HRP20100258T1 - Heksahidro ciklooktil pirazol kanabinoidni modulatori - Google Patents
Heksahidro ciklooktil pirazol kanabinoidni modulatori Download PDFInfo
- Publication number
- HRP20100258T1 HRP20100258T1 HR20100258T HRP20100258T HRP20100258T1 HR P20100258 T1 HRP20100258 T1 HR P20100258T1 HR 20100258 T HR20100258 T HR 20100258T HR P20100258 T HRP20100258 T HR P20100258T HR P20100258 T1 HRP20100258 T1 HR P20100258T1
- Authority
- HR
- Croatia
- Prior art keywords
- halogen
- optionally substituted
- hydroxy
- absent
- alkyl
- Prior art date
Links
- NNRSEKSIYNJCLU-UHFFFAOYSA-N 5-cyclooctyl-1h-pyrazole Chemical compound C1CCCCCCC1C1=NNC=C1 NNRSEKSIYNJCLU-UHFFFAOYSA-N 0.000 title 1
- 229930003827 cannabinoid Natural products 0.000 title 1
- 239000003557 cannabinoid Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 claims abstract 66
- 150000002367 halogens Chemical class 0.000 claims abstract 66
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 60
- 125000000217 alkyl group Chemical group 0.000 claims abstract 54
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 48
- 125000003118 aryl group Chemical group 0.000 claims abstract 44
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract 38
- 150000001875 compounds Chemical class 0.000 claims abstract 37
- 150000003839 salts Chemical class 0.000 claims abstract 20
- 125000002947 alkylene group Chemical group 0.000 claims abstract 17
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 12
- 239000001257 hydrogen Substances 0.000 claims abstract 12
- 125000004103 aminoalkyl group Chemical group 0.000 claims abstract 10
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 10
- 150000002431 hydrogen Chemical class 0.000 claims abstract 7
- 125000001118 alkylidene group Chemical group 0.000 claims abstract 6
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 claims abstract 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims abstract 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 10
- 125000005102 carbonylalkoxy group Chemical group 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- -1 carboxy, carbonyl Chemical group 0.000 claims 6
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 5
- 125000004104 aryloxy group Chemical group 0.000 claims 5
- 125000005242 carbamoyl alkyl group Chemical group 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 239000003433 contraceptive agent Substances 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 230000002254 contraceptive effect Effects 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 229940125425 inverse agonist Drugs 0.000 claims 4
- 208000011580 syndromic disease Diseases 0.000 claims 4
- 102000009132 CB1 Cannabinoid Receptor Human genes 0.000 claims 3
- 108010073366 CB1 Cannabinoid Receptor Proteins 0.000 claims 3
- 102000018208 Cannabinoid Receptor Human genes 0.000 claims 3
- 108050007331 Cannabinoid receptor Proteins 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000006872 improvement Effects 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical group C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 230000001773 anti-convulsant effect Effects 0.000 claims 2
- 239000001961 anticonvulsive agent Substances 0.000 claims 2
- 230000036528 appetite Effects 0.000 claims 2
- 235000019789 appetite Nutrition 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 230000004060 metabolic process Effects 0.000 claims 2
- 239000000583 progesterone congener Substances 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- MNHBMBLQTYNCLS-SXKRPYPPSA-N (9e)-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-n-[(1r)-1-phenylethyl]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound N([C@H](C)C=1C=CC=CC=1)C(=O)C1=NN(C=2C(=CC(Cl)=CC=2)Cl)C2=C1CCCCC\C2=C/C1=CC=C(F)C=C1 MNHBMBLQTYNCLS-SXKRPYPPSA-N 0.000 claims 1
- JXIBYNYOXLGQRZ-OXMAITBSSA-N (9e)-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-n-[(1r)-1-pyridin-2-ylethyl]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound N([C@H](C)C=1N=CC=CC=1)C(=O)C1=NN(C=2C(=CC(Cl)=CC=2)Cl)C2=C1CCCCC\C2=C/C1=CC=C(F)C=C1 JXIBYNYOXLGQRZ-OXMAITBSSA-N 0.000 claims 1
- MNHBMBLQTYNCLS-KNOQIOAQSA-N (9e)-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-n-[(1s)-1-phenylethyl]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound N([C@@H](C)C=1C=CC=CC=1)C(=O)C1=NN(C=2C(=CC(Cl)=CC=2)Cl)C2=C1CCCCC\C2=C/C1=CC=C(F)C=C1 MNHBMBLQTYNCLS-KNOQIOAQSA-N 0.000 claims 1
- NIHUXQKCSPXBKR-LVZFUZTISA-N (9e)-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-n-piperidin-1-yl-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound C1=CC(F)=CC=C1\C=C/1C(N(N=C2C(=O)NN3CCCCC3)C=3C(=CC(Cl)=CC=3)Cl)=C2CCCCC\1 NIHUXQKCSPXBKR-LVZFUZTISA-N 0.000 claims 1
- YPDNHQRYJSSZOF-NBVRZTHBSA-N (9e)-n',1-bis(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carbohydrazide Chemical compound C1=CC(F)=CC=C1\C=C/1C(N(N=C2C(=O)NNC=3C(=CC(Cl)=CC=3)Cl)C=3C(=CC(Cl)=CC=3)Cl)=C2CCCCC\1 YPDNHQRYJSSZOF-NBVRZTHBSA-N 0.000 claims 1
- OWGJZOMZWAGXRN-HMMYKYKNSA-N (9e)-n-(3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl)-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound C1=CC(F)=CC=C1\C=C/1C(N(N=C2C(=O)NN3CC4CCCC4C3)C=3C(=CC(Cl)=CC=3)Cl)=C2CCCCC\1 OWGJZOMZWAGXRN-HMMYKYKNSA-N 0.000 claims 1
- ITQYXNBKWNXDRL-SXKRPYPPSA-N (9e)-n-[(1r)-1-cyclohexylethyl]-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound N([C@H](C)C1CCCCC1)C(=O)C1=NN(C=2C(=CC(Cl)=CC=2)Cl)C2=C1CCCCC\C2=C/C1=CC=C(F)C=C1 ITQYXNBKWNXDRL-SXKRPYPPSA-N 0.000 claims 1
- ITQYXNBKWNXDRL-KNOQIOAQSA-N (9e)-n-[(1s)-1-cyclohexylethyl]-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazole-3-carboxamide Chemical compound N([C@@H](C)C1CCCCC1)C(=O)C1=NN(C=2C(=CC(Cl)=CC=2)Cl)C2=C1CCCCC\C2=C/C1=CC=C(F)C=C1 ITQYXNBKWNXDRL-KNOQIOAQSA-N 0.000 claims 1
- JXJUOZBHERCWDJ-UHFFFAOYSA-N 1-cyclohexyl-n-(2,2,4-trimethyl-3-bicyclo[2.2.1]heptanyl)-4,5,6,7,8,9-hexahydrocycloocta[c]pyrazole-3-carboxamide Chemical compound C1C2(C)CCC1C(C)(C)C2NC(=O)C(C=1CCCCCCC=11)=NN1C1CCCCC1 JXJUOZBHERCWDJ-UHFFFAOYSA-N 0.000 claims 1
- 102000009135 CB2 Cannabinoid Receptor Human genes 0.000 claims 1
- 108010073376 CB2 Cannabinoid Receptor Proteins 0.000 claims 1
- 102100033868 Cannabinoid receptor 1 Human genes 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000007101 Muscle Cramp Diseases 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- CXOFVDLJLONNDW-UHFFFAOYSA-N Phenytoin Chemical compound N1C(=O)NC(=O)C1(C=1C=CC=CC=1)C1=CC=CC=C1 CXOFVDLJLONNDW-UHFFFAOYSA-N 0.000 claims 1
- 208000005392 Spasm Diseases 0.000 claims 1
- SPKANWAMBRARSP-LVZFUZTISA-N [(9e)-1-(2,4-dichlorophenyl)-9-[(4-fluorophenyl)methylidene]-5,6,7,8-tetrahydro-4h-cycloocta[c]pyrazol-3-yl]-piperidin-1-ylmethanone Chemical compound C1=CC(F)=CC=C1\C=C/1C(N(N=C2C(=O)N3CCCCC3)C=3C(=CC(Cl)=CC=3)Cl)=C2CCCCC\1 SPKANWAMBRARSP-LVZFUZTISA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229940125681 anticonvulsant agent Drugs 0.000 claims 1
- 229960003965 antiepileptics Drugs 0.000 claims 1
- 229960000623 carbamazepine Drugs 0.000 claims 1
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000019771 cognition Effects 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 230000008602 contraction Effects 0.000 claims 1
- NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- VPYISQPGRNSXRT-UHFFFAOYSA-N ethyl 3-[(1-cyclohexyl-4,5,6,7,8,9-hexahydrocycloocta[c]pyrazole-3-carbonyl)amino]bicyclo[2.2.1]heptane-3-carboxylate Chemical compound C1C(C2)CCC2C1(C(=O)OCC)NC(=O)C(C=1CCCCCCC=11)=NN1C1CCCCC1 VPYISQPGRNSXRT-UHFFFAOYSA-N 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 229960002870 gabapentin Drugs 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 229960001848 lamotrigine Drugs 0.000 claims 1
- PYZRQGJRPPTADH-UHFFFAOYSA-N lamotrigine Chemical compound NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl PYZRQGJRPPTADH-UHFFFAOYSA-N 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 230000006742 locomotor activity Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- JUAASCSVJGFOKG-UHFFFAOYSA-N n-(1-adamantylmethyl)-1-cyclohexyl-4,5,6,7,8,9-hexahydrocycloocta[c]pyrazole-3-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13CNC(=O)C(C=1CCCCCCC=11)=NN1C1CCCCC1 JUAASCSVJGFOKG-UHFFFAOYSA-N 0.000 claims 1
- JCPDFDIHQOALNH-UHFFFAOYSA-N n-(1-adamantylmethyl)-1-cyclopentyl-4,5,6,7,8,9-hexahydrocycloocta[c]pyrazole-3-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13CNC(=O)C(C=1CCCCCCC=11)=NN1C1CCCC1 JCPDFDIHQOALNH-UHFFFAOYSA-N 0.000 claims 1
- TUKOQUXZXVOJHW-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-1-cyclohexyl-4,5,6,7,8,9-hexahydrocycloocta[c]pyrazole-3-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C(C=1CCCCCCC=11)=NN1C1CCCCC1 TUKOQUXZXVOJHW-UHFFFAOYSA-N 0.000 claims 1
- NYAGJMVAYPPWBV-UHFFFAOYSA-N n-[1-(1-adamantyl)ethyl]-1-cyclopentyl-4,5,6,7,8,9-hexahydrocycloocta[c]pyrazole-3-carboxamide Chemical compound C1C(C2)CC(C3)CC2CC13C(C)NC(=O)C(C=1CCCCCCC=11)=NN1C1CCCC1 NYAGJMVAYPPWBV-UHFFFAOYSA-N 0.000 claims 1
- 230000004112 neuroprotection Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229940127234 oral contraceptive Drugs 0.000 claims 1
- 239000003539 oral contraceptive agent Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229960002036 phenytoin Drugs 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 239000000779 smoke Substances 0.000 claims 1
- 201000009032 substance abuse Diseases 0.000 claims 1
- 231100000736 substance abuse Toxicity 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229960004394 topiramate Drugs 0.000 claims 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 1
- 229960000604 valproic acid Drugs 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71988405P | 2005-09-23 | 2005-09-23 | |
| PCT/US2006/037350 WO2007044215A1 (en) | 2005-09-23 | 2006-09-22 | Hexahydro cyclooctyl pyrazole cannabinoid modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100258T1 true HRP20100258T1 (hr) | 2010-06-30 |
Family
ID=37651059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100258T HRP20100258T1 (hr) | 2005-09-23 | 2010-05-10 | Heksahidro ciklooktil pirazol kanabinoidni modulatori |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US7851498B2 (zh) |
| EP (1) | EP1931335B1 (zh) |
| JP (1) | JP5162461B2 (zh) |
| KR (1) | KR20080066924A (zh) |
| CN (1) | CN101312725B (zh) |
| AT (1) | ATE458480T1 (zh) |
| AU (1) | AU2006302659A1 (zh) |
| BR (1) | BRPI0616401A2 (zh) |
| CA (1) | CA2623535A1 (zh) |
| CY (1) | CY1110020T1 (zh) |
| DE (1) | DE602006012514D1 (zh) |
| DK (1) | DK1931335T3 (zh) |
| EA (1) | EA200800889A1 (zh) |
| EC (1) | ECSP088315A (zh) |
| ES (1) | ES2340201T3 (zh) |
| HR (1) | HRP20100258T1 (zh) |
| IL (1) | IL190348A0 (zh) |
| MY (1) | MY148863A (zh) |
| NO (1) | NO20081950L (zh) |
| NZ (1) | NZ567006A (zh) |
| PL (1) | PL1931335T3 (zh) |
| PT (1) | PT1931335E (zh) |
| RS (1) | RS51298B (zh) |
| SI (1) | SI1931335T1 (zh) |
| UA (1) | UA93389C2 (zh) |
| WO (1) | WO2007044215A1 (zh) |
| ZA (1) | ZA200803533B (zh) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825151B2 (en) * | 2005-09-23 | 2010-11-02 | Janssen Pharmaceutica Nv | Hexahydro-cyclooctyl pyrazole cannabinoid modulators |
| US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| KR20090047458A (ko) | 2006-08-08 | 2009-05-12 | 사노피-아벤티스 | 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도 |
| CA2681384A1 (en) * | 2007-03-21 | 2008-09-25 | Janssen Pharmaceutica N.V. | Method for treating cb2 receptor mediated pain |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PT2963031T (pt) | 2007-11-30 | 2019-03-20 | Zynerba Pharmaceuticals Inc | Pró-fármacos de tetrahidrocanabinol, composições compreendendo pró-fármacos de tetrahidrocanabinol e métodos de utilização dos mesmos |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| ES2443016T3 (es) | 2009-08-26 | 2014-02-17 | Sanofi | Nuevos hidratos cristalinos de fluoroglicósidos heteroaromáticos, productos farmacéuticos que comprenden estos compuestos, y su empleo |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2948718A (en) | 1960-08-09 | New n-heterocyclic compounds | ||
| US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| PL124029B1 (en) | 1979-06-01 | 1982-12-31 | Wellcome Found | Process for preparing novel derivatives of 1,2,4-triazine |
| LU83729A1 (fr) | 1981-11-04 | 1983-09-01 | Galephar | Sels d'acide valproique,leur preparation et leur utilisation |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US5242942A (en) | 1992-04-28 | 1993-09-07 | Mcneilab, Inc. | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
| US5384327A (en) | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| FR2800375B1 (fr) * | 1999-11-03 | 2004-07-23 | Sanofi Synthelabo | Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
| FR2800372B1 (fr) * | 1999-11-03 | 2001-12-07 | Sanofi Synthelabo | Derives tricycliques d'acide 1-benzylpyrazole-3- carboxylique, leur preparation, les medicaments en contenant |
| JPWO2005063241A1 (ja) * | 2003-12-26 | 2007-07-19 | 小野薬品工業株式会社 | ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤 |
| CN1956964B (zh) | 2004-03-24 | 2011-06-15 | 詹森药业有限公司 | 四氢-吲唑大麻素调节剂 |
| FR2875230A1 (fr) * | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| BRPI0517378A (pt) | 2004-10-27 | 2008-10-07 | Janssen Pharmaceutica Nv | moduladores de tetraidro piridinil pirazol canabinóide |
-
2006
- 2006-09-22 UA UAA200803833A patent/UA93389C2/ru unknown
- 2006-09-22 US US11/525,573 patent/US7851498B2/en not_active Expired - Fee Related
- 2006-09-22 NZ NZ567006A patent/NZ567006A/en not_active IP Right Cessation
- 2006-09-22 CN CN200680043512XA patent/CN101312725B/zh not_active Expired - Fee Related
- 2006-09-22 ES ES06804133T patent/ES2340201T3/es active Active
- 2006-09-22 DK DK06804133.4T patent/DK1931335T3/da active
- 2006-09-22 JP JP2008532489A patent/JP5162461B2/ja not_active Expired - Fee Related
- 2006-09-22 AT AT06804133T patent/ATE458480T1/de active
- 2006-09-22 WO PCT/US2006/037350 patent/WO2007044215A1/en active Application Filing
- 2006-09-22 KR KR1020087009596A patent/KR20080066924A/ko not_active Application Discontinuation
- 2006-09-22 EP EP06804133A patent/EP1931335B1/en active Active
- 2006-09-22 MY MYPI20080784A patent/MY148863A/en unknown
- 2006-09-22 SI SI200630638T patent/SI1931335T1/sl unknown
- 2006-09-22 AU AU2006302659A patent/AU2006302659A1/en not_active Abandoned
- 2006-09-22 RS RSP-2010/0185A patent/RS51298B/sr unknown
- 2006-09-22 BR BRPI0616401-3A patent/BRPI0616401A2/pt not_active IP Right Cessation
- 2006-09-22 PL PL06804133T patent/PL1931335T3/pl unknown
- 2006-09-22 CA CA002623535A patent/CA2623535A1/en not_active Abandoned
- 2006-09-22 PT PT06804133T patent/PT1931335E/pt unknown
- 2006-09-22 EA EA200800889A patent/EA200800889A1/ru unknown
- 2006-09-22 DE DE602006012514T patent/DE602006012514D1/de active Active
-
2008
- 2008-03-20 IL IL190348A patent/IL190348A0/en unknown
- 2008-03-26 EC EC2008008315A patent/ECSP088315A/es unknown
- 2008-04-22 ZA ZA200803533A patent/ZA200803533B/xx unknown
- 2008-04-23 NO NO20081950A patent/NO20081950L/no not_active Application Discontinuation
-
2010
- 2010-05-07 CY CY20101100396T patent/CY1110020T1/el unknown
- 2010-05-10 HR HR20100258T patent/HRP20100258T1/hr unknown
- 2010-05-24 US US12/785,625 patent/US8101592B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007044215A1 (en) | 2007-04-19 |
| SI1931335T1 (sl) | 2010-06-30 |
| RS51298B (sr) | 2010-12-31 |
| CN101312725B (zh) | 2012-01-11 |
| DK1931335T3 (da) | 2010-06-07 |
| UA93389C2 (en) | 2011-02-10 |
| ES2340201T3 (es) | 2010-05-31 |
| CN101312725A (zh) | 2008-11-26 |
| EP1931335B1 (en) | 2010-02-24 |
| JP5162461B2 (ja) | 2013-03-13 |
| MY148863A (en) | 2013-06-14 |
| EA200800889A1 (ru) | 2008-12-30 |
| CA2623535A1 (en) | 2007-04-19 |
| US20100234331A1 (en) | 2010-09-16 |
| NZ567006A (en) | 2010-11-26 |
| AU2006302659A1 (en) | 2007-04-19 |
| ATE458480T1 (de) | 2010-03-15 |
| NO20081950L (no) | 2008-05-16 |
| US20070129417A1 (en) | 2007-06-07 |
| KR20080066924A (ko) | 2008-07-17 |
| CY1110020T1 (el) | 2015-01-14 |
| IL190348A0 (en) | 2009-09-22 |
| US7851498B2 (en) | 2010-12-14 |
| ZA200803533B (en) | 2009-10-28 |
| DE602006012514D1 (de) | 2010-04-08 |
| US8101592B2 (en) | 2012-01-24 |
| EP1931335A1 (en) | 2008-06-18 |
| BRPI0616401A2 (pt) | 2011-06-21 |
| JP2009509973A (ja) | 2009-03-12 |
| ECSP088315A (es) | 2008-04-28 |
| PL1931335T3 (pl) | 2010-07-30 |
| PT1931335E (pt) | 2010-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20100258T1 (hr) | Heksahidro ciklooktil pirazol kanabinoidni modulatori | |
| AU718763B2 (en) | 3-pyrazolecarboxamide derivatives having cannabinoid receptor affinity | |
| US8497285B2 (en) | Therapy of autoimmune colitis using a TIP60 inhibitor | |
| US8044088B2 (en) | 1-acetic acid-indole derivatives with PGD2 antagonist activity | |
| TWI409062B (zh) | 作為５-ｈｔ２ａ５-羥色胺受體之調節子而有用於與該受體有關的疾病之治療之３-苯基吡唑衍生物 | |
| ES2372307T3 (es) | Compuestos de pirazolina sustituida, su preparación y uso como medicamentos. | |
| JP2010523623A (ja) | Ｐ２ｘ７調節因子としてのピラゾール誘導体 | |
| TW200522944A (en) | CB1 modulator compounds | |
| CN105121429A (zh) | 补体途径调节剂和其用途 | |
| US11298346B2 (en) | Methods for treatment of fibrotic diseases | |
| ES2326357B1 (es) | Fase amorfa de una pirazolina sustituida, su preparacion y su uso como medicamento. | |
| CA2880542A1 (en) | Antibacterial protein kinase inhibitors | |
| RU2010109369A (ru) | Замещенные 5-винилфенил-1-фенилпиразолы в качестве модуляторов каннабиноидов | |
| ES2319074B1 (es) | Combinacion de principios activos. | |
| HRP20120159T1 (hr) | Modulatori heksahidro-cikloheptapirazol kanabinoida | |
| TW201446243A (zh) | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 | |
| JPH07504890A (ja) | Ｎｍｄａ拮抗剤の相乗効果 | |
| JP2019509987A (ja) | Ｅａａｔ３阻害剤としてのピラゾール−ピリジン誘導体 | |
| WO2020135569A1 (zh) | 乙二胺类化合物及其用途 | |
| TW589181B (en) | Lymphocytic activation inhibitor and remedial agent for autoimmune disease | |
| EP2989105A1 (en) | PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | |
| ES2316306B1 (es) | Combinacion de un compuesto de pirazolina sustituido y un farmaco utilizado en trastornos relacionados con los alimentos. | |
| JP2008535829A5 (zh) | ||
| ES2323403B1 (es) | Uso de compuestos de pirazolina sustituidos para la preparacion de medicamentos pediatricos. | |
| WO2004063201A1 (ja) | 統合失調症治療剤 |