WO2005121074A3 - Processes for the preparation of sertraline hydrochloride - Google Patents

Processes for the preparation of sertraline hydrochloride Download PDF

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Publication number
WO2005121074A3
WO2005121074A3 PCT/IB2005/051911 IB2005051911W WO2005121074A3 WO 2005121074 A3 WO2005121074 A3 WO 2005121074A3 IB 2005051911 W IB2005051911 W IB 2005051911W WO 2005121074 A3 WO2005121074 A3 WO 2005121074A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
processes
sertraline hydrochloride
sertraline
schiff
Prior art date
Application number
PCT/IB2005/051911
Other languages
French (fr)
Other versions
WO2005121074A2 (en
Inventor
Kintali Venkata Ramana
Kaptan Singh
Mohan Prasad
Keshav Deo
Yatendra Kumar
Original Assignee
Ranbaxy Lab Ltd
Kintali Venkata Ramana
Kaptan Singh
Mohan Prasad
Keshav Deo
Yatendra Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Kintali Venkata Ramana, Kaptan Singh, Mohan Prasad, Keshav Deo, Yatendra Kumar filed Critical Ranbaxy Lab Ltd
Publication of WO2005121074A2 publication Critical patent/WO2005121074A2/en
Publication of WO2005121074A3 publication Critical patent/WO2005121074A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to processes for the preparation of Schiff's base, and to the use of Schiff's base as intermediate in the preparation of naphthalenamine derivatives which are active compounds for treating the anxiety related disorders. The invention also relates to processes for the preparation of sertraline or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions that include the sertraline.
PCT/IB2005/051911 2004-06-09 2005-06-09 Processes for the preparation of sertraline hydrochloride WO2005121074A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1085DE2004 2004-06-09
IN1085/DEL/2004 2004-06-09
IN1394/DEL/2004 2004-07-28
IN1394DE2004 2004-07-28

Publications (2)

Publication Number Publication Date
WO2005121074A2 WO2005121074A2 (en) 2005-12-22
WO2005121074A3 true WO2005121074A3 (en) 2006-05-18

Family

ID=34970662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/051911 WO2005121074A2 (en) 2004-06-09 2005-06-09 Processes for the preparation of sertraline hydrochloride

Country Status (1)

Country Link
WO (1) WO2005121074A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119247A2 (en) * 2006-04-17 2007-10-25 Unichem Laboratories Limited Improved manufacturing procedure for the preparation of polymorphic form ii of cis-(1s)-n-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthleneamine hydrochloride (sertraline hydrochloride)
CN101462964A (en) * 2007-12-19 2009-06-24 北京德众万全药物技术开发有限公司 Preparation of sertraline key intermediate
CN104826619A (en) * 2015-05-08 2015-08-12 广州研创生物技术发展有限公司 Application of bonded 3,5-dimethylcarbaniloylated beta-cyclodextrin chiral stationary phase in chiral analysis and/or separation of sertraline hydrochloride intermediate (+/-)-Tetralone

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341015A2 (en) * 1988-05-04 1989-11-08 Pfizer Inc. Improved process for preparing a ketimine
WO2001068566A1 (en) * 2000-03-14 2001-09-20 Teva Pharmaceutical Industries Ltd. Novel process for preparing (+)-cis-sertraline
WO2002102761A1 (en) * 2001-06-15 2002-12-27 Orion Corporation Fermion A novel process for the preparation of (is-cis) -4-(3, 4-dichlorophenyl) -1, 2, 3, 4 - tetrahydro-n-methyl-1-naphthalenamine
WO2003093217A1 (en) * 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341015A2 (en) * 1988-05-04 1989-11-08 Pfizer Inc. Improved process for preparing a ketimine
WO2001068566A1 (en) * 2000-03-14 2001-09-20 Teva Pharmaceutical Industries Ltd. Novel process for preparing (+)-cis-sertraline
WO2002102761A1 (en) * 2001-06-15 2002-12-27 Orion Corporation Fermion A novel process for the preparation of (is-cis) -4-(3, 4-dichlorophenyl) -1, 2, 3, 4 - tetrahydro-n-methyl-1-naphthalenamine
WO2003093217A1 (en) * 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Process for preparation of polymorphic form ii of sertraline hydrochloride, pharmaceutical formulations and methods of administration thereof

Also Published As

Publication number Publication date
WO2005121074A2 (en) 2005-12-22

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