 2004-06-25 NZ NZ543586A patent/NZ543586A/en unknown
- 2004-06-25 JP JP2006515735A patent/JP2007508236A/ja active Pending
-
2005
- 2005-12-15 IL IL172631A patent/IL172631A0/en unknown
-
2009
- 2009-11-12 IL IL202106A patent/IL202106A0/en unknown
-
2010
- 2010-05-14 CY CY20101100433T patent/CY1110046T1/el unknown
- 2010-05-18 HR HR20100276T patent/HRP20100276T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
EP2145620A3 (de) | 2010-03-17 |
WO2004112786A3 (en) | 2005-04-14 |
EP1641456B1 (de) | 2010-03-03 |
ES2341004T3 (es) | 2010-06-14 |
IL202106A0 (en) | 2010-06-16 |
SI1641456T1 (sl) | 2010-06-30 |
JP2007508236A (ja) | 2007-04-05 |
PL1641456T3 (pl) | 2010-08-31 |
MXPA05013016A (es) | 2006-03-02 |
WO2004112786A2 (en) | 2004-12-29 |
ATE459353T1 (de) | 2010-03-15 |
CY1110046T1 (el) | 2015-01-14 |
IL172631A0 (en) | 2006-04-10 |
AU2004248890A1 (en) | 2004-12-29 |
NZ543586A (en) | 2009-07-31 |
EP2145620A2 (de) | 2010-01-20 |
DK1641456T3 (da) | 2010-06-21 |
DE602004025808D1 (de) | 2010-04-15 |
BRPI0410857A (pt) | 2006-07-04 |
PT1641456E (pt) | 2010-06-01 |
EP1641456A2 (de) | 2006-04-05 |
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